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18. | | CASTRO, V. L. S. S. de. Avaliacao ecotoxicologica de agrotoxicos e biopesticidas. In: CONGRESSO BRASILEIRO DE TOXICOLOGIA, 9., 1995, Ribeirao Preto, SP. Revista Brasileira de Toxicologia, Ribeirao Preto, Sao Paulo, v.8, n.1, p.12, 1995. Resumo. ref.1.6.4 Biblioteca(s): Embrapa Meio Ambiente. |
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Registros recuperados : 220 | |
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Registro Completo
Biblioteca(s): |
Embrapa Gado de Leite; Embrapa Instrumentação; Embrapa Meio Ambiente. |
Data corrente: |
05/04/2021 |
Data da última atualização: |
09/08/2021 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Circulação/Nível: |
A - 2 |
Autoria: |
BECARO, A. A.; OLIVEIRA, L. P. de; CASTRO, V. L. S. S. de; SIQUEIRA, M. C.; BRANDAO, H. de M.; CORREA, D. S.; FERREIRA, M. D. |
Afiliação: |
ALINE APARECIDA BECARO, UFSCar; LUZIA PEDROSO DE OLIVEIRA, UNIFESP; VERA LUCIA SCHERHOLZ S DE CASTRO, CNPMA; MARIA CELIA SIQUEIRA, UFSCar; HUMBERTO DE MELLO BRANDAO, CNPGL; DANIEL SOUZA CORREA, CNPDIA; MARCOS DAVID FERREIRA, CNPDIA. |
Título: |
Effects of silver nanoparticles prenatal exposure on rat offspring development. |
Ano de publicação: |
2021 |
Fonte/Imprenta: |
Environmental Toxicology and Pharmacology, v. 81, article 103546, 2021. |
ISSN: |
1382-6689 |
DOI: |
https://doi.org/10.1016/j.etap.2020.103546 |
Idioma: |
Inglês |
Conteúdo: |
Abstract: Abstract: Many types of nanocomposites employed in food packaging are based on silver nanoparticles (AgNP) because of their antibacterial properties, which can increase food shelf-life. As the commercialization of AgNP products has been expanding, the released of such nanoparticles in the environment has caused enormous concern, once they can pose potential risks to the environment and human beings. For instance, exposure of the maternal environment to nanomaterials during pregnancy may impact the health of the dam, fetus and offspring. In this context, here we investigated the effects of prenatal exposure of AgNP on the pregnancy outcomes of dams and postnatal development of their offspring. Pregnant Wistar rats were exposed to distinct AgNP concentrations (0, 1, 3 and 5 micrograms/kg/day) from beginning to the end of pregnancy. At parturition, newborns were observed regarding clinical signs of toxicity and survival rate. The offspring was examined by evaluating developmental endpoints. A delay in time for vaginal opening and testes descent were detected in the offspring exposed to AgNP during embryonic development. Our results indicate that prenatal exposure to AgNP can compromise neonatal rats' postnatal development, especially the reproductive features. |
Palavras-Chave: |
Developmental endpoints; Silver nanoparticles. |
Thesagro: |
Animal de Laboratório; Composto Químico; Embrião; Prenhez; Toxidez. |
Thesaurus NAL: |
Animal reproduction; Ecotoxicology; Nanomaterials; Nanosilver; pregnancy; rats; reproduction. |
Categoria do assunto: |
H Saúde e Patologia |
Marc: |
LEADER 02398naa a2200385 a 4500 001 2131061 005 2021-08-09 008 2021 bl uuuu u00u1 u #d 022 $a1382-6689 024 7 $ahttps://doi.org/10.1016/j.etap.2020.103546$2DOI 100 1 $aBECARO, A. A. 245 $aEffects of silver nanoparticles prenatal exposure on rat offspring development.$h[electronic resource] 260 $c2021 520 $aAbstract: Abstract: Many types of nanocomposites employed in food packaging are based on silver nanoparticles (AgNP) because of their antibacterial properties, which can increase food shelf-life. As the commercialization of AgNP products has been expanding, the released of such nanoparticles in the environment has caused enormous concern, once they can pose potential risks to the environment and human beings. For instance, exposure of the maternal environment to nanomaterials during pregnancy may impact the health of the dam, fetus and offspring. In this context, here we investigated the effects of prenatal exposure of AgNP on the pregnancy outcomes of dams and postnatal development of their offspring. Pregnant Wistar rats were exposed to distinct AgNP concentrations (0, 1, 3 and 5 micrograms/kg/day) from beginning to the end of pregnancy. At parturition, newborns were observed regarding clinical signs of toxicity and survival rate. The offspring was examined by evaluating developmental endpoints. A delay in time for vaginal opening and testes descent were detected in the offspring exposed to AgNP during embryonic development. Our results indicate that prenatal exposure to AgNP can compromise neonatal rats' postnatal development, especially the reproductive features. 650 $aAnimal reproduction 650 $aEcotoxicology 650 $aNanomaterials 650 $aNanosilver 650 $apregnancy 650 $arats 650 $areproduction 650 $aAnimal de Laboratório 650 $aComposto Químico 650 $aEmbrião 650 $aPrenhez 650 $aToxidez 653 $aDevelopmental endpoints 653 $aSilver nanoparticles 700 1 $aOLIVEIRA, L. P. de 700 1 $aCASTRO, V. L. S. S. de 700 1 $aSIQUEIRA, M. C. 700 1 $aBRANDAO, H. de M. 700 1 $aCORREA, D. S. 700 1 $aFERREIRA, M. D. 773 $tEnvironmental Toxicology and Pharmacology$gv. 81, article 103546, 2021.
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