| |
|
|
| Registros recuperados : 134 | |
| 2. |  | PIRES, A. V.; LOPES, P. S.; GUIMARAES, S. E. F.; GUIMARAES, C. T.; PEIXOTO, J. O. Mapeamento de locos de características quantitativas associados à composição de carcaça, no cromossomo seis de suíno Arquivo Brasileiro de Medicina Veterinária e Zootecnia, Belo Horizonte, v. 60, n. 3, p. 725-732, 2008.| Biblioteca(s): Embrapa Milho e Sorgo. |
|    |
| 3. | | ARAÚJO, A. M.; GUIMARÃES, S. E. F.; COLUMBIANO, V. S.; TEIXEIRA, M. R.; LOPES, P. S. Descrição de cinco loci de microsatélite em uma população de caprinos da raça Alpina e sua utilização em testes de confirmação de paternidade em casos onde o genótipo materno é ou não informado. In: REUNIÃO ANUAL DA SOCIEDADE BRASILEIRA DE ZOOTECNIA, 40., 2003, Santa Maria, RS. Otimizando a produção animal: anais. Santa Maria: Sociedade Brasileira de Zootecnia, 2003. 5 f. 1 CD ROM.| Biblioteca(s): Embrapa Caprinos e Ovinos. |
| |
| 4. | | DANTAS, W. de M. F.; RIBEIRO FILHO, J. D.; GUIMARÃES, J. D.; GUIMARÃES, S. E. F. Perfil metabólico e ponderal de leitões submetidos a dietas com diferentes teores de fósforo em ambientes térmicos distintos. Pesquisa Agropecuária Brasileira, Brasília, DF, v. 49, n. 11, p. 901-910, nov. 2014. Título em inglês: Metabolic profile and body weight of piglets fed with different levels of phosphorus in distinct thermal environments.| Biblioteca(s): Embrapa Unidades Centrais. |
| |
| 6. | | SOLLERO, B. P.; YAMAKI, M.; GUIMARÃES, S. E. F.; CARNEIRO, P. L. S.; PAIVA, S. R.; MARIANTE, A. da S. Análise de componentes principais como ferramenta na avaliação da diversidade genética de suínos. In: SIMPÓSIO BRASILEIRO DE MELHORAMENTO ANIMAL, 7., 2008, São Carlos, SP. Anais... São Carlos, SP: SBMA: Embrapa Pecuária Sudeste, 2008.| Biblioteca(s): Embrapa Recursos Genéticos e Biotecnologia. |
| |
| 8. | | DOMINGUES, R.; GASPARINI, K.; BERNARDO, K. B.; REIS, D. R. L.; GUIMARÃES, S. E. F.; MACHADO, M. A. Differential expression of CXCL10 in peripheral blood of resistant and susceptible cattle to tick infestation. In: CONGRESSO BRASILEIRO BRASILEIRO DE GENÉTICA, 57., 2011, Águas de Lindóia. Resumos... Brasília, DF: Sociedade Brasileira de Genética, 2011.| Biblioteca(s): Embrapa Gado de Leite. |
| |
| 9. | | FONSECA, I.; ANTUNES, G. R.; PAIVA, D. de S.; LANGE, C. C.; GUIMARÃES, S. E. F.; MARTINS, M. F. Differential expression of genes during mastitis in Holstein-Zebu crossbreed dairy cows. Genetics and Molecular Research, v. 10, n. 3, p. 1295-1303, 2011.| Biblioteca(s): Embrapa Gado de Leite. |
| |
| 10. | | DOMINGUES, R.; PALLA, P. C.; CESTARO, L. S.; CUNHA, A. C. L. M.; GUIMARÃES, S. E. F.; MACHADO, M. A. Differential gene expression profiles in skin of resistant and susceptible cattle to tick infestation. In: CONGRESSO BRASILEIRO BRASILEIRO DE GENÉTICA, 57., 2011, Águas de Lindóia. Resumos... Brasília, DF: Sociedade Brasileira de Genética, 2011.| Biblioteca(s): Embrapa Gado de Leite. |
| |
| 13. | | SILVA, P. V.; FONSECA, I.; GUIMARÃES, S. E. F.; GUIMARÃES, M. F. M.; SERÃO, N. V. L.; LOPES, M. S. Expressão relativa da IL - 10 em células do leite de vacas holandesas saudáveis e com mastite clínica. In: REUNIÃO ANUAL DA SOCIEDADE BRASILEIRA DE ZOOTECNIA. 45., 2008, Lavras, MG. Anais... Viçosa, MG: Sociedade Brasileira de Zootecnia, 2008.| Biblioteca(s): Embrapa Gado de Leite. |
| |
| 14. | | FONSECA, I.; SILVA, P. V.; MIRANDA, C. L.; GUIMARÃES, M. F. M.; GUIMARÃES, S. E. F.; MACHADO, M. A. Expressão diferencial do gene interleucina 6 em células do leite de vacas sadias e com mastite. In: CONGRESSO BRASILEIRO DE GENÉTICA, 53., 2007, Águas de Lindóia. Resumos... Ribeirão Preto: SBG, 2007. p. 97.| Biblioteca(s): Embrapa Gado de Leite. |
| |
| 17. | | PEIXOTO, J. de O.; FARIA, D. A. de; SILVA, P. V.; FONSECA, I.; LOPES, P. S.; GUIMARÃES, S. E. F. Association between leptin genes single nucleotide polymorphisms and carcass traits in pigs Revista Brasileira de Zootecnia, v.38, n.2, p.271-276, 2009 Subprojeto: 16.00.30004-00| Biblioteca(s): Embrapa Suínos e Aves. |
|  |
| 18. | | ARAÚJO, A. M.; GUIMARÃES, S. E. F.; RODRIGUES, M. T.; PAIVA, A. L. C.; LOPES, P. S.; COLUMBIANO, V. S. Sistema Multiplex de microssatélite para teste de paternidade em caprinos da raça Alpina. Revista Brasileira de Reprodução Animal, Belo Horizonte, v. 27, n. 3, p. 590-591, 2003.| Biblioteca(s): Embrapa Caprinos e Ovinos. |
| |
| 20. | | FONSECA, I.; SILVA, P. V.; GUIMARÃES, S. E. F.; LOPES, P. S.; LANGE, C. C.; GUIMARÃES, M. F. M. Perfil da expressão dos genes IL-4 e IFN-y em células do leite de vacas da raça Gir Leiteiro saudáveis e com mastite clínica. In: REUNIÃO ANUAL DA SOCIEDADE BRASILEIRA DE ZOOTECNIA. 45., 2008, Lavras, MG. Anais... Viçosa, MG: Sociedade Brasileira de Zootecnia, 2008.| Biblioteca(s): Embrapa Gado de Leite. |
| |
| Registros recuperados : 134 | |
|
|
|
 | Acesso ao texto completo restrito à biblioteca da Embrapa Gado de Leite. Para informações adicionais entre em contato com cnpgl.biblioteca@embrapa.br. |
Registro Completo
|
Biblioteca(s): |
Embrapa Gado de Leite. |
|
Data corrente: |
18/12/2018 |
|
Data da última atualização: |
24/01/2023 |
|
Tipo da produção científica: |
Artigo em Periódico Indexado |
|
Circulação/Nível: |
A - 1 |
|
Autoria: |
OTTO, P. I.; GUIMARÃES, S. E. F.; VERARDO, L. L.; AZEVEDO, A. L. S.; VANDENPLAS, J.; SOARES, A. C. C.; SEVILLANO, C. A.; VERONEZE R; PIRES, M. de F. A.; FREITAS, C. de; PRATA, M. C. de A.; FURLONG, J.; VERNEQUE, R. da S.; MARTINS, M. F.; PANETTO, J. C. do C.; CARVALHO, W. A.; GOBO, D. O. R.; SILVA, M. V. G. B.; MACHADO, M. A. |
|
Afiliação: |
PAMELA I. OTTO, UFV; SIMONE ELIZA FACIONI GUIMARAES, UFV; LUCAS L. VERARDO, UFV; ANA LUISA SOUSA AZEVEDO, CNPGL; J. VANDENPLAS, Wageningen University; ALINE C. C. SOARES, UFV; CLAUDIA A. SEVILLANO, Wageningen University; Topigs Norsvin Research Center, Beuningen; RENATA VERONEZE, UFV; MARIA DE FATIMA AVILA PIRES, CNPGL; CELIO DE FREITAS, CNPGL; MARCIA CRISTINA DE AZEVEDO PRATA, CNPGL; JOHN FURLONG, CNPGL; RUI DA SILVA VERNEQUE, CNPGL; MARTA FONSECA MARTINS, CNPGL; JOAO CLAUDIO DO CARMO PANETTO, CNPGL; WANESSA ARAUJO CARVALHO, CNPGL; DIEGO O. R. GOBO, UFV; MARCOS VINICIUS GUALBERTO B SILVA, CNPGL; MARCO ANTONIO MACHADO, CNPGL. |
|
Título: |
Genome-wide association studies for tick resistance in Bos taurus × Bos indicus crossbred cattle: A deeper look into this intricate mechanism. |
|
Ano de publicação: |
2018 |
|
Fonte/Imprenta: |
Journal of Dairy Science, v. 101, n. 12, p. 11020-11032, 2018. |
|
DOI: |
10.3168/jds.2017-14223 |
|
Idioma: |
Inglês |
|
Conteúdo: |
ABSTRACT Rhipicephalus (Boophilus) microplus is the main cattle ectoparasite in tropical areas. Gir × Holstein crossbred cows are well adapted to different production systems in Brazil. In this context, we performed genome-wide association study (GWAS) and post-GWAS analyses for R. microplus resistance in an experimental Gir × Holstein F2 population. Single nucleotide polymorphisms (SNP) identified in GWAS were used to build gene networks and to investigate the breed of origin for its alleles. Tick artificial infestations were performed during the dry and rainy seasons. Illumina BovineSNP50 BeadChip (Illumina Inc., San Diego, CA) and single-step BLUP procedure was used for GWAS. Post-GWAS analyses were performed by gene ontology terms enrichment and gene transcription factors networks, generated from enriched transcription factors, identified from the promoter sequences of selected gene sets. The genetic origin of marker alleles in the F2 population was assigned using the breed of origin of alleles approach. Heritability estimates for tick counts were 0.40 ± 0.11 in the rainy season and 0.54 ± 0.11 in the dry season. The top ten 0.5-Mbp windows with the highest percentage of genetic variance explained by SNP markers were found in chromosomes 10 and 23 for both the dry and rainy seasons. Gene network analyses allowed the identification of genes involved with biological processes relevant to immune system functions (TREM1, TREM2, and CD83). Gene-transcription factors network allowed the identification of genes involved with immune functions (MYO5A, TREML1, and PRSS16). In resistant animals, the average proportion of animals showing significant SNPs with paternal and maternal alleles originated from Gir breed was 44.8% whereas the proportion of animals with both paternal and maternal alleles originated from Holstein breed was 11.3%. Susceptible animals showing both paternal and maternal alleles originated from Holstein breed represented 44.6% on average, whereas both paternal and maternal alleles originated from Gir breed animals represented 9.3%. This study allowed us to identify candidate genes for tick resistance in Gir × Holstein crossbreds in both rainy and dry seasons. According to the origin of alleles analysis, we found that most animals classified as resistant showed 2 alleles from Gir breed, while the susceptible ones showed alleles from Holstein. Based on these results, the identified genes may be thoroughly investigated in additional experiments aiming to validate their effects on tick resistance phenotype in cattle. MenosABSTRACT Rhipicephalus (Boophilus) microplus is the main cattle ectoparasite in tropical areas. Gir × Holstein crossbred cows are well adapted to different production systems in Brazil. In this context, we performed genome-wide association study (GWAS) and post-GWAS analyses for R. microplus resistance in an experimental Gir × Holstein F2 population. Single nucleotide polymorphisms (SNP) identified in GWAS were used to build gene networks and to investigate the breed of origin for its alleles. Tick artificial infestations were performed during the dry and rainy seasons. Illumina BovineSNP50 BeadChip (Illumina Inc., San Diego, CA) and single-step BLUP procedure was used for GWAS. Post-GWAS analyses were performed by gene ontology terms enrichment and gene transcription factors networks, generated from enriched transcription factors, identified from the promoter sequences of selected gene sets. The genetic origin of marker alleles in the F2 population was assigned using the breed of origin of alleles approach. Heritability estimates for tick counts were 0.40 ± 0.11 in the rainy season and 0.54 ± 0.11 in the dry season. The top ten 0.5-Mbp windows with the highest percentage of genetic variance explained by SNP markers were found in chromosomes 10 and 23 for both the dry and rainy seasons. Gene network analyses allowed the identification of genes involved with biological processes relevant to immune system functions (TREM1, TREM2, and CD83). Gene-transcription factors network a... Mostrar Tudo |
|
Palavras-Chave: |
Breed of origin; Gene network; Gir × Holstein crossbred. |
|
Thesaurus NAL: |
Genetic variance. |
|
Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
|
Marc: |
LEADER 03793naa a2200397 a 4500
001 2101869
005 2023-01-24
008 2018 bl uuuu u00u1 u #d
024 7 $a10.3168/jds.2017-14223$2DOI
100 1 $aOTTO, P. I.
245 $aGenome-wide association studies for tick resistance in Bos taurus × Bos indicus crossbred cattle$bA deeper look into this intricate mechanism.$h[electronic resource]
260 $c2018
520 $aABSTRACT Rhipicephalus (Boophilus) microplus is the main cattle ectoparasite in tropical areas. Gir × Holstein crossbred cows are well adapted to different production systems in Brazil. In this context, we performed genome-wide association study (GWAS) and post-GWAS analyses for R. microplus resistance in an experimental Gir × Holstein F2 population. Single nucleotide polymorphisms (SNP) identified in GWAS were used to build gene networks and to investigate the breed of origin for its alleles. Tick artificial infestations were performed during the dry and rainy seasons. Illumina BovineSNP50 BeadChip (Illumina Inc., San Diego, CA) and single-step BLUP procedure was used for GWAS. Post-GWAS analyses were performed by gene ontology terms enrichment and gene transcription factors networks, generated from enriched transcription factors, identified from the promoter sequences of selected gene sets. The genetic origin of marker alleles in the F2 population was assigned using the breed of origin of alleles approach. Heritability estimates for tick counts were 0.40 ± 0.11 in the rainy season and 0.54 ± 0.11 in the dry season. The top ten 0.5-Mbp windows with the highest percentage of genetic variance explained by SNP markers were found in chromosomes 10 and 23 for both the dry and rainy seasons. Gene network analyses allowed the identification of genes involved with biological processes relevant to immune system functions (TREM1, TREM2, and CD83). Gene-transcription factors network allowed the identification of genes involved with immune functions (MYO5A, TREML1, and PRSS16). In resistant animals, the average proportion of animals showing significant SNPs with paternal and maternal alleles originated from Gir breed was 44.8% whereas the proportion of animals with both paternal and maternal alleles originated from Holstein breed was 11.3%. Susceptible animals showing both paternal and maternal alleles originated from Holstein breed represented 44.6% on average, whereas both paternal and maternal alleles originated from Gir breed animals represented 9.3%. This study allowed us to identify candidate genes for tick resistance in Gir × Holstein crossbreds in both rainy and dry seasons. According to the origin of alleles analysis, we found that most animals classified as resistant showed 2 alleles from Gir breed, while the susceptible ones showed alleles from Holstein. Based on these results, the identified genes may be thoroughly investigated in additional experiments aiming to validate their effects on tick resistance phenotype in cattle.
650 $aGenetic variance
653 $aBreed of origin
653 $aGene network
653 $aGir × Holstein crossbred
700 1 $aGUIMARÃES, S. E. F.
700 1 $aVERARDO, L. L.
700 1 $aAZEVEDO, A. L. S.
700 1 $aVANDENPLAS, J.
700 1 $aSOARES, A. C. C.
700 1 $aSEVILLANO, C. A.
700 1 $aVERONEZE R
700 1 $aPIRES, M. de F. A.
700 1 $aFREITAS, C. de
700 1 $aPRATA, M. C. de A.
700 1 $aFURLONG, J.
700 1 $aVERNEQUE, R. da S.
700 1 $aMARTINS, M. F.
700 1 $aPANETTO, J. C. do C.
700 1 $aCARVALHO, W. A.
700 1 $aGOBO, D. O. R.
700 1 $aSILVA, M. V. G. B.
700 1 $aMACHADO, M. A.
773 $tJournal of Dairy Science$gv. 101, n. 12, p. 11020-11032, 2018.
Download
Esconder MarcMostrar Marc Completo |
|
Registro original: |
Embrapa Gado de Leite (CNPGL) |
|
|
Biblioteca |
ID |
Origem |
Tipo/Formato |
Classificação |
Cutter |
Registro |
Volume |
Status |
Fechar
|
| Nenhum registro encontrado para a expressão de busca informada. |
|
|
