Data/hora: 02/06/2024 00:02:34

Biblioteca(s): 	Embrapa Milho e Sorgo.	
Data corrente: 	21/07/2023	
Data da última atualização: 	02/09/2023	
Autoria: 	LÚCIO, H. G.; GRANCIERI, M.; MARTINEZ, O. D. M.; TOLEDO, R. C. L.; MENEZES, C. B. de; COSTA, N. M. B.; QUEIROZ, V. A. V.; SILVA, B. P. da; MARTINO, H. S. D.	
Afiliação: 	HAIRA GUEDES LÚCIO, Universidade Federal de Viçosa; MARIANA GRANCIERI, Universidade Federal do Espírito Santo; OSCAR DAVID MEDINA MARTINEZ, Universidade Federal de Viçosa; RENATA CELI LOPES TOLEDO, Universidade Federal de Viçosa; CICERO BESERRA DE MENEZES, CNPMS; NEUZA MARIA BRUNORO COSTA, Universidade Federal do Espírito Santo; VALERIA APARECIDA VIEIRA QUEIROZ, CNPMS; BARBARA PEREIRA DA SILVA, Universidade Federal de Viçosa; HERCIA STAMPINI DUARTE MARTINO, Universidade Federal de Viçosa.	
Título: 	Dry heat whole Sorghum BRS 305 flour modulate satiety and improves antioxidant response in brain of Wistar rats fed with high-fat high-fructose diet.	
Ano de publicação: 	2023	
Fonte/Imprenta: 	Food Research International, v. 173, 113252, 2023.	
DOI: 	https://doi.org/10.1016/j.foodres.2023.113252	
Idioma: 	Inglês	
Conteúdo: 	Sorghum BRS 305 (Sorghum bicolor L. Moench) is a cereal with high tannins and anthocyanins content and keep better the resistant starch when submitted to dry heat treatment. Our objective was to investigate the effects of BRS 305 dry heat treatment whole sorghum flour on satiety and antioxidant response in brain and adipose tissue of Wistar rats fed with a high fat high fructose diet (HFHF). Male Wistar rats were divided in two groups: control (n = 8) and HFHF (n = 16) for eight weeks. After, animals of HFHF group were divided: HFHF (n = 8) and HFHF + BRS 305 sorghum whole flour (n = 8), for 10 weeks. Sorghum consumption reduced gene expression of leptin, resistin, and endocannabinoid receptor 1 type (CB1) in adipose and brain tissues compared to HFHF group. In brain, sorghum consumption also promotes reduction in neuropeptide Y (NPY) gene expression. BRS305 sorghum consumption improved gene expression of sirtuin-1 (SIRT1) in adipose tissue, and in the brain increased heat shock protein 72 (HSP72), erythroid-derived nuclear factor 2 (NRF2), peroxisome proliferator-activated receptor alpha (PPAR&#945;), superoxide dismutase (SOD) and catalase activity compared to HFHF. In silico analysis showed interaction with PPAR&#945;, CB1, and leptin receptors. Advanced glycation end products (AGEs) concentrations in group HFHF + sorghum did not differ from HFHF group. Advanced glycation end products receptors (RAGEs) concentrations did not differ among experimental groups. Then, BRS 305 sorghum submitted to dry treatment was able to modulate gene expression of markers related to satiety and improve antioxidant capacity of rats fed with HFHF diet.	
Palavras-Chave: 	3-desoxiantocianinas; Atividade antioxidante.	
Thesagro: 	Antioxidante; Dieta; Farinha; Frutose; Gordura; Sorgo.	
Categoria do assunto: 	Q Alimentos e Nutrição Humana	
Registro original: 	Embrapa Milho e Sorgo (CNPMS)	
Exemplares: 	CNPMS - (30108-1) - UPC - AP - DD -  -  -  - DIS