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Registro Completo |
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Biblioteca(s): |
Embrapa Uva e Vinho. |
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Data corrente: |
10/02/2016 |
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Data da última atualização: |
08/03/2019 |
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Tipo da produção científica: |
Artigo de Divulgação na Mídia |
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Autoria: |
CONCEIÇÃO, M. A. F. |
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Afiliação: |
MARCO ANTONIO FONSECA CONCEICAO, CNPUV. |
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Título: |
Boa notícia: chuvas em dezembro ficam acima da média. |
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Ano de publicação: |
2015 |
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Fonte/Imprenta: |
Jornal de Jales, Jales, 04 jan. 2015. p. 12. |
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Idioma: |
Português |
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Thesagro: |
Chuva; Clima. |
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Categoria do assunto: |
-- |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/138637/1/JJales2015-01-04.jpg
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Marc: |
LEADER 00366nam a2200121 a 4500
001 2036423
005 2019-03-08
008 2015 bl uuuu u00u1 u #d
100 1 $aCONCEIÇÃO, M. A. F.
245 $aBoa notícia$bchuvas em dezembro ficam acima da média.$h[electronic resource]
260 $aJornal de Jales, Jales, 04 jan. 2015. p. 12.$c2015
650 $aChuva
650 $aClima
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Embrapa Uva e Vinho (CNPUV) |
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 | Acesso ao texto completo restrito à biblioteca da Embrapa Caprinos e Ovinos. Para informações adicionais entre em contato com cnpc.biblioteca@embrapa.br. |
Registro Completo
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Biblioteca(s): |
Embrapa Caprinos e Ovinos. |
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Data corrente: |
13/12/2017 |
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Data da última atualização: |
10/01/2019 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 2 |
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Autoria: |
SANTOS, J. M. L. dos; VASCONCELOS, J. F.; FROTA, G. A.; RIBEIRO, W. L. C.; ANDDRÉ, W. P. P.; VIEIRA, L. da S.; TEIXEIRA, M.; BEVILAQUA, C. M. L.; MONTEIRO, J. P. |
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Afiliação: |
Jessica Maria Leite dos Santos, Pós-graduação - Universidade Estadual do Ceará (UECe) - Fortaleza, CE, Brazil; Janaelia Ferreira Vasconcelos, Universidade Estadual Vale do Acaraú (UVA) - Sobral, CE, Brazil; Gracielle Araújo Frota, UVA - Sobral, CE, Brazil; Wesley Lyeverton Correia Ribeiro, UECe - Fortaleza, CE, Brazil; Weibson Paz Pinheiro André, UECe - Fortaleza, CE, Brazil; LUIZ DA SILVA VIEIRA, CNPC; MARCEL TEIXEIRA, CNPC; Claudia Maria Leal Bevilaqua, UECe - Fortaleza, CE, Brazil; JOMAR PATRICIO MONTEIRO, CNPC. |
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Título: |
Haemonchus contortus Beta-tubulin isotype 1 gene F200Y and F167Y SNPs are both selected by ivermectin and oxfendazole treatments with differing impacts on anthelmintic resistance. |
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Ano de publicação: |
2017 |
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Fonte/Imprenta: |
Veterinary Parasitology, v. 248, p. 90-95, Dec. 2017. |
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DOI: |
10.1016/j.vetpar.2017.11.003 |
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Idioma: |
Inglês |
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Conteúdo: |
Abstract: Parasitism by Haemonchus contortus is one of the main limiting factors in small ruminant production in tropical areas. Benzimidazoles (BZ) and macrocyclic lactones (ML) are the most used anthelmintic classes in gastrointestinal nematodes control. There is considerable scientific evidence of a possible relation between the anthelmintic resistance to BZ and ML. This study aimed to characterize the dynamics of anthelmintic resistance in an H. contortus susceptible isolate under selection pressure for BZ and ML alone or in combination and the role of isotype 1 Beta-tubulin gene SNPs in these situations. A total of 12 Somali sheep were infected with 5000 third stage larvae of H. contortus Inbred-Susceptible Edinburgh (ISE) isolate. Once infection was established, animals were distributed in three groups (n=4), each treated with crescent doses of oxfendazole (OXF), ivermectin (IVM) and oxfendazole plus ivermectin (IVMOXF). An additional control group with untreated animals was maintained during the entire experiment. After each treatment, eggs were collected and real-time PCR was performed to identify single nucleotide polymorphisms (SNPs) F167Y, F200Y and E198A, in addition to egg hatch test (EHT) for BZ and larval development test (LDT) for ivermectin resistance. All treatments led to increased resistance allelic frequencies at SNPs F200Y and F167Y (p <0.05). In vitro results showed increased phenotypic resistance against both anthelmintic classes in groups IVM and IVMOXF while group OXF only developed resistance against BZ. Finally, we provide evidence that while isotype 1 ?-tubulin gene SNPs may have some involvement with ML resistance, the presence of these ?-tubulin SNPs alone are not sufficient to develop ML resistance. MenosAbstract: Parasitism by Haemonchus contortus is one of the main limiting factors in small ruminant production in tropical areas. Benzimidazoles (BZ) and macrocyclic lactones (ML) are the most used anthelmintic classes in gastrointestinal nematodes control. There is considerable scientific evidence of a possible relation between the anthelmintic resistance to BZ and ML. This study aimed to characterize the dynamics of anthelmintic resistance in an H. contortus susceptible isolate under selection pressure for BZ and ML alone or in combination and the role of isotype 1 Beta-tubulin gene SNPs in these situations. A total of 12 Somali sheep were infected with 5000 third stage larvae of H. contortus Inbred-Susceptible Edinburgh (ISE) isolate. Once infection was established, animals were distributed in three groups (n=4), each treated with crescent doses of oxfendazole (OXF), ivermectin (IVM) and oxfendazole plus ivermectin (IVMOXF). An additional control group with untreated animals was maintained during the entire experiment. After each treatment, eggs were collected and real-time PCR was performed to identify single nucleotide polymorphisms (SNPs) F167Y, F200Y and E198A, in addition to egg hatch test (EHT) for BZ and larval development test (LDT) for ivermectin resistance. All treatments led to increased resistance allelic frequencies at SNPs F200Y and F167Y (p <0.05). In vitro results showed increased phenotypic resistance against both anthelmintic classes in groups IVM and IVM... Mostrar Tudo |
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Palavras-Chave: |
Nematode; Nematódeo gastrintestinal; Pequeno ruminante; Resistance to anthelmintics. |
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Thesagro: |
Anti-helmíntico; Caprino; Haemonchus Contortus; Helminto gastrintestinal; Nematóide; Ovino; Resistência química; Verminose. |
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Thesaurus NAL: |
Anthelmintics; Benzimidazoles; Drug resistance; Goats; Ivermectin; Nematode control; Oxfendazole; Parasitism; Polymorphism; Sheep; Small ruminants. |
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Categoria do assunto: |
H Saúde e Patologia |
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Marc: |
LEADER 03267naa a2200505 a 4500
001 2082384
005 2019-01-10
008 2017 bl uuuu u00u1 u #d
024 7 $a10.1016/j.vetpar.2017.11.003$2DOI
100 1 $aSANTOS, J. M. L. dos
245 $aHaemonchus contortus Beta-tubulin isotype 1 gene F200Y and F167Y SNPs are both selected by ivermectin and oxfendazole treatments with differing impacts on anthelmintic resistance.$h[electronic resource]
260 $c2017
520 $aAbstract: Parasitism by Haemonchus contortus is one of the main limiting factors in small ruminant production in tropical areas. Benzimidazoles (BZ) and macrocyclic lactones (ML) are the most used anthelmintic classes in gastrointestinal nematodes control. There is considerable scientific evidence of a possible relation between the anthelmintic resistance to BZ and ML. This study aimed to characterize the dynamics of anthelmintic resistance in an H. contortus susceptible isolate under selection pressure for BZ and ML alone or in combination and the role of isotype 1 Beta-tubulin gene SNPs in these situations. A total of 12 Somali sheep were infected with 5000 third stage larvae of H. contortus Inbred-Susceptible Edinburgh (ISE) isolate. Once infection was established, animals were distributed in three groups (n=4), each treated with crescent doses of oxfendazole (OXF), ivermectin (IVM) and oxfendazole plus ivermectin (IVMOXF). An additional control group with untreated animals was maintained during the entire experiment. After each treatment, eggs were collected and real-time PCR was performed to identify single nucleotide polymorphisms (SNPs) F167Y, F200Y and E198A, in addition to egg hatch test (EHT) for BZ and larval development test (LDT) for ivermectin resistance. All treatments led to increased resistance allelic frequencies at SNPs F200Y and F167Y (p <0.05). In vitro results showed increased phenotypic resistance against both anthelmintic classes in groups IVM and IVMOXF while group OXF only developed resistance against BZ. Finally, we provide evidence that while isotype 1 ?-tubulin gene SNPs may have some involvement with ML resistance, the presence of these ?-tubulin SNPs alone are not sufficient to develop ML resistance.
650 $aAnthelmintics
650 $aBenzimidazoles
650 $aDrug resistance
650 $aGoats
650 $aIvermectin
650 $aNematode control
650 $aOxfendazole
650 $aParasitism
650 $aPolymorphism
650 $aSheep
650 $aSmall ruminants
650 $aAnti-helmíntico
650 $aCaprino
650 $aHaemonchus Contortus
650 $aHelminto gastrintestinal
650 $aNematóide
650 $aOvino
650 $aResistência química
650 $aVerminose
653 $aNematode
653 $aNematódeo gastrintestinal
653 $aPequeno ruminante
653 $aResistance to anthelmintics
700 1 $aVASCONCELOS, J. F.
700 1 $aFROTA, G. A.
700 1 $aRIBEIRO, W. L. C.
700 1 $aANDDRÉ, W. P. P.
700 1 $aVIEIRA, L. da S.
700 1 $aTEIXEIRA, M.
700 1 $aBEVILAQUA, C. M. L.
700 1 $aMONTEIRO, J. P.
773 $tVeterinary Parasitology$gv. 248, p. 90-95, Dec. 2017.
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