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Registro Completo |
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Biblioteca(s): |
Embrapa Suínos e Aves; Embrapa Unidades Centrais. |
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Data corrente: |
11/09/2023 |
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Data da última atualização: |
11/09/2023 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
HAACH, V.; BASTOS, A. P. A.; GAVA, D.; FONSECA, F. M. da; MORES, M. A. Z.; COLDEBELLA, A.; FRANCO, A. C.; SCHAEFER, R. |
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Afiliação: |
VANESSA HAACH, Universidade Federal do Rio Grande do Sul; ANA PAULA ALMEIDA BASTOS, CNPSA; DANIELLE GAVA, CNPSA; FRANCISCO NOE DA FONSECA, GEM; MARCOS ANTONIO ZANELLA MORES, CNPSA; ARLEI COLDEBELLA, CNPSA; ANA CLÁUDIA FRANCO, Universidade Federal do Rio Grande do Sul; REJANE SCHAEFER, CNPSA. |
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Título: |
A polyvalent virosomal infuenza vaccine induces broad cellular and humoral immunity in pigs. |
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Ano de publicação: |
2023 |
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Fonte/Imprenta: |
Virology Journal, v. 20, article number 181, 2023. |
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DOI: |
https://doi.org/10.1186/s12985-023-02153-5 |
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Idioma: |
Inglês |
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Conteúdo: |
Abstract: Background: Influenza A virus (IAV) is endemic in pigs globally and co-circulation of genetically and antigenically diverse virus lineages of subtypes H1N1, H1N2 and H3N2 is a challenge for the development of effective vaccines. Virosomes are virus-like particles that mimic virus infection and have proven to be a successful vaccine platform against several animal and human viruses. Methods: This study evaluated the immunogenicity of a virosome-based influenza vaccine containing the surface glycoproteins of H1N1 pandemic, H1N2 and H3N2 in pigs. Results: A robust humoral and cellular immune response was induced against the three IAV subtypes in pigs after two vaccine doses. The influenza virosome vaccine elicited hemagglutinin-specific antibodies and virus-neutralizing activity. Furthermore, it induced a significant maturation of macrophages, and proliferation of B lymphocytes, effector and central memory CD4+ and CD8+ T cells, and CD8+ T lymphocytes producing interferon-γ. Also, the vaccine demonstrated potential to confer long-lasting immunity until the market age of pigs and proved to be safe and non-cytotoxic to pigs. Conclusions: This virosome platform allows flexibility to adjust the vaccine content to reflect the diversity of circulating IAVs in swine in Brazil. The vaccination of pigs may reduce the impact of the disease on swine production and the risk of swine-to-human transmission. |
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Palavras-Chave: |
Cellular immunity; Virosomal vaccine. |
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Thesagro: |
Imunidade; Suíno; Vacina. |
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Thesaurus Nal: |
Humoral immunity; Influenza A virus; Swine. |
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Categoria do assunto: |
--
L Ciência Animal e Produtos de Origem Animal |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/doc/1156557/1/final10093.pdf
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Marc: |
LEADER 02316naa a2200313 a 4500
001 2156557
005 2023-09-11
008 2023 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1186/s12985-023-02153-5$2DOI
100 1 $aHAACH, V.
245 $aA polyvalent virosomal infuenza vaccine induces broad cellular and humoral immunity in pigs.$h[electronic resource]
260 $c2023
520 $aAbstract: Background: Influenza A virus (IAV) is endemic in pigs globally and co-circulation of genetically and antigenically diverse virus lineages of subtypes H1N1, H1N2 and H3N2 is a challenge for the development of effective vaccines. Virosomes are virus-like particles that mimic virus infection and have proven to be a successful vaccine platform against several animal and human viruses. Methods: This study evaluated the immunogenicity of a virosome-based influenza vaccine containing the surface glycoproteins of H1N1 pandemic, H1N2 and H3N2 in pigs. Results: A robust humoral and cellular immune response was induced against the three IAV subtypes in pigs after two vaccine doses. The influenza virosome vaccine elicited hemagglutinin-specific antibodies and virus-neutralizing activity. Furthermore, it induced a significant maturation of macrophages, and proliferation of B lymphocytes, effector and central memory CD4+ and CD8+ T cells, and CD8+ T lymphocytes producing interferon-γ. Also, the vaccine demonstrated potential to confer long-lasting immunity until the market age of pigs and proved to be safe and non-cytotoxic to pigs. Conclusions: This virosome platform allows flexibility to adjust the vaccine content to reflect the diversity of circulating IAVs in swine in Brazil. The vaccination of pigs may reduce the impact of the disease on swine production and the risk of swine-to-human transmission.
650 $aHumoral immunity
650 $aInfluenza A virus
650 $aSwine
650 $aImunidade
650 $aSuíno
650 $aVacina
653 $aCellular immunity
653 $aVirosomal vaccine
700 1 $aBASTOS, A. P. A.
700 1 $aGAVA, D.
700 1 $aFONSECA, F. M. da
700 1 $aMORES, M. A. Z.
700 1 $aCOLDEBELLA, A.
700 1 $aFRANCO, A. C.
700 1 $aSCHAEFER, R.
773 $tVirology Journal$gv. 20, article number 181, 2023.
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Registro original: |
Embrapa Suínos e Aves (CNPSA) |
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Origem |
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Voltar
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Registro Completo
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Biblioteca(s): |
Embrapa Meio-Norte. |
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Data corrente: |
27/03/2003 |
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Data da última atualização: |
25/07/2011 |
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Autoria: |
RIBEIRO, J. L.; FREIRE, E. C.; FARIAS, F. J. C.; ANDRADE, F. P. de; COSTA, J. N. da; MEDEIROS, J. da C.; SANTANA, J. C. F. de. |
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Título: |
Cultivares de algodoeiro herbáceo recomendadas para os cerrados do Meio-Norte do Brasil. |
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Ano de publicação: |
2002 |
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Fonte/Imprenta: |
Teresina: Embrapa Meio-Norte, 2002. |
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Páginas: |
4 p. |
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Série: |
(Embrapa Meio-Norte. Comunicado Técnico, 139). |
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Idioma: |
Português |
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Palavras-Chave: |
Brasil; Cultivar; Meio-Norte. |
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Thesagro: |
Algodão; Cerrado; Gossypium Hirsutum; Variedade. |
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Thesaurus NAL: |
Brazil; cotton. |
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Categoria do assunto: |
-- |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/CPAMN-2009-09/16752/1/CT139.pdf
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Marc: |
LEADER 00827nam a2200301 a 4500
001 1065332
005 2011-07-25
008 2002 bl uuuu u0uu1 u #d
100 1 $aRIBEIRO, J. L.
245 $aCultivares de algodoeiro herbáceo recomendadas para os cerrados do Meio-Norte do Brasil.
260 $aTeresina: Embrapa Meio-Norte$c2002
300 $a4 p.
490 $a(Embrapa Meio-Norte. Comunicado Técnico, 139).
650 $aBrazil
650 $acotton
650 $aAlgodão
650 $aCerrado
650 $aGossypium Hirsutum
650 $aVariedade
653 $aBrasil
653 $aCultivar
653 $aMeio-Norte
700 1 $aFREIRE, E. C.
700 1 $aFARIAS, F. J. C.
700 1 $aANDRADE, F. P. de
700 1 $aCOSTA, J. N. da
700 1 $aMEDEIROS, J. da C.
700 1 $aSANTANA, J. C. F. de
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Embrapa Meio-Norte (CPAMN) |
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