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Registro Completo
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Biblioteca(s): |
Embrapa Meio Ambiente. |
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Data corrente: |
30/07/2013 |
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Data da última atualização: |
30/07/2013 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 2 |
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Autoria: |
SANTOS, S. N.; FERRARIS, F. K.; SOUZA, A. O. de; HENRIQUES, M. das G. M. O.; MELO, I. S. de. |
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Afiliação: |
SUIKINAI NOBRE SANTOS, ESALQ-USP; FAUSTO KLABUND FERRARIS, FIOCRUZ; ANA OLIVIA DE SOUZA, INSTITUTO BUTANTAN; MARIA DAS GRACAS MULLER DE OLIVEIRA HENRIQUES, FIOCRUZ; ITAMAR SOARES DE MELO, CNPMA. |
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Título: |
Endophytic fungi from Combretum leprosum with potential anticancer and antifungal activity. |
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Ano de publicação: |
2012 |
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Fonte/Imprenta: |
Symbiosis, Philadelphia, v. 58, p. 109-117, 2012. |
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Idioma: |
Inglês |
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Conteúdo: |
The recent increase in human diseases and cancers requires new drugs to combat them. Sources have been found in rare microorganisms, those from extreme habitats, and from endophytes. In this study, the biological activity of endophytic fungi associated with the Brazilian medicinal plant Combretum leprosum was assessed. Cytotoxic and antiproliferative effects were evaluated using seven human cancer cells lines (HeLa, ECV304, B16F10, J744, P388, Jurkat and k562). In addition the minimum inhibitory concentration (MIC) against pathogenic human fungal was determined using four Candida species and the filamentous fungi Cryptococcus neoformans and Trichophyton rubrum. A compound from extracts of phylotype Aspergillus oryzae CFE108 exhibited the most significant cytotoxicity effect against histiocytic sarcoma J774 (IC50 of 0.80 ?gmL?1), leukemia Jurkat (IC50 of 0.89 ?gmL?1), bladder carcinoma ECV304 (IC50 of 3.08 ?gmL?1) and cervical cancer HeLa (IC50 of 2.97 ?gmL?1). The extract from phylotypes Fusarium oxysporum CFE177 displayed antifungal activity and inhibited the growth of Candida glabrata (4 ?gmL?1) as well as that of C. neoformans and T. rubrum with the lowest MIC being 62.5 ?gmL?1. In addition, the fractions from A. oryzae CFE108 showed marked morphological activity (rounding up) on endothelial cells (tEnd.1 cells), which is indicative of potential antivascular activity. Our results indicate that the endophytes associated with this medicinal plant may be a source of novel drugs. MenosThe recent increase in human diseases and cancers requires new drugs to combat them. Sources have been found in rare microorganisms, those from extreme habitats, and from endophytes. In this study, the biological activity of endophytic fungi associated with the Brazilian medicinal plant Combretum leprosum was assessed. Cytotoxic and antiproliferative effects were evaluated using seven human cancer cells lines (HeLa, ECV304, B16F10, J744, P388, Jurkat and k562). In addition the minimum inhibitory concentration (MIC) against pathogenic human fungal was determined using four Candida species and the filamentous fungi Cryptococcus neoformans and Trichophyton rubrum. A compound from extracts of phylotype Aspergillus oryzae CFE108 exhibited the most significant cytotoxicity effect against histiocytic sarcoma J774 (IC50 of 0.80 ?gmL?1), leukemia Jurkat (IC50 of 0.89 ?gmL?1), bladder carcinoma ECV304 (IC50 of 3.08 ?gmL?1) and cervical cancer HeLa (IC50 of 2.97 ?gmL?1). The extract from phylotypes Fusarium oxysporum CFE177 displayed antifungal activity and inhibited the growth of Candida glabrata (4 ?gmL?1) as well as that of C. neoformans and T. rubrum with the lowest MIC being 62.5 ?gmL?1. In addition, the fractions from A. oryzae CFE108 showed marked morphological activity (rounding up) on endothelial cells (tEnd.1 cells), which is indicative of potential antivascular activity. Our results indicate that the endophytes associated with this medicinal plant may be a source of novel dr... Mostrar Tudo |
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Palavras-Chave: |
Anticancer; Bioprospection; Combretum leprosum; Fusarium spp. |
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Thesagro: |
Aspergillus oryzae; Fusarium oxysporum. |
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Thesaurus NAL: |
Antineoplastic agents; Aspergillus; Endophytes. |
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Categoria do assunto: |
V Taxonomia de Organismos |
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Marc: |
LEADER 02313naa a2200277 a 4500
001 1963044
005 2013-07-30
008 2012 bl uuuu u00u1 u #d
100 1 $aSANTOS, S. N.
245 $aEndophytic fungi from Combretum leprosum with potential anticancer and antifungal activity.$h[electronic resource]
260 $c2012
520 $aThe recent increase in human diseases and cancers requires new drugs to combat them. Sources have been found in rare microorganisms, those from extreme habitats, and from endophytes. In this study, the biological activity of endophytic fungi associated with the Brazilian medicinal plant Combretum leprosum was assessed. Cytotoxic and antiproliferative effects were evaluated using seven human cancer cells lines (HeLa, ECV304, B16F10, J744, P388, Jurkat and k562). In addition the minimum inhibitory concentration (MIC) against pathogenic human fungal was determined using four Candida species and the filamentous fungi Cryptococcus neoformans and Trichophyton rubrum. A compound from extracts of phylotype Aspergillus oryzae CFE108 exhibited the most significant cytotoxicity effect against histiocytic sarcoma J774 (IC50 of 0.80 ?gmL?1), leukemia Jurkat (IC50 of 0.89 ?gmL?1), bladder carcinoma ECV304 (IC50 of 3.08 ?gmL?1) and cervical cancer HeLa (IC50 of 2.97 ?gmL?1). The extract from phylotypes Fusarium oxysporum CFE177 displayed antifungal activity and inhibited the growth of Candida glabrata (4 ?gmL?1) as well as that of C. neoformans and T. rubrum with the lowest MIC being 62.5 ?gmL?1. In addition, the fractions from A. oryzae CFE108 showed marked morphological activity (rounding up) on endothelial cells (tEnd.1 cells), which is indicative of potential antivascular activity. Our results indicate that the endophytes associated with this medicinal plant may be a source of novel drugs.
650 $aAntineoplastic agents
650 $aAspergillus
650 $aEndophytes
650 $aAspergillus oryzae
650 $aFusarium oxysporum
653 $aAnticancer
653 $aBioprospection
653 $aCombretum leprosum
653 $aFusarium spp
700 1 $aFERRARIS, F. K.
700 1 $aSOUZA, A. O. de
700 1 $aHENRIQUES, M. das G. M. O.
700 1 $aMELO, I. S. de
773 $tSymbiosis, Philadelphia$gv. 58, p. 109-117, 2012.
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