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Registro Completo |
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Biblioteca(s): |
Embrapa Unidades Centrais. |
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Data corrente: |
31/01/2018 |
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Data da última atualização: |
31/01/2018 |
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Autoria: |
ESTIMA-SILVA, P.; MARCOLONGO-PEREIRA, C.; SANTOS, B. L. dos; COELHO, A. C. B.; AMARAL, L. A.; LIM, A.; BOLIN, S. R.; SCHILD, A. L. |
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Afiliação: |
Pablo Estima-Silva, Programa de Pós-Graduação em Veterinária/Faculdade de Veterinária - FV/Universidade Federal de Pelotas - UFPel; Clairton Marcolongo-Pereira, Faculdade de Veterinária/Centro Universitário Ritter dos Reis - UniRitter; Bianca Lemos dos Santos, Programa de Pós-Graduação em Veterinária/Faculdade de Veterinária - FV/Universidade Federal de Pelotas - UFPel; Ana Carolina Barreto Coelho, Programa de Pós-Graduação em Veterinária/Faculdade de Veterinária - FV/Universidade Federal de Pelotas - UFPel; Lorena Alvariza Amaral, Médica Veterinária Autônoma; Ailam Lim, Diagnostic Center for Population and Animal Health, Michigan State University; Steven R. Bolin, Diagnostic Center for Population and Animal Health/Michigan State University; Ana Lucia Schild, Laboratório Regional de Diagnóstico/Faculdade de Veterinária - UFPel. |
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Título: |
Equine multinodular pulmonary fibrosis in southern Brazil: pathology and differential diagnosis. |
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Ano de publicação: |
2017 |
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Fonte/Imprenta: |
Pesquisa Veterinária Brasileira, Rio de Janeiro, v. 37, n. 11, p. 1247-1252, novembro 2017. |
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Idioma: |
Inglês |
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Notas: |
Título em português: Fibrose pulmonar multinodular em equinos no Sul do Rio Grande do Sul: patologia e diagnóstico diferencial. |
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Conteúdo: |
Equine multinodular pulmonary fibrosis (EMPF) diagnosed at the Laboratório Regional de Diagnóstico of Faculdade de Medicina Veterinária, Universidade Federal de Pelotas (LRD/UFPel), is described. Differential aspects of other pulmonary diseases in horses with pneumonia and interstitial fibrosis were discussed. The disease occurred in a 15-year-old equine that presented with clinical signs of respiratory distress, intermittent fever, anorexia, and dyspnea. Macroscopically, there was enlargement of the lungs with whitish, pale, firm and well-delimited nodules, approximately 7-10 cm in diameter, distributed throughout the parenchyma. Histologically, the lung nodules had alveolar spaces with walls covered by cuboidal epithelium containing macrophages, neutrophils, lymphocytes, hyperplasia of type II pneumocytes and, eventually, multinucleated giant cells. The interstitium was markedly thickened by mature fibrous connective tissue and collagen. There were intranuclear inclusion bodies in the macrophages. The PCR technique for detecting the EHV-5 DNA was positive. In a retrospective study of pneumonia cases in horses with interstitial fibrosis diagnosed in the LRD/UFPel, two animals had macroscopic and histological lesions similar to those with EMPF, but they were negative for EHV-5 in PCR. Four cases diagnosed with pneumonia and interstitial tissue fibrosis had a histological pattern that was different from that observed in the EMPF animal, thus eliminating the possibility of EMPF. It is concluded that EMPF is a sporadic disease that should be considered in cases of respiratory disease in horses. Reports of such cases are important to alert technicians about the occurrence of rare diseases in Brazil. It is also necessary to establish the true role of EHV-5 in the pathogenesis of EMPF. Cases of pulmonary fibrosis such as EMPF, in which the virus is not present, should be studied to establish whether it could be an idiopathic form of the disease. MenosEquine multinodular pulmonary fibrosis (EMPF) diagnosed at the Laboratório Regional de Diagnóstico of Faculdade de Medicina Veterinária, Universidade Federal de Pelotas (LRD/UFPel), is described. Differential aspects of other pulmonary diseases in horses with pneumonia and interstitial fibrosis were discussed. The disease occurred in a 15-year-old equine that presented with clinical signs of respiratory distress, intermittent fever, anorexia, and dyspnea. Macroscopically, there was enlargement of the lungs with whitish, pale, firm and well-delimited nodules, approximately 7-10 cm in diameter, distributed throughout the parenchyma. Histologically, the lung nodules had alveolar spaces with walls covered by cuboidal epithelium containing macrophages, neutrophils, lymphocytes, hyperplasia of type II pneumocytes and, eventually, multinucleated giant cells. The interstitium was markedly thickened by mature fibrous connective tissue and collagen. There were intranuclear inclusion bodies in the macrophages. The PCR technique for detecting the EHV-5 DNA was positive. In a retrospective study of pneumonia cases in horses with interstitial fibrosis diagnosed in the LRD/UFPel, two animals had macroscopic and histological lesions similar to those with EMPF, but they were negative for EHV-5 in PCR. Four cases diagnosed with pneumonia and interstitial tissue fibrosis had a histological pattern that was different from that observed in the EMPF animal, thus eliminating the possibility of EMP... Mostrar Tudo |
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Palavras-Chave: |
Diagnóstico diferencial; Differential diagnosis; Disease of horses; Doença pulmonar; Equine multinodular pulmonary fibrosis; Fibrose pulmonar multinodular; Herpesvírus equino-5; Pathology; Retrospective study. |
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Thesagro: |
Doença; Eqüino. |
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Categoria do assunto: |
-- |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/171993/1/Equine-multinodular-pulmonary-fibrosis.pdf
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Marc: |
LEADER 03176naa a2200349 a 4500
001 2086863
005 2018-01-31
008 2017 bl uuuu u00u1 u #d
100 1 $aESTIMA-SILVA, P.
245 $aEquine multinodular pulmonary fibrosis in southern Brazil$bpathology and differential diagnosis.$h[electronic resource]
260 $c2017
500 $aTítulo em português: Fibrose pulmonar multinodular em equinos no Sul do Rio Grande do Sul: patologia e diagnóstico diferencial.
520 $aEquine multinodular pulmonary fibrosis (EMPF) diagnosed at the Laboratório Regional de Diagnóstico of Faculdade de Medicina Veterinária, Universidade Federal de Pelotas (LRD/UFPel), is described. Differential aspects of other pulmonary diseases in horses with pneumonia and interstitial fibrosis were discussed. The disease occurred in a 15-year-old equine that presented with clinical signs of respiratory distress, intermittent fever, anorexia, and dyspnea. Macroscopically, there was enlargement of the lungs with whitish, pale, firm and well-delimited nodules, approximately 7-10 cm in diameter, distributed throughout the parenchyma. Histologically, the lung nodules had alveolar spaces with walls covered by cuboidal epithelium containing macrophages, neutrophils, lymphocytes, hyperplasia of type II pneumocytes and, eventually, multinucleated giant cells. The interstitium was markedly thickened by mature fibrous connective tissue and collagen. There were intranuclear inclusion bodies in the macrophages. The PCR technique for detecting the EHV-5 DNA was positive. In a retrospective study of pneumonia cases in horses with interstitial fibrosis diagnosed in the LRD/UFPel, two animals had macroscopic and histological lesions similar to those with EMPF, but they were negative for EHV-5 in PCR. Four cases diagnosed with pneumonia and interstitial tissue fibrosis had a histological pattern that was different from that observed in the EMPF animal, thus eliminating the possibility of EMPF. It is concluded that EMPF is a sporadic disease that should be considered in cases of respiratory disease in horses. Reports of such cases are important to alert technicians about the occurrence of rare diseases in Brazil. It is also necessary to establish the true role of EHV-5 in the pathogenesis of EMPF. Cases of pulmonary fibrosis such as EMPF, in which the virus is not present, should be studied to establish whether it could be an idiopathic form of the disease.
650 $aDoença
650 $aEqüino
653 $aDiagnóstico diferencial
653 $aDifferential diagnosis
653 $aDisease of horses
653 $aDoença pulmonar
653 $aEquine multinodular pulmonary fibrosis
653 $aFibrose pulmonar multinodular
653 $aHerpesvírus equino-5
653 $aPathology
653 $aRetrospective study
700 1 $aMARCOLONGO-PEREIRA, C.
700 1 $aSANTOS, B. L. dos
700 1 $aCOELHO, A. C. B.
700 1 $aAMARAL, L. A.
700 1 $aLIM, A.
700 1 $aBOLIN, S. R.
700 1 $aSCHILD, A. L.
773 $tPesquisa Veterinária Brasileira, Rio de Janeiro$gv. 37, n. 11, p. 1247-1252, novembro 2017.
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Registro original: |
Embrapa Unidades Centrais (AI-SEDE) |
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Biblioteca(s): |
Embrapa Café. |
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Data corrente: |
16/11/2022 |
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Data da última atualização: |
16/11/2022 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 1 |
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Autoria: |
AQUINO, S. O. de; KIWUKA, C.; TOURNEBIZE, R.; GAIN, C.; MARRACCINI, P.; MARIAC, C.; BETHUNE, K.; COUDERC, M.; CUBRY, P.; ANDRADE, A. C.; LEPELLEY, M.; DARRACQ, O.; CROUZILLAT, D.; ANTEN, N.; MUSOLI, P.; VIGOUROUX, Y.; KOCHKO, A. de; MANEL, S.; FRANÇOIS, O.; PONCET, V. |
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Afiliação: |
SINARA OLIVEIRA DE AQUINO, UNIVERSITY OF MONTPELLIER; CATHERINE KIWUKA, WAGENINGEN UNIVERSITY; RÉMI TOURNEBIZE, UNIVERSITY OF MONTPELLIER; CLÉMENT GAIN, U. GRENOBLE-ALPES; PIERRE MARRACCINI, UNIVERSITY OF MONTPELLIER; CÉDRIC MARIAC, UNIVERSITY OF MONTPELLIER; KÉVIN BETHUNE, UNIVERSITY OF MONTPELLIER; MARIE COUDERC, UNIVERSITY OF MONTPELLIER; PHILIPPE CUBRY, UNIVERSITY OF MONTPELLIER; ALAN CARVALHO ANDRADE, CNPCa; MAUD LEPELLEY, NESTLE; OLIVIER DARRACQ, NESTLE; DOMINIQUE CROUZILLAT, NESTLE; NIELS ANTEN, WAGENINGEN UNIVERSITY; PASCAL MUSOLI, NARO; YVES VIGOUROUX, UNIVERSITY OF MONTPELLIER; ALEXANDRE DE KOCHKO, UNIVERSITY OF MONTPELLIER; STÉPHANIE MANEL, UNIVERSITY OF MONTPELLIER; OLIVIER FRANÇOIS, U. GRENOBLE-ALPES; VALÉRIE PONCET, UNIVERSITY OF MONTPELLIER. |
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Título: |
Adaptive potential of Coffea canephora from Uganda in response to climate change. |
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Ano de publicação: |
2022 |
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Fonte/Imprenta: |
Molecular ecology, v. 31, n. 6, p. 180-1819, Jan. 2022. |
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DOI: |
https://doi.org/10.1111/mec.16360 |
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Idioma: |
Inglês |
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Conteúdo: |
Understanding vulnerabilities of plant populations to climate change could help preserve their biodiversity and reveal new elite parents for future breeding programmes. To this end, landscape genomics is a useful approach for assessing putative adaptations to future climatic conditions, especially in long-lived species such as trees. We conducted a population genomics study of 207 Coffea canephora trees from seven forests along different climate gradients in Uganda. For this, we sequenced 323 candidate genes involved in key metabolic and defence pathways in coffee. Seventy-one single nucleotide polymorphisms (SNPs) were found to be significantly associated with bioclimatic variables, and were thereby considered as putatively adaptive loci. These SNPs were linked to key candidate genes, including transcription factors, like DREB-like and MYB family genes controlling plant responses to abiotic stresses, as well as other genes of organoleptic interest, such as the DXMT gene involved in caffeine biosynthesis and a putative pest repellent. These climate-associated genetic markers were used to compute genetic offsets, predicting population responses to future climatic conditions based on local climate change forecasts. Using these measures of maladaptation to future conditions, substantial levels of genetic differentiation between present and future diversity were estimated for all populations and scenarios considered. The populations from the forests Zoka and Budongo, in the northernmost zone of Uganda, appeared to have the lowest genetic offsets under all predicted climate change patterns, while populations from Kalangala and Mabira, in the Lake Victoria region, exhibited the highest genetic offsets. The potential of these findings in terms of ex situ conservation strategies are discussed. MenosUnderstanding vulnerabilities of plant populations to climate change could help preserve their biodiversity and reveal new elite parents for future breeding programmes. To this end, landscape genomics is a useful approach for assessing putative adaptations to future climatic conditions, especially in long-lived species such as trees. We conducted a population genomics study of 207 Coffea canephora trees from seven forests along different climate gradients in Uganda. For this, we sequenced 323 candidate genes involved in key metabolic and defence pathways in coffee. Seventy-one single nucleotide polymorphisms (SNPs) were found to be significantly associated with bioclimatic variables, and were thereby considered as putatively adaptive loci. These SNPs were linked to key candidate genes, including transcription factors, like DREB-like and MYB family genes controlling plant responses to abiotic stresses, as well as other genes of organoleptic interest, such as the DXMT gene involved in caffeine biosynthesis and a putative pest repellent. These climate-associated genetic markers were used to compute genetic offsets, predicting population responses to future climatic conditions based on local climate change forecasts. Using these measures of maladaptation to future conditions, substantial levels of genetic differentiation between present and future diversity were estimated for all populations and scenarios considered. The populations from the forests Zoka and Budongo, in the nort... Mostrar Tudo |
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Thesaurus NAL: |
Climate change; Coffea canephora var. ugandae; Genomics; Landscapes; Plant breeding. |
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Categoria do assunto: |
-- |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/doc/1148279/1/Molecular-Ecology-2022-Aquino-Adaptive-potential-of-Coffea-canephora-from-Uganda-in-response-to-climate-change.pdf
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Marc: |
LEADER 02955naa a2200421 a 4500
001 2148279
005 2022-11-16
008 2022 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1111/mec.16360$2DOI
100 1 $aAQUINO, S. O. de
245 $aAdaptive potential of Coffea canephora from Uganda in response to climate change.$h[electronic resource]
260 $c2022
520 $aUnderstanding vulnerabilities of plant populations to climate change could help preserve their biodiversity and reveal new elite parents for future breeding programmes. To this end, landscape genomics is a useful approach for assessing putative adaptations to future climatic conditions, especially in long-lived species such as trees. We conducted a population genomics study of 207 Coffea canephora trees from seven forests along different climate gradients in Uganda. For this, we sequenced 323 candidate genes involved in key metabolic and defence pathways in coffee. Seventy-one single nucleotide polymorphisms (SNPs) were found to be significantly associated with bioclimatic variables, and were thereby considered as putatively adaptive loci. These SNPs were linked to key candidate genes, including transcription factors, like DREB-like and MYB family genes controlling plant responses to abiotic stresses, as well as other genes of organoleptic interest, such as the DXMT gene involved in caffeine biosynthesis and a putative pest repellent. These climate-associated genetic markers were used to compute genetic offsets, predicting population responses to future climatic conditions based on local climate change forecasts. Using these measures of maladaptation to future conditions, substantial levels of genetic differentiation between present and future diversity were estimated for all populations and scenarios considered. The populations from the forests Zoka and Budongo, in the northernmost zone of Uganda, appeared to have the lowest genetic offsets under all predicted climate change patterns, while populations from Kalangala and Mabira, in the Lake Victoria region, exhibited the highest genetic offsets. The potential of these findings in terms of ex situ conservation strategies are discussed.
650 $aClimate change
650 $aCoffea canephora var. ugandae
650 $aGenomics
650 $aLandscapes
650 $aPlant breeding
700 1 $aKIWUKA, C.
700 1 $aTOURNEBIZE, R.
700 1 $aGAIN, C.
700 1 $aMARRACCINI, P.
700 1 $aMARIAC, C.
700 1 $aBETHUNE, K.
700 1 $aCOUDERC, M.
700 1 $aCUBRY, P.
700 1 $aANDRADE, A. C.
700 1 $aLEPELLEY, M.
700 1 $aDARRACQ, O.
700 1 $aCROUZILLAT, D.
700 1 $aANTEN, N.
700 1 $aMUSOLI, P.
700 1 $aVIGOUROUX, Y.
700 1 $aKOCHKO, A. de
700 1 $aMANEL, S.
700 1 $aFRANÇOIS, O.
700 1 $aPONCET, V.
773 $tMolecular ecology$gv. 31, n. 6, p. 180-1819, Jan. 2022.
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Embrapa Café (CNPCa) |
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