Data/hora: 04/06/2024 18:10:35

Biblioteca(s): | Embrapa Pecuária Sul.
Data corrente: | 05/12/2019
Data da última atualização: | 13/04/2020
Autoria: | NICIURA, S. C. M.; CRUVINEL, G. G.; MORAES, C. V.; CHAGAS, A. C. de S.; ESTEVES, S. N.; BENAVIDES, M. V.; AMARANTE, A. F. T. do.
Afiliação: | SIMONE CRISTINA MEO NICIURA, CPPSE; Giovana Gabrielle Cruvinel, UNICEP; Caroline Valério Moraes, UFSCAR; ANA CAROLINA DE SOUZA CHAGAS, CPPSE; SERGIO NOVITA ESTEVES, CPPSE; MAGDA VIEIRA BENAVIDES, CPPSUL; Alessandro Francisco Talamini do Amarante, UNESP.
Título: | In vivo selection for Haemonchus contortus resistance to monepantel.
Ano de publicação: | 2019
Fonte/Imprenta: | Journal of Helminthology, v. 94, e-46, p. 1-5, 2020.
DOI: | doi.org/10.1017/S0022149X19000221
Idioma: | Inglês
Conteúdo: | Gastrointestinal nematodes significantly affect the ovine industry, and Haemonchus contortus is considered the most pathogenic parasite in tropical regions. This situation is aggravated when the main strategy to control worms fails because of the genetic resistance that parasites acquire against anthelmintics. Aiming to anticipate the events involved in anthelmintic resistance, we induced monepantel resistance in H. contortus by in vivo subdosing of sheep hosts. Four successive passages of a monepantel-susceptible H. contortus isolate in Santa Ines or Ile de France sheep hosts resulted in three monepantel-resistant (efficacy varying from 0 to 58.5%) H. contortus isolates. Sheep hosts were treated from 0.075 mg/kg to the therapeutic dose of 2.5 mg/kg of monepantel in 19?26 rounds of selection for 112?133 weeks. Success in inducing H. contortus resistance to monepantel may have been affected by worm burden and by host?parasite interactions, including a possible effect of the breed of sheep hosts. We conclude that subdosing of sheep, although time-consuming, is an efficient in vivo strategy for the induction of monepantel resistance in H. contortus. The resistant parasites can be used in further studies to elucidate the genetic and biochemical events involved in the acquisition of anthelmintic resistance.
Palavras-Chave: | Host-parasite interaction; Induction of anthelmintic resistance; Pathogenic parasite; Worms.
Thesagro: | Ovino.
Thesaurus Nal: | Anthelmintics; Gastrointestinal nematodes; Sheep.
Categoria do assunto: | L Ciência Animal e Produtos de Origem Animal
Registro original: | Embrapa Pecuária Sul (CPPSUL)
Exemplares: | CPPSUL - (14640-1) - UPC - AP - DD -  -  -  - DIS