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| 43. |  | RABEL, M.; VIEIRA, E. S. N.; LANA, U. G. de P.; PAIVA, E.; SEHNEM, M. A. S.; SCHUSTER, I. Marcadores moleculares microssatélites na avaliação de sementes de soja com variação na coloração do hilo. Revista Brasileira de Sementes, Londrina, v. 32, n. 2, p. 19-25, 2010.| Biblioteca(s): Embrapa Milho e Sorgo. |
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| 45. | | GOMES, E. A.; LANA, U. G. de P.; OLIVEIRA-PAIVA, C. A.; NODA, R. W.; ZHANG, B.; TIEDJE, J. Metagenoma das comunidades microbianas presentes na rizosfera e raízes de genótipos de milho contrastantes para eficiência no uso de P. In: CONGRESSO NACIONAL DE MILHO E SORGO, 30.; SIMPÓSIO SOBRE LEPDÓPTEROS COMUNS A MILHO, SOJA E ALGODÃO, 1., 2014, Salvador. Eficiência nas cadeias produtivas e o abastecimento global: resumos expandidos. Sete Lagoas: Associação Brasileira de Milho e Sorgo, 2014. 1 CD-ROM.| Biblioteca(s): Embrapa Milho e Sorgo. |
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| 46. | | RABEL, M.; GUIMARAES, C. T.; PARENTONI, S. N.; LANA, U. G. de P.; MAGALHAES, P. C.; PAIVA, E. Obtenção de genótipos de milho tropicais indutores de haploidia. In: CONGRESSO NACIONAL DE MILHO E SORGO, 27.; SIMPOSIO BRASILEIRO SOBRE A LAGARTA-DO-CARTUCHO, SPODOPTERA FRUGIPERDA, 3.; WORKSHOP SOBRE MANEJO E ETIOLOGIA DA MANCHA BRANCA DO MILHO, 2008, Londrina. Agroenergia, produção de alimentos e mudanças climáticas: desafios para milho e sorgo: trabalhos e palestras. [Londrina]: IAPAR; [Sete Lagoas]: Embrapa Milho e Sorgo, 2008. 1 CD-ROM.| Biblioteca(s): Embrapa Milho e Sorgo. |
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| 48. | | CAMPOLINO, M. L.; LANA, U. G. de P.; COELHO, A. M.; GOMES, E. A.; SOUSA, S. M. de. Phosphate fertilization impacts the structure of bacterial community of maize and sorghum rhizosphere In: CONGRESSO INTERNACIONAL EM CIÊNCIAS, BIODIVERSIDADE E SUSTENTABILIDADE, 1., 2019, Belo Horizonte. Resumos. Belo Horizonte: Universidade Federal de Minas Gerais, 2019. SciBioSus - 2019.
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| 54. | | DUARTE, J. M.; GUIMARAES, C. T.; LANA, U. G. de P.; PACHECO, C. A. P.; GUIMARAES, P. E.; PAIVA, E. Retrocruzamento assistido por marcadores moleculares para conversão de linhagem de milho normal em QPM. In: CONGRESSO BRASILEIRO DE MELHORAMENTO DE PLANTAS, 2., Porto Seguro, BA. Melhoramento e qualidade de vida. Porto Seguro: SBMP, 2003. 1 CD-ROM.| Biblioteca(s): Embrapa Milho e Sorgo. |
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| 56. | | GOMES, E. A.; SILVA, U. de C.; MARRIEL, I. E.; OLIVEIRA-PAIVA, C. A.; LANA, U. G. de P. Rock phosphate solubilizing microorganisms isolated from maize rhizosphere soil. Revista Brasileira de Milho e Sorgo, Sete Lagoas, v. 13, n. 1, p. 69-81, 2014.| Biblioteca(s): Embrapa Milho e Sorgo. |
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| 59. | | RIBEIRO, V. P.; GOMES, E. A.; SOUSA, S. M. de; LANA, U. G. de P.; COELHO, A. M.; MARRIEL, I. E.; OLIVEIRA-PAIVA, C. A. Co-inoculation with tropical strains of Azospirillum and Bacillus is more efficient than single inoculation for improving plant growth and nutrient uptake in maize. Archives of Microbiology, v. 204, article 143, 2022.| Biblioteca(s): Embrapa Milho e Sorgo. |
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Registro Completo
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Biblioteca(s): |
Embrapa Milho e Sorgo. |
|
Data corrente: |
12/08/2019 |
|
Data da última atualização: |
24/01/2020 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 2 |
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Autoria: |
OLIVEIRA, G. P.; LOPES, B. A.; MARRIEL, I. E.; LANA, U. G. de P.; TAKAHASHIA, J. A. |
|
Afiliação: |
Geane P. Oliveira, Universidade Fedral de Minas Gerais; Barbara O. Lopes, Universidade Fedral de Minas Gerais; IVANILDO EVODIO MARRIEL, CNPMS; UBIRACI GOMES DE PAULA LANA, CNPMS; Jacqueline A. Takahashia, Universidade Fedral de Minas Gerais. |
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Título: |
Design of intelligent molecules as models for production of new anti-Alzheimer's medicines using epigenetic modulation. |
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Ano de publicação: |
2019 |
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Fonte/Imprenta: |
Chemical Engineering Transactions, v. 74, p. 1561-1566, 2019. |
|
DOI: |
10.3303/CET1974261 |
|
Idioma: |
Inglês |
|
Conteúdo: |
Alzheimer's disease is a neurodegenerative illness, so far without cure, that affects an increasing number of people around the world. Due to the adverse effects caused by drugs for treating this disease currently in clinical use, it is necessary to search for more effective and less aggressive therapeutic resources. In this work a modern technological alternative was used to build new drugs useful for the treatment of Alzheimer's disease from fungi. This strategy consists on the development of pools of fungal molecules able of act in intelligent synergistic mechanisms to block acetylcholinesterase, enzyme involved in the development of Alzheimer's disease. Expression of pools containing new secondary metabolites can be achieved by adding DNA methyltransferase inhibitors to the fermentative process. This fast in vitro approach was used to build a combination of fungal metabolites containing acetylcholinesterase inhibitors. Biosynthesis elicitation was achieved by adding DNA methyltransferases inhibitors (hydralazine and procainamide) to solid culture media and then filamentous fungi Aspergillus chevalieri, Talaromyces calidicanius, Clonostachys rogersoniana, Fusarium nygamai, and Penicillium sp. were added. Straightforward HPLC analysis showed elicitation of new compounds by all species, being hydralazine the most effective epigenetic modifier especially towards T. calidicanius. Procainamide was able to enable expression of several major new secondary metabolites as for A. chevalieri (RT 51 min), and F. nygamai (RT 21.5 min). In general, the pools of molecules expressed after epigenetic modulation were more effective in acetylcholinesterase inhibition than the metabolites expressed without modulation. Modulation of C. rogersoniana by procainamide increased approximately four times the biosynthesis of antiacetylcholinesterase metabolites in relation to the control. T. calidicanius and Penicillium species modulated with procainamide produced a pool of metabolites about twice more active in regarding to the basal metabolome, while the pool of metabolites from C. rogersoniana and T. calidicanius were five and three times more active (40.34 ± 0.15% and 48.54 ± 1.34%, respectively) than the non-modulated extracts. MenosAlzheimer's disease is a neurodegenerative illness, so far without cure, that affects an increasing number of people around the world. Due to the adverse effects caused by drugs for treating this disease currently in clinical use, it is necessary to search for more effective and less aggressive therapeutic resources. In this work a modern technological alternative was used to build new drugs useful for the treatment of Alzheimer's disease from fungi. This strategy consists on the development of pools of fungal molecules able of act in intelligent synergistic mechanisms to block acetylcholinesterase, enzyme involved in the development of Alzheimer's disease. Expression of pools containing new secondary metabolites can be achieved by adding DNA methyltransferase inhibitors to the fermentative process. This fast in vitro approach was used to build a combination of fungal metabolites containing acetylcholinesterase inhibitors. Biosynthesis elicitation was achieved by adding DNA methyltransferases inhibitors (hydralazine and procainamide) to solid culture media and then filamentous fungi Aspergillus chevalieri, Talaromyces calidicanius, Clonostachys rogersoniana, Fusarium nygamai, and Penicillium sp. were added. Straightforward HPLC analysis showed elicitation of new compounds by all species, being hydralazine the most effective epigenetic modifier especially towards T. calidicanius. Procainamide was able to enable expression of several major new secondary metabolites as for A. c... Mostrar Tudo |
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Palavras-Chave: |
Doença neurodegenerativa; Moléculas fúngicas. |
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Thesagro: |
Doença; Fungo; Medicamento. |
|
Categoria do assunto: |
S Ciências Biológicas |
|
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/200581/1/Design-intelligent.pdf
|
|
Marc: |
LEADER 02999naa a2200241 a 4500
001 2111258
005 2020-01-24
008 2019 bl uuuu u00u1 u #d
024 7 $a10.3303/CET1974261$2DOI
100 1 $aOLIVEIRA, G. P.
245 $aDesign of intelligent molecules as models for production of new anti-Alzheimer's medicines using epigenetic modulation.$h[electronic resource]
260 $c2019
520 $aAlzheimer's disease is a neurodegenerative illness, so far without cure, that affects an increasing number of people around the world. Due to the adverse effects caused by drugs for treating this disease currently in clinical use, it is necessary to search for more effective and less aggressive therapeutic resources. In this work a modern technological alternative was used to build new drugs useful for the treatment of Alzheimer's disease from fungi. This strategy consists on the development of pools of fungal molecules able of act in intelligent synergistic mechanisms to block acetylcholinesterase, enzyme involved in the development of Alzheimer's disease. Expression of pools containing new secondary metabolites can be achieved by adding DNA methyltransferase inhibitors to the fermentative process. This fast in vitro approach was used to build a combination of fungal metabolites containing acetylcholinesterase inhibitors. Biosynthesis elicitation was achieved by adding DNA methyltransferases inhibitors (hydralazine and procainamide) to solid culture media and then filamentous fungi Aspergillus chevalieri, Talaromyces calidicanius, Clonostachys rogersoniana, Fusarium nygamai, and Penicillium sp. were added. Straightforward HPLC analysis showed elicitation of new compounds by all species, being hydralazine the most effective epigenetic modifier especially towards T. calidicanius. Procainamide was able to enable expression of several major new secondary metabolites as for A. chevalieri (RT 51 min), and F. nygamai (RT 21.5 min). In general, the pools of molecules expressed after epigenetic modulation were more effective in acetylcholinesterase inhibition than the metabolites expressed without modulation. Modulation of C. rogersoniana by procainamide increased approximately four times the biosynthesis of antiacetylcholinesterase metabolites in relation to the control. T. calidicanius and Penicillium species modulated with procainamide produced a pool of metabolites about twice more active in regarding to the basal metabolome, while the pool of metabolites from C. rogersoniana and T. calidicanius were five and three times more active (40.34 ± 0.15% and 48.54 ± 1.34%, respectively) than the non-modulated extracts.
650 $aDoença
650 $aFungo
650 $aMedicamento
653 $aDoença neurodegenerativa
653 $aMoléculas fúngicas
700 1 $aLOPES, B. A.
700 1 $aMARRIEL, I. E.
700 1 $aLANA, U. G. de P.
700 1 $aTAKAHASHIA, J. A.
773 $tChemical Engineering Transactions$gv. 74, p. 1561-1566, 2019.
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