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Registro Completo |
Biblioteca(s): |
Embrapa Pecuária Sudeste. |
Data corrente: |
09/11/2017 |
Data da última atualização: |
21/11/2017 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Autoria: |
SILVA, I. C. da; MAGALHAES, P. M. de; SOUSA, I. M. de O.; FOGLIO, M. A.; LEONARDECZ, E.; ESTEVES, S. N.; CHAGAS, A. C. de S. |
Afiliação: |
Ives Charlie da Silva, UNESP; Pedro Melillo de Magalhães, UNICAMP; Ilza Maria de Oliveira Sousa, UNICAMP; Mary Ann Foglio, UNICAMP; Eduardo Leonardecz, UFSCar; SERGIO NOVITA ESTEVES, CPPSE; ANA CAROLINA DE SOUZA CHAGAS, CPPSE. |
Título: |
Anthelmintic activity of Artemisia annua in sheepmodel. |
Ano de publicação: |
2017 |
Fonte/Imprenta: |
Journal of Medicinal Plants Research, v. 11, n. 7, p. 137-143, 2017. |
DOI: |
10.5897/JMPR2016.6318 |
Idioma: |
Inglês |
Conteúdo: |
Artemisia annua L. is a well-known source of artemisinin, an antimalarial drug. This compound has been used in traditional medicine to treat malaria for many years. The anthelmintic property of A. annua has also been attributed to artemisinin, hence the belief that artemisinin could be useful as an alternative anthelmintic to control Haemonchus contortus in livestock. The present study focused on evaluating the anthelmintic activity of A. annua against H. contortus by oral administration on infected sheep in a controlled clinical trial. The trial was conducted using 24 male sheep of the Santa Inês breed, with average weight of 20 kg, artificially infected with H. contortus (Embrapa 2010 isolate). The animals were kept in metabolic cages and randomly divided into four homogeneous groups with six animals each, being: (T1) negative control (untreated), (T2) positive control: 10 mg/kg BW of levamisole phosphate, (T3) fed 10% A. annua (0.2% BW), (T4) fed 20% A. annua (0.4% BW). EPG counts were conducted on days -3, -2, -1, 0 (treatment day), 3, 7, 10, 14, 17, 21, 24 and 28 post-treatment. After extraction of the artemisinin in plant material, it was quantified in triplicate and analyzed by high-performance liquid chromatography with infrared detection. The average efficacy in the positive control treated with levamisole was 89%. Moderate anthelmintic efficacy against H. contortus was observed in the groups fed 0.2 and 0.4% BW A. annua for 30 days (32.9 and 14.8%, respectively), mainly from day 21 post treatment (47.1 and 25.2%, respectively). At the highest dose, the animals avoided eating due to the compound?s bitter taste. It is concluded that A. annua presents moderate anthelmintic activity in sheep in both doses. The lowest dose was accepted by animals and seems to have practical use. Oral administration was safe and after further in vivo trials could be introduced in organic farms in tropical countries. MenosArtemisia annua L. is a well-known source of artemisinin, an antimalarial drug. This compound has been used in traditional medicine to treat malaria for many years. The anthelmintic property of A. annua has also been attributed to artemisinin, hence the belief that artemisinin could be useful as an alternative anthelmintic to control Haemonchus contortus in livestock. The present study focused on evaluating the anthelmintic activity of A. annua against H. contortus by oral administration on infected sheep in a controlled clinical trial. The trial was conducted using 24 male sheep of the Santa Inês breed, with average weight of 20 kg, artificially infected with H. contortus (Embrapa 2010 isolate). The animals were kept in metabolic cages and randomly divided into four homogeneous groups with six animals each, being: (T1) negative control (untreated), (T2) positive control: 10 mg/kg BW of levamisole phosphate, (T3) fed 10% A. annua (0.2% BW), (T4) fed 20% A. annua (0.4% BW). EPG counts were conducted on days -3, -2, -1, 0 (treatment day), 3, 7, 10, 14, 17, 21, 24 and 28 post-treatment. After extraction of the artemisinin in plant material, it was quantified in triplicate and analyzed by high-performance liquid chromatography with infrared detection. The average efficacy in the positive control treated with levamisole was 89%. Moderate anthelmintic efficacy against H. contortus was observed in the groups fed 0.2 and 0.4% BW A. annua for 30 days (32.9 and 14.8%, respectively), m... Mostrar Tudo |
Thesaurus Nal: |
artemisinin; gastrointestinal nematodes; sesquiterpenoids. |
Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
Marc: |
LEADER 02655naa a2200241 a 4500 001 2079284 005 2017-11-21 008 2017 bl uuuu u00u1 u #d 024 7 $a10.5897/JMPR2016.6318$2DOI 100 1 $aSILVA, I. C. da 245 $aAnthelmintic activity of Artemisia annua in sheepmodel.$h[electronic resource] 260 $c2017 520 $aArtemisia annua L. is a well-known source of artemisinin, an antimalarial drug. This compound has been used in traditional medicine to treat malaria for many years. The anthelmintic property of A. annua has also been attributed to artemisinin, hence the belief that artemisinin could be useful as an alternative anthelmintic to control Haemonchus contortus in livestock. The present study focused on evaluating the anthelmintic activity of A. annua against H. contortus by oral administration on infected sheep in a controlled clinical trial. The trial was conducted using 24 male sheep of the Santa Inês breed, with average weight of 20 kg, artificially infected with H. contortus (Embrapa 2010 isolate). The animals were kept in metabolic cages and randomly divided into four homogeneous groups with six animals each, being: (T1) negative control (untreated), (T2) positive control: 10 mg/kg BW of levamisole phosphate, (T3) fed 10% A. annua (0.2% BW), (T4) fed 20% A. annua (0.4% BW). EPG counts were conducted on days -3, -2, -1, 0 (treatment day), 3, 7, 10, 14, 17, 21, 24 and 28 post-treatment. After extraction of the artemisinin in plant material, it was quantified in triplicate and analyzed by high-performance liquid chromatography with infrared detection. The average efficacy in the positive control treated with levamisole was 89%. Moderate anthelmintic efficacy against H. contortus was observed in the groups fed 0.2 and 0.4% BW A. annua for 30 days (32.9 and 14.8%, respectively), mainly from day 21 post treatment (47.1 and 25.2%, respectively). At the highest dose, the animals avoided eating due to the compound?s bitter taste. It is concluded that A. annua presents moderate anthelmintic activity in sheep in both doses. The lowest dose was accepted by animals and seems to have practical use. Oral administration was safe and after further in vivo trials could be introduced in organic farms in tropical countries. 650 $aartemisinin 650 $agastrointestinal nematodes 650 $asesquiterpenoids 700 1 $aMAGALHAES, P. M. de 700 1 $aSOUSA, I. M. de O. 700 1 $aFOGLIO, M. A. 700 1 $aLEONARDECZ, E. 700 1 $aESTEVES, S. N. 700 1 $aCHAGAS, A. C. de S. 773 $tJournal of Medicinal Plants Research$gv. 11, n. 7, p. 137-143, 2017.
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Embrapa Pecuária Sudeste (CPPSE) |
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Registro Completo
Biblioteca(s): |
Embrapa Milho e Sorgo. |
Data corrente: |
19/03/1997 |
Data da última atualização: |
14/06/2018 |
Tipo da produção científica: |
Resumo em Anais de Congresso |
Autoria: |
MATRANGOLO, W. J. R.; DELLA LUCIA, T. M. C.; CRUZ, I. |
Afiliação: |
WALTER JOSE RODRIGUES MATRANGOLO, CNPMS; IVAN CRUZ, CNPMS. |
Título: |
Fitófagos presentes em estilos estigmas e espigas de milho. |
Ano de publicação: |
1995 |
Fonte/Imprenta: |
In: CONGRESSO BRASILEIRO DE ENTOMOLOGIA, 15.; ENCONTRO NACIONAL DE FITOSSANITARISTAS, 6.; SIMPÓSIO INTEGRADO DE MANEJO DE PRAGAS, 2., 1995, Caxambu, MG. Resumos. [Caxambu]: Sociedade Entomologica do Brasil; Lavras: ESAL, 1995. p. 269. |
Idioma: |
Português |
Palavras-Chave: |
Maize; Ocorrencia; Pest; Pragas. |
Thesagro: |
Milho; Zea Mays. |
Categoria do assunto: |
O Insetos e Entomologia |
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/41734/1/Fitofagos-presentes.pdf
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Marc: |
LEADER 00720nam a2200193 a 4500 001 1474795 005 2018-06-14 008 1995 bl uuuu u00u1 u #d 100 1 $aMATRANGOLO, W. J. R. 245 $aFitófagos presentes em estilos estigmas e espigas de milho.$h[electronic resource] 260 $aIn: CONGRESSO BRASILEIRO DE ENTOMOLOGIA, 15.; ENCONTRO NACIONAL DE FITOSSANITARISTAS, 6.; SIMPÓSIO INTEGRADO DE MANEJO DE PRAGAS, 2., 1995, Caxambu, MG. Resumos. [Caxambu]: Sociedade Entomologica do Brasil; Lavras: ESAL, 1995. p. 269.$c1995 650 $aMilho 650 $aZea Mays 653 $aMaize 653 $aOcorrencia 653 $aPest 653 $aPragas 700 1 $aDELLA LUCIA, T. M. C. 700 1 $aCRUZ, I.
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