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| Registros recuperados : 101 | |
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 | Acesso ao texto completo restrito à biblioteca da Embrapa Instrumentação. Para informações adicionais entre em contato com cnpdia.biblioteca@embrapa.br. |
Registro Completo
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Biblioteca(s): |
Embrapa Instrumentação. |
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Data corrente: |
20/06/2022 |
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Data da última atualização: |
20/06/2022 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 1 |
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Autoria: |
BORGES, F. A.; DRAGO, B. C.; BAGGIO, L. O.; BARROS, N. R. de; BRASIL, G. S. P.; SCONTRI, M.; MUSSAGY, C. U.; RIBEIRO, M. C. S.; MILORI, D. M. B. P.; MORAIS, C. P. de; MARANGONI, B. S.; NICOLODELLI, G.; MECWAN, M.; MANDAL, K.; GUERRA, N. B.; MENEGATTI, C. R.; HERCULANO, R. D. |
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Afiliação: |
DEBORA MARCONDES BASTOS PEREIRA, CNPDIA. |
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Título: |
Metronidazole-loaded gold nanoparticles in natural rubber latex as a potential wound dressing. |
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Ano de publicação: |
2022 |
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Fonte/Imprenta: |
International Journal of Biological Macromolecules, v. 211, 2022. |
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Páginas: |
568?579 |
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ISSN: |
0141-8130 |
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DOI: |
https://doi.org/10.1016/j.ijbiomac.2022.05.025 |
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Idioma: |
Inglês |
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Conteúdo: |
Gold nanoparticles (AuNPs) have shown interesting properties and specific biofunctions, providing benefits and new opportunities for controlled release systems. In this research, we demonstrated the use of natural rubber latex (NRL) from Hevea brasiliensis as a carrier of AuNPs and the antibiotic metronidazole (MET). We prepared AuNP-MET-NRL and characterized by physicochemical, biological and in vitro release assays. The effect of AuNPs on MET release was evaluated using UV?Vis and Laser-Induced Breakdown Spectroscopy (LIBS) techniques. AuNPs synthesized by Turkevich and Frens method resulted in a spherical shape with diameters of 34.8 ± 5.5 nm. We verified that there was no emergence or disappearance of new vibrational bands. Qualitatively and quantitatively, we showed that the MET crystals dispersed throughout the NRL. The Young's modulus and elongation values at dressing rupture were in the range appropriate for human skin application. 64.70% of the AuNP-MET complex was released within 100 h, exhibiting a second-order exponential release profile. The LIBS technique allowed monitoring of the AuNP release, indicating the Au emission peak reduction at 267.57 nm over time. Moreover, the dressing displayed an excellent hemocompatibility and fibroblast cell viability. These results demonstrated that the AuNP-MET-NRL wound dressing is a promising approach for dermal applications |
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Palavras-Chave: |
Gold nanoparticles; LIBS; Sustained release. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 02515naa a2200385 a 4500
001 2144181
005 2022-06-20
008 2022 bl uuuu u00u1 u #d
022 $a0141-8130
024 7 $ahttps://doi.org/10.1016/j.ijbiomac.2022.05.025$2DOI
100 1 $aBORGES, F. A.
245 $aMetronidazole-loaded gold nanoparticles in natural rubber latex as a potential wound dressing.$h[electronic resource]
260 $c2022
300 $a568?579
520 $aGold nanoparticles (AuNPs) have shown interesting properties and specific biofunctions, providing benefits and new opportunities for controlled release systems. In this research, we demonstrated the use of natural rubber latex (NRL) from Hevea brasiliensis as a carrier of AuNPs and the antibiotic metronidazole (MET). We prepared AuNP-MET-NRL and characterized by physicochemical, biological and in vitro release assays. The effect of AuNPs on MET release was evaluated using UV?Vis and Laser-Induced Breakdown Spectroscopy (LIBS) techniques. AuNPs synthesized by Turkevich and Frens method resulted in a spherical shape with diameters of 34.8 ± 5.5 nm. We verified that there was no emergence or disappearance of new vibrational bands. Qualitatively and quantitatively, we showed that the MET crystals dispersed throughout the NRL. The Young's modulus and elongation values at dressing rupture were in the range appropriate for human skin application. 64.70% of the AuNP-MET complex was released within 100 h, exhibiting a second-order exponential release profile. The LIBS technique allowed monitoring of the AuNP release, indicating the Au emission peak reduction at 267.57 nm over time. Moreover, the dressing displayed an excellent hemocompatibility and fibroblast cell viability. These results demonstrated that the AuNP-MET-NRL wound dressing is a promising approach for dermal applications
653 $aGold nanoparticles
653 $aLIBS
653 $aSustained release
700 1 $aDRAGO, B. C.
700 1 $aBAGGIO, L. O.
700 1 $aBARROS, N. R. de
700 1 $aBRASIL, G. S. P.
700 1 $aSCONTRI, M.
700 1 $aMUSSAGY, C. U.
700 1 $aRIBEIRO, M. C. S.
700 1 $aMILORI, D. M. B. P.
700 1 $aMORAIS, C. P. de
700 1 $aMARANGONI, B. S.
700 1 $aNICOLODELLI, G.
700 1 $aMECWAN, M.
700 1 $aMANDAL, K.
700 1 $aGUERRA, N. B.
700 1 $aMENEGATTI, C. R.
700 1 $aHERCULANO, R. D.
773 $tInternational Journal of Biological Macromolecules$gv. 211, 2022.
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