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Registro Completo |
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Biblioteca(s): |
Embrapa Pecuária Sudeste; Embrapa Solos. |
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Data corrente: |
23/02/2017 |
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Data da última atualização: |
10/11/2021 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
GONZALEZ, M. H.; SILVA, C. S. da; AMARAL, C. D. B.; BIANCHI, S. R.; OLIVEIRA, L. H. B. de; COELHO, J. S.; OLIVEIRA, A.; NOGUEIRA, A. R. de A. |
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Afiliação: |
Mario Henrique Gonzalez, UNESP; Caroline Santos da Silva, UFSCar; Clarice Dias Britto do Amaral, UFSCar; SILMARA ROSSANA BIANCHI, CNPS; Luciano Henrique Barca de Oliveira, UNESP; Jessica Silva Coelho, UNESP; Andrea Oliveira, UFPR; ANA RITA DE ARAUJO NOGUEIRA, CPPSE. |
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Título: |
Determination of elemental impurities in acyclovir ointment and raw materials using microwave acid digestion (MW-AD) and ICP-MS. |
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Ano de publicação: |
2017 |
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Fonte/Imprenta: |
Journal of the Brazilian Chemical Society, v. 28, n. 1, p. 98-105, 2017. |
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DOI: |
https://doi.org/10.5935/0103-5053.20160151 |
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Idioma: |
Inglês
Português |
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Conteúdo: |
Inorganic elements present in pharmaceutical products were determined by inductively coupled plasma-mass spectrometer (ICP-MS), employing microwave acid digestion as a sample preparation method. The most abundant isotopes, 75As+ , 65Cu+ , 52Cr+ , 58Ni+ , 208Pb+ , and 51V+ , were determined in acyclovir ointment and its constituents. Elemental impurities in the pharmaceutical samples were determined using an inductively coupled plasma-universal cell technology-mass spectrometer (ICP-UCT-MS) operated in kinetic energy discrimination (KED) and standard mode. The accuracy of the method was assessed by means of addition and recovery experiments. Except for Cr, spiked recoveries of the elements added to the samples before microwave acid digestion (MW-AD) step were between 95.1 and 126%, and after MW-AD step ranged from 85.6 to 132%. Limits of detection (LOD) obtained by proposed method is in agreement to those required by the U.S. Pharmacopeia Convention (USP), showing that the ICP-MS technique is well suited for quantification of these elements. The LOD's (ng L-1) for 51V+ , 52Cr+ , 58Ni+ , 65Cu+ , 75As+ and 208Pb+ in 1% v v-1 HNO3 medium were: 2.2, 81.3, 91.9, 6.9, 0.2 and 3.1, respectively. The concentration of the analytes in these samples presented a wide range, varying from 2.3 ± 0.8 µg kg-1 for As to 3446 ± 47 µg kg-1 for Cr. |
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Palavras-Chave: |
Acyclovir; Elemental impurity; Impureza elementar; Pharmaceutical product; Produto farmacêutico. |
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Categoria do assunto: |
X Pesquisa, Tecnologia e Engenharia |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/156641/1/0103-5053-jbchs-28-01-0098.pdf
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Marc: |
LEADER 02269naa a2200277 a 4500
001 2067515
005 2021-11-10
008 2017 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.5935/0103-5053.20160151$2DOI
100 1 $aGONZALEZ, M. H.
245 $aDetermination of elemental impurities in acyclovir ointment and raw materials using microwave acid digestion (MW-AD) and ICP-MS.$h[electronic resource]
260 $c2017
520 $aInorganic elements present in pharmaceutical products were determined by inductively coupled plasma-mass spectrometer (ICP-MS), employing microwave acid digestion as a sample preparation method. The most abundant isotopes, 75As+ , 65Cu+ , 52Cr+ , 58Ni+ , 208Pb+ , and 51V+ , were determined in acyclovir ointment and its constituents. Elemental impurities in the pharmaceutical samples were determined using an inductively coupled plasma-universal cell technology-mass spectrometer (ICP-UCT-MS) operated in kinetic energy discrimination (KED) and standard mode. The accuracy of the method was assessed by means of addition and recovery experiments. Except for Cr, spiked recoveries of the elements added to the samples before microwave acid digestion (MW-AD) step were between 95.1 and 126%, and after MW-AD step ranged from 85.6 to 132%. Limits of detection (LOD) obtained by proposed method is in agreement to those required by the U.S. Pharmacopeia Convention (USP), showing that the ICP-MS technique is well suited for quantification of these elements. The LOD's (ng L-1) for 51V+ , 52Cr+ , 58Ni+ , 65Cu+ , 75As+ and 208Pb+ in 1% v v-1 HNO3 medium were: 2.2, 81.3, 91.9, 6.9, 0.2 and 3.1, respectively. The concentration of the analytes in these samples presented a wide range, varying from 2.3 ± 0.8 µg kg-1 for As to 3446 ± 47 µg kg-1 for Cr.
653 $aAcyclovir
653 $aElemental impurity
653 $aImpureza elementar
653 $aPharmaceutical product
653 $aProduto farmacêutico
700 1 $aSILVA, C. S. da
700 1 $aAMARAL, C. D. B.
700 1 $aBIANCHI, S. R.
700 1 $aOLIVEIRA, L. H. B. de
700 1 $aCOELHO, J. S.
700 1 $aOLIVEIRA, A.
700 1 $aNOGUEIRA, A. R. de A.
773 $tJournal of the Brazilian Chemical Society$gv. 28, n. 1, p. 98-105, 2017.
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Registro original: |
Embrapa Solos (CNPS) |
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Registro Completo
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Biblioteca(s): |
Embrapa Meio Ambiente. |
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Data corrente: |
13/03/2024 |
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Data da última atualização: |
14/03/2024 |
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Tipo da produção científica: |
Artigo em Anais de Congresso |
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Autoria: |
ANDRADE, C. A. de; TRETTEL, M.; GERDES, L; BARBOSA, C. M. P; RODRIGUES, P. H. M.; LIGO, M. A. V.; NOGUEIRA, S. F.; LIMA, M. A. de; CARVALHO, T. A.; BETTANIN, V. C.; SANTOS, J. de O.; VASO, L. M. |
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Afiliação: |
CRISTIANO ALBERTO DE ANDRADE, CNPMA; MURILO TRETTEL, FMV/USP; LUCIANO GERGES, FMV/USP; CRISTINA M. PACHECO BARBOSA, FMV/USP; PAULO H. MAZZA RODRIGUES, FMV/USP; MARCOS ANTONIO VIEIRA LIGO, EMBRAPA MEIO AMBIENTE; SANDRA FURLAN NOGUEIRA, CNPMA; MAGDA APARECIDA DE LIMA, CNPMA; TAÍS ALBES CARVALHO, BOLSISTA EMBRAPA MEIO AMBIENTE; VIVIANE CRISTINA BETTANIN, CNPMA; JULIANA DE OLIVEIRA SANTOS MARCATTO, CNPMA. |
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Título: |
Emission of greenhouse gases from soils under pastures submitted to diferent grazing managements and nitrogen fertilization rates, and intercropping with macrotyloma. |
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Ano de publicação: |
2023 |
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Fonte/Imprenta: |
In: SYMPOSIUM STRATEGIC PRACTICES FOR MITIGATING GREENHOUSE GAS EMISSION IN GRASSLAND. Proceedings... São Carlos: Embrapa Pecuária Sudeste, 2023. p. 28-30. |
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Páginas: |
p. 28-30 |
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Idioma: |
Português |
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Conteúdo: |
In Brazil, agriculture contributes to the emission of greenhouse gases, but has great power to sequester carbon (C) in the soil. The objective of this research was to quantify the C stock in the soil due to land use change (LUC) from forest (Atlantic Forest biome) to Urochloa brizantha pasture, obtaining LUC factors; as well as determining C sequestration rates resultant of the adoption of better pasture management practices. The soil C stocks with the change of land use from forest to pasture was investigated in two locations, one with Dystrophic Red Oxisol and Dystrophic Red Argisol, and the other with Dark Red Oxisol, in the cities of Nova Odessa and Pirassununga, both in the State of São Paulo. Soil C stocks were obtained from soil sampling in pits with an auger, in different layers, down to 100 cm deep. The LUC factor was calculated from the ratio between the C stock in the forest soil and the C stock in the soil under pasture, for each location and soil type. The intensification of pasture management was studied in Pirassununga, resultant ofnitrogen fertilization and deferred or rotated grazing, while in Nova Odessa nitrogen fertilization and intercropping between U. brizantha and Macrotyloma axillare were tested. Soil sampling to obtain initial C stocks and after two years of implementing the new management was carried out in a similar way to that mentioned for LUC, but only considering the soil downto 30 cm deep. The factors for LUC varied between 0.76 and 0.98, demonstrating that inadequate management can affect the C stock in the soil in relation to the forest (standard IPCC value of 1), but that these factors increased when an appropriate management was applied, varying between 1.04 and 1.18, when compared to the IPCC factor standard value of 1.17. Furthermore, management practices resulted in C sequestration rates ranging between 1.2 and 4.4 t C ha-1 year-1, relatively high values that demonstrate the high potential of soils under pasture for C sequestration. MenosIn Brazil, agriculture contributes to the emission of greenhouse gases, but has great power to sequester carbon (C) in the soil. The objective of this research was to quantify the C stock in the soil due to land use change (LUC) from forest (Atlantic Forest biome) to Urochloa brizantha pasture, obtaining LUC factors; as well as determining C sequestration rates resultant of the adoption of better pasture management practices. The soil C stocks with the change of land use from forest to pasture was investigated in two locations, one with Dystrophic Red Oxisol and Dystrophic Red Argisol, and the other with Dark Red Oxisol, in the cities of Nova Odessa and Pirassununga, both in the State of São Paulo. Soil C stocks were obtained from soil sampling in pits with an auger, in different layers, down to 100 cm deep. The LUC factor was calculated from the ratio between the C stock in the forest soil and the C stock in the soil under pasture, for each location and soil type. The intensification of pasture management was studied in Pirassununga, resultant ofnitrogen fertilization and deferred or rotated grazing, while in Nova Odessa nitrogen fertilization and intercropping between U. brizantha and Macrotyloma axillare were tested. Soil sampling to obtain initial C stocks and after two years of implementing the new management was carried out in a similar way to that mentioned for LUC, but only considering the soil downto 30 cm deep. The factors for LUC varied between 0.76 and 0.98, demo... Mostrar Tudo |
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Palavras-Chave: |
Gases de efeito estufa; Macrotyloma axillare; Óxido nitriso. |
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Thesaurus NAL: |
Emissions factor; Greenhouse gas emissions; Nitrous oxide; Urochloa brizantha. |
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Categoria do assunto: |
P Recursos Naturais, Ciências Ambientais e da Terra |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/doc/1162777/1/AA-Andrade.pdf
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Marc: |
LEADER 03178nam a2200337 a 4500
001 2162777
005 2024-03-14
008 2023 bl uuuu u00u1 u #d
100 1 $aANDRADE, C. A. de
245 $aEmission of greenhouse gases from soils under pastures submitted to diferent grazing managements and nitrogen fertilization rates, and intercropping with macrotyloma.$h[electronic resource]
260 $aIn: SYMPOSIUM STRATEGIC PRACTICES FOR MITIGATING GREENHOUSE GAS EMISSION IN GRASSLAND. Proceedings... São Carlos: Embrapa Pecuária Sudeste, 2023. p. 28-30.$c2023
300 $ap. 28-30
520 $aIn Brazil, agriculture contributes to the emission of greenhouse gases, but has great power to sequester carbon (C) in the soil. The objective of this research was to quantify the C stock in the soil due to land use change (LUC) from forest (Atlantic Forest biome) to Urochloa brizantha pasture, obtaining LUC factors; as well as determining C sequestration rates resultant of the adoption of better pasture management practices. The soil C stocks with the change of land use from forest to pasture was investigated in two locations, one with Dystrophic Red Oxisol and Dystrophic Red Argisol, and the other with Dark Red Oxisol, in the cities of Nova Odessa and Pirassununga, both in the State of São Paulo. Soil C stocks were obtained from soil sampling in pits with an auger, in different layers, down to 100 cm deep. The LUC factor was calculated from the ratio between the C stock in the forest soil and the C stock in the soil under pasture, for each location and soil type. The intensification of pasture management was studied in Pirassununga, resultant ofnitrogen fertilization and deferred or rotated grazing, while in Nova Odessa nitrogen fertilization and intercropping between U. brizantha and Macrotyloma axillare were tested. Soil sampling to obtain initial C stocks and after two years of implementing the new management was carried out in a similar way to that mentioned for LUC, but only considering the soil downto 30 cm deep. The factors for LUC varied between 0.76 and 0.98, demonstrating that inadequate management can affect the C stock in the soil in relation to the forest (standard IPCC value of 1), but that these factors increased when an appropriate management was applied, varying between 1.04 and 1.18, when compared to the IPCC factor standard value of 1.17. Furthermore, management practices resulted in C sequestration rates ranging between 1.2 and 4.4 t C ha-1 year-1, relatively high values that demonstrate the high potential of soils under pasture for C sequestration.
650 $aEmissions factor
650 $aGreenhouse gas emissions
650 $aNitrous oxide
650 $aUrochloa brizantha
653 $aGases de efeito estufa
653 $aMacrotyloma axillare
653 $aÓxido nitriso
700 1 $aTRETTEL, M.
700 1 $aGERDES, L
700 1 $aBARBOSA, C. M. P
700 1 $aRODRIGUES, P. H. M.
700 1 $aLIGO, M. A. V.
700 1 $aNOGUEIRA, S. F.
700 1 $aLIMA, M. A. de
700 1 $aCARVALHO, T. A.
700 1 $aBETTANIN, V. C.
700 1 $aSANTOS, J. de O.
700 1 $aVASO, L. M.
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Embrapa Meio Ambiente (CNPMA) |
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