Data/hora: 07/06/2024 13:49:44

Biblioteca(s): | Embrapa Unidades Centrais.
Data corrente: | 15/08/2016
Data da última atualização: | 15/08/2016
Autoria: | ARGOLO NETO, N. M.; DEL CARLO, R. J.; MONTEIRO, B. S.; NARDI, N. B.; CHAGASTELLES, P. C.; BRITO, A. F. S.; REIS, A. M. S.; SILVA, L. M. C.
Afiliação: | NAPOLEÃO C. CHAGASTELLES, UFPI; RICARDO J. DEL CARLO, UFV; BETÂNEA S. MONTEIRO, UFV; NACE B. NARDI, ULBRA; PEDRO C. CHAGASTELLES, UFRGS; ANA FLORA S. BRITO, UFV; AMANDA M. S. REIS, UFV; LAÍS M. C. SILVA, UFPI.
Título: | Role of the autologous mesenchymal stem cells compared with platelet rich plasma on cicatrization of cutaneous wounds in diabetic mice.
Ano de publicação: | 2016
Fonte/Imprenta: | Pesquisa Veterinária Brasileira, Brasília, DF, v.36, n. 7, p. 617-624, jul. 2016.
Idioma: | Inglês
Conteúdo: | Chronic cutaneous lesions affect 15% of diabetic human patients and represent a risk 15 to 46 times larger of limb amputations compared to people with normal glycemia. It is assumed that half of these amputations could be prevented by early treatment of wounds, for example, with proper cell therapy. Objectives: In this study, the action of the autologous transplant of mesenchymal stem-cells (MSC) was evaluated compared to the treatment with autologous platelet rich plasma (PRP) in the cicatrization of cutaneous lesions induced in diabetic mice. These animals were previously treated with streptozootocin to induce diabetes mellitus and round wounds of 1.5cm in diameter were created in the posterior region. Diameters of the wounds and healing time were evaluated during 30 days and the results were submitted to variance analysis and Tukey?s test average. It was noticed that the animals treated with MSC presented a more accelerated cicatrization of the cutaneous lesion than the animals treated with PRP. However, the treatment with PRP presented better results than just the daily asepsis of the lesions with saline or covering them with semi-permeable bandage. Besides, the use of semi-permeable bandage kept the cutaneous lesions of diabetic mice did not interfere negatively with cicatrization, proved to be harmless to use, but kept the cutaneous lesions more hydrated than the ones exposed to the environment.
Palavras-Chave: | Célula-troncos mesenquimais; Cicatrização da lesão; Cicatrization; Mesenchymal stem cells.
Thesagro: | Lesão cutânea.
Thesaurus Nal: | diabetes mellitus; Skin lesions; Tissue repair.
Categoria do assunto: | --
URL: | http://ainfo.cnptia.embrapa.br/digital/bitstream/item/146380/1/Role-of-the-autologous.pdf
Registro original: | Embrapa Unidades Centrais (AI-SEDE)
Exemplares: | AI-SEDE - (59876-1) - UPE - AP - PP - 636.08905 - P474 -  - DIS