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Registro Completo |
Biblioteca(s): |
Embrapa Agroindústria Tropical; Embrapa Alimentos e Territórios. |
Data corrente: |
02/01/2023 |
Data da última atualização: |
29/02/2024 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Autoria: |
LIMA, L. F. DE; ANDRADE-PINHEIRO, J. C.; FREITAS, M. A.; SILVA, A. I. DA; FONSECA, V. J. A.; SILVA, T. G. DA; SILVA, J. C. P. DA; LIMA, R. H. DE; SALES, D. L.; NEVES, R. P.; BRITO, E. S. de; RIBEIRO, P. R. V.; CANUTO, K. M.; COUTINHO, H. D. M.; SIYADATPANAH, A.; KIM, B.; MORAIS-BRAGA, M. F. B. |
Afiliação: |
LUCIENE FERREIRA DE LIMA, University Regional of Cariri; JACQUELINE COSMO ANDRADE-PINHEIRO, University Regional of Cariri; MARIA AUDILENE FREITAS, University Federal of Pernambuco; ADRIELY IDALINA DA SILVA, University Federal of Pernambuco; VICTOR JUNO ALENCAR FONSECA, University Regional of Cariri; TAÍS GUSMÃO DA SILVA, University Regional of Cariri; JOSEFA CAROLAINE PEREIRA DA SILVA, University Regional of Cariri; ROSILAINE HONORATO DE LIMA, University Regional of Cariri; DÉBORA LIMA SALES, University Regional of Cariri; REJANE PEREIRA NEVES, University Federal of Pernambuco; EDY SOUSA DE BRITO, CNAT; PAULO RICELI VASCONCELOS RIBEIRO, CNPAT; KIRLEY MARQUES CANUTO, CNPAT; HENRIQUE DOUGLAS MELO COUTINHO, University Regional of Cariri; ABOLGHASEM SIYADATPANAH, Birjand University of Medical Sciences; BONGLEE KIM, Kyung Hee University; MARIA FLAVIANA BEZERRA MORAIS-BRAGA, University Regional of Cariri. |
Título: |
Anti-Candida properties of Gossypium hirsutum L.: enhancement of fungal growth, biofilm production and antifungal resistance. |
Ano de publicação: |
2022 |
Fonte/Imprenta: |
Pharmaceutics, v. 14, n. 698, 2022. |
Páginas: |
18 p. |
DOI: |
https://doi.org/10.3390/pharmaceutics140406982022 |
Idioma: |
Inglês |
Conteúdo: |
(1) Background: Candida is a genus of yeasts with notable pathogenicity and significant ability to develop antimicrobial resistance. Gossypium hirsutum L., a medicinal plant that is traditionally used due to its antimicrobial properties, has demonstrated significant antifungal activity. Therefore, this study investigated the chemical composition and anti-Candida effects of aqueous (AELG) and hydroethanolic (HELG) extracts obtained from the leaves of this plant. (2) Methods: The extracts were chemically characterized by UPLC-QTOF-MS/MS, and their anti-Candida activities were investigated by analyzing cell viability, biofilm production, morphological transition, and enhancement of antifungal resistance. (3) Results: The UPLC-QTOF-MS/MS analysis revealed the presence of twenty-one compounds in both AELG and HELG, highlighting the predominance of flavonoids. The combination of the extracts with fluconazole significantly reduced its IC50 values against Candida albicans INCQS 40006, Candida tropicalis INCQS 40042, and C. tropicalis URM 4262 strains, indicating enhanced antifungal activity. About biofilm production, significant inhibition was observed only for the AELG-treated C. tropicalis URM 4262 strain in comparison with the untreated control. Accordingly, this extract showed more significant inhibitory effects on the morphological transition of the INCQS 40006 and URM 4387 strains of C. albicans (4) Conclusions: Gossypium hirsutum L. presents promising antifungal effects, that may be potentially linked to the combined activity of chemical constituents identified in its extracts. Menos(1) Background: Candida is a genus of yeasts with notable pathogenicity and significant ability to develop antimicrobial resistance. Gossypium hirsutum L., a medicinal plant that is traditionally used due to its antimicrobial properties, has demonstrated significant antifungal activity. Therefore, this study investigated the chemical composition and anti-Candida effects of aqueous (AELG) and hydroethanolic (HELG) extracts obtained from the leaves of this plant. (2) Methods: The extracts were chemically characterized by UPLC-QTOF-MS/MS, and their anti-Candida activities were investigated by analyzing cell viability, biofilm production, morphological transition, and enhancement of antifungal resistance. (3) Results: The UPLC-QTOF-MS/MS analysis revealed the presence of twenty-one compounds in both AELG and HELG, highlighting the predominance of flavonoids. The combination of the extracts with fluconazole significantly reduced its IC50 values against Candida albicans INCQS 40006, Candida tropicalis INCQS 40042, and C. tropicalis URM 4262 strains, indicating enhanced antifungal activity. About biofilm production, significant inhibition was observed only for the AELG-treated C. tropicalis URM 4262 strain in comparison with the untreated control. Accordingly, this extract showed more significant inhibitory effects on the morphological transition of the INCQS 40006 and URM 4387 strains of C. albicans (4) Conclusions: Gossypium hirsutum L. presents promising antifungal effects, that... Mostrar Tudo |
Palavras-Chave: |
Antimicrobial resistance; Biofilm eradication; Erradicação do biofilme; Resistência antimicrobiana; UPLC-QTOF-MS/MS. |
Thesagro: |
Gossypium Hirsutum; Malvaceae. |
Categoria do assunto: |
-- W Química e Física |
Marc: |
LEADER 02880naa a2200421 a 4500 001 2153889 005 2024-02-29 008 2022 bl uuuu u00u1 u #d 024 7 $ahttps://doi.org/10.3390/pharmaceutics140406982022$2DOI 100 1 $aLIMA, L. F. DE 245 $aAnti-Candida properties of Gossypium hirsutum L.$benhancement of fungal growth, biofilm production and antifungal resistance.$h[electronic resource] 260 $c2022 300 $a18 p. 520 $a(1) Background: Candida is a genus of yeasts with notable pathogenicity and significant ability to develop antimicrobial resistance. Gossypium hirsutum L., a medicinal plant that is traditionally used due to its antimicrobial properties, has demonstrated significant antifungal activity. Therefore, this study investigated the chemical composition and anti-Candida effects of aqueous (AELG) and hydroethanolic (HELG) extracts obtained from the leaves of this plant. (2) Methods: The extracts were chemically characterized by UPLC-QTOF-MS/MS, and their anti-Candida activities were investigated by analyzing cell viability, biofilm production, morphological transition, and enhancement of antifungal resistance. (3) Results: The UPLC-QTOF-MS/MS analysis revealed the presence of twenty-one compounds in both AELG and HELG, highlighting the predominance of flavonoids. The combination of the extracts with fluconazole significantly reduced its IC50 values against Candida albicans INCQS 40006, Candida tropicalis INCQS 40042, and C. tropicalis URM 4262 strains, indicating enhanced antifungal activity. About biofilm production, significant inhibition was observed only for the AELG-treated C. tropicalis URM 4262 strain in comparison with the untreated control. Accordingly, this extract showed more significant inhibitory effects on the morphological transition of the INCQS 40006 and URM 4387 strains of C. albicans (4) Conclusions: Gossypium hirsutum L. presents promising antifungal effects, that may be potentially linked to the combined activity of chemical constituents identified in its extracts. 650 $aGossypium Hirsutum 650 $aMalvaceae 653 $aAntimicrobial resistance 653 $aBiofilm eradication 653 $aErradicação do biofilme 653 $aResistência antimicrobiana 653 $aUPLC-QTOF-MS/MS 700 1 $aANDRADE-PINHEIRO, J. C. 700 1 $aFREITAS, M. A. 700 1 $aSILVA, A. I. DA 700 1 $aFONSECA, V. J. A. 700 1 $aSILVA, T. G. DA 700 1 $aSILVA, J. C. P. DA 700 1 $aLIMA, R. H. DE 700 1 $aSALES, D. L. 700 1 $aNEVES, R. P. 700 1 $aBRITO, E. S. de 700 1 $aRIBEIRO, P. R. V. 700 1 $aCANUTO, K. M. 700 1 $aCOUTINHO, H. D. M. 700 1 $aSIYADATPANAH, A. 700 1 $aKIM, B. 700 1 $aMORAIS-BRAGA, M. F. B. 773 $tPharmaceutics$gv. 14, n. 698, 2022.
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Registro original: |
Embrapa Alimentos e Territórios (CNAT) |
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| Acesso ao texto completo restrito à biblioteca da Embrapa Recursos Genéticos e Biotecnologia. Para informações adicionais entre em contato com cenargen.biblioteca@embrapa.br. |
Registro Completo
Biblioteca(s): |
Embrapa Recursos Genéticos e Biotecnologia. |
Data corrente: |
21/11/2022 |
Data da última atualização: |
24/01/2023 |
Tipo da produção científica: |
Resumo em Anais de Congresso |
Autoria: |
BURLE, M. L.; FERREIRA, M. A. J. F.; HIRAGI, G. de O.; RAMOS, S. R. R.; MEDEIROS, M. B. de; ANTUNES, I. F.; DIAS, T. A. B. |
Afiliação: |
MARILIA LOBO BURLE, Cenargen; MARIA ALDETE JUSTINIANO DA FONSECA, Cenargen; GILBERTO DE OLIVEIRA HIRAGI, Cenargen; SEMIRAMIS RABELO RAMALHO RAMOS, CNAT; MARCELO BRILHANTE DE MEDEIROS, Cenargen; IRAJA FERREIRA ANTUNES, CPACT; TEREZINHA APARECIDA BORGES DIAS, Cenargen. |
Título: |
Rede de Apoio ao Uso e Conservação Local dos Recursos Genéticos no Brasil. |
Ano de publicação: |
2022 |
Fonte/Imprenta: |
In: CONGRESSO BRASILEIRO DE RECURSOS GENÉTICOS, 7., 2022. Multifuncionalidade e Qualidade de Vida: [anais...]. Brasília, DF: Sociedade Brasileira de Recursos Genéticos, 2022. |
Idioma: |
Inglês |
Notas: |
Na publicação: M. Aldete J. da Fonseca. |
Palavras-Chave: |
Conservação in situ; Conservação on farm; Guardiões da agrobiodiversidade. |
Categoria do assunto: |
-- |
Marc: |
LEADER 00844nam a2200217 a 4500 001 2148537 005 2023-01-24 008 2022 bl uuuu u00u1 u #d 100 1 $aBURLE, M. L. 245 $aRede de Apoio ao Uso e Conservação Local dos Recursos Genéticos no Brasil.$h[electronic resource] 260 $aIn: CONGRESSO BRASILEIRO DE RECURSOS GENÉTICOS, 7., 2022. Multifuncionalidade e Qualidade de Vida: [anais...]. Brasília, DF: Sociedade Brasileira de Recursos Genéticos$c2022 500 $aNa publicação: M. Aldete J. da Fonseca. 653 $aConservação in situ 653 $aConservação on farm 653 $aGuardiões da agrobiodiversidade 700 1 $aFERREIRA, M. A. J. F. 700 1 $aHIRAGI, G. de O. 700 1 $aRAMOS, S. R. R. 700 1 $aMEDEIROS, M. B. de 700 1 $aANTUNES, I. F. 700 1 $aDIAS, T. A. B.
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