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 | Acesso ao texto completo restrito à biblioteca da Embrapa Agricultura Digital. Para informações adicionais entre em contato com cnptia.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Agricultura Digital. |
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Data corrente: |
10/02/2014 |
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Data da última atualização: |
08/01/2020 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
MENDES, T. A. O.; LOBO, F. P.; RODRIGUES, T. S.; RODRIGUES-LUIZ, G. F.; ROCHA, W. D. da; FUJIWARA, R. T.; TEIXEIRA, S. M. R.; BARTHOLOMEU, D. C. |
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Afiliação: |
UFMG; FRANCISCO PEREIRA LOBO, CNPTIA; Centro Federal de Educação Tecnológica de Minas Gerais; UFMG; UFPR; UFMG; UFMG; UFMG. |
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Título: |
Repeat-enriched proteins are related to host cell invasion and immune evasion in parasitic protozoa. |
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Ano de publicação: |
2013 |
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Fonte/Imprenta: |
Molecular Biology and Evolution, Chicago, v. 30, n. 4, p. 951-963, 2013. |
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DOI: |
10.1093/molbev/mst001 |
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Idioma: |
Inglês |
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Conteúdo: |
Proteins containing repetitive amino acid domains are widespread in all life forms. In parasitic organisms, proteins containing repeats play important roles such as cell adhesion and invasion and immune evasion. Therefore, extracellular and intracellular parasites are expected to be under different selective pressures regarding the repetitive content in their genomes. Here, we investigated whether there is a bias in the repetitive content found in the predicted proteomes of 6 exclusively extracellular and 17 obligate intracellular protozoan parasites, as well as 4 free-living protists. We also attempted to correlate the results with the distinct ecological niches they occupy and with distinct protein functions. We found that intracellular parasites have higher repetitive content in their proteomes than do extracellular parasites and free-living protists. In intracellular parasites, these repetitive proteins are located mainly at the parasite surface or are secreted and are enriched in amino acids known to be part of N- and O-glycosylation sites. Furthermore, in intracellular parasites, the developmental stages that are able to invade host cells express a higher proportion of proteins with perfect repeats relative to other life cycle stages, and these proteins have molecular functions associated with cell invasion. In contrast, in extracellular parasites, degenerate repetitive motifs are enriched in proteins that are likely to play roles in evading host immune response. Altogether, our results support the hypothesis that both the ability to invade host cells and to escape the host immune response may have shaped the expansion and maintenance of perfect and degenerate repeats in the genomes of intra- and extracellular parasites. MenosProteins containing repetitive amino acid domains are widespread in all life forms. In parasitic organisms, proteins containing repeats play important roles such as cell adhesion and invasion and immune evasion. Therefore, extracellular and intracellular parasites are expected to be under different selective pressures regarding the repetitive content in their genomes. Here, we investigated whether there is a bias in the repetitive content found in the predicted proteomes of 6 exclusively extracellular and 17 obligate intracellular protozoan parasites, as well as 4 free-living protists. We also attempted to correlate the results with the distinct ecological niches they occupy and with distinct protein functions. We found that intracellular parasites have higher repetitive content in their proteomes than do extracellular parasites and free-living protists. In intracellular parasites, these repetitive proteins are located mainly at the parasite surface or are secreted and are enriched in amino acids known to be part of N- and O-glycosylation sites. Furthermore, in intracellular parasites, the developmental stages that are able to invade host cells express a higher proportion of proteins with perfect repeats relative to other life cycle stages, and these proteins have molecular functions associated with cell invasion. In contrast, in extracellular parasites, degenerate repetitive motifs are enriched in proteins that are likely to play roles in evading host immune response. Altog... Mostrar Tudo |
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Palavras-Chave: |
Evasão imune; Evolução genômica; Invasão celular; Parasitas; Proteínas. |
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Thesaurus Nal: |
Cell invasion; Evolution; Immune evasion; Parasites; Proteins; Protozoa. |
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Categoria do assunto: |
S Ciências Biológicas |
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Marc: |
LEADER 02770naa a2200349 a 4500
001 1979314
005 2020-01-08
008 2013 bl uuuu u00u1 u #d
024 7 $a10.1093/molbev/mst001$2DOI
100 1 $aMENDES, T. A. O.
245 $aRepeat-enriched proteins are related to host cell invasion and immune evasion in parasitic protozoa.$h[electronic resource]
260 $c2013
520 $aProteins containing repetitive amino acid domains are widespread in all life forms. In parasitic organisms, proteins containing repeats play important roles such as cell adhesion and invasion and immune evasion. Therefore, extracellular and intracellular parasites are expected to be under different selective pressures regarding the repetitive content in their genomes. Here, we investigated whether there is a bias in the repetitive content found in the predicted proteomes of 6 exclusively extracellular and 17 obligate intracellular protozoan parasites, as well as 4 free-living protists. We also attempted to correlate the results with the distinct ecological niches they occupy and with distinct protein functions. We found that intracellular parasites have higher repetitive content in their proteomes than do extracellular parasites and free-living protists. In intracellular parasites, these repetitive proteins are located mainly at the parasite surface or are secreted and are enriched in amino acids known to be part of N- and O-glycosylation sites. Furthermore, in intracellular parasites, the developmental stages that are able to invade host cells express a higher proportion of proteins with perfect repeats relative to other life cycle stages, and these proteins have molecular functions associated with cell invasion. In contrast, in extracellular parasites, degenerate repetitive motifs are enriched in proteins that are likely to play roles in evading host immune response. Altogether, our results support the hypothesis that both the ability to invade host cells and to escape the host immune response may have shaped the expansion and maintenance of perfect and degenerate repeats in the genomes of intra- and extracellular parasites.
650 $aCell invasion
650 $aEvolution
650 $aImmune evasion
650 $aParasites
650 $aProteins
650 $aProtozoa
653 $aEvasão imune
653 $aEvolução genômica
653 $aInvasão celular
653 $aParasitas
653 $aProteínas
700 1 $aLOBO, F. P.
700 1 $aRODRIGUES, T. S.
700 1 $aRODRIGUES-LUIZ, G. F.
700 1 $aROCHA, W. D. da
700 1 $aFUJIWARA, R. T.
700 1 $aTEIXEIRA, S. M. R.
700 1 $aBARTHOLOMEU, D. C.
773 $tMolecular Biology and Evolution, Chicago$gv. 30, n. 4, p. 951-963, 2013.
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Embrapa Agricultura Digital (CNPTIA) |
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Registro Completo
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Biblioteca(s): |
Embrapa Algodão. |
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Data corrente: |
14/01/2010 |
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Data da última atualização: |
14/01/2010 |
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Tipo da produção científica: |
Resumo em Anais de Congresso |
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Autoria: |
FERNANDES, V. M. C.; MORAIS, J. P. S.; PINHEIRO, M. V. M.; CARVALHO, A. C. P. P. de; BARROS, L. de M.; ARAGÃO, F. A. S. de. |
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Afiliação: |
Vanessa Moreira Câmara Fernandes, UFC;; João Paulo Saraiva Morais, CNPA;; Marcos Vinícios Marques Pinheiro, UFV;; Ana Cristina Portugal Pinto Carvalho, CNPAT;; Levi de Moura Barros, CNPAT;; Fenando Antônio Sousa Aragão, CNPAT.; JOÃO PAULO SARAIVA MORAIS. |
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Título: |
Efeito de diferentes auxinas na indução de calos embriogênicos em três cultivares de antúrio. |
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Ano de publicação: |
2009 |
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Fonte/Imprenta: |
In: CONGRESSO BRASILEIRO DE CULTURA DE TECIDOS DE PLANTAS, 4., 2009, Aracaju. Resumos... Aracaju: Embrapa Tabuleiros Costeiros, 2009. |
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Descrição Física: |
1 CD-ROM. |
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ISSN: |
1678-1953 |
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Idioma: |
Português |
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Palavras-Chave: |
Propagação in vitro; Segmento nodais. |
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Thesagro: |
Anthurium Andraeanum. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 00782naa a2200229 a 4500
001 1580569
005 2010-01-14
008 2009 bl uuuu u00u1 u #d
022 $a1678-1953
100 1 $aFERNANDES, V. M. C.
245 $aEfeito de diferentes auxinas na indução de calos embriogênicos em três cultivares de antúrio.
260 $c2009
300 $c1 CD-ROM.
650 $aAnthurium Andraeanum
653 $aPropagação in vitro
653 $aSegmento nodais
700 1 $aMORAIS, J. P. S.
700 1 $aPINHEIRO, M. V. M.
700 1 $aCARVALHO, A. C. P. P. de
700 1 $aBARROS, L. de M.
700 1 $aARAGÃO, F. A. S. de
773 $tIn: CONGRESSO BRASILEIRO DE CULTURA DE TECIDOS DE PLANTAS, 4., 2009, Aracaju. Resumos... Aracaju: Embrapa Tabuleiros Costeiros, 2009.
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