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| 221. |  | TRIQUES, N. J.; NOGUEIRA, M. G.; LOCATELLI, C.; ROSA, G. B.; USINGER, F.; VIZZOTTO, R.; KRAMER, B.; CARDOSO, M.; FRANCISCON, L.; COLDEBELLA, A.; SILVA, V. S.; KICH, J. D. Prevalência de Salmonella em suínos criados em cama sobreposta nas fases de crescimento e terminação - resultados preliminares. In: CONGRESSO BRASILEIRO DE VETERINÁRIOS ESPECIALISTAS EM SUÍNOS, 13., 2007, Florianópolis. Anais... Concórdia: Embrapa Suínos e Aves, 2007. 1 CD-ROM. Projeto n. 03.04.35.100-02.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 222. | | FERREIRA, M. R. A.; FINGER, P. F.; MAGALHÃES, C. G.; CUNHA, C. E. P. da; MOREIRA JÚNIOR, C.; KICH, J. D.; MORES, M. A. Z.; MOREIRA, A. N.; DELLAGOSTIN, O. A.; CONCEIÇÃO, F. R. Protection efficacy of the rLTB-R1 chimera against experimental swine mycoplasmal pneumonia. Acta Scientiae Veterinária, v. 47, n. 1660, 2019.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 223. | | KLEIN, C. S.; REBELATTO, R.; MORES, N.; LOCATELLI, C.; BELLAVER, F. A. V.; MORES, M. A. Z.; GAVA, D.; SILVA, G. B.; KICH, J. D.; COLDEBELLA, A.; SILVA, V. S.; ZANELLA, J. R. C. Diagnostic methods to detect Mycoplasma hyopneumoniae in pig farms. In: SIMPÓSIO EMBRAPA LabEx EUA DE SANIDADE ANIMAL, 2., 2012, Brasília. Anais... Brasília: Embrapa Estudos e Capacitação, 2012. p. 72-73. Projeto/Plano de Ação: 03.09.00.046.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 224. | | DALLA COSTA, O. A.; LUDKE, J. V.; COLDEBELLA, A.; KICH, J. D.; COSTA, M. J. R. P. da; PELOSO, J. V.; FAUCITANO, L.; DALLA ROZA, D.; TRIQUES, N. J. Efeito do manejo pré-abate sobre a perda de peso dos suínos. Concórdia: EMBRAPA-CNPSA, 2006 4 (EMBRAPA-CNPSA. Comunicado técnico, 423)| Biblioteca(s): Embrapa Suínos e Aves. |
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| 225. | | OLIVEIRA FILHO, J. X. de; MORES, M. A. Z.; REBELATTO, R.; KICH, J. D.; CANTAO, M. E.; KLEIN, C. S.; GUEDES, R. M. C.; COLDEBELLA, A.; BARCELLOS, D. E. S. N. de; MORES, N. Pathogenic variability among Pasteurella multocida type A isolates from Brazilian pig farms. BMC Veterinary Research, v. 14, n. 244, 2018.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 226. | | SERIBELLI, A. A.; SILVA, P. da; CRUZ, M. F. da; ALMEIDA, F. de; FRAZÃO, M. R.; MEDEIROS, M. I. C.; RODRIGUES, D. dos P.; KICH, J. D.; BENEVIDES, L. de J.; SOARES, S. de C.; ALLARD, M. W.; FALCÃO, J. P. Insights about the epidemiology of Salmonella typhimurium isolates from different sources in Brazil using comparative genomics. Gut Pathogens, v. 13, n. 27, 2021.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 227. | | BELTRAME, L. C.; ZAMPARETTE, C. P.; FELTRIN, C.; CUNHA, C. R. da; COLTRO, E. P.; ATHAYDE, G. S. da S.; BENETTI FILHO, V.; TÁPPARO, D. C.; MONTEIRO, J.; KICH, J. D.; PALMEIRO, J. K.; WAGNER, G.; FONGARO, G.; ZÁRATE-BLADÉS, C. R.; SINCERO, T. C. M. Different swine production systems can shape slurry resistome at mechanism and class levels based on swine manure evaluation. Frontiers in Cellular and Infection Microbiology, v. 12, n. 879656, 2022.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 228. | | ABREU, P. G. de; DALLA COSTA, O. A.; SOUSA JÚNIOR, V. R. de; COLDEBELLA, A.; ABREU, V. M. N.; MORES, N.; AJALA, L. C.; LOPES, L. dos S.; KICH, J. D.; AMARAL, A. L. do; SANTOS FILHO, J. I. dos; SABINO, L. A. Efeito do sistema de resfriamento evaporativo acoplado a ventiladores nas características térmicas ambientais, bem-estar, saúde e desempenho de suínos nas fases de crescimento e terminação. In: COLDEBELLA, A.; SCHEUERMANN, G. N. (Ed.). Relatório de projetos concluídos 2011. Concórdia: Embrapa Suínos e Aves, 2012. p. 143-149. (Embrapa Suínos e Aves. Documentos, 156) Projeto/Plano de Ação: 03.07.09.049.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 229. | | MACHADO, A. R.; COLDEBELLA, A.; LIMA, G. J. M. M. de; KICH, J. D.; CALVEYRA, J. C.; LOPES, L. dos S.; PICININ, L. C.; SILVA, L. E. da; CORBELLINI, L. G.; SILVA, M. C. da; NOGUEIRA, M. G.; CARDOSO, M. R. de I.; MORÉS, N.; SCHWARZ, P.; FERRAZ, S. M.; DUTRA, V. Estratégias de controle para infecção por Salmonella em suínos. In: COLDEBELLA, A.; SCHEUERMANN, G.N. (Ed.). Relatório de projetos concluídos 2013. Concórdia: Embrapa Suínos e Aves, p. 15-28. (Embrapa Suínos e Aves. Documentos, 167).| Biblioteca(s): Embrapa Suínos e Aves. |
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Registro Completo
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Biblioteca(s): |
Embrapa Suínos e Aves. |
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Data corrente: |
11/05/2021 |
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Data da última atualização: |
11/05/2021 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 2 |
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Autoria: |
SERIBELLI, A. A.; SILVA, P. da; CRUZ, M. F. da; ALMEIDA, F. de; FRAZÃO, M. R.; MEDEIROS, M. I. C.; RODRIGUES, D. dos P.; KICH, J. D.; BENEVIDES, L. de J.; SOARES, S. de C.; ALLARD, M. W.; FALCÃO, J. P. |
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Afiliação: |
AMANDA APARECIDA SERIBELLI, USP; PATRICK DA SILVA, UNESP; MARCELO FERREIRA DA CRUZ, USP; FERNANDA DE ALMEIDA, USP; MILIANE RODRIGUES FRAZÃO, USP; MARTA I. C. MEDEIROS, Instituto Adolfo Lutz; DÁLIA DOS PRAZERES RODRIGUES, FIOCRUZ; JALUSA DEON KICH, CNPSA; LEANDRO DE JESUS BENEVIDES, UFTM; SIOMAR DE C. SOARES, UFTM; MARC WILLIAN ALLARD, Food and Drug Administration; JULIANA PFRIMER FALCÃO, USP. |
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Título: |
Insights about the epidemiology of Salmonella typhimurium isolates from different sources in Brazil using comparative genomics. |
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Ano de publicação: |
2021 |
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Fonte/Imprenta: |
Gut Pathogens, v. 13, n. 27, 2021. |
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DOI: |
https://doi.org/10.1186/s13099-021-00423-7 |
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Idioma: |
Inglês |
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Conteúdo: |
Abstract Background: Salmonella enterica subsp. enterica serovar Typhimurium (S. Typhimurium) is an important zoonotic agent worldwide. The aim of this work was to compare genetically 117 S. Typhimurium isolated from different sources over 30 years in Brazil using different genomics strategies. Results: The majority of the 117 S. Typhimurium strains studied were grouped into a single cluster (≅ 90%) by the core genome multilocus sequence typing and (≅ 77%) by single copy marker genes. The phylogenetic analysis based on single nucleotide polymorphism (SNP) grouped most strains from humans into a single cluster (≅ 93%), while the strains isolated from food and swine were alocated into three clusters. The different orthologous protein clusters found for some S. Typhimurium isolated from humans and food are involved in metabolic and regulatory processes. For 26 isolates from swine the sequence types (ST) 19 and ST1921 were the most prevalent ones, and the ST14, ST64, ST516 and ST639 were also detected. Previous results typed the 91 S. Typhimurium isolates from humans and foods as ST19, ST313, ST1921, ST3343 and ST1649. The main prophages detected were: Gifsy-2 in 79 (67.5%) and Gifsy-1 in 63 (54%) strains. All of the S. Typhimurium isolates contained the acrA, acrB, macA, macB, mdtK, emrA, emrB, emrR and tolC efflux pump genes. Conclusions: The phylogenetic trees grouped the majority of the S. Typhimurium isolates from humans into a single cluster suggesting that there is one prevalent subtype in Brazil. Regarding strains isolated from food and swine, the SNPs’ results suggested the circulation of more than one subtype over 30 years in this country. The orthologous protein clusters analysis revealed unique genes in the strains studied mainly related to bacterial metabolism. S. Typhimurium strains from swine showed greater diversity of STs and prophages in comparison to strains isolated from humans and foods. The pathogenic potential of S. Typhimurium strains was corroborated by the presence of exclusive prophages of this serovar involved in its virulence. The high number of resistance genes related to efflux pumps is worrying and may lead to therapeutic failures when clinical treatment is needed. MenosAbstract Background: Salmonella enterica subsp. enterica serovar Typhimurium (S. Typhimurium) is an important zoonotic agent worldwide. The aim of this work was to compare genetically 117 S. Typhimurium isolated from different sources over 30 years in Brazil using different genomics strategies. Results: The majority of the 117 S. Typhimurium strains studied were grouped into a single cluster (≅ 90%) by the core genome multilocus sequence typing and (≅ 77%) by single copy marker genes. The phylogenetic analysis based on single nucleotide polymorphism (SNP) grouped most strains from humans into a single cluster (≅ 93%), while the strains isolated from food and swine were alocated into three clusters. The different orthologous protein clusters found for some S. Typhimurium isolated from humans and food are involved in metabolic and regulatory processes. For 26 isolates from swine the sequence types (ST) 19 and ST1921 were the most prevalent ones, and the ST14, ST64, ST516 and ST639 were also detected. Previous results typed the 91 S. Typhimurium isolates from humans and foods as ST19, ST313, ST1921, ST3343 and ST1649. The main prophages detected were: Gifsy-2 in 79 (67.5%) and Gifsy-1 in 63 (54%) strains. All of the S. Typhimurium isolates contained the acrA, acrB, macA, macB, mdtK, emrA, emrB, emrR and tolC efflux pump genes. Conclusions: The phylogenetic trees grouped the majority of the S. Typhimurium isolates from humans into a single cluster suggesting that there is one pr... Mostrar Tudo |
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Palavras-Chave: |
Aglomerados ortólogos de proteínas; Árvores filogenéticas; Bombas de efluxo; Efflux pumps; Phylogenetic trees; Profagos; Prophages; Protein orthologous clusters. |
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Thesagro: |
Salmonella Typhimurium. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 03391naa a2200373 a 4500
001 2131761
005 2021-05-11
008 2021 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1186/s13099-021-00423-7$2DOI
100 1 $aSERIBELLI, A. A.
245 $aInsights about the epidemiology of Salmonella typhimurium isolates from different sources in Brazil using comparative genomics.$h[electronic resource]
260 $c2021
520 $aAbstract Background: Salmonella enterica subsp. enterica serovar Typhimurium (S. Typhimurium) is an important zoonotic agent worldwide. The aim of this work was to compare genetically 117 S. Typhimurium isolated from different sources over 30 years in Brazil using different genomics strategies. Results: The majority of the 117 S. Typhimurium strains studied were grouped into a single cluster (≅ 90%) by the core genome multilocus sequence typing and (≅ 77%) by single copy marker genes. The phylogenetic analysis based on single nucleotide polymorphism (SNP) grouped most strains from humans into a single cluster (≅ 93%), while the strains isolated from food and swine were alocated into three clusters. The different orthologous protein clusters found for some S. Typhimurium isolated from humans and food are involved in metabolic and regulatory processes. For 26 isolates from swine the sequence types (ST) 19 and ST1921 were the most prevalent ones, and the ST14, ST64, ST516 and ST639 were also detected. Previous results typed the 91 S. Typhimurium isolates from humans and foods as ST19, ST313, ST1921, ST3343 and ST1649. The main prophages detected were: Gifsy-2 in 79 (67.5%) and Gifsy-1 in 63 (54%) strains. All of the S. Typhimurium isolates contained the acrA, acrB, macA, macB, mdtK, emrA, emrB, emrR and tolC efflux pump genes. Conclusions: The phylogenetic trees grouped the majority of the S. Typhimurium isolates from humans into a single cluster suggesting that there is one prevalent subtype in Brazil. Regarding strains isolated from food and swine, the SNPs’ results suggested the circulation of more than one subtype over 30 years in this country. The orthologous protein clusters analysis revealed unique genes in the strains studied mainly related to bacterial metabolism. S. Typhimurium strains from swine showed greater diversity of STs and prophages in comparison to strains isolated from humans and foods. The pathogenic potential of S. Typhimurium strains was corroborated by the presence of exclusive prophages of this serovar involved in its virulence. The high number of resistance genes related to efflux pumps is worrying and may lead to therapeutic failures when clinical treatment is needed.
650 $aSalmonella Typhimurium
653 $aAglomerados ortólogos de proteínas
653 $aÁrvores filogenéticas
653 $aBombas de efluxo
653 $aEfflux pumps
653 $aPhylogenetic trees
653 $aProfagos
653 $aProphages
653 $aProtein orthologous clusters
700 1 $aSILVA, P. da
700 1 $aCRUZ, M. F. da
700 1 $aALMEIDA, F. de
700 1 $aFRAZÃO, M. R.
700 1 $aMEDEIROS, M. I. C.
700 1 $aRODRIGUES, D. dos P.
700 1 $aKICH, J. D.
700 1 $aBENEVIDES, L. de J.
700 1 $aSOARES, S. de C.
700 1 $aALLARD, M. W.
700 1 $aFALCÃO, J. P.
773 $tGut Pathogens$gv. 13, n. 27, 2021.
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