Data/hora: 14/06/2024 06:06:28

Biblioteca(s): | Embrapa Agroindústria de Alimentos.
Data corrente: | 27/05/2021
Data da última atualização: | 28/09/2021
Autoria: | THEODORO, J. M. V.; MARTINEZ, O. D. M.; GRANCIERI, M.; TOLEDO, R. C. L.; BINOTI, M. L.; MARTINS, A. M. D.; CARVALHO, C. W. P. de; LISBOA, P. C.; MARTINO, H. S.
Afiliação: | JAQUELINE MACIEL VIEIRA THEODORO, UFV; OSCAR DAVID MEDINA MARTINEZ, UFV; MARIANA GRANCIERI, UFV; RENATA CELI LOPES TOLEDO, UFV; MIRELLA LIMA BINOTI, UFV; AMANDA M. DIAS MARTINS, UFRRJ; CARLOS WANDERLEI PILER DE CARVALHO, CTAA; PATRÍCIA CRISTINA LISBOA, Universidade Estadual do Rio de Janeiro; HÉRCIA STAMPINI DUARTE MARTINO, UFV.
Título: | Germinated millet flour (Pennisetum Glaucum (L.) R. BR.) improves adipogenesis and glucose metabolism and maintains thyroid function in vivo.
Ano de publicação: | 2021
Fonte/Imprenta: | Food & Function, v. 12, p. 6083-6090, 2021.
DOI: | https://doi.org/10.1039/D0FO03388J
Idioma: | Inglês
Conteúdo: | This study investigated the effects of germinated millet flour on adipogenesis, insulin resistance, glucose tolerance and thyroid function in Wistar rats fed with a high-fat high-fructose diet (HFHF). The experiment was divided into two phases. Phase 1: control group, which received AIN-93M diet (n = 10) and HFHF group (n = 20), which received a diet rich in saturated fat (31%) and fructose (20%), for eight weeks. Phase 2: intervention: the control group maintained the AIN-93M diet (n = 10) and the HFHF group was divided into two groups: the HFHF (n = 10) and the germinated millet group (n = 10), for 10 weeks. The germinated millet flour maintained (p>0, 05) the plasma levels of thyroid hormones, increased (p<0.05) the protein kinase B (AKT) mRNA expression and the phospho-AKT1 protein concentration, the phosphofructokinase (PFK) mRNA and activated protein kinase (AMPK) mRNA expression, and the brown adipose tissue and reduced (p<0.05) the glucose triglyceride index (TyG), glucose, insulin and hypercorticosteronemia, compared to the HFHF group. These effects contributed to reduce the gluconeogenesis, hyperinsulinemia and adiposity. Thus, germinated millet flour is a good alternative for modulating the adipogenesis and glucose metabolism, without interfering with the thyroid hormones, in rats with an insulin resistance condition with a high-fat high-fructose diet.
Thesaurus Nal: | Food technology.
Categoria do assunto: | --
Registro original: | Embrapa Agroindústria de Alimentos (CTAA)
Exemplares: | CTAA - (15175-1) - UPC - AP - DD -  -  -  - DIS