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| Registros recuperados : 121 | |
| 10. |  | PEDROSA, M. B.; VASCONCELOS, O. L.; MORELLO, C. de L.; FREIRE, E. C.; PEREIRA, A. F.; ALENCAR, A. R. de. Comportamento de linhagens e cultivares de algodoeiro no Vale do Yuyu, região do Vale do Rio São Francisco - safra 2006/2007. In: SILVA FILHO, J. L. da; PEDROSA, M. B. (Coord.). Pesquisas com algodoeiro no Estado da Bahia - safra 2006/2007. Campina Grande: Embrapa Algodão, 2008. p. 45-58 (Embrapa Algodão. Documentos, 188).| Biblioteca(s): Embrapa Algodão. |
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| 11. | | PEDROSA, M. B.; VASCONCELOS, O. L.; FERREIRA, A. F.; MORELLO, C. de L.; FREIRE, E. C.; ALENCAR, A. R. de. Comportamento de linhagens finais do programa de melhoramento genético do algodoeiro, no Vale do Iuiu, safra 2006/07. In: CONGRESSO BRASILEIRO DO ALGODÃO, 7., 2009, Foz do Iguaçu. Sustentabilidade da cotonicultura brasileira e expansão dos mercados: anais. Campina Grande: Embrapa Algodão, 2009. 1 CD-ROM| Biblioteca(s): Embrapa Algodão. |
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| 13. | | PEDROSA, M. B.; SILVA FILHO, J. L. da; SANTOS, J. B. dos; ALENCAR, A. R. de; OLIVEIRA, W. P. Perdas causadas pelo apodrecimento de maçãs em cultivares de algodoeiro no Oeste da Bahia, safra 2005/2006. In: SILVA FILHO, J. L. da; PEDROSA, M. B.; SANTOS, J. B. dos. (Coord.). Pesquisas com algodoeiro no Estado da Bahia - safra 2005/2006. Campina Grande: Embrapa Algodão, 2007. p. 53-58 (Embrapa Algodão. Documentos, 164)| Biblioteca(s): Embrapa Algodão. |
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| 15. | | BOGIANI, J. C.; SOFIATTI, V.; COSTA, A. G. F.; ALENCAR, A. R. DE; SILVA, F. I. S. DA. Espaçamentos e épocas de plantio de mamoneira no cerrado baiano. In: CONGRESSO BRASILEIRO DE MAMONA, 6.; SIMPÓSIO INTERNACIONAL DE OLEAGINOSAS ENERGÉTICAS, 3., 2014, Fortaleza. Energia e segurança alimentar na agricultura familiar: anais. Campina Grande, PB: Embrapa Algodão, 2014. p. 156| Biblioteca(s): Embrapa Algodão. |
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| 17. | | PEDROSA, M. B.; VASCONCELOS, O. L.; FERREIRA, A. F.; MORELLO, C. de L.; FREIRE, E. C.; ALENCAR, A. R. de. Avaliação de linhagens de algodoeiro de fibras longas e linhagens de fibras coloridas no Vale do Iuiu, safra 2007/08. In: CONGRESSO BRASILEIRO DO ALGODÃO, 7., 2009, Foz do Iguaçu. Sustentabilidade da cotonicultura brasileira e expansão dos mercados: anais. Campina Grande: Embrapa Algodão, 2009. 1 CD-ROM| Biblioteca(s): Embrapa Algodão. |
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| 19. | | SILVA FILHO, J. L. da; PEDROSA, M. B.; BARROSO, P. A. V.; ALENCAR, A. R. de; OLIVEIRA, W. P. Determinação do fluxo gênico entre lavouras de algodão no Estado da Bahia, safras 2004/2005 e 2005/2006. In: SILVA FILHO, J. L. da; PEDROSA, M. B.; SANTOS, J. B. dos. Pesquisas com algodoeiro no Estado da Bahia - safra 2005/2006. Campina Grande: Embrapa Algodão, 2007. p.43-52 (Embrapa Algodão. Documentos, 164).| Biblioteca(s): Embrapa Algodão. |
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| 20. | | PEDROSA, M. B.; SILVA FILHO, J. L. da; FREIRE, E. C.; SANTOS, J. B. dos; ALENCAR, A. R. de; OLIVEIRA, W. P. Competição de cultivares de algodoeiro no cerrado da Bahia. In: CONGRESSO BRASILEIRO DO ALGODÃO, 6., 2007, Uberlândia. Resumos... Uberlândia, 2007. p. 1-6 1 CD-ROM| Biblioteca(s): Embrapa Algodão. |
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| Registros recuperados : 121 | |
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Registro Completo
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Biblioteca(s): |
Embrapa Suínos e Aves. |
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Data corrente: |
12/08/2022 |
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Data da última atualização: |
12/08/2022 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 1 |
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Autoria: |
IBELLI, A. M. G.; PEIXOTO, J. de O.; ZANELLA, R.; GOUVEIA, J. J. de S.; CANTAO, M. E.; COUTINHO, L. L.; MARCHESI, J. A. P.; DAL PIZZOL, M. S.; MARCELINO, D. E. P.; LEDUR, M. C. |
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Afiliação: |
ADRIANA MERCIA GUARATINI IBELLI, CNPSA; JANE DE OLIVEIRA PEIXOTO, CNPSA; RICARDO ZANELLA, UPF; JOÃO JOSÉ DE SIMONI GOUVEIA, UNIVASF; MAURICIO EGIDIO CANTAO, CNPSA; LUIZ LEHMANN COUTINHO, Esalq; JORGE AUGUSTO PETROLI MARCHESI, USP; MARIANE SPUDEIT DAL PIZZOL, UDESC/Chapecó; DÉBORA ESTER PETRY MARCELINO, FACC; MONICA CORREA LEDUR, CNPSA. |
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Título: |
Downregulation of growth plate genes involved with the onset of femoral head separation in young broilers. |
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Ano de publicação: |
2022 |
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Fonte/Imprenta: |
Frontiers in Physiology, v. 3, n. 941134, 2022. doi: 10.3389/fphys.2022.941134 |
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DOI: |
https://doi.org/10.3389/fphys.2022.941134 |
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Idioma: |
Inglês |
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Conteúdo: |
Abstract: Femoral head separation (FHS) is characterized by the detachment of growth plate (GP) and articular cartilage, occurring in tibia and femur. However, the molecular mechanisms involved with this condition are not completely understood. Therefore, genes and biological processes (BP) involved with FHS were identified in 21-day-old broilers through RNA sequencing of the femoral GP. 13,487 genes were expressed in the chicken femoral head transcriptome of normal and FHS-affected broilers. From those, 34 were differentially expressed (DE; FDR ≤0.05) between groups, where all of them were downregulated in FHS-affected broilers. The main BP were enriched in receptor signaling pathways, ossification, bone mineralization and formation, skeletal morphogenesis, and vascularization. RNA-Seq datasets comparison of normal and FHS-affected broilers with 21, 35 and 42 days of age has shown three shared DE genes (FBN2, C1QTNF8, and XYLT1) in GP among ages. Twelve genes were exclusively DE at 21 days, where 10 have already been characterized (SHISA3, FNDC1, ANGPTL7, LEPR, ENSGALG00000049529, OXTR, ENSGALG00000045154, COL16A1, RASD2, BOC, GDF10, and THSD7B). Twelve SNPs were associated with FHS (p < 0.0001). Out of those, 5 were novel and 7 were existing variants located in 7 genes (RARS, TFPI2, TTI1, MAP4K3, LINK54, and AREL1). We have shown that genes related to chondrogenesis and bone differentiation were downregulated in the GP of FHS-affected young broilers. Therefore, these findings evince that candidate genes pointed out in our study are probably related to the onset of FHS in broilers. MenosAbstract: Femoral head separation (FHS) is characterized by the detachment of growth plate (GP) and articular cartilage, occurring in tibia and femur. However, the molecular mechanisms involved with this condition are not completely understood. Therefore, genes and biological processes (BP) involved with FHS were identified in 21-day-old broilers through RNA sequencing of the femoral GP. 13,487 genes were expressed in the chicken femoral head transcriptome of normal and FHS-affected broilers. From those, 34 were differentially expressed (DE; FDR ≤0.05) between groups, where all of them were downregulated in FHS-affected broilers. The main BP were enriched in receptor signaling pathways, ossification, bone mineralization and formation, skeletal morphogenesis, and vascularization. RNA-Seq datasets comparison of normal and FHS-affected broilers with 21, 35 and 42 days of age has shown three shared DE genes (FBN2, C1QTNF8, and XYLT1) in GP among ages. Twelve genes were exclusively DE at 21 days, where 10 have already been characterized (SHISA3, FNDC1, ANGPTL7, LEPR, ENSGALG00000049529, OXTR, ENSGALG00000045154, COL16A1, RASD2, BOC, GDF10, and THSD7B). Twelve SNPs were associated with FHS (p < 0.0001). Out of those, 5 were novel and 7 were existing variants located in 7 genes (RARS, TFPI2, TTI1, MAP4K3, LINK54, and AREL1). We have shown that genes related to chondrogenesis and bone differentiation were downregulated in the GP of FHS-affected young broilers. Therefore, these... Mostrar Tudo |
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Palavras-Chave: |
FBN2; Femoral head necrosis; FHS; Necrose da cabeça femoral; RNA-Seq. |
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Thesagro: |
Frango; Galinha; Genética Animal. |
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Thesaurus NAL: |
Chickens; Gene expression. |
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Categoria do assunto: |
-- |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/doc/1145416/1/final9937.pdf
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Marc: |
LEADER 02692naa a2200361 a 4500
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024 7 $ahttps://doi.org/10.3389/fphys.2022.941134$2DOI
100 1 $aIBELLI, A. M. G.
245 $aDownregulation of growth plate genes involved with the onset of femoral head separation in young broilers.$h[electronic resource]
260 $c2022
520 $aAbstract: Femoral head separation (FHS) is characterized by the detachment of growth plate (GP) and articular cartilage, occurring in tibia and femur. However, the molecular mechanisms involved with this condition are not completely understood. Therefore, genes and biological processes (BP) involved with FHS were identified in 21-day-old broilers through RNA sequencing of the femoral GP. 13,487 genes were expressed in the chicken femoral head transcriptome of normal and FHS-affected broilers. From those, 34 were differentially expressed (DE; FDR ≤0.05) between groups, where all of them were downregulated in FHS-affected broilers. The main BP were enriched in receptor signaling pathways, ossification, bone mineralization and formation, skeletal morphogenesis, and vascularization. RNA-Seq datasets comparison of normal and FHS-affected broilers with 21, 35 and 42 days of age has shown three shared DE genes (FBN2, C1QTNF8, and XYLT1) in GP among ages. Twelve genes were exclusively DE at 21 days, where 10 have already been characterized (SHISA3, FNDC1, ANGPTL7, LEPR, ENSGALG00000049529, OXTR, ENSGALG00000045154, COL16A1, RASD2, BOC, GDF10, and THSD7B). Twelve SNPs were associated with FHS (p < 0.0001). Out of those, 5 were novel and 7 were existing variants located in 7 genes (RARS, TFPI2, TTI1, MAP4K3, LINK54, and AREL1). We have shown that genes related to chondrogenesis and bone differentiation were downregulated in the GP of FHS-affected young broilers. Therefore, these findings evince that candidate genes pointed out in our study are probably related to the onset of FHS in broilers.
650 $aChickens
650 $aGene expression
650 $aFrango
650 $aGalinha
650 $aGenética Animal
653 $aFBN2
653 $aFemoral head necrosis
653 $aFHS
653 $aNecrose da cabeça femoral
653 $aRNA-Seq
700 1 $aPEIXOTO, J. de O.
700 1 $aZANELLA, R.
700 1 $aGOUVEIA, J. J. de S.
700 1 $aCANTAO, M. E.
700 1 $aCOUTINHO, L. L.
700 1 $aMARCHESI, J. A. P.
700 1 $aDAL PIZZOL, M. S.
700 1 $aMARCELINO, D. E. P.
700 1 $aLEDUR, M. C.
773 $tFrontiers in Physiology$gv. 3, n. 941134, 2022. doi: 10.3389/fphys.2022.941134
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Embrapa Suínos e Aves (CNPSA) |
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