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Registro Completo |
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Biblioteca(s): |
Ebooks. |
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Data corrente: |
15/08/2008 |
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Data da última atualização: |
16/06/2011 |
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Autoria: |
HUANG, L.; HUNG, M.-C.; WAGNER, E. |
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Afiliação: |
Leaf Huang; Mien-chie. Hung; Ernst Wagner. |
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Título: |
Nonviral vectors for gene therapy |
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Ano de publicação: |
1999 |
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Fonte/Imprenta: |
San Diego, CA : Academic Press, c1999. |
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Páginas: |
xxv, 442 p. |
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Descrição Física: |
ill. (some col.) ;24 cm. |
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ISBN: |
9780123584656 |
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Idioma: |
Inglês |
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Conteúdo: |
Introduction, L.Huang and E. Viroonhatapan. -- Cationic Liposomes: -- Progress in Gene Delivery Research and Development, P. Felgner. -- Cationic Lipid-Mediated Gene Delivery to the Airways, J. Marshall, N. Yew, S. Eastman, C. Jiang, R. Scheule, S. Cheng. -- Structure and Structure-Activity Relationship of Lipid-Based Gene Delivery Systems, D. Lasic. -- Self-Assembled Structures of Lipid/DNA Nonviral Gene Delivery Systems from Synchorotron X-Ray Diffraction, C. Safinya, I. Koltover. -- Sites of Uptake and Expression of Cationic Liposome/DNA Complexes Injected Intravenously, J. McLean, G. Thurston, D. McDonald. -- Other Vectors: -- Nuclear Transport of Exogenous DNA, M. Sebestyâen and J. Wolff. -- Particle-Mediated Gene Delivery: Applications to Canine and Other Larger Animal Systems, N.-S. Yang, G. Hogge, E.G. MacEwen. -- Polyethylenimines: A Family of Potent Polymers for Nucleic Acid Delivery, A. Kichler, J.-P. Behr, P. Erbacher. -- Ligand-Polycation Conjugates for Receptor-Targeted Gene Transfer, E. Wagner. -- The Perplexing Delivery Mechanism of Lipoplexes, L. Barron and F. Szoka, Jr.. -- Biopolymer-DNA Nanospheres, K. Leong. -- Novel Lipidic Vectors for Gene Transfer, S. Li, L. Huang. -- Animal Models and Clinical Trials: -- Mechanisms of Cationic Liposome-Mediated Transfection of the Lung Endothelium, D. Liu, J. Knapp, Y. Song. -- Cystic Fibrosis Gene Therapy, U. Griesenbach, D. Geddes, E. Alton. -- Targeting HER-2/neu-Overexpressing Cancer Cells with Transcriptional Repressor Genes Delivered by Cationic Liposome, M.-C. Hung, S.-C. Wang, G. Hortobagyi. -- Immune Pathways Used in Nucleic Acid Vaccination, G. Rhodes. -- A Novel Gene Regulatory System, S. Chua, M. Burcin, Y. Wang, S. Tsai. -- Index.Gene transfer within humans has been an obstacle until about 10 years ago. At that time, it was found that viral vectors were effective carriers of "healthy genes" into patients' cells. The problem, however, was that viral vectors proved unnecessarily harmful to humans: subjects experienced inflamatory activity and negative immunological responses to the genes. Viral vectors were also unable to meet the needs of the pharmaceutical community: they were not reproducible in large-scale proportions in cost-effective ways. Thus, research was undertaken to find a safer way to transfer genes to patients without jeopardizing the safety of the patient. And so non-viral vectors were discovered. This volume presents the various non-viral vectors currently under development. Although not methodologically oriented, it will provide the necessary details behind the development of the vectors. This information will prove useful to both researchers and clinicians. Key Features * Presents state-of-the art developments of nonviral vectors as tools for modern molecular medicine * Covers all types of nonviral vectors, from molecular structure to therapeutic application Provides a comprehensive review of synthetic vectors * Includes contributions from major investigators and leading experts in the field. MenosIntroduction, L.Huang and E. Viroonhatapan. -- Cationic Liposomes: -- Progress in Gene Delivery Research and Development, P. Felgner. -- Cationic Lipid-Mediated Gene Delivery to the Airways, J. Marshall, N. Yew, S. Eastman, C. Jiang, R. Scheule, S. Cheng. -- Structure and Structure-Activity Relationship of Lipid-Based Gene Delivery Systems, D. Lasic. -- Self-Assembled Structures of Lipid/DNA Nonviral Gene Delivery Systems from Synchorotron X-Ray Diffraction, C. Safinya, I. Koltover. -- Sites of Uptake and Expression of Cationic Liposome/DNA Complexes Injected Intravenously, J. McLean, G. Thurston, D. McDonald. -- Other Vectors: -- Nuclear Transport of Exogenous DNA, M. Sebestyâen and J. Wolff. -- Particle-Mediated Gene Delivery: Applications to Canine and Other Larger Animal Systems, N.-S. Yang, G. Hogge, E.G. MacEwen. -- Polyethylenimines: A Family of Potent Polymers for Nucleic Acid Delivery, A. Kichler, J.-P. Behr, P. Erbacher. -- Ligand-Polycation Conjugates for Receptor-Targeted Gene Transfer, E. Wagner. -- The Perplexing Delivery Mechanism of Lipoplexes, L. Barron and F. Szoka, Jr.. -- Biopolymer-DNA Nanospheres, K. Leong. -- Novel Lipidic Vectors for Gene Transfer, S. Li, L. Huang. -- Animal Models and Clinical Trials: -- Mechanisms of Cationic Liposome-Mediated Transfection of the Lung Endothelium, D. Liu, J. Knapp, Y. Song. -- Cystic Fibrosis Gene Therapy, U. Griesenbach, D. Geddes, E. Alton. -- Targeting HER-2/neu-Overexpressing Cancer Cells with Transcriptional Re... Mostrar Tudo |
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Palavras-Chave: |
Gene Therapymethods; Gene Transfer Techniques; Genetic; therapeutic use; Transformation. |
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Thesaurus Nal: |
genetic transformation. |
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Categoria do assunto: |
-- |
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URL: |
https://www.sciencedirect.com/science/book/9780123584656
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Marc: |
LEADER 03668nam a2200229 a 4500
001 1711309
005 2011-06-16
008 1999 bl uuuu u0uu1 u #d
020 $a9780123584656
100 1 $aHUANG, L.
245 $aNonviral vectors for gene therapy$h[electronic resource]
260 $aSan Diego, CA : Academic Press$c1999
300 $axxv, 442 p. $cill. (some col.) ;24 cm.
520 $aIntroduction, L.Huang and E. Viroonhatapan. -- Cationic Liposomes: -- Progress in Gene Delivery Research and Development, P. Felgner. -- Cationic Lipid-Mediated Gene Delivery to the Airways, J. Marshall, N. Yew, S. Eastman, C. Jiang, R. Scheule, S. Cheng. -- Structure and Structure-Activity Relationship of Lipid-Based Gene Delivery Systems, D. Lasic. -- Self-Assembled Structures of Lipid/DNA Nonviral Gene Delivery Systems from Synchorotron X-Ray Diffraction, C. Safinya, I. Koltover. -- Sites of Uptake and Expression of Cationic Liposome/DNA Complexes Injected Intravenously, J. McLean, G. Thurston, D. McDonald. -- Other Vectors: -- Nuclear Transport of Exogenous DNA, M. Sebestyâen and J. Wolff. -- Particle-Mediated Gene Delivery: Applications to Canine and Other Larger Animal Systems, N.-S. Yang, G. Hogge, E.G. MacEwen. -- Polyethylenimines: A Family of Potent Polymers for Nucleic Acid Delivery, A. Kichler, J.-P. Behr, P. Erbacher. -- Ligand-Polycation Conjugates for Receptor-Targeted Gene Transfer, E. Wagner. -- The Perplexing Delivery Mechanism of Lipoplexes, L. Barron and F. Szoka, Jr.. -- Biopolymer-DNA Nanospheres, K. Leong. -- Novel Lipidic Vectors for Gene Transfer, S. Li, L. Huang. -- Animal Models and Clinical Trials: -- Mechanisms of Cationic Liposome-Mediated Transfection of the Lung Endothelium, D. Liu, J. Knapp, Y. Song. -- Cystic Fibrosis Gene Therapy, U. Griesenbach, D. Geddes, E. Alton. -- Targeting HER-2/neu-Overexpressing Cancer Cells with Transcriptional Repressor Genes Delivered by Cationic Liposome, M.-C. Hung, S.-C. Wang, G. Hortobagyi. -- Immune Pathways Used in Nucleic Acid Vaccination, G. Rhodes. -- A Novel Gene Regulatory System, S. Chua, M. Burcin, Y. Wang, S. Tsai. -- Index.Gene transfer within humans has been an obstacle until about 10 years ago. At that time, it was found that viral vectors were effective carriers of "healthy genes" into patients' cells. The problem, however, was that viral vectors proved unnecessarily harmful to humans: subjects experienced inflamatory activity and negative immunological responses to the genes. Viral vectors were also unable to meet the needs of the pharmaceutical community: they were not reproducible in large-scale proportions in cost-effective ways. Thus, research was undertaken to find a safer way to transfer genes to patients without jeopardizing the safety of the patient. And so non-viral vectors were discovered. This volume presents the various non-viral vectors currently under development. Although not methodologically oriented, it will provide the necessary details behind the development of the vectors. This information will prove useful to both researchers and clinicians. Key Features * Presents state-of-the art developments of nonviral vectors as tools for modern molecular medicine * Covers all types of nonviral vectors, from molecular structure to therapeutic application Provides a comprehensive review of synthetic vectors * Includes contributions from major investigators and leading experts in the field.
650 $agenetic transformation
653 $aGene Therapymethods
653 $aGene Transfer Techniques
653 $aGenetic
653 $atherapeutic use
653 $aTransformation
700 1 $aHUNG, M.-C.
700 1 $aWAGNER, E.
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Registro original: |
Ebooks (Ebooks) |
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Registro Completo
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Biblioteca(s): |
Embrapa Unidades Centrais. |
|
Data corrente: |
07/12/2016 |
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Data da última atualização: |
29/12/2017 |
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Autoria: |
ALMEIDA, A. C. de; MORÃO, R. P.; MARTINS, E. R.; FONSECA, F. S. A. da; SOUZA, C. N. de; PRATES, J. P. B.; OLIVEIRA, F. D. de; SILVA, L. M. V. |
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Afiliação: |
ANNA CHRISTINA DE ALMEIDA, UFMG; RODRIGO PEREIRA MORÃO, UFMG; ERNANE RONIE MARTINS, UFMG; FRANCINE SOUZA ALVES DA FONSECA, UFMG; CINTYA NEVES DE SOUZA, UFMG; JOÃO PAULO BICALHO PRATES, UFMG; FÁBIO DIAS DE OLIVEIRA, UFMG; LÍVIA MARA VITORINO DA SILVA, UFMG. |
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Título: |
Atividade antisséptica do óleo essencial de Lippia origanoides Cham. (Alecrim-pimenta) na presença de leite bovino. |
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Ano de publicação: |
2016 |
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Fonte/Imprenta: |
Pesquisa Veterinária Brasileira, Rio de Janeiro, v. 36, n. 9, p. 905-911, set. 2016. |
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Idioma: |
Português |
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Conteúdo: |
Objetivou-se determinar atividade antisséptica do óleo essencial de Lippia origanoides na presença de leite bovino. A composição química do óleo essencial de alecrim pimenta foi determinada por cromatografia gasosa acoplada à espectrometria de massas (CG-EM), sendo detectados 53 compostos, dos quais 16 foram identificados (>0,1% área total). O carvacrol (32,7%), p-cimeno (23%), timilmetil éter, cariofileno (7,98%) e o γ-terpineno (5,40%) foram os componentes mais abundantes. A concentração inibitória mínima para Staphylococcus aureus ATCC 25923 e E. coli ATCC 8739 foi de 60μL/mL, enquanto para Salmonella Choleraesuis ATCC 35640 foi de 90μL/mL. A concentração bactericida mínima foi de 120μL/mL para as três bactérias. Avaliou-se a atividade antisséptica do óleo essencial na concentração de 120μL/mL na presença de leite bovino sobre as mesmas cepas bacterianas. O óleo em estudo apresentou efeito inibitório do crescimento das cepas em diferentes tempos de ação (p<0,05). S. aureus apresentou maiores índices de inibição após 5 min de contato e Escherichia coli e Salmonella Choleraesuis após 15 min. O óleo essencial de alecrim-pimenta revelou ser um potencial antimicrobiano natural, mesmo na presença de matéria orgânica constituída de uma matriz nutricional complexa que é o leite bovino. |
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Palavras-Chave: |
Alecrim-pimenta; Antimicrobiano natural; Antiseptic activity; Atividade antisséptica; Efeito inibitório; Inhibitory effect; Leite bovino; Natural antimicrobials; Timol. |
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Thesagro: |
Óleo essencial. |
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Thesaurus NAL: |
Carvacrol; Essential oils; Lippia origanoides; Milk; Thymol. |
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Categoria do assunto: |
-- |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/151444/1/Atividade-antisseptica-do-oleo.pdf
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Marc: |
LEADER 02504naa a2200385 a 4500
001 2058219
005 2017-12-29
008 2016 bl uuuu u00u1 u #d
100 1 $aALMEIDA, A. C. de
245 $aAtividade antisséptica do óleo essencial de Lippia origanoides Cham. (Alecrim-pimenta) na presença de leite bovino.
260 $c2016
520 $aObjetivou-se determinar atividade antisséptica do óleo essencial de Lippia origanoides na presença de leite bovino. A composição química do óleo essencial de alecrim pimenta foi determinada por cromatografia gasosa acoplada à espectrometria de massas (CG-EM), sendo detectados 53 compostos, dos quais 16 foram identificados (>0,1% área total). O carvacrol (32,7%), p-cimeno (23%), timilmetil éter, cariofileno (7,98%) e o γ-terpineno (5,40%) foram os componentes mais abundantes. A concentração inibitória mínima para Staphylococcus aureus ATCC 25923 e E. coli ATCC 8739 foi de 60μL/mL, enquanto para Salmonella Choleraesuis ATCC 35640 foi de 90μL/mL. A concentração bactericida mínima foi de 120μL/mL para as três bactérias. Avaliou-se a atividade antisséptica do óleo essencial na concentração de 120μL/mL na presença de leite bovino sobre as mesmas cepas bacterianas. O óleo em estudo apresentou efeito inibitório do crescimento das cepas em diferentes tempos de ação (p<0,05). S. aureus apresentou maiores índices de inibição após 5 min de contato e Escherichia coli e Salmonella Choleraesuis após 15 min. O óleo essencial de alecrim-pimenta revelou ser um potencial antimicrobiano natural, mesmo na presença de matéria orgânica constituída de uma matriz nutricional complexa que é o leite bovino.
650 $aCarvacrol
650 $aEssential oils
650 $aLippia origanoides
650 $aMilk
650 $aThymol
650 $aÓleo essencial
653 $aAlecrim-pimenta
653 $aAntimicrobiano natural
653 $aAntiseptic activity
653 $aAtividade antisséptica
653 $aEfeito inibitório
653 $aInhibitory effect
653 $aLeite bovino
653 $aNatural antimicrobials
653 $aTimol
700 1 $aMORÃO, R. P.
700 1 $aMARTINS, E. R.
700 1 $aFONSECA, F. S. A. da
700 1 $aSOUZA, C. N. de
700 1 $aPRATES, J. P. B.
700 1 $aOLIVEIRA, F. D. de
700 1 $aSILVA, L. M. V.
773 $tPesquisa Veterinária Brasileira, Rio de Janeiro$gv. 36, n. 9, p. 905-911, set. 2016.
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