| |
|
|
| Registros recuperados : 223 | |
| 121. |  | NEAL, A. L.; MCLAREN, T.; CAMPOLINO, M. L.; HUGHES, D.; COELHO, A. M.; LANA, U. G. de P.; GOMES, E. A.; SOUSA, S. M. de. Crop type exerts greater influence upon rhizosphere phosphohydrolase gene abundance and phylogenetic diversity than phosphorus fertilization. FEMS Microbiology Ecology, v. 97, fiab033, 2021.| Biblioteca(s): Embrapa Milho e Sorgo. |
|    |
| 122. | | SILVA, U. C.; LANA, U. G. de P.; GOMES, E. A.; CUADROS, S.; MEDEIROS, J. D.; OLIVEIRA-PAIVA, C. A.; SANTOS, V. L. dos. Comunidade bacteriana e fúngica da rizosfera de milho cultivado sob diferentes fontes de fosfato utilizando sequenciamento de nova geração. In: CONGRESSO NACIONAL DE MILHO E SORGO, 31., 2016, Bento Gonçalves. Milho e sorgo: inovações, mercados e segurança alimentar: anais. Sete Lagoas: Associação Brasileira de Milho e Sorgo, 2016.| Biblioteca(s): Embrapa Milho e Sorgo. |
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| 123. | | GOMES, E. A.; MARRIEL, I. E.; PARENTONI, S. N.; GUIMARAES, C. T.; OLIVEIRA-PAIVA, C. A.; LANA, U. G. de P.; SCHAFFERT, R. E.; ALVES, V. M. C. Comunidade de fungos micorrízicos associada a genótipos de milho contrastantes para eficiência no uso de fósforo. In: SIMPÓSIO SOBRE INOVAÇÃO E CRIATIVIDADE CIENTÍFICA NA EMBRAPA, 1., 2008, Brasília, DF. Resumos... Brasília, DF: Embrapa, 2008.| Biblioteca(s): Embrapa Milho e Sorgo. |
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| 124. | | TINOCO, C. F. D. S.; MAGALHAES, J. V. de; LANA, U. G. de P.; NODA, R. W.; SIMÕES, C. C.; GUIMARAES, C. T. Data mining and phylogeny to select candidate genes responsible for aluminum tolerance in maize. In: INTERNATIONAL CONFERENCE OF THE BRAZILIAN ASSOCIATION FOR BIOINFORMATICS AND COMPUTATIONAL BIOLOGY, 6., 2010, Ouro Preto. Abstracts... [S.l.: s.n.], 2010. p. 15. AB3C X-meeting 2010.| Biblioteca(s): Embrapa Milho e Sorgo. |
| |
| 127. | | VELLOSO, C. C. V.; GODINHO, B. T. V.; CARVALHO, C. G. de; OLIVEIRA-PAIVA, C. A.; GOMES, E. A.; LANA, U. G. de P.; SOUSA, S. M. de. Evaluation of two Bacillus strains for plant growth promotion in vitro. In: CONGRESSO INTERNACIONAL EM CIÊNCIAS, BIODIVERSIDADE E SUSTENTABILIDADE, 1., 2019, Belo Horizonte. Resumos. Belo Horizonte: Universidade Federal de Minas Gerais, 2019. SciBioSus - 2019.
Congress Science Biodiversity Sustainabilty.| Biblioteca(s): Embrapa Milho e Sorgo. |
| |
| 130. | | OLIVEIRA-PAIVA, C. A.; GOMES, E. A.; MARRIEL, I. E.; LANA, U. G. de P.; CARNEIRO, N. P.; GUIMARAES, C. T.; SCHAFFERT, R. E.; ALVES, V. M. C. Microrganismos solubilizadores de fosfato isolados da rizosfera de genótipos de milho em plantio direto e convencional. Sete Lagoas: Embrapa Milho e Sorgo, 2008. 21 p. (Embrapa Milho e Sorgo. Boletim de Pesquisa e Desenvolvimento, 04).| Biblioteca(s): Embrapa Milho e Sorgo. |
| |
| 131. | | OLIVEIRA-PAIVA, C. A.; ALVES, V. M. C.; GOMES, E. A.; SOUSA, S. M. de; LANA, U. G. de P.; MARRIEL, I. E. Microrganismos solubilizadores de fósforo e potássio na cultura da soja. In: MEYER, M. C.; BUENO, A. de F.; MAZARO, S. M.; SILVA, J. C. da (ed.). Bioinsumos na cultura da soja. Brasília, DF: Embrapa, 2022. p. 163-179.| Biblioteca(s): Embrapa Milho e Sorgo. |
| |
| 133. | | LIU, J.; MAGALHAES, J. V. de; GUIMARAES, C. T.; LANA, U. G. de P.; HOEKENGA, O.; SHAFF, J.; PINEROS, M.; WANG, Y.; SCHAFFERT, R. E.; KOCHIAN, L. Molecular cloning and characterization of AltSB, a major aluminum tolerance gene in sorghum. In: INTERNATIONAL PLANT & ANIMAL GENOMES CONFERENCE, 15., 2007, San Diego, CA. [Proceedings...]. [S. l.: s.n.], 2007.| Biblioteca(s): Embrapa Milho e Sorgo. |
| |
| 134. | | FIGUEIREDO, J. E. F.; GOMES, E. A.; GUIMARAES, C. T.; LANA, U. G. de P.; TEIXEIRA, M. A.; LIMA, G. V. C.; BRESSAN, W. Molecular analysis endophytic bacteria from the genus Bacillus isolated from tropical maize (Zea mays L.). Brazilian Journal of Microbiology, São Paulo, v. 40, n. 3, p. 522-534, 2009.| Biblioteca(s): Embrapa Milho e Sorgo. |
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| 140. | | TINOCO, C. F. da S.; MAGALHAES, J. V. de; LANA, U. G. de P.; BELICUAS, S. N. J.; PARENTONI, S. N.; GUIMARAES, L. J. M.; GUIMARAES, C. T. Obtenção de linhagens isogênicas para QTLs de tolerância ao alumínio em milho utilizando retrocruzamento assistido por marcadores. In: CONGRESSO NACIONAL DE MILHO E SORGO, 28.; SIMPÓSIO BRASILEIRO SOBRE A LAGARTA DO CARTUCHO, 4., 2010, Goiânia. Potencialidades, desafios e sustentabilidade: resumos expandidos... Sete Lagoas: ABMS, 2010. 1 CD-ROM.| Biblioteca(s): Embrapa Milho e Sorgo. |
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Registro Completo
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Biblioteca(s): |
Embrapa Milho e Sorgo. |
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Data corrente: |
12/08/2019 |
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Data da última atualização: |
24/01/2020 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 2 |
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Autoria: |
DOMINGUETEA, L. C. B.; LIMA, P. V. M.; NUNES, I. V.; SANDE, D.; LANA, U. G. de P.; MARRIEL, I. E.; TAKAHASHI, J. A. |
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Afiliação: |
Laura C. B. Dominguetea, Universidade Federal de Minas Gerais; Paulo V. M. Lima, Universidade Federal de Minas Gerais; Isabela V. Nunes, Universidade Federal de Minas Gerais; Denise Sande, Centro Universitário de Belo Horizonte; UBIRACI GOMES DE PAULA LANA, CNPMS; IVANILDO EVODIO MARRIEL, CNPMS; Jacqueline A. Takahashi, Universidade Federal de Minas Gerais. |
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Título: |
Epigenetic-induced production of promising food supplements ingredients with antioxidant and anti-acetylcholinesterase activities |
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Ano de publicação: |
2019 |
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Fonte/Imprenta: |
Chemical Engineering Transactions, v. 74, p. 331-336, 2019. |
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DOI: |
10.3303/CET1975056 |
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Idioma: |
Inglês |
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Conteúdo: |
Fungal metabolites with antioxidant and acetylcholinesterase inhibitory activities can be developed as food supplements helpful for treatment of neurodegenerative diseases, like Alzheimer's disease. Fungal biosynthesis depends on the expression of several enzymes that can change chromatin?s conformation, provoking activation or silencing of gene transcription. In this sense, the use of epigenetic modulators, able to alter chromatin?s conformation, has been a modern technique used to induce the expression of silenced genes in fungi. In the present study the metabolic profile and the antioxidant and anti-acetylcholinesterase activities of the extracts of Penicillium flavigenum (PF) and P. tanzanicum (PT) grown in the presence of epigenetic modulators were analyzed. The fungi were grown in liquid media, with or without (control) the epigenetic modulators azacytidine (AZA), hydralazine (HYDRA), procainamide (PRO), suberoyl hydroxamic acid (SAHA) and sodium butyrate (BUT) (500 uM). The modulators changed the expression of exogenous metabolites produced by the fungi with overexpression of some compounds in comparison to the controls, according to the HPLC chromatographic profiles. The treatment PF-SAHA presented the higher content of total phenolic compounds (27.86 mg GAE/g) (together with PF-HYDRA and PF-BUT) and the higher total antioxidant content (25.70 mg AAE/g). Besides, PF-SAHA and PF-PRO extracts presented higher antiacetylcholinesterase activity compared to others extracts. AZA was one of the most effective treatments for increasing expression of metabolites with antioxidant activity by P. tanzanicum in at least half of the assays. Treatments PT-AZA, PT-HYDRA and PT-BUT showed statistically similar anti-acetylcholinesterase activity, which were superior to the activity of the fungal control (15%). In overall, fermentative conditions using PFSAHA and PF-PRO showed to be the most favorable to produce new bioactive metabolites to be used as food supplements for palliative treatment or prevention of Alzheimer?s disease, while complete cure is not possible so far. MenosFungal metabolites with antioxidant and acetylcholinesterase inhibitory activities can be developed as food supplements helpful for treatment of neurodegenerative diseases, like Alzheimer's disease. Fungal biosynthesis depends on the expression of several enzymes that can change chromatin?s conformation, provoking activation or silencing of gene transcription. In this sense, the use of epigenetic modulators, able to alter chromatin?s conformation, has been a modern technique used to induce the expression of silenced genes in fungi. In the present study the metabolic profile and the antioxidant and anti-acetylcholinesterase activities of the extracts of Penicillium flavigenum (PF) and P. tanzanicum (PT) grown in the presence of epigenetic modulators were analyzed. The fungi were grown in liquid media, with or without (control) the epigenetic modulators azacytidine (AZA), hydralazine (HYDRA), procainamide (PRO), suberoyl hydroxamic acid (SAHA) and sodium butyrate (BUT) (500 uM). The modulators changed the expression of exogenous metabolites produced by the fungi with overexpression of some compounds in comparison to the controls, according to the HPLC chromatographic profiles. The treatment PF-SAHA presented the higher content of total phenolic compounds (27.86 mg GAE/g) (together with PF-HYDRA and PF-BUT) and the higher total antioxidant content (25.70 mg AAE/g). Besides, PF-SAHA and PF-PRO extracts presented higher antiacetylcholinesterase activity compared to others extract... Mostrar Tudo |
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Palavras-Chave: |
Doença neurodegenerativa. |
|
Thesagro: |
Enzima; Fungo. |
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Categoria do assunto: |
S Ciências Biológicas |
|
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/200582/1/Epigenetic-induced.pdf
|
|
Marc: |
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100 1 $aDOMINGUETEA, L. C. B.
245 $aEpigenetic-induced production of promising food supplements ingredients with antioxidant and anti-acetylcholinesterase activities$h[electronic resource]
260 $c2019
520 $aFungal metabolites with antioxidant and acetylcholinesterase inhibitory activities can be developed as food supplements helpful for treatment of neurodegenerative diseases, like Alzheimer's disease. Fungal biosynthesis depends on the expression of several enzymes that can change chromatin?s conformation, provoking activation or silencing of gene transcription. In this sense, the use of epigenetic modulators, able to alter chromatin?s conformation, has been a modern technique used to induce the expression of silenced genes in fungi. In the present study the metabolic profile and the antioxidant and anti-acetylcholinesterase activities of the extracts of Penicillium flavigenum (PF) and P. tanzanicum (PT) grown in the presence of epigenetic modulators were analyzed. The fungi were grown in liquid media, with or without (control) the epigenetic modulators azacytidine (AZA), hydralazine (HYDRA), procainamide (PRO), suberoyl hydroxamic acid (SAHA) and sodium butyrate (BUT) (500 uM). The modulators changed the expression of exogenous metabolites produced by the fungi with overexpression of some compounds in comparison to the controls, according to the HPLC chromatographic profiles. The treatment PF-SAHA presented the higher content of total phenolic compounds (27.86 mg GAE/g) (together with PF-HYDRA and PF-BUT) and the higher total antioxidant content (25.70 mg AAE/g). Besides, PF-SAHA and PF-PRO extracts presented higher antiacetylcholinesterase activity compared to others extracts. AZA was one of the most effective treatments for increasing expression of metabolites with antioxidant activity by P. tanzanicum in at least half of the assays. Treatments PT-AZA, PT-HYDRA and PT-BUT showed statistically similar anti-acetylcholinesterase activity, which were superior to the activity of the fungal control (15%). In overall, fermentative conditions using PFSAHA and PF-PRO showed to be the most favorable to produce new bioactive metabolites to be used as food supplements for palliative treatment or prevention of Alzheimer?s disease, while complete cure is not possible so far.
650 $aEnzima
650 $aFungo
653 $aDoença neurodegenerativa
700 1 $aLIMA, P. V. M.
700 1 $aNUNES, I. V.
700 1 $aSANDE, D.
700 1 $aLANA, U. G. de P.
700 1 $aMARRIEL, I. E.
700 1 $aTAKAHASHI, J. A.
773 $tChemical Engineering Transactions$gv. 74, p. 331-336, 2019.
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