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4. | | OLIVEIRA, P. S. N. de; TIZIOTO, P. C.; NORONHA, C. T.; MALAGO JUNIOR, W.; MUDADU, M. de A.; REGITANO, L. C. de A. A SNP in NEUROD1 is associated with production traits in Nelore beef cattle. In: REUNIÃO ANUAL DA SOCIEDADE BRASILEIRA DE ZOOTECNIA, 51., 2014, Barra dos Coqueiros. A produção animal frente às mudanças climáticas e tecnológicas - anais. Barra dos coqueiros: Sociedade Brasileira de Zootecnia, 2014. 1 CD-ROM. Biblioteca(s): Embrapa Pecuária Sudeste. |
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6. | | SERRA, V.; TIZIOTO, P. C.; OLIVEIRA, P. S. N. de; LIMA, A. O. de; GASPARIN, G.; COUTINHO, L. L.; MOURÃO, G. B.; REGITANO, L. C. de A. Análise de qualidade de RNA para estudo do perfil transcriptômico de animais extremos para eficiência alimentar da raça Nelore. In: JORNADA CIENTÍFICA - EMBRAPA SÃO CARLOS, 5., 2013, São Carlos, SP. Anais... São Carlos, SP: Embrapa Pecuária Sudeste: Embrapa Instrumentação , 2013. p. 12 (Embrapa Pecuária Sudeste. Documentos, 110). Editado por Ana Rita de Araújo nogueira, simone Cristina Méo Nicura Biblioteca(s): Embrapa Pecuária Sudeste. |
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9. | | DINIZ, W. J. S.; ROSA, K. O. da; TIZIOTO, P. C.; MOURÃO, G. B.; OLIVEIRA, P. S. N. de; SOUZA, M. M. de; REGITANO, L. C. de A. FABP1 and SLC2A5 expression levels affect feed efficiency-related traits. Agri Gene, v. 15, p. 1-7, e100100, mar. 2020. Biblioteca(s): Embrapa Pecuária Sudeste. |
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10. | | TIZIOTO, P. C.; MEIRELLES, S. L.; SOUZA, M. M. de; OLIVEIRA, P. S. N. de; SIQUEIRA, F.; ROSA, A. do N.; TULLIO, R. R. Screening for single nucleotide polymorphisms in MYOD1 gene and its association with meat tenderness in cattle. In: INTERNATIONAL CONFERENCE OF BRAZIL ASSOCIATION AND COMPUTER BIOLOGY 7.; INTERNATIONAL CONFERENCE OF THE IBEROAMERICAN SOCIETY FOR BIOINFORMATICS, 3., 2011, Florianópolis. Proceedings... Florianóplis: ABC3C: SolBio, 2011. ID 126 Biblioteca(s): Embrapa Gado de Corte; Embrapa Pecuária Sudeste. |
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11. | | DINIZ, W. J. da S.; CESAR, A. S. M.; GEISTLINGER, L.; TIZIOTO, P. C.; OLIVEIRA, P. S. N. de; AFONSO, J.; ROCHA, M. I. P.; LIMA, A. O. de; BUSS, C. E.; COUTINHO, L. L.; REGITANO, L. C. de A. Co-expression network analysis identifies genes associated with iron content in bovine muscle. In: WORKSHOP ON OMICS STRATEGIES APPLIED TO LIVESTOCK SCIENCE, 1., 2017, Piracicaba, SP. Proceedings... São Carlos, SP: Embrapa Pecuária Sudeste, 2017. p. 19. (Embrapa Pecuária Sudeste. Documentos, 125) Editores: Luiz Lehmann Coutinho, ESALQ/USP; Luciana Correia de Almeida Regitano, Embrapa Pecuária Sudeste; Gerson Barreto Mourão, ESALQ/USP; Aline Silva Mello Cesar, ESALQ/USP; Bárbara Silva Vignato, FZEA/USP; Mirele Daiana Poleti,... Biblioteca(s): Embrapa Pecuária Sudeste. |
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12. | | DINIZ, W. J. da S.; CESAR, A. S. M.; GEISTLINGER, L.; TIZIOTO, P. C.; OLIVEIRA, P. S. N. de; AFONSO, J.; ROCHA, M. I. P.; LIMA, A. O. de; BUSS, C. E.; COUTINHO, L. L.; REGITANO, L. C. de A. Co-expression network analysis identifies genes associated with meat tenderness. In: INTERNATIONAL SOCIETY FOR ANIMAL GENETICS CONFERENCE, 36., 2017, Dublin. Proceedings... Dublin: University College Dublin, 2017. p. 144. Biblioteca(s): Embrapa Pecuária Sudeste. |
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13. | | SOMAVILLA, A. L.; REGITANO, L. C. de A.; ROSA, G. J. M.; MOKRY, F. B.; MUDADU, M. de A.; TIZIOTO, P. C.; OLIVEIRA, P. S. N. de; SOUZA, M. M. de; COUTINHO, L. L.; MUNARI, D. P. Genome-enabled prediction of breeding values for feedlot average daily weight gain in nelore cattle. G3: Genes, Genomes, Genetics, v. 7, p. 1-17, 2017. Biblioteca(s): Embrapa Agricultura Digital; Embrapa Pecuária Sudeste. |
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14. | | BUSS, C. E.; TIZIOTO, P. C.; OLIVEIRA, P. S. N. de; MUDADU, M. de A.; CESAR, A. S. M.; VENTURA, R. V.; AFONSO, J.; LIMA, A. O. de; COUTINHO, L. L.; TULLIO, R. R.; REGITANO, L. C. de A. Genome-wide efficient mixed-model study for meat quality in Nellore cattle. Journal of Animal Science, v. 94, e-suppl. 5; Journal of Dairy Science, v. 99, e-suppl. 1, p. 159, jul. 2016. Biblioteca(s): Embrapa Pecuária Sudeste. |
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15. | | OLIVEIRA, P. S. N. de; TIZIOTO, P. C.; OLIVEIRA, G. B.; CESAR, A. S. M.; DINIZ, W. J. da S.; LIMA, A. O. de; REECY, J. M.; COUTINHO, L. L.; REGITANO, L. C. de A. Differentially expressed miRNAs in skeletal muscle related to feed efficiency in Nellore cattle. Journal of Animal Science, v. 94, e-suppl. 5; Journal of Dairy Science, v. 99, e-suppl. 1, p. 159, jul. 2016. Biblioteca(s): Embrapa Pecuária Sudeste. |
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16. | | OLIVEIRA, P. S. N. DE; ANDRADE, B. G.; CARDOSO, T. F.; PASCHOAL, J. J.; JOSAHKIAN, L. A.; ALMEIDA, L. F.; MARCONDES, C. R.; MOURÃO, G. B.; COUTINHO, L. L.; REECY, J. M.; REGITANO, L. C. de A. Differentially expressed miRNAs in the stool of Bos indicus divergent for feed efficiency. Italian Journal of Animal Science, v. 22, supplement 1, 2023. p. 193-194. Congress of the Animal Science and Production Association, 25., Monopoli (BARI – ITALY), June 13–16, 2023. Biblioteca(s): Embrapa Pecuária Sudeste. |
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17. | | ROCHA, M. I. P.; SOUZA, M. M. de; ZERLOTINI NETO, A.; TIZIOTO, P. C.; OLIVEIRA, P. S. N. de; LIMA, A. O. de; AFONSO, J.; COUTINHO, L. L.; REGITANO, L. C. de A.; NICIURA, S. C. M. Allele-specific gene expression in liver of Nelore cattle extremes for feed efficiency. In: INTERNATIONAL SOCIETY FOR ANIMAL GENETICS CONFERENCE, 36., 2017, Dublin. Proceedings... Dublin: University College Dublin, 2017. p. 156 - 157. Biblioteca(s): Embrapa Pecuária Sudeste. |
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18. | | DINIZ, W. J. da S.; COUTINHO, L. L.; TIZIOTO, P. C.; CESAR, A. S. M.; GROMBONI, C. F.; NOGUEIRA, A. R. de A.; OLIVEIRA, P. S. N. de; SOUZA, M. M. de; REGITANO, L. C. de A. Iron content affects lipogenic gene expression in the muscle of nelore beef cattle. Plos One, aug. 2016. Biblioteca(s): Embrapa Pecuária Sudeste. |
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19. | | DINIZ, W. J. S.; ROSA, K. O.; COUTINHO, L. L.; TIZIOTO, P. C.; OLIVEIRA, P. S. N. de; SOUZA, M. M. de S.; CHAVES, A. S.; LANNA, D. P. D.; MOURÃO, G. B.; REGITANO, L. C. de A. KCNJ11 gene expression is associated to feed consumption and growth traits in Nelore beef cattle. Agri Gene, v. 9, p. 1-4, 2018. Biblioteca(s): Embrapa Pecuária Sudeste. |
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20. | | OLIVEIRA, P. S. N. DE; ANDRADE, B. G.; CONTEVILLE, L. C.; CARDOSO, T. F.; PASCHOAL, J. J.; JOSAHKIAN, L. A.; ALMEIDA, L. F.; MARCONDES, C. R.; MOURÃO, G. B.; COUTINHO, L. L.; REECY, J. M.; REGITANO, L. C. de A. Microbial diversity in the stool of Bos indicus divergent for feed efficiency. Italian Journal of Animal Science, v. 22, supplement 1, 2023. p. 194. Congress of the Animal Science and Production Association, 25., Monopoli (BARI – ITALY), June 13–16, 2023. Biblioteca(s): Embrapa Pecuária Sudeste. |
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Registro Completo
Biblioteca(s): |
Embrapa Agricultura Digital; Embrapa Pecuária Sudeste. |
Data corrente: |
24/07/2019 |
Data da última atualização: |
09/01/2020 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Circulação/Nível: |
A - 1 |
Autoria: |
OLIVEIRA, P. S. N. de; COUTINHO, L. L.; CESAR, A. S. M.; DINIZ, W. J. da S.; SOUZA, M. de S.; ANDRADE, B. G.; KOLTES, J. E.; MOURÃO, G. B.; ZERLOTINI NETO, A.; REECY, J. M.; REGITANO, L. C. de A. |
Afiliação: |
PRISCILA S. N. DE OLIVEIRA, CPPSE; LUIZ L. COUTINHO, Esalq/USP; ALINE S. M. CESAR, Esalq/USP; WELLISON J. DA SILVA DINIZ, UFSCar; MARCELA M. DE SOUZA, Iowa State University; BRUNO G. ANDRADE, CPPSE; JAMES E. KOLTES, Iowa State University; GERSON B. MOURÃO, Esalq/USP; ADHEMAR ZERLOTINI NETO, CNPTIA; JAMES M. REECY, Iowa State University; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE. |
Título: |
Co-expression networks reveal potential regulatory roles of miRNAs in fatty acid composition of nelore cattle. |
Ano de publicação: |
2019 |
Fonte/Imprenta: |
Frontiers in Genetics, v. 10, p. 1-14, July 2019. |
DOI: |
10.3389/fgene.2019.00651 |
Idioma: |
Inglês |
Notas: |
Article 651. Na publicação: Adhemar Zerlotini, Luciana C.A. Regitano. |
Conteúdo: |
Fatty acid (FA) content affects the sensorial and nutritional value of meat and plays a significant role in biological processes such as adipogenesis and immune response. It is well known that, in beef, the main FAs associated with these biological processes are oleic acid (C18:1 cis9, OA) and conjugated linoleic acid (CLA-c9t11), which may have beneficial effects on metabolic diseases such as type 2 diabetes and obesity. Here, we performed differential expression and co-expression analyses, weighted gene co-expression network analysis (WGCNA) and partial correlation with information theory (PCIT), to uncover the complex interactions between miRNAs and mRNAs expressed in skeletal muscle associated with FA content. miRNA and mRNA expression data were obtained from skeletal muscle of Nelore cattle that had extreme genomic breeding values for OA and CLA. Insulin and MAPK signaling pathways were identified by WGCNA as central pathways associated with both of these fatty acids. Co-expression network analysis identified bta-miR-33a/b, bta-miR-100, bta-miR-204, bta-miR-365-5p, btamiR-660, bta-miR-411a, bta-miR-136, bta-miR-30-5p, bta-miR-146b, bta-let-7a-5p, bta-let-7f, bta-let-7, bta-miR 339, bta-miR-10b, bta-miR 486, and the genes ACTA1 and ALDOA as potential regulators of fatty acid synthesis. This study provides evidence and insights into the molecular mechanisms and potential target genes involved in fatty acid content differences in Nelore beef cattle, revealing new candidate pathways of phenotype modulation that could positively benefit beef production and human consumption. MenosFatty acid (FA) content affects the sensorial and nutritional value of meat and plays a significant role in biological processes such as adipogenesis and immune response. It is well known that, in beef, the main FAs associated with these biological processes are oleic acid (C18:1 cis9, OA) and conjugated linoleic acid (CLA-c9t11), which may have beneficial effects on metabolic diseases such as type 2 diabetes and obesity. Here, we performed differential expression and co-expression analyses, weighted gene co-expression network analysis (WGCNA) and partial correlation with information theory (PCIT), to uncover the complex interactions between miRNAs and mRNAs expressed in skeletal muscle associated with FA content. miRNA and mRNA expression data were obtained from skeletal muscle of Nelore cattle that had extreme genomic breeding values for OA and CLA. Insulin and MAPK signaling pathways were identified by WGCNA as central pathways associated with both of these fatty acids. Co-expression network analysis identified bta-miR-33a/b, bta-miR-100, bta-miR-204, bta-miR-365-5p, btamiR-660, bta-miR-411a, bta-miR-136, bta-miR-30-5p, bta-miR-146b, bta-let-7a-5p, bta-let-7f, bta-let-7, bta-miR 339, bta-miR-10b, bta-miR 486, and the genes ACTA1 and ALDOA as potential regulators of fatty acid synthesis. This study provides evidence and insights into the molecular mechanisms and potential target genes involved in fatty acid content differences in Nelore beef cattle, revealing new candidate... Mostrar Tudo |
Palavras-Chave: |
Ácido linoleico conjugado; Ácido oleico; Ácidos graxos; Genômica; Integrative genomics; MiRNA; MRNA; Redes de co-expressão. |
Thesagro: |
Bos Indicus; Gado de Corte. |
Thesaurus NAL: |
Beef cattle; Conjugated linoleic acid; Oleic acid. |
Categoria do assunto: |
-- L Ciência Animal e Produtos de Origem Animal |
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/199817/1/AP-Coexpression-networks.pdf
|
Marc: |
LEADER 02877naa a2200421 a 4500 001 2110872 005 2020-01-09 008 2019 bl uuuu u00u1 u #d 024 7 $a10.3389/fgene.2019.00651$2DOI 100 1 $aOLIVEIRA, P. S. N. de 245 $aCo-expression networks reveal potential regulatory roles of miRNAs in fatty acid composition of nelore cattle.$h[electronic resource] 260 $c2019 500 $aArticle 651. Na publicação: Adhemar Zerlotini, Luciana C.A. Regitano. 520 $aFatty acid (FA) content affects the sensorial and nutritional value of meat and plays a significant role in biological processes such as adipogenesis and immune response. It is well known that, in beef, the main FAs associated with these biological processes are oleic acid (C18:1 cis9, OA) and conjugated linoleic acid (CLA-c9t11), which may have beneficial effects on metabolic diseases such as type 2 diabetes and obesity. Here, we performed differential expression and co-expression analyses, weighted gene co-expression network analysis (WGCNA) and partial correlation with information theory (PCIT), to uncover the complex interactions between miRNAs and mRNAs expressed in skeletal muscle associated with FA content. miRNA and mRNA expression data were obtained from skeletal muscle of Nelore cattle that had extreme genomic breeding values for OA and CLA. Insulin and MAPK signaling pathways were identified by WGCNA as central pathways associated with both of these fatty acids. Co-expression network analysis identified bta-miR-33a/b, bta-miR-100, bta-miR-204, bta-miR-365-5p, btamiR-660, bta-miR-411a, bta-miR-136, bta-miR-30-5p, bta-miR-146b, bta-let-7a-5p, bta-let-7f, bta-let-7, bta-miR 339, bta-miR-10b, bta-miR 486, and the genes ACTA1 and ALDOA as potential regulators of fatty acid synthesis. This study provides evidence and insights into the molecular mechanisms and potential target genes involved in fatty acid content differences in Nelore beef cattle, revealing new candidate pathways of phenotype modulation that could positively benefit beef production and human consumption. 650 $aBeef cattle 650 $aConjugated linoleic acid 650 $aOleic acid 650 $aBos Indicus 650 $aGado de Corte 653 $aÁcido linoleico conjugado 653 $aÁcido oleico 653 $aÁcidos graxos 653 $aGenômica 653 $aIntegrative genomics 653 $aMiRNA 653 $aMRNA 653 $aRedes de co-expressão 700 1 $aCOUTINHO, L. L. 700 1 $aCESAR, A. S. M. 700 1 $aDINIZ, W. J. da S. 700 1 $aSOUZA, M. de S. 700 1 $aANDRADE, B. G. 700 1 $aKOLTES, J. E. 700 1 $aMOURÃO, G. B. 700 1 $aZERLOTINI NETO, A. 700 1 $aREECY, J. M. 700 1 $aREGITANO, L. C. de A. 773 $tFrontiers in Genetics$gv. 10, p. 1-14, July 2019.
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Embrapa Pecuária Sudeste (CPPSE) |
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