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| 1. |  | REIS, A. C. C.; JORGE, B. C.; PASCHALINI, B. R.; BUENO, J. N.; STEIN, J.; MOREIRA, S. da S.; MANOEL, B. de M.; FERNANDES, G. S. A.; HISANO, H.; ARENA, A. C. Long-term reproductive effects of benzo(a)pyrene at environmentally relevant dose on juvenile female rats. Drug and Chemical Toxicology, 2022. On-line first.| Biblioteca(s): Embrapa Meio Ambiente. |
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| Registros recuperados : 1 | |
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 | Acesso ao texto completo restrito à biblioteca da Embrapa Meio Ambiente. Para informações adicionais entre em contato com cnpma.biblioteca@embrapa.br. |
Registro Completo
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Biblioteca(s): |
Embrapa Meio Ambiente. |
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Data corrente: |
28/11/2022 |
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Data da última atualização: |
28/11/2022 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 2 |
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Autoria: |
REIS, A. C. C.; JORGE, B. C.; PASCHALINI, B. R.; BUENO, J. N.; STEIN, J.; MOREIRA, S. da S.; MANOEL, B. de M.; FERNANDES, G. S. A.; HISANO, H.; ARENA, A. C. |
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Afiliação: |
ANA CAROLINA CASALI REIS, UNIVERSIDADE ESTADUAL PAULISTA; BÁRBARA CAMPOS JORGE, UNIVERSIDADE ESTADUAL PAULISTA; BEATRIZ RIZZO PASCHOALINI, UNIVERSIDADE ESTADUAL PAULISTA; JÉSSICA NOGUEIRA BUENO, UNIVERSIDADE ESTADUAL PAULISTA; JULIA STEIN, UNIVERSIDADE ESTADUAL PAULISTA; SUYANE DA SILVA MOREIRA, UNIVERSIDADE ESTADUAL PAULISTA; BEATRIZ DE MATOS MANOEL, UNIVERSIDADE ESTADUAL PAULISTA; GLAURA SCANTAMBURLO ALVES FERNANDES, UNIVERSIDADE ESTADUAL DE LONDRINA; HAMILTON HISANO, CNPMA; ARIELLE CRISTINA ARENA, UNIVERSIDADE ESTADUAL PAULISTA. |
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Título: |
Long-term reproductive effects of benzo(a)pyrene at environmentally relevant dose on juvenile female rats. |
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Ano de publicação: |
2022 |
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Fonte/Imprenta: |
Drug and Chemical Toxicology, 2022. |
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ISSN: |
0148-0545 |
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DOI: |
https://doi.org/10.1080/01480545.2022.2105864 |
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Idioma: |
Inglês |
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Notas: |
On-line first. |
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Conteúdo: |
Abstract: Since studies on the reproductive consequences after the exposure to environmentally relevant doses of Benzo(a)pyrene (BaP) during critical stages of development are scarce, this study evaluated female reproductive parameters of adult rats exposed to a low dose of BaP during the juvenile phase. Female rats (Post-natal 21) were treated with BaP (0 or 0.1 µg/kg/day; gavage) for 21 consecutive days. During the treatment, no clinical signs of toxicity were observed. Nevertheless, the ages of vaginal opening and first estrus were anticipated by the BaP-exposure. At the sexual maturity, the juvenile exposure compromised the sexual behavior, as well as the placental efficiency, follicle stimulating hormone levels, placenta histological analysis, and ovarian follicle count. A decrease in erythrocyte, platelet, and lymphocyte counts also was observed in the exposed-females. Moreover, the dose of BaP used in this study was not able to produce estrogenic activity in vivo. These data showed that juvenile BaP-exposure, at environmentally relevant dose, compromised the female reproductive system, possibly by an endocrine deregulation; however, this requires further investigation. |
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Palavras-Chave: |
Endocrine disruptor; Hidrocarboneto policíclico aromático; Juvenile period. |
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Thesagro: |
Aparelho Reprodutor; Fêmea; Hidrocarboneto; Impacto Ambiental; Rato; Reprodução Animal. |
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Thesaurus NAL: |
Benzo(a)pyrene; Female fertility; Female reproductive system; Health effects assessments; Polycyclic aromatic hydrocarbons; Puberty; Rats. |
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Categoria do assunto: |
H Saúde e Patologia |
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Marc: |
LEADER 02533naa a2200457 a 4500
001 2148863
005 2022-11-28
008 2022 bl uuuu u00u1 u #d
022 $a0148-0545
024 7 $ahttps://doi.org/10.1080/01480545.2022.2105864$2DOI
100 1 $aREIS, A. C. C.
245 $aLong-term reproductive effects of benzo(a)pyrene at environmentally relevant dose on juvenile female rats.$h[electronic resource]
260 $c2022
500 $aOn-line first.
520 $aAbstract: Since studies on the reproductive consequences after the exposure to environmentally relevant doses of Benzo(a)pyrene (BaP) during critical stages of development are scarce, this study evaluated female reproductive parameters of adult rats exposed to a low dose of BaP during the juvenile phase. Female rats (Post-natal 21) were treated with BaP (0 or 0.1 µg/kg/day; gavage) for 21 consecutive days. During the treatment, no clinical signs of toxicity were observed. Nevertheless, the ages of vaginal opening and first estrus were anticipated by the BaP-exposure. At the sexual maturity, the juvenile exposure compromised the sexual behavior, as well as the placental efficiency, follicle stimulating hormone levels, placenta histological analysis, and ovarian follicle count. A decrease in erythrocyte, platelet, and lymphocyte counts also was observed in the exposed-females. Moreover, the dose of BaP used in this study was not able to produce estrogenic activity in vivo. These data showed that juvenile BaP-exposure, at environmentally relevant dose, compromised the female reproductive system, possibly by an endocrine deregulation; however, this requires further investigation.
650 $aBenzo(a)pyrene
650 $aFemale fertility
650 $aFemale reproductive system
650 $aHealth effects assessments
650 $aPolycyclic aromatic hydrocarbons
650 $aPuberty
650 $aRats
650 $aAparelho Reprodutor
650 $aFêmea
650 $aHidrocarboneto
650 $aImpacto Ambiental
650 $aRato
650 $aReprodução Animal
653 $aEndocrine disruptor
653 $aHidrocarboneto policíclico aromático
653 $aJuvenile period
700 1 $aJORGE, B. C.
700 1 $aPASCHALINI, B. R.
700 1 $aBUENO, J. N.
700 1 $aSTEIN, J.
700 1 $aMOREIRA, S. da S.
700 1 $aMANOEL, B. de M.
700 1 $aFERNANDES, G. S. A.
700 1 $aHISANO, H.
700 1 $aARENA, A. C.
773 $tDrug and Chemical Toxicology, 2022.
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