Data/hora: 07/06/2024 13:14:47

Biblioteca(s): | Embrapa Alimentos e Territórios.
Data corrente: | 18/07/2023
Data da última atualização: | 16/11/2023
Autoria: | BEZERRA, J. N.; GOMEZ, M. C. V.; ROLÓN, M.; CORONEL, C.; ALMEIDA-BEZERRA, J. W.; FIDELIS, K. R.; MENEZES, S. A. de; CRUZ, R. P. da; DUARTE, A. E.; RIBEIRO, P. R. V.; BRITO, E. S. de; COUTINHO, H. D. M.; MORAIS-BRAGA, M. F. B.; BEZERRA, C. F.
Afiliação: | JÉSSICA NOGUEIRA BEZERRA, URCA; MARIA CELESTE VEGA GOMEZ, FUNDACIÓN MOISÉS BERTONI; MÍRIAN ROLÓN, FUNDACIÓN MOISÉS BERTONI; CATHIA CORONEL, FUNDACIÓN MOISÉS BERTONI; JOSÉ WEVERTON ALMEIDA-BEZERRA, UFPE; KLEBER RIBEIRO FIDELIS, UFPE; SAULO ALMEIDA DE MENEZES, UFPE; RAFAEL PEREIRA DA CRUZ, URCA; ANTÔNIA ELIENE DUARTE, URCA; PAULO RICELI VASCONCELOS RIBEIRO, CNAT; EDY SOUSA DE BRITO, CNAT; HENRIQUE DOUGLAS MELO COUTINHO, URCA; MARIA FLAVIANA BEZERRA MORAIS-BRAGA, URCA; CAMILA FONSECA BEZERRA, URCA.
Título: | Chemical composition, Evaluation of Antiparasitary and Cytotoxic Activity of the essential oil of Psidium brownianum MART EX. DC.
Ano de publicação: | 2022
Fonte/Imprenta: | Biocatalysis and Agricultural Biotechnology, v. 39, 102247, 2022.
ISSN: | 1878-8181
DOI: | https://doi.org/10.1016/j.bcab.2021.102247
Idioma: | Inglês
Conteúdo: | Chagas Disease and Leishmaniasis are neglected parasitic diseases that constitute a major public health problem. In the search for new therapeutic alternatives for such pathologies, the essential oil of the leaves of Psidium brownianum Mart ex DC was investigated egarding its chemical composition, antiparasitic, and cytotoxic effects. The chemical composition of the oil was analyzed by gas chromatography coupled to mass spectrometry (GC/MS), showing two major constituents: Isogermafurene (52.93%) and Germacrone (16.02%). In antiparasitic activity, the oil was tested against the epimastigote forms of Trypanosoma cruzi, revealing 57.05% inhibition at the highest tested concentration (1000 &#956;g/mL). In regard to antiparasitic activity against promastigote forms of Leishmania braziliensis and ishmania infantum, it obtained 92.61% and 84.16% inhibition, respectively, at the highest concentrations (1000 &#956;g/mL). As for the cytotoxic effects, it showed high cytotoxicity, with IC50 = 328.9 &#956;g/mL. The inhibitory concentration (IC50) obtained the best result for the promastigote forms of L. braziliensis (IC50 = 37.53 &#956;g/mL), as well as the selectivity index (SI = 8.76). Such results generate perspectives for new research and may contribute to more effective drug discoveries.
Palavras-Chave: | Anti kinetoplastid; Antiparasitic; Citotóxicos; Doenças parasitárias; Efeito antiparasitário; Parasitic disease; Pathologies; Phytochemistry; Psidium brownianum Mart ex DC; Terapêutica alternativa; Therapeutic alternatives.
Thesagro: | Doença de Chagas; Leishmaniose; Myrtaceae; Óleo Vegetal; Saúde Pública.
Thesaurus Nal: | Chagas disease; Cytotoxicity; Public health; Vegetable oil.
Categoria do assunto: | H Saúde e Patologia
Registro original: | Embrapa Alimentos e Territórios (CNAT)
Exemplares: | CNAT - (26-1) - UPC - AP - DD -  -  -  - DIS