Data/hora: 14/06/2024 01:39:17

Biblioteca(s): | Embrapa Agricultura Digital.
Data corrente: | 19/06/2009
Data da última atualização: | 15/01/2020
Autoria: | CASTRO, A. de; ALVES, D.
Afiliação: | ALEXANDRE DE CASTRO, CNPTIA; DOMINGOS ALVES, UNIFESP.
Título: | Viral mutation and its influence in the time evolution of the immunizations.
Ano de publicação: | 2009
Fonte/Imprenta: | The European Physical Journal Applied Physics, v. 27, n. 3, p. 31401-p1-31406-p5, 2009.
DOI: | 10.1051/epjap/2009098
Idioma: | Inglês
Conteúdo: | In this paper, we study the behavior of immune memory against antigenic mutation. Using a dynamic model proposed by one of the authors in a previous study (A. de Castro [Phys. J. Appl. Phys. 33, 147 (2006) and Simul. Mod. Pract. Theory. 15, 831 (2007)]), we have performed simulations of several inoculations, where in each virtual sample the viral population undergoes mutations. Our results suggest that the sustainability of the immunizations is dependent on viral variability and that the memory lifetimes are not random, what contradicts what was suggested by Tarlinton et al. [Curr. Opin. Immunol. 20, 162 (2008)]. We show that what may cause an apparent random behavior of the immune memory is the antigenic variability.
Palavras-Chave: | Immune memory; Memória imunológica; Modelo de bit-strings; Mutação antigênica; Mutação viral.
Thesagro: | Imunização; Inoculação; Simulação.
Thesaurus Nal: | Immunization; Mutation.
Categoria do assunto: | X Pesquisa, Tecnologia e Engenharia
Registro original: | Embrapa Agricultura Digital (CNPTIA)

Exemplares:

CNPTIA - (13161-1) - UPC - AP - PP -  -  - 2009.00067 - DES
CNPTIA - (13161-2) - UPC - AP - DD -  -  -  - DIS