Data/hora: 14/06/2024 19:27:16

Biblioteca(s): 	Embrapa Amapá.	
Data corrente: 	30/09/2011	
Data da última atualização: 	29/05/2017	
Autoria: 	SILVA, C. A. da; OBA, E. T.; RAMSDORF, W. A.; MAGALHÃES, V. F.; CESTARI, M. M.; RIBEIRO, C. A. O.; ASSIS, H. C. S. de.	
Afiliação: 	ELIANE TIE OBA YOSHIOKA, CPAF-AP.	
Título: 	First report about saxitoxins in freshwater fish Hoplias malabaricus through trophic exposure.	
Ano de publicação: 	2011	
Fonte/Imprenta: 	Toxicon, Oxford, v. 57, n. 1, p. 141-147, jan. 2011.	
Idioma: 	Inglês	
Conteúdo: 	Cyanobacterial waterblooms, such as the saxitoxin (STX) producer Cylindrospermopsis raciborskii, have been a worldwide concern in environmental health. However, the bioaccumulation of this neurotoxin in the trophic chain is not completely known. The aim of the present work was to evaluate STX bioaccumulation through chemical analyses and the toxic and trophic effects using biomarkers in the tropical freshwater fish Hoplias malabaricus. They were fed once every five days with Astyanax sp. before being subjected to intraperitoneal inoculation with STX extract (0.08 mg/100 g) obtained by lysis of toxic C. raciborskii strain (T3). After 20 days the brain was collected for acetylcholinesterase (AChE), superoxide dismutase (SOD), catalase (CAT), glutathione S-transferase (GST), glutathione peroxidase (GPx), glutathione (GSH), lipoperoxidation (LPO), protein carbonylation (PCO), and comet assay analysis. The muscle was collected for STX chemical analysis. The activities of SOD and concentrations of PCO and LPO increased. The CAT, GST, and GPx activities decreased. Genotoxicity was observed in the experimental group. STX was not detected in muscle samples. Thus, an oxidative stress was observed in the brain, leading to the damage of lipids, proteins, and DNA. The mechanism of action of the neurotoxin in this subchronic exposure suggests an apoptotic cellular process.	
Thesagro: 	Peixe de água doce; Toxina; Traíra.	
Categoria do assunto: 	L Ciência Animal e Produtos de Origem Animal	
URL: 	http://ainfo.cnptia.embrapa.br/digital/bitstream/item/42710/1/AP-2011-First-report-.pdf	
Registro original: 	Embrapa Amapá (CPAF-AP)	
Exemplares: 	CPAF-AP - (15430-1) - UPC - AP - DD -  -  -  - DIS