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Registros recuperados : 4 | |
1. | | MAZARRO, R. D.; RIZKALLAH, I. P. J.; LUZ, F. S.; LORENSETTI, D. M.; COGLIATI, B.; FIGHERA, R. A. Aspectos epidemiológicos, clínicos e anatomopatológicos do linfoma folicular em cães. Pesquisa Veterinária Brasileira, Rio de Janeiro, v. 38, n. 9, p. 1772-1780, setembro 2018 Título em inglês: Epidemiological, clinical and pathological aspects of follicular lymphoma in dogs. Biblioteca(s): Embrapa Unidades Centrais. |
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2. | | ROMUALDO, G. R.; SOUZA, I. P. de; SOUZA, L. V. de; SANTIAGO, M. C. P. de A.; BORGUINI, R. G.; COGLIATI, B.; BARBISAN, L. F. The effects of anthocyanin-rich Myrtaceae fruits peel powder on fibrosis-associated hepatocarcinogenesisin mice. In: WORLD TOXICOLOGIC PATHOLOGY CONGRESS, 2018, São Paulo. [Anais... São Paulo: Galoá, 2018] 4. p. WTPC. 21 a 26 de abril. Biblioteca(s): Embrapa Agroindústria de Alimentos. |
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3. | | PELLEGRINO, A.; DANIEL, A. G. T.; PESSOA, R.; GUERRA, J. M.; LUCCA, G. G.; GOISSIS, M. D.; FREITAS, M. F.; COGLIATI, B.; LARSSON, M. H. M. A. Sensibilidade e especificidade do exame eletrocardiográfico na detecção de sobrecargas atriais e/ou ventriculares em gatos da raça Persa com cardiomiopatia hipertrófica. Pesquisa Veterinária Brasileira, Rio de Janeiro, v. 36, n. 3, p. 187-196, mar. 2016. Biblioteca(s): Embrapa Unidades Centrais. |
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4. | | ROMUALDO, G. R.; SOUZA, I. P. de; SOUZA, L. V. de; PRATA, G. B.; FRAGA-SILVA, T. F. de; SARTORI, A.; BORGUINI, R. G.; SANTIAGO, M. C. P. de A.; FERNANDES, A. A. H.; COGLIATI, B.; BARBOSAN, L. F. Beneficial effects of anthocyanin-rich peels of Myrtaceae fruits on chemically-induced liver fibrosis and carcinogenesis in mice. Food Research International, v. 139, 109964, 2021. p. 1-11. Biblioteca(s): Embrapa Agroindústria de Alimentos. |
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Registros recuperados : 4 | |
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| Acesso ao texto completo restrito à biblioteca da Embrapa Agroindústria de Alimentos. Para informações adicionais entre em contato com ctaa.biblioteca@embrapa.br. |
Registro Completo
Biblioteca(s): |
Embrapa Agroindústria de Alimentos. |
Data corrente: |
16/12/2020 |
Data da última atualização: |
05/02/2021 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Circulação/Nível: |
A - 1 |
Autoria: |
ROMUALDO, G. R.; SOUZA, I. P. de; SOUZA, L. V. de; PRATA, G. B.; FRAGA-SILVA, T. F. de; SARTORI, A.; BORGUINI, R. G.; SANTIAGO, M. C. P. de A.; FERNANDES, A. A. H.; COGLIATI, B.; BARBOSAN, L. F. |
Afiliação: |
Guilherme Ribeiro Romualdo, UNESP; Isadora Penedo de Souza, UNESP; Lucas Vilhegas de Souza, UNESP; Gabriel Bacil Prata, UNESP; Thais Fernanda de Campos Fraga-Silva, UNESP; Alexandrina Sartori, UNESP; RENATA GALHARDO BORGUINI, CTAA; MANUELA CRISTINA P DE A SANTIAGO, CTAA; Ana Angélica Henrique Fernandes, UNESP; Bruno Cogliati, USP; Luís Fernando Barbisan, UNESP. |
Título: |
Beneficial effects of anthocyanin-rich peels of Myrtaceae fruits on chemically-induced liver fibrosis and carcinogenesis in mice. |
Ano de publicação: |
2021 |
Fonte/Imprenta: |
Food Research International, v. 139, 109964, 2021. p. 1-11. |
DOI: |
https://doi.org/10.1016/j.foodres.2020.109964 |
Idioma: |
Inglês |
Conteúdo: |
Hepatocellular carcinoma (HCC) arising from fibrosis/cirrhosis is the most common type of primary liver cancer. Conversely, a higher intake of fruits and vegetables might play a protective role in HCC risk. Recently, Myrtaceae family tropical fruits have raised great interest due to the high levels of anthocyanins especially in their peels, which are usually discarded upon consumption. Anthocyanins are antioxidant pigments known to have beneficial effects in vivo/in vitro cancer bioassays. Thus, we evaluated whether dietary Myrciaria jaboticaba, Syzygium cumini, and Syzygium malaccense fruit peel powders reduce fibrosis and hepatocarcinogenesis in mice. Female C3H/HeJ mice were submitted to the model of diethylnitrosamine/carbon tetrachloride-induced liver fibrosis and carcinogenesis. Concomitantly, mice received a basal diet containing 2% of M. jaboticaba, S. cumini, or S. malaccense fruit peel powders, obtained by convective drying, for 10 weeks. M. jaboticaba peel powder showed the highest levels of total anthocyanins, while S. cumini peel powder displayed the greatest diversity of these pigments. All Myrtaceae family peel powders reduced the serum levels of the liver injury marker alanine aminotransferase. M. jaboticaba peel feeding reduced the incidence of liver preneoplastic foci, hepatocyte proliferation (Ki-67), and the protein levels of hepato-mitogen tumor necrosis factor-alpha (TNF-?). M. jaboticaba peel feeding also diminished liver lipid peroxidation and increased total glutathione levels. S. cumini peel feeding reduced hepatic collagen, lipid peroxidation, and TNF-? levels while increased catalase activity. Although S. malaccense peel powder, which displayed the lowest anthocyanin levels, decreased oxidative stress, and cytokine levels, no effects were observed on liver fibrosis or preneoplastic lesion outcomes. Findings indicate a protective effect of anthocyanin-rich M. jaboticaba and S. cumini peel powder feeding on preneoplastic lesion development and fibrosis, respectively. Results indicate that differential biological responses may be attributed to distinct anthocyanin profiles and levels, assigning a functional/market value to the underutilized peel fraction. MenosHepatocellular carcinoma (HCC) arising from fibrosis/cirrhosis is the most common type of primary liver cancer. Conversely, a higher intake of fruits and vegetables might play a protective role in HCC risk. Recently, Myrtaceae family tropical fruits have raised great interest due to the high levels of anthocyanins especially in their peels, which are usually discarded upon consumption. Anthocyanins are antioxidant pigments known to have beneficial effects in vivo/in vitro cancer bioassays. Thus, we evaluated whether dietary Myrciaria jaboticaba, Syzygium cumini, and Syzygium malaccense fruit peel powders reduce fibrosis and hepatocarcinogenesis in mice. Female C3H/HeJ mice were submitted to the model of diethylnitrosamine/carbon tetrachloride-induced liver fibrosis and carcinogenesis. Concomitantly, mice received a basal diet containing 2% of M. jaboticaba, S. cumini, or S. malaccense fruit peel powders, obtained by convective drying, for 10 weeks. M. jaboticaba peel powder showed the highest levels of total anthocyanins, while S. cumini peel powder displayed the greatest diversity of these pigments. All Myrtaceae family peel powders reduced the serum levels of the liver injury marker alanine aminotransferase. M. jaboticaba peel feeding reduced the incidence of liver preneoplastic foci, hepatocyte proliferation (Ki-67), and the protein levels of hepato-mitogen tumor necrosis factor-alpha (TNF-?). M. jaboticaba peel feeding also diminished liver lipid peroxidation and increas... Mostrar Tudo |
Thesaurus NAL: |
Anthocyanins; Fruit peels; Myrciaria; Syzygium cumini. |
Categoria do assunto: |
X Pesquisa, Tecnologia e Engenharia |
Marc: |
LEADER 03166naa a2200301 a 4500 001 2128263 005 2021-02-05 008 2021 bl uuuu u00u1 u #d 024 7 $ahttps://doi.org/10.1016/j.foodres.2020.109964$2DOI 100 1 $aROMUALDO, G. R. 245 $aBeneficial effects of anthocyanin-rich peels of Myrtaceae fruits on chemically-induced liver fibrosis and carcinogenesis in mice.$h[electronic resource] 260 $c2021 520 $aHepatocellular carcinoma (HCC) arising from fibrosis/cirrhosis is the most common type of primary liver cancer. Conversely, a higher intake of fruits and vegetables might play a protective role in HCC risk. Recently, Myrtaceae family tropical fruits have raised great interest due to the high levels of anthocyanins especially in their peels, which are usually discarded upon consumption. Anthocyanins are antioxidant pigments known to have beneficial effects in vivo/in vitro cancer bioassays. Thus, we evaluated whether dietary Myrciaria jaboticaba, Syzygium cumini, and Syzygium malaccense fruit peel powders reduce fibrosis and hepatocarcinogenesis in mice. Female C3H/HeJ mice were submitted to the model of diethylnitrosamine/carbon tetrachloride-induced liver fibrosis and carcinogenesis. Concomitantly, mice received a basal diet containing 2% of M. jaboticaba, S. cumini, or S. malaccense fruit peel powders, obtained by convective drying, for 10 weeks. M. jaboticaba peel powder showed the highest levels of total anthocyanins, while S. cumini peel powder displayed the greatest diversity of these pigments. All Myrtaceae family peel powders reduced the serum levels of the liver injury marker alanine aminotransferase. M. jaboticaba peel feeding reduced the incidence of liver preneoplastic foci, hepatocyte proliferation (Ki-67), and the protein levels of hepato-mitogen tumor necrosis factor-alpha (TNF-?). M. jaboticaba peel feeding also diminished liver lipid peroxidation and increased total glutathione levels. S. cumini peel feeding reduced hepatic collagen, lipid peroxidation, and TNF-? levels while increased catalase activity. Although S. malaccense peel powder, which displayed the lowest anthocyanin levels, decreased oxidative stress, and cytokine levels, no effects were observed on liver fibrosis or preneoplastic lesion outcomes. Findings indicate a protective effect of anthocyanin-rich M. jaboticaba and S. cumini peel powder feeding on preneoplastic lesion development and fibrosis, respectively. Results indicate that differential biological responses may be attributed to distinct anthocyanin profiles and levels, assigning a functional/market value to the underutilized peel fraction. 650 $aAnthocyanins 650 $aFruit peels 650 $aMyrciaria 650 $aSyzygium cumini 700 1 $aSOUZA, I. P. de 700 1 $aSOUZA, L. V. de 700 1 $aPRATA, G. B. 700 1 $aFRAGA-SILVA, T. F. de 700 1 $aSARTORI, A. 700 1 $aBORGUINI, R. G. 700 1 $aSANTIAGO, M. C. P. de A. 700 1 $aFERNANDES, A. A. H. 700 1 $aCOGLIATI, B. 700 1 $aBARBOSAN, L. F. 773 $tFood Research International$gv. 139, 109964, 2021. p. 1-11.
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