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 | Acesso ao texto completo restrito à biblioteca da Embrapa Agricultura Digital. Para informações adicionais entre em contato com cnptia.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Agricultura Digital. |
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Data corrente: |
04/08/2005 |
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Data da última atualização: |
17/01/2020 |
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Autoria: |
HIGA, R. H.; OLIVEIRA, A. G.; HORITA, L. G.; MIURA, R. T.; INOUE, M. K.; FALCAO, P. R. K.; MANCINI, A. L.; YAMAGISHI, M. E. B.; TOGAWA, R. C.; NESHICH, G. |
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Afiliação: |
ROBERTO HIROSHI HIGA, CNPTIA; PAULA REGINA KUSER FALCAO, CNPTIA; ADAUTO LUIZ MANCINI, CNPTIA; MICHEL EDUARDO BELEZA YAMAGISHI, CNPTIA; ROBERTO COITI TOGAWA, Cenargen; GORAN NESIC, CNPTIA. |
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Título: |
Defining 3D residue environment in protein structures using SCORPION and FORMIGA. |
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Ano de publicação: |
2004 |
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Fonte/Imprenta: |
Bioinformatics, v. 20, n. 12, p. 1989-1991, 2004. |
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DOI: |
10.1093/bioinformatics/bth190 |
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Idioma: |
Inglês |
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Notas: |
Na publicação: P. R. Kuser. |
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Conteúdo: |
Two web-based applications to analyze amino acids three-dimensional (3D) local environment within protein structures-SCORPION and FORMIGA-are presented. SCORPION and FORMIGA produce a graphical presentation for simple statistical data showing the frequency of residue occurrence within a given sphere (defined here as the 3D contacts). |
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Palavras-Chave: |
Sting Millennium Suite. |
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Thesagro: |
Aminoácido; Proteina. |
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Thesaurus Nal: |
Amino acids; Proteins. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 01230naa a2200313 a 4500
001 1009083
005 2020-01-17
008 2004 bl uuuu u00u1 u #d
024 7 $a10.1093/bioinformatics/bth190$2DOI
100 1 $aHIGA, R. H.
245 $aDefining 3D residue environment in protein structures using SCORPION and FORMIGA.$h[electronic resource]
260 $c2004
500 $aNa publicação: P. R. Kuser.
520 $aTwo web-based applications to analyze amino acids three-dimensional (3D) local environment within protein structures-SCORPION and FORMIGA-are presented. SCORPION and FORMIGA produce a graphical presentation for simple statistical data showing the frequency of residue occurrence within a given sphere (defined here as the 3D contacts).
650 $aAmino acids
650 $aProteins
650 $aAminoácido
650 $aProteina
653 $aSting Millennium Suite
700 1 $aOLIVEIRA, A. G.
700 1 $aHORITA, L. G.
700 1 $aMIURA, R. T.
700 1 $aINOUE, M. K.
700 1 $aFALCAO, P. R. K.
700 1 $aMANCINI, A. L.
700 1 $aYAMAGISHI, M. E. B.
700 1 $aTOGAWA, R. C.
700 1 $aNESHICH, G.
773 $tBioinformatics$gv. 20, n. 12, p. 1989-1991, 2004.
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Registro original: |
Embrapa Agricultura Digital (CNPTIA) |
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Registro Completo
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Biblioteca(s): |
Embrapa Amazônia Ocidental. |
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Data corrente: |
16/10/2023 |
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Data da última atualização: |
16/10/2023 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 2 |
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Autoria: |
CHURA, S. S. D.; MEMÓRIA, K. A. S.; LOPES, A. T.; PELISSARI, F. M.; SILVEIRA, J. V. W. da; BEZERRA, J. de A.; CHAVES, F. C. M.; RODRIGUES, A. P.; FARIA, J. A. Q. A.; CARNEIRO, G. |
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Afiliação: |
SOFIA SANTOS DONAIRE CHURA, FEDERAL UNIVERSITY OF JEQUITINHONHA AND MUCURI VALLEYS; KATHELEN ANNE SUDO MEMÓRIA, UNIVERSIDADE FEDERAL DO AMAZONAS; AMANDA TIBÃES LOPES, FEDERAL UNIVERSITY OF JEQUITINHONHA AND MUCURI VALLEYS; FRANCIELE MARIA PELISSARI, FEDERAL UNIVERSITY OF JEQUITINHONHA AND MUCURI VALLEYS; JOÃO VINÍCIOS WIRBITZKI DA SILVEIRA, FEDERAL UNIVERSITY OF JEQUITINHONHA AND MUCURI VALLEYS; JAQUELINE DE ARAÚJO BEZERRA, FEDERAL INSTITUTE OF EDUCATION, SCIENCE AND TECHNOLOGY OF AMAZONAS; FRANCISCO CELIO MAIA CHAVES, CPAA; ANA PAULA RODRIGUES, FEDERAL UNIVERSITY OF JEQUITINHONHA AND MUCURI VALLEYS; JERUSA ARAÚJO QUINTÃO ARANTES FARIA, UNIVERSIDADE FEDERAL DO AMAZONAS; GUILHERME CARNEIRO, FEDERAL UNIVERSITY OF JEQUITINHONHA AND MUCURI VALLEYS. |
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Título: |
Red sacaca essential oil-loaded nanostructured lipid carriers optimized by factorial design: cytotoxicity and cellular reactive oxygen species levels. |
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Ano de publicação: |
2023 |
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Fonte/Imprenta: |
Frontiers in Pharmacology, v. 14, art. 1176629, 2023. |
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DOI: |
https://doi.org/10.3389/fphar.2023.1176629 |
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Idioma: |
Inglês |
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Conteúdo: |
Amazonian flora includes several species with the potential to develop pharmaceutical and biotechnological products. The essential oils from Amazonian species possess some biological properties, such as antioxidant, antibacterial, and cytotoxic activities. The essential oil of red sacaca (RSO), Croton cajucara Benth., contains metabolites characterized by antioxidant and anti-inflammatory activities. Nanostructured lipid carriers (NLC) are an advantageous alternative for the effective delivery of drugs because they can solubilize lipophilic actives and reduce their cytotoxicity. This study aimed to optimize the synthesis of RSO-loaded nanostructured lipid carriers (NLC-RSO) using a 23 factorial design and investigate their antioxidant and cytotoxic effects. The red sacaca essential oil (RSO) metabolite profile was characterized using gas chromatography coupled with a mass spectrometer (GC-MS), identifying 33 metabolites, with linalool and 7-hydroxy-calamenene as the major ones, as reported in the literature. |
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Palavras-Chave: |
Amazon plants; Nanotecnologia; Plant metabolites; Rotational central composite design; Sacaca. |
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Thesaurus NAL: |
Croton cajucara; Nanotechnology. |
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Categoria do assunto: |
-- |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/doc/1157230/1/fphar-14-1176629.pdf
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Marc: |
LEADER 02071naa a2200325 a 4500
001 2157230
005 2023-10-16
008 2023 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.3389/fphar.2023.1176629$2DOI
100 1 $aCHURA, S. S. D.
245 $aRed sacaca essential oil-loaded nanostructured lipid carriers optimized by factorial design$bcytotoxicity and cellular reactive oxygen species levels.$h[electronic resource]
260 $c2023
520 $aAmazonian flora includes several species with the potential to develop pharmaceutical and biotechnological products. The essential oils from Amazonian species possess some biological properties, such as antioxidant, antibacterial, and cytotoxic activities. The essential oil of red sacaca (RSO), Croton cajucara Benth., contains metabolites characterized by antioxidant and anti-inflammatory activities. Nanostructured lipid carriers (NLC) are an advantageous alternative for the effective delivery of drugs because they can solubilize lipophilic actives and reduce their cytotoxicity. This study aimed to optimize the synthesis of RSO-loaded nanostructured lipid carriers (NLC-RSO) using a 23 factorial design and investigate their antioxidant and cytotoxic effects. The red sacaca essential oil (RSO) metabolite profile was characterized using gas chromatography coupled with a mass spectrometer (GC-MS), identifying 33 metabolites, with linalool and 7-hydroxy-calamenene as the major ones, as reported in the literature.
650 $aCroton cajucara
650 $aNanotechnology
653 $aAmazon plants
653 $aNanotecnologia
653 $aPlant metabolites
653 $aRotational central composite design
653 $aSacaca
700 1 $aMEMÓRIA, K. A. S.
700 1 $aLOPES, A. T.
700 1 $aPELISSARI, F. M.
700 1 $aSILVEIRA, J. V. W. da
700 1 $aBEZERRA, J. de A.
700 1 $aCHAVES, F. C. M.
700 1 $aRODRIGUES, A. P.
700 1 $aFARIA, J. A. Q. A.
700 1 $aCARNEIRO, G.
773 $tFrontiers in Pharmacology$gv. 14, art. 1176629, 2023.
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Embrapa Amazônia Ocidental (CPAA) |
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