| |
|
|
 | Acesso ao texto completo restrito à biblioteca da Embrapa Agroenergia. Para informações adicionais entre em contato com cnpae.biblioteca@embrapa.br. |
|
Registro Completo |
|
Biblioteca(s): |
Embrapa Agroenergia. |
|
Data corrente: |
20/02/2024 |
|
Data da última atualização: |
22/02/2024 |
|
Tipo da produção científica: |
Artigo em Periódico Indexado |
|
Autoria: |
RODRIGUES, C. M.; BENTO, C. C.; MORAES, C. B.; GOMES, C.; IOSHINO, R. S.; FREITAS-JUNIOR, L. H.; SPADARI, C. de C.; ISHIDA, K.; VILEGAS, W.; CARVALHO, J. C. S.; FERREIRA, M. J. P.; CARBONE, V.; PIACENTE, S.; ANGELO, R. M. de; HONORIO, K. M.; SANNOMIYA, M. |
|
Afiliação: |
CLENILSON MARTINS RODRIGUES, CNPAE; CHARLYANA CARVALHO BENTO, UNIVERSIDADE DE SÃO PAULO; CAROLINA BORSOI MORAES, UNIVERSIDADE DE SÃO PAULO; CECILIA GOMES, UNIVERSIDADE DE SÃO PAULO; RAFAELLA SAYURI IOSHINO, UNIVERSIDADE DE SÃO PAULO; LUCIO H. FREITAS-JUNIOR, UNIVERSIDADE DE SÃO PAULO; CRISTINA DE CASTRO SPADARI, UNIVERSIDADE DE SÃO PAULO; KELLY ISHIDA, UNIVERSIDADE DE SÃO PAULO; WAGNER VILEGAS, UNIVERSIDADE ESTADUAL PAULISTA JÚLIO DE MESQUITA FILHO.; JULIANA CAJADO SOUZA CARVALHO, UNIVERSIDADE DE SÃO PAULO; MARCELO JOSÉ PENA FERREIRA, UNIVERSIDADE DE SÃO PAULO; VIRGINIA CARBONE, Institute of Food Sciences; SONIA PIACENTE, UNIVERSITY OF SALERNO; RAFAELA MOLINA DE ANGELO, UNIVERSIDADE DE SÃO PAULO; KATHIA MARIA HONORIO, UNIVERSIDADE DE SÃO PAULO; MIRIAM SANNOMIYA, UNIVERSIDADE DE SÃO PAULO. |
|
Título: |
A potential antiviral against COVID-19 obtained from Byrsonima coccolobifolia leaves extract. |
|
Ano de publicação: |
2024 |
|
Fonte/Imprenta: |
Fitoterapia, v. 173, Mar. 2024. |
|
DOI: |
https://doi.org/10.1016/j.fitote.2024.105820 |
|
Idioma: |
Inglês |
|
Conteúdo: |
In this study, we specifically focused on the crude methanolic leaf extract of Byrsonima coccolobifolia, investigating its antifungal potential against human pathogenic fungi and its antiviral activity against COVID-19. Through the use of high-performance liquid chromatography coupled with electrospray ionization ion trap tandem mass spectrometry, direct infusion electrospray ionization ion trap tandem mass spectrometry, and chromatographic dereplication procedures, we identified galloyl quinic acid derivatives, catechin derivatives, proanthocyanidins, and flavonoid glycosides. The broth dilution assay revealed that the methanolic leaf extract of B. coccolobifolia exhibits antifungal activity against Cryptococcus neoformans (IC50 = 4 μg/mL). Additionally, docking studies were conducted to elucidate the interactions between the identified compounds and the central residues at the binding site of biological targets associated with COVID-19. Furthermore, the extract demonstrated an in vitro half maximum effective concentration (EC50 = 7 μg/mL) and exhibited significant selectivity (>90%) toward SARS-CoV-2. |
|
Palavras-Chave: |
COVID-19. |
|
Thesaurus Nal: |
Antifungal agents; Antifungal properties; Byrsonima; Flavonoids. |
|
Categoria do assunto: |
S Ciências Biológicas |
|
Marc: |
LEADER 02178naa a2200373 a 4500
001 2162123
005 2024-02-22
008 2024 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1016/j.fitote.2024.105820$2DOI
100 1 $aRODRIGUES, C. M.
245 $aA potential antiviral against COVID-19 obtained from Byrsonima coccolobifolia leaves extract.$h[electronic resource]
260 $c2024
520 $aIn this study, we specifically focused on the crude methanolic leaf extract of Byrsonima coccolobifolia, investigating its antifungal potential against human pathogenic fungi and its antiviral activity against COVID-19. Through the use of high-performance liquid chromatography coupled with electrospray ionization ion trap tandem mass spectrometry, direct infusion electrospray ionization ion trap tandem mass spectrometry, and chromatographic dereplication procedures, we identified galloyl quinic acid derivatives, catechin derivatives, proanthocyanidins, and flavonoid glycosides. The broth dilution assay revealed that the methanolic leaf extract of B. coccolobifolia exhibits antifungal activity against Cryptococcus neoformans (IC50 = 4 μg/mL). Additionally, docking studies were conducted to elucidate the interactions between the identified compounds and the central residues at the binding site of biological targets associated with COVID-19. Furthermore, the extract demonstrated an in vitro half maximum effective concentration (EC50 = 7 μg/mL) and exhibited significant selectivity (>90%) toward SARS-CoV-2.
650 $aAntifungal agents
650 $aAntifungal properties
650 $aByrsonima
650 $aFlavonoids
653 $aCOVID-19
700 1 $aBENTO, C. C.
700 1 $aMORAES, C. B.
700 1 $aGOMES, C.
700 1 $aIOSHINO, R. S.
700 1 $aFREITAS-JUNIOR, L. H.
700 1 $aSPADARI, C. de C.
700 1 $aISHIDA, K.
700 1 $aVILEGAS, W.
700 1 $aCARVALHO, J. C. S.
700 1 $aFERREIRA, M. J. P.
700 1 $aCARBONE, V.
700 1 $aPIACENTE, S.
700 1 $aANGELO, R. M. de
700 1 $aHONORIO, K. M.
700 1 $aSANNOMIYA, M.
773 $tFitoterapia$gv. 173, Mar. 2024.
Download
Esconder MarcMostrar Marc Completo |
|
Registro original: |
Embrapa Agroenergia (CNPAE) |
|
|
Biblioteca |
ID |
Origem |
Tipo/Formato |
Classificação |
Cutter |
Registro |
Volume |
Status |
URL |
Voltar
|
|
|
Registro Completo
|
Biblioteca(s): |
Embrapa Meio Ambiente. |
|
Data corrente: |
29/04/2020 |
|
Data da última atualização: |
29/04/2020 |
|
Tipo da produção científica: |
Artigo em Periódico Indexado |
|
Circulação/Nível: |
A - 1 |
|
Autoria: |
FARIA, M. R. de; GUIMARÃES, R. A.; PINTO, F. A. M. F.; SIQUEIRA, C. da S.; SILVA, C. A.; MEDEIROS, F. H. V.; BETTIOL, W. |
|
Afiliação: |
MÍRIAN RABELO DE FARIA, UFLA; RAFAELA ARAÚJO GUIMARÃES, UFLA; FELIPE AUGUSTO MORETTI FERREIRA PINTO, UFLA; CAROLINA DA SILVA SIQUEIRA, UFLA; CARLOS ALBERTO SILVA, UFLA; FLÁVIO HENRIQUE VASCONCELOS DE MEDEIROS, UFLA; WAGNER BETTIOL, CNPMA. |
|
Título: |
Contribution of organic amendments to soil properties and survival of Stenocarpella on maize stalk. |
|
Ano de publicação: |
2020 |
|
Fonte/Imprenta: |
Scientia Agricola, Piracicaba, v. 77, n. 6, e20180033, 2020. |
|
ISSN: |
1678-992X |
|
DOI: |
http://dx.doi.org/10.1590/1678-992x-2018-0289 |
|
Idioma: |
Inglês |
|
Conteúdo: |
Abstract: The incorporation of organic matter to the soil not only improves nutrient content, but also reduces the survival of Stenocarpella, the causal agent of stalk rot, Diplodia ear rot, and grey leaf spot, in maize stubble. We evaluated the effect of organic waste incorporation on Stenocarpella survival in maize stalks, the activity of suppressiveness-related enzymes, and nutrient contents. We conducted the assays in the municipalities of Lavras and Sete Lagoas, Minas Gerais State, Brazil. Maize stalks infested with Stenocarpella were kept in field conditions for three months after poultry litter, swine manure, fish hydrolysate, compost sewage sludge, and urea application. Infested stalks, without residue amendment, were kept on surface or incorporated into the soil, representing negative and positive controls. Stenocarpella concentration in stalks was assessed using qPCR expressed as cycle threshold number. Sewage sludge, buried stalks, and stalks retained on the surface showed reduction of pathogen inoculum. Swine manure and urea did not reduce the quantity of DNA. In the experiment conducted in Lavras, poultry litter stimulated ?-glucosidase, urease and hydrolysis of fluorescein diacetate activities when compared to the negative control. Sewage sludge, poultry litter, and swine manure increased Ca in the soil by 44 %, 38 % and 36 %, respectively, in the experiment conducted in Lavras. Poultry litter increased Ntotal three months after application. The results indicate that organic wastes are promising in improving nutrient content, activity of hydrolysis-related enzymes, but Stenocarpella inoculum dynamics should be taken into consideration when deciding on the specific organic amendment. MenosAbstract: The incorporation of organic matter to the soil not only improves nutrient content, but also reduces the survival of Stenocarpella, the causal agent of stalk rot, Diplodia ear rot, and grey leaf spot, in maize stubble. We evaluated the effect of organic waste incorporation on Stenocarpella survival in maize stalks, the activity of suppressiveness-related enzymes, and nutrient contents. We conducted the assays in the municipalities of Lavras and Sete Lagoas, Minas Gerais State, Brazil. Maize stalks infested with Stenocarpella were kept in field conditions for three months after poultry litter, swine manure, fish hydrolysate, compost sewage sludge, and urea application. Infested stalks, without residue amendment, were kept on surface or incorporated into the soil, representing negative and positive controls. Stenocarpella concentration in stalks was assessed using qPCR expressed as cycle threshold number. Sewage sludge, buried stalks, and stalks retained on the surface showed reduction of pathogen inoculum. Swine manure and urea did not reduce the quantity of DNA. In the experiment conducted in Lavras, poultry litter stimulated ?-glucosidase, urease and hydrolysis of fluorescein diacetate activities when compared to the negative control. Sewage sludge, poultry litter, and swine manure increased Ca in the soil by 44 %, 38 % and 36 %, respectively, in the experiment conducted in Lavras. Poultry litter increased Ntotal three months after application. The results indicat... Mostrar Tudo |
|
Palavras-Chave: |
Stalk rot; Stenocarpella macrospora. |
|
Thesagro: |
Adubo de Esgoto; Esterco; Matéria Orgânica; Milho; Podridão do Caule; Solo; Uréia; Zea Mays. |
|
Thesaurus NAL: |
Corn; Disease control; organic matter; Soil conditioners; Stem rot; Stenocarpella maydis. |
|
Categoria do assunto: |
H Saúde e Patologia |
|
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/212615/1/Bettiol-contribution-organic-2020.pdf
|
|
Marc: |
LEADER 02886naa a2200409 a 4500
001 2121946
005 2020-04-29
008 2020 bl uuuu u00u1 u #d
022 $a1678-992X
024 7 $ahttp://dx.doi.org/10.1590/1678-992x-2018-0289$2DOI
100 1 $aFARIA, M. R. de
245 $aContribution of organic amendments to soil properties and survival of Stenocarpella on maize stalk.$h[electronic resource]
260 $c2020
520 $aAbstract: The incorporation of organic matter to the soil not only improves nutrient content, but also reduces the survival of Stenocarpella, the causal agent of stalk rot, Diplodia ear rot, and grey leaf spot, in maize stubble. We evaluated the effect of organic waste incorporation on Stenocarpella survival in maize stalks, the activity of suppressiveness-related enzymes, and nutrient contents. We conducted the assays in the municipalities of Lavras and Sete Lagoas, Minas Gerais State, Brazil. Maize stalks infested with Stenocarpella were kept in field conditions for three months after poultry litter, swine manure, fish hydrolysate, compost sewage sludge, and urea application. Infested stalks, without residue amendment, were kept on surface or incorporated into the soil, representing negative and positive controls. Stenocarpella concentration in stalks was assessed using qPCR expressed as cycle threshold number. Sewage sludge, buried stalks, and stalks retained on the surface showed reduction of pathogen inoculum. Swine manure and urea did not reduce the quantity of DNA. In the experiment conducted in Lavras, poultry litter stimulated ?-glucosidase, urease and hydrolysis of fluorescein diacetate activities when compared to the negative control. Sewage sludge, poultry litter, and swine manure increased Ca in the soil by 44 %, 38 % and 36 %, respectively, in the experiment conducted in Lavras. Poultry litter increased Ntotal three months after application. The results indicate that organic wastes are promising in improving nutrient content, activity of hydrolysis-related enzymes, but Stenocarpella inoculum dynamics should be taken into consideration when deciding on the specific organic amendment.
650 $aCorn
650 $aDisease control
650 $aorganic matter
650 $aSoil conditioners
650 $aStem rot
650 $aStenocarpella maydis
650 $aAdubo de Esgoto
650 $aEsterco
650 $aMatéria Orgânica
650 $aMilho
650 $aPodridão do Caule
650 $aSolo
650 $aUréia
650 $aZea Mays
653 $aStalk rot
653 $aStenocarpella macrospora
700 1 $aGUIMARÃES, R. A.
700 1 $aPINTO, F. A. M. F.
700 1 $aSIQUEIRA, C. da S.
700 1 $aSILVA, C. A.
700 1 $aMEDEIROS, F. H. V.
700 1 $aBETTIOL, W.
773 $tScientia Agricola, Piracicaba$gv. 77, n. 6, e20180033, 2020.
Download
Esconder MarcMostrar Marc Completo |
|
Registro original: |
Embrapa Meio Ambiente (CNPMA) |
|
|
Biblioteca |
ID |
Origem |
Tipo/Formato |
Classificação |
Cutter |
Registro |
Volume |
Status |
Fechar
|
| Expressão de busca inválida. Verifique!!! |
|
|
