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 | Acesso ao texto completo restrito à biblioteca da Embrapa Amazônia Ocidental. Para informações adicionais entre em contato com cpaa.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Amazônia Ocidental. |
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Data corrente: |
02/12/2008 |
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Data da última atualização: |
15/05/2018 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
PINTO, A. C. S.; SILVA, L. F. R. e; CAVALCANTI, B. C.; MELO, M. R. S.; CHAVES, F. C. M.; LOTUFO, L. V. C.; MORAIS, M. O. de; ANDRADE-NETO, V. F.; TADEI, W. P.; PESSOA, C. O.; VIEIRA, P. P. R.; POHLIT, A. M. |
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Afiliação: |
Ana Cristina da Silva Pinto, UFAM; Luis Francisco Rocha e Silva, FMTAM; Bruno Coelho Cavalcanti, UFCE; Márcia Rúbia Silva Melo, INPA; FRANCISCO CELIO MAIA CHAVES, CPAA; Letícia Vera Costa Lotufo, UFCE; Manoel Odorico de Moraes, UFCE; Valter Ferreira de Andrade-Neto, Universidade Federal do Rio Grande do Norte; Wanderli Pedro Tadei, INPA; Claudia O. Pessoa, UFCE; Pedro Paulo Ribeiro Vieira, FMTAM; Adrian Martin Pohlit, INPA. |
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Título: |
New antimalarial and cytotoxic 4-nerolidylcatechol derivatives. |
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Ano de publicação: |
2009 |
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Fonte/Imprenta: |
European Journal of Medicinal Chemistry, v. 44, n. 6, p. 2731-2735, June 2009. |
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DOI: |
10.1016/j.ejmech.2008.10.025 |
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Idioma: |
Inglês |
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Conteúdo: |
4-nerolidylcatechol (1) was isolated from cultivated Pothomorphe peltata root on a multi-gram scale using straight-forward solvent extraction-column chromatography. New semisynthetic derivatives of 1 were prepared and tested in vitro against multidrug-resistant Plasmodium falciparum K1 strain. Mono-O-methyl, mono-O-benzyl, O,O-dibenzyl and O,Odibenzoyl derivatives 2-8 exhibited IC50 in the 0.67?22.52 ìM range. Mono-O-methyl ethers 6 and 7 inhibited the in vitro growth of human tumor cell lines HCT-8 (colon carcinoma), SF-295 (central nervous system), LH-60 (human myeloblastic leukemia) and MDA/MB-435 (melanoma). In general, derivatives 2-8 are more stable to light, air and pH at ambient temperatures than their labile, natural precursor 1. These derivatives provide leads for the development of a novel class of antimalarial drugs with enhanced chemical and pharmacological properties. |
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Palavras-Chave: |
Plantas medicinais. |
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Thesagro: |
Caapeba; Câncer; Química. |
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Thesaurus Nal: |
malaria; Plasmodium falciparum. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 01861naa a2200337 a 4500
001 1683881
005 2018-05-15
008 2009 bl uuuu u00u1 u #d
024 7 $a10.1016/j.ejmech.2008.10.025$2DOI
100 1 $aPINTO, A. C. S.
245 $aNew antimalarial and cytotoxic 4-nerolidylcatechol derivatives.$h[electronic resource]
260 $c2009
520 $a4-nerolidylcatechol (1) was isolated from cultivated Pothomorphe peltata root on a multi-gram scale using straight-forward solvent extraction-column chromatography. New semisynthetic derivatives of 1 were prepared and tested in vitro against multidrug-resistant Plasmodium falciparum K1 strain. Mono-O-methyl, mono-O-benzyl, O,O-dibenzyl and O,Odibenzoyl derivatives 2-8 exhibited IC50 in the 0.67?22.52 ìM range. Mono-O-methyl ethers 6 and 7 inhibited the in vitro growth of human tumor cell lines HCT-8 (colon carcinoma), SF-295 (central nervous system), LH-60 (human myeloblastic leukemia) and MDA/MB-435 (melanoma). In general, derivatives 2-8 are more stable to light, air and pH at ambient temperatures than their labile, natural precursor 1. These derivatives provide leads for the development of a novel class of antimalarial drugs with enhanced chemical and pharmacological properties.
650 $amalaria
650 $aPlasmodium falciparum
650 $aCaapeba
650 $aCâncer
650 $aQuímica
653 $aPlantas medicinais
700 1 $aSILVA, L. F. R. e
700 1 $aCAVALCANTI, B. C.
700 1 $aMELO, M. R. S.
700 1 $aCHAVES, F. C. M.
700 1 $aLOTUFO, L. V. C.
700 1 $aMORAIS, M. O. de
700 1 $aANDRADE-NETO, V. F.
700 1 $aTADEI, W. P.
700 1 $aPESSOA, C. O.
700 1 $aVIEIRA, P. P. R.
700 1 $aPOHLIT, A. M.
773 $tEuropean Journal of Medicinal Chemistry$gv. 44, n. 6, p. 2731-2735, June 2009.
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Registro original: |
Embrapa Amazônia Ocidental (CPAA) |
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Biblioteca |
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Origem |
Tipo/Formato |
Classificação |
Cutter |
Registro |
Volume |
Status |
URL |
Voltar
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Registro Completo
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Biblioteca(s): |
Embrapa Tabuleiros Costeiros. |
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Data corrente: |
22/12/2022 |
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Data da última atualização: |
26/12/2022 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 2 |
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Autoria: |
COUTO, M. V. S. do; SOUSA, N. C.; ABE, H. A.; CUNHA, F. S.; MENESES, J. O.; PAIXÃO, P. E. G.; MOURINO, J. L. P.; MARTINS, M. L.; CORDEIRO, C. A. M.; FUJIMOTO, R. Y. |
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Afiliação: |
MÁRCIA VALÉRIA SILVA DO COUTO; NATALINO COSTA SOUSA; HIGO ANDRADE ABE; FERNANDA SANTOS CUNHA; JULIANA OLIVEIRA MENESES; PETERSON EMMANUEL GUIMARÃES PAIXÃO; JOSE LUIZ PEDREIRA MOURINO; MAURÍCIO LATERÇA MARTINS; CARLOS ALBERTO MARTINS CORDEIRO; RODRIGO YUDI FUJIMOTO, CPATC. |
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Título: |
Dietary supplementation of Probiotic Enterococcus faecium improve resistance in Arapaima gigas against Aeromonas hydrophila. |
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Ano de publicação: |
2022 |
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Fonte/Imprenta: |
Aquaculture Research, v. 53, p. 3453-3463, 2022. |
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Idioma: |
Inglês |
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Conteúdo: |
This study evaluated the mortality rate, histopathology and haematological param-eters of Arapaima gigas against Aeromonas hydrophila after 68 days of dietary probiotic supplementation with autochthonous bacterium Enterococcus faecium. Three experi-ments were carried out: the first assay evaluated the lethality of A. hydrophila, the second and the third assay evaluated the fish supplemented subjected to A. hydrophilalethal dose 30% (106 CFU ml−1) and lethal dose 100% (108CFU ml−1) respectively. The clinical signs, blood changes, histopathological alterations and mortalities were evalu-ated. At the first experiment, the concentrations of 106 and 108CFU.mL−1 with A. hy-drophila caused 33% and 100% of mortality. The A. hydrophila infection provoked clinical signs such as dark skin, ulceration, haemorrhage, pale gills and liver, hepatic alterations, hyperaemia, hepatic cord breakdown, cellular deforming, lipid degener-ation and necrosis. In the second experiment, no mortality occurred onto fish fed with probiotic. Furthermore, in the third experiment, fish submitted to probiotic sup-plementation showed reduction in mortality of 75% compared with the control and fish fed with probiotic diets at 108CFU g−1 not presented any clinical signs. For these reasons, Arapaima gigas juveniles previously submitted to probiotic supplementation with E. faecium (108CFU g−1) shows better physiological and immunological response, improving resistance against A. hydrophila infection. |
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Thesagro: |
Doença Animal; Hematologia; Peixe; Pirarucu. |
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Thesaurus NAL: |
Fish; Fish diseases; Hematology. |
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Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/doc/1150243/1/Dietary-supplementation-of-Probiotic-Enterococcus-faecium-improve-resistance-in.pdf
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Marc: |
LEADER 02385naa a2200313 a 4500
001 2150243
005 2022-12-26
008 2022 bl uuuu u00u1 u #d
100 1 $aCOUTO, M. V. S. do
245 $aDietary supplementation of Probiotic Enterococcus faecium improve resistance in Arapaima gigas against Aeromonas hydrophila.$h[electronic resource]
260 $c2022
520 $aThis study evaluated the mortality rate, histopathology and haematological param-eters of Arapaima gigas against Aeromonas hydrophila after 68 days of dietary probiotic supplementation with autochthonous bacterium Enterococcus faecium. Three experi-ments were carried out: the first assay evaluated the lethality of A. hydrophila, the second and the third assay evaluated the fish supplemented subjected to A. hydrophilalethal dose 30% (106 CFU ml−1) and lethal dose 100% (108CFU ml−1) respectively. The clinical signs, blood changes, histopathological alterations and mortalities were evalu-ated. At the first experiment, the concentrations of 106 and 108CFU.mL−1 with A. hy-drophila caused 33% and 100% of mortality. The A. hydrophila infection provoked clinical signs such as dark skin, ulceration, haemorrhage, pale gills and liver, hepatic alterations, hyperaemia, hepatic cord breakdown, cellular deforming, lipid degener-ation and necrosis. In the second experiment, no mortality occurred onto fish fed with probiotic. Furthermore, in the third experiment, fish submitted to probiotic sup-plementation showed reduction in mortality of 75% compared with the control and fish fed with probiotic diets at 108CFU g−1 not presented any clinical signs. For these reasons, Arapaima gigas juveniles previously submitted to probiotic supplementation with E. faecium (108CFU g−1) shows better physiological and immunological response, improving resistance against A. hydrophila infection.
650 $aFish
650 $aFish diseases
650 $aHematology
650 $aDoença Animal
650 $aHematologia
650 $aPeixe
650 $aPirarucu
700 1 $aSOUSA, N. C.
700 1 $aABE, H. A.
700 1 $aCUNHA, F. S.
700 1 $aMENESES, J. O.
700 1 $aPAIXÃO, P. E. G.
700 1 $aMOURINO, J. L. P.
700 1 $aMARTINS, M. L.
700 1 $aCORDEIRO, C. A. M.
700 1 $aFUJIMOTO, R. Y.
773 $tAquaculture Research$gv. 53, p. 3453-3463, 2022.
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Embrapa Tabuleiros Costeiros (CPATC) |
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