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| Registros recuperados : 25 | |
| 14. |  | MOURA, N. G.; LEES, A. C.; ALEIXO, A.; BARLOW, J.; BERENGUER, E.; FERREIRA, J.; NALLY, R. M.; THOMSON, J. R.; GARDNER, T. A. Idiosyncratic responses of Amazonian birds to primary forest disturbance. Oecologia, v. 180, n. 3, p. 903-916, Mar. 2016.| Biblioteca(s): Embrapa Amazônia Oriental. |
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| 15. | | BERENGUER, E.; GARDNER, T. A.; FERREIRA, J. N.; ARAGÃO, L. E. O. C.; NALLY, R. M.; THOMSON, J. R.; VIEIRA, I. C. G.; BARLOW, J. Seeing the woods through the saplings: Using wood density to assess the recovery of human-modified Amazonian forests. Journal of Ecology, v. 106, n. 6, p. 2190-2203, Nov. 2018.| Biblioteca(s): Embrapa Amazônia Oriental. |
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| 16. | | LEAL, C. G.; POMPEU, P. S.; GARDNER, T. A.; LEITÃO, R. P.; HUGHES, R. M.; KAUFMANN, P. R.; ZUANON, J.; PAULA, F. R. de; FERRAZ, S. F. B.; THOMSON, J. R.; NALLY, R. M.; FERREIRA, J.; BARLOW, J. Multi-scale assessment of human-induced changes to Amazonian instream habitats. Landscape Ecology, v. 31, n. 8, p. 1725-1745, Oct. 2016.| Biblioteca(s): Embrapa Amazônia Oriental. |
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| 17. | | SOLAR, R.; BARLOW, J.; FERREIRA, J.; BERENGUER, E.; LEES, A.; LOUZADA, J.; MAUES, M.; MOURA, N.; OLIVEIRA, V.; CHAUL, J.; RIBAS, C.; SCHOEREDER, J. H.; MAC NALLY, R.; THOMSON, J. R.; VIEIRA, I. C. G.; GARDNER, T. How pervasive is biotic homogenization in human-modified tropical forests? In: INTERNATIONAL CONGRESS FOR CONSERVATION BIOLOGY, 27.; EUROPEAN CONGRESS FOR CONSERVATION BIOLOGY, 4., 2015, Montpellier. Mission biodiversity: choosing new paths for conservation: abstract book. [S.l.]: Society for Conservation Biology, 2015. p. 658-659.| Biblioteca(s): Embrapa Amazônia Oriental. |
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| 18. | | LEAL, C. G.; BARLOW, J.; GARDNER, T. A.; HUGHES, R. M.; LEITÃO, R. P.; NALLY, R. M.; KAUFMANN, P. R.; FERRAZ, S. F. B.; ZUANON, J.; PAULA, F. R. de; FERREIRA, J. N.; THOMSON, J. R.; LENNOX, G. D.; DARY, E. P.; RÖPKE, C. P.; POMPEU, P. S. Is environmental legislation conserving tropical stream faunas? A large-scale assessment of local, riparian and catchment-scale influences on Amazonian fish. Journal of Applied Ecology, v. 55, n. 3, p. 1312-1326, May 2018.| Biblioteca(s): Embrapa Amazônia Oriental. |
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| 19. | | FERREIRA, J. N.; LENNOX, G. D.; GARDNER, T. A.; THOMSON, J. R.; BERENGUER, E.; LEES, A. C.; MAC BALLY, R.; ARAGÃO, L. E. O. C.; FERRAZ, S. F. B.; LOUZADA, J.; MOURA, N. G.; OLIVEIRA, V. H. F.; PARDINI, R.; SOLAR, R. R. C.; VIEIRA, I. C. G.; BARLOW, J. Carbon-focused conservation may fail to protect the most biodiverse tropical forests. Nature Climate Change, v. 8, n. 8, p. 744-749, Aug. 2018.| Biblioteca(s): Embrapa Amazônia Oriental. |
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| 20. | | SOLAR, R. R. de C.; BARLOW, J.; FERREIRA, J.; BERENGUER, E.; LEES, A. C.; THOMSON, J. R.; LOUZADA, J.; MAUES, M.; MOURA, N. G.; OLIVEIRA, V. H. F.; CHAUL, J. C. M.; SCHOEREDER, J. H.; VIEIRA, I. C. G.; NALLY, R. M.; GARDNER, T. A. How pervasive is biotic homogenization in human-modified tropical forest landscapes? Ecology Letters, v. 18, n. 10, p. 1108-1118, Oct. 2015.| Biblioteca(s): Embrapa Amazônia Oriental. |
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| Registros recuperados : 25 | |
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Registro Completo
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Biblioteca(s): |
Embrapa Clima Temperado. |
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Data corrente: |
04/08/2023 |
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Data da última atualização: |
04/08/2023 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 4 |
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Autoria: |
PEREIRA, R. S.; COSTA, V. V.; GOMES, G. L. M.; CAMPANA, P. R. V.; PÁDUA, R. M. de; BARBOSA, M.; OKI, Y.; HEIDEN, G.; FERNANDES, G. W.; OLIVEIRA, D. M. de; SOUZA, D. G.; TEIXEIRA, M. M.; BRAGA, F. C. |
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Afiliação: |
ROSÂNGELA SANTOS PEREIRA, Universidade Federal de Minas Gerais; VIVIAN VASCONCELOS COSTA, Universidade Federal de Minas Gerais; GABRIEL LUIZ MENEZES GOMES, Universidade Federal de Minas Gerais; PRISCILLA RODRIGUES VALADARES CAMPANA, Universidade Federal de Minas Gerais; RODRIGO MAIA DE PÁDUA, Universidade Federal de Minas Gerais; MILTON BARBOSA, Universidade Federal de Minas Gerais; YUMI OKI, Universidade Federal de Minas Gerais; GUSTAVO HEIDEN, CPACT; GERALDO WILSON FERNANDES, Universidade Federal de Minas Gerais; DJALMA MENEZES DE OLIVEIRA, Universidade Estadual do Sudoeste da Bahia; DANIELE G. SOUZA, Universidade Federal de Minas Gerais; MAURO MARTINS TEIXEIRA, Universidade Federal de Minas Gerais; FERNÃO CASTRO BRAGA, Universidade Federal de Minas Gerais. |
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Título: |
Anti-Zika Virus Activity of Plant Extracts Containing Polyphenols and Triterpenes on Vero CCL-81 and Human Neuroblastoma SH-SY5Y Cells. |
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Ano de publicação: |
2022 |
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Fonte/Imprenta: |
Chemistry & Biodiversity, v. 19, n. 4, e202100842, April 2022. |
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DOI: |
https://doi.org/10.1002/cbdv.202100842 |
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Idioma: |
Inglês |
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Conteúdo: |
Zika virus (ZIKV) infection is a global threat associated to neurological disorders in adults and microcephaly in children born to infected mothers. No vaccine or drug is available against ZIKV. We herein report the anti-ZIKV activity of 36 plant extracts containing polyphenols and/or triterpenes. ZIKV-infected Vero CCL-81 cells were treated with samples at non-cytotoxic concentrations, determined by MTT and LDH assays. One third of the extracts elicited concentration-dependent anti-ZIKV effect, with viral loads reduction from 0.4 to 3.8?log units. The 12 active extracts were tested on ZIKV-infected SH-SY5Y cells and significant reductions of viral loads (in log units) were induced by Maytenus ilicifolia (4.5?log), Terminalia phaeocarpa (3.7?log), Maytenus rigida (1.7?log) and Echinodorus grandiflorus (1.7?log) extracts. Median cytotoxic concentration (CC50) of these extracts in Vero cells were higher than in SH-SY5Y lineage. M. ilicifolia (IC50=16.8±10.3??g/mL, SI=3.4) and T. phaeocarpa (IC50=22.0±6.8??g/mL, SI=4.8) were the most active extracts. UPLC-ESI-MS/MS analysis of M. ilicifolia extract led to the identification of 7 triterpenes, of which lupeol and a mixture of friedelin/friedelinol showed no activity against ZIKV. The composition of T. phaeocarpa extract comprises phenolic acids, ellagitannins and flavonoids, as recently reported by us. In conclusion, the anti-ZIKV activity of 12 plant extracts is here described for the first time and polyphenols and triterpenes were identified as the probable bioactive constituents of T. phaeocarpa and M. ilicifolia, respectively. MenosZika virus (ZIKV) infection is a global threat associated to neurological disorders in adults and microcephaly in children born to infected mothers. No vaccine or drug is available against ZIKV. We herein report the anti-ZIKV activity of 36 plant extracts containing polyphenols and/or triterpenes. ZIKV-infected Vero CCL-81 cells were treated with samples at non-cytotoxic concentrations, determined by MTT and LDH assays. One third of the extracts elicited concentration-dependent anti-ZIKV effect, with viral loads reduction from 0.4 to 3.8?log units. The 12 active extracts were tested on ZIKV-infected SH-SY5Y cells and significant reductions of viral loads (in log units) were induced by Maytenus ilicifolia (4.5?log), Terminalia phaeocarpa (3.7?log), Maytenus rigida (1.7?log) and Echinodorus grandiflorus (1.7?log) extracts. Median cytotoxic concentration (CC50) of these extracts in Vero cells were higher than in SH-SY5Y lineage. M. ilicifolia (IC50=16.8±10.3??g/mL, SI=3.4) and T. phaeocarpa (IC50=22.0±6.8??g/mL, SI=4.8) were the most active extracts. UPLC-ESI-MS/MS analysis of M. ilicifolia extract led to the identification of 7 triterpenes, of which lupeol and a mixture of friedelin/friedelinol showed no activity against ZIKV. The composition of T. phaeocarpa extract comprises phenolic acids, ellagitannins and flavonoids, as recently reported by us. In conclusion, the anti-ZIKV activity of 12 plant extracts is here described for the first time and polyphenols and triterpenes w... Mostrar Tudo |
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Thesagro: |
Biodiversidade; Extrato Vegetal; Vírus. |
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Categoria do assunto: |
-- |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/doc/1155672/1/Artigo-Anti8208Zika-Virus-Activity-of-Plant-Extracts.pdf
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Marc: |
LEADER 02560naa a2200313 a 4500
001 2155672
005 2023-08-04
008 2022 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1002/cbdv.202100842$2DOI
100 1 $aPEREIRA, R. S.
245 $aAnti-Zika Virus Activity of Plant Extracts Containing Polyphenols and Triterpenes on Vero CCL-81 and Human Neuroblastoma SH-SY5Y Cells.$h[electronic resource]
260 $c2022
520 $aZika virus (ZIKV) infection is a global threat associated to neurological disorders in adults and microcephaly in children born to infected mothers. No vaccine or drug is available against ZIKV. We herein report the anti-ZIKV activity of 36 plant extracts containing polyphenols and/or triterpenes. ZIKV-infected Vero CCL-81 cells were treated with samples at non-cytotoxic concentrations, determined by MTT and LDH assays. One third of the extracts elicited concentration-dependent anti-ZIKV effect, with viral loads reduction from 0.4 to 3.8?log units. The 12 active extracts were tested on ZIKV-infected SH-SY5Y cells and significant reductions of viral loads (in log units) were induced by Maytenus ilicifolia (4.5?log), Terminalia phaeocarpa (3.7?log), Maytenus rigida (1.7?log) and Echinodorus grandiflorus (1.7?log) extracts. Median cytotoxic concentration (CC50) of these extracts in Vero cells were higher than in SH-SY5Y lineage. M. ilicifolia (IC50=16.8±10.3??g/mL, SI=3.4) and T. phaeocarpa (IC50=22.0±6.8??g/mL, SI=4.8) were the most active extracts. UPLC-ESI-MS/MS analysis of M. ilicifolia extract led to the identification of 7 triterpenes, of which lupeol and a mixture of friedelin/friedelinol showed no activity against ZIKV. The composition of T. phaeocarpa extract comprises phenolic acids, ellagitannins and flavonoids, as recently reported by us. In conclusion, the anti-ZIKV activity of 12 plant extracts is here described for the first time and polyphenols and triterpenes were identified as the probable bioactive constituents of T. phaeocarpa and M. ilicifolia, respectively.
650 $aBiodiversidade
650 $aExtrato Vegetal
650 $aVírus
700 1 $aCOSTA, V. V.
700 1 $aGOMES, G. L. M.
700 1 $aCAMPANA, P. R. V.
700 1 $aPÁDUA, R. M. de
700 1 $aBARBOSA, M.
700 1 $aOKI, Y.
700 1 $aHEIDEN, G.
700 1 $aFERNANDES, G. W.
700 1 $aOLIVEIRA, D. M. de
700 1 $aSOUZA, D. G.
700 1 $aTEIXEIRA, M. M.
700 1 $aBRAGA, F. C.
773 $tChemistry & Biodiversity$gv. 19, n. 4, e202100842, April 2022.
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