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2. | | PAUVOLID-CORRÊA, A.; JULIANO, R. S.; VELEZ, J.; SCHATZMAYR, H.; NOGUEIRA, R. M. R.; KOMAR, N. Neutralizing antibodies for venezuelan equine encephalitis virus in horses from brazilian Pantanal. Virus Reviews & Research, v. 18, p. 245, 2013. Supplement 1. Trabalho apresentado no XXIV Congresso Brasileiro de Virologia & VIII Reunião do Mercosul de Virologia, Porto Seguro, BA. VV561. Biblioteca(s): Embrapa Pantanal. |
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3. | | PAUVOLID-CORRÊA, A.; LANCELLOTI, S. R.; GONÇALVES, M. C. R.; JULIANO, R. S.; BARTH, O. M.; SCHATZMAYR, H. G. Preliminary investigation of the orthopoxvirus circulation in sheep from the Nhecolândia Sub-region in Pantanal of Mato Grosso do Sul, Central - West Brazil. Virus Reviews and Research, v. 15, supl. 1, p. 253, oct. 2010. Trabalho apresentado no NATIONAL MEETING OF VIROLOGY, 21.; MERCOSUL MEETING OF VIROLOGY, 5. Biblioteca(s): Embrapa Pantanal. |
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4. | | PAUVOLID-CORRÊA, A.; KENNEY, J. L.; COUTO-LIMA, D.; CAMPOS, Z.; SCHATZMAYR, H. G.; NOGUEIRA, R. M. R.; BRAULT, A. C.; KOMAR, N. Ilheus virus isolation in the Pantanal, west-central Brazil. PLoS Neglected Tropical Diseases, v. 7, n. 7, p. 1-7, 2013. 8 p. Biblioteca(s): Embrapa Pantanal. |
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5. | | SCHATZMAYR, O. M. B.; MAJEROWICZ, S.; ROMIJN, P. C.; SILVA, R. de C. F.; COSTA, C. H. C.; RAPOSO, O. J.; PIRES, A. R.; SCHATZMAYR, H. G. Ocorrência de parapoxvírus em rebanho ovino no estado do Rio de Janeiro. Revista Brasileira de Medicina Veterinária, Rio de Janeiro, v. 28, n. 2, p. 60-62, 2006. Biblioteca(s): Embrapa Caprinos e Ovinos. |
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6. | | PAUVOLID - CORREA, A.; MORALES, M. A.; LEVIS, S.; FIGUEIREDO, L. T. M.; COUTO-LIMA, D.; NOGUEIRA, M. F.; SILVA, E. E.; NOGUEIRA, R. M. R; SCHATZMAYR, H. G. Detection of neutralizing antibodies for west nile virus in resident horses from Brazilian Pantanal. Virus Reviews and Research, v. 15, supl. 1, p. 265, oct. 2010. Trabalho apresentado no NATIONAL MEETING OF VIROLOGY, 21.; MERCOSUL MEETING OF VIROLOGY, 5. Biblioteca(s): Embrapa Pantanal. |
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7. | | PAUVOLID CORRÊA, A.; FIGUEIREDO, L. T. M.; MORALES, M. A.; LEVIS, S.; COUTO-LIMA, D.; NOGUEIRA, M. F.; SCHATZMAYR, H. G. Serological evidence of cacipacore virus circulation in horses from Brazilian Pantanal. Virus Reviews and Research, v. 15, supl. 1, p. 264-265, oct. 2010. Trabalho apresentado no NATIONAL MEETING OF VIROLOGY, 21.; MERCOSUL MEETING OF VIROLOGY, 5. Biblioteca(s): Embrapa Pantanal. |
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8. | | PAUVOLID-CORRÊA, A.; MORALES, MARIA ALEJANDRA; LEVIS, S.; FIGUEIREDO, L. T. M.; COUTO-LIMA, D.; CAMPOS, Z.; NOGUEIRA, M. F.; SILVA, E. E. da; NOGUEIRA, R. M. R.; SCHATZMAYR, H. G. Neutralising antibodies for West Nile virus in horses from Brazilian Pantanal. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 106, n.4, p. 467-474, jun. 2011. Biblioteca(s): Embrapa Pantanal. |
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| Acesso ao texto completo restrito à biblioteca da Embrapa Amazônia Oriental. Para informações adicionais entre em contato com cpatu.biblioteca@embrapa.br. |
Registro Completo
Biblioteca(s): |
Embrapa Amazônia Oriental. |
Data corrente: |
08/09/2017 |
Data da última atualização: |
20/05/2022 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Circulação/Nível: |
A - 1 |
Autoria: |
DUARTE JUNIOR, A. P.; TAVARES, E. J. M.; ALVES, T. V. G.; MOURA, M. R. de; COSTA, C. E. F. da; SILVA JÚNIOR, J. O. C.; COSTA, R. M. R. |
Afiliação: |
Anivaldo Pereira Duarte Junior, UFPA; ERALDO JOSE MADUREIRA TAVARES, CPATU; Taís Vanessa Gabbay Alves, UFPA; Márcia Regina de Moura, UNESP; Carlos Emmerson Ferreira da Costa, UFPA; José Otávio Carréra Silva Júnior, UFPA; Roseane Maria Ribeiro Costa, UFPA. |
Título: |
Chitosan nanoparticles as a modified diclofenac drug release system. |
Ano de publicação: |
2017 |
Fonte/Imprenta: |
Journal of Nanoparticle Research, v. 19, n. 8, article 274, 2017. |
DOI: |
10.1007/s11051-017-3968-6 |
Idioma: |
Inglês |
Conteúdo: |
This study evaluated a modified nanostructured release system employing diclofenac as a drug model. Biodegradable chitosan nanoparticles were prepared with chitosan concentrations between 0.5 and 0.8% ( w/ v) by template polymerization method using methacrylic acid in aqueous solution. Chitosan-poly(methacrylic acid) (CS-PMAA) nanoparticles showed uniform size around 50?100 nm, homogeneous morphology, and spherical shape. Raw material and chitosan nanoparticles were characterized by thermal analysis, Fourier transform infrared spectroscopy (FT-IR), and transmission electron microscopy (TEM), confirming the interaction between chitosan and methacrylic acid during nanoparticles preparation. Diclofenac sorption on the chitosan nanoparticles surface was achieved by incubation in water/ethanol (1:1) drug solution in concentrations of 0.5 and 0.8 mg/mL. The diclofenac amount sorbed per gram of CS-PMAA nanoparticles, when in a 0.5 mg/mL sodium diclofenac solution, was as follows: 12.93, 15, 20.87, and 29.63 mg/g for CS-PMAA nanoparticles 0.5, 0.6, 0.7, and 0.8% ( w/ v), respectively. When a 0.8 mg/mL sodium diclofenac solution was used, higher sorption efficiencies were obtained: For CS-PMAA nanoparticles with chitosan concentrations of 0.5, 0.6, 0.7, and 0.8% ( w/ v), the sorption efficiencies were 33.39, 49.58, 55.23, and 67.2 mg/g, respectively. Diclofenac sorption kinetics followed a second-order kinetics. Drug release from nanoparticles occurred in a period of up to 48 h and obeyed Korsmeyer-Peppas model, which was characterized mainly by Fickian diffusion transport. MenosThis study evaluated a modified nanostructured release system employing diclofenac as a drug model. Biodegradable chitosan nanoparticles were prepared with chitosan concentrations between 0.5 and 0.8% ( w/ v) by template polymerization method using methacrylic acid in aqueous solution. Chitosan-poly(methacrylic acid) (CS-PMAA) nanoparticles showed uniform size around 50?100 nm, homogeneous morphology, and spherical shape. Raw material and chitosan nanoparticles were characterized by thermal analysis, Fourier transform infrared spectroscopy (FT-IR), and transmission electron microscopy (TEM), confirming the interaction between chitosan and methacrylic acid during nanoparticles preparation. Diclofenac sorption on the chitosan nanoparticles surface was achieved by incubation in water/ethanol (1:1) drug solution in concentrations of 0.5 and 0.8 mg/mL. The diclofenac amount sorbed per gram of CS-PMAA nanoparticles, when in a 0.5 mg/mL sodium diclofenac solution, was as follows: 12.93, 15, 20.87, and 29.63 mg/g for CS-PMAA nanoparticles 0.5, 0.6, 0.7, and 0.8% ( w/ v), respectively. When a 0.8 mg/mL sodium diclofenac solution was used, higher sorption efficiencies were obtained: For CS-PMAA nanoparticles with chitosan concentrations of 0.5, 0.6, 0.7, and 0.8% ( w/ v), the sorption efficiencies were 33.39, 49.58, 55.23, and 67.2 mg/g, respectively. Diclofenac sorption kinetics followed a second-order kinetics. Drug release from nanoparticles occurred in a period of up to 48 h and o... Mostrar Tudo |
Palavras-Chave: |
Biopolímero; Nanopartícula; Nanotecnologia; Quitosana. |
Categoria do assunto: |
X Pesquisa, Tecnologia e Engenharia |
Marc: |
LEADER 02347naa a2200253 a 4500 001 2075279 005 2022-05-20 008 2017 bl uuuu u00u1 u #d 024 7 $a10.1007/s11051-017-3968-6$2DOI 100 1 $aDUARTE JUNIOR, A. P. 245 $aChitosan nanoparticles as a modified diclofenac drug release system.$h[electronic resource] 260 $c2017 520 $aThis study evaluated a modified nanostructured release system employing diclofenac as a drug model. Biodegradable chitosan nanoparticles were prepared with chitosan concentrations between 0.5 and 0.8% ( w/ v) by template polymerization method using methacrylic acid in aqueous solution. Chitosan-poly(methacrylic acid) (CS-PMAA) nanoparticles showed uniform size around 50?100 nm, homogeneous morphology, and spherical shape. Raw material and chitosan nanoparticles were characterized by thermal analysis, Fourier transform infrared spectroscopy (FT-IR), and transmission electron microscopy (TEM), confirming the interaction between chitosan and methacrylic acid during nanoparticles preparation. Diclofenac sorption on the chitosan nanoparticles surface was achieved by incubation in water/ethanol (1:1) drug solution in concentrations of 0.5 and 0.8 mg/mL. The diclofenac amount sorbed per gram of CS-PMAA nanoparticles, when in a 0.5 mg/mL sodium diclofenac solution, was as follows: 12.93, 15, 20.87, and 29.63 mg/g for CS-PMAA nanoparticles 0.5, 0.6, 0.7, and 0.8% ( w/ v), respectively. When a 0.8 mg/mL sodium diclofenac solution was used, higher sorption efficiencies were obtained: For CS-PMAA nanoparticles with chitosan concentrations of 0.5, 0.6, 0.7, and 0.8% ( w/ v), the sorption efficiencies were 33.39, 49.58, 55.23, and 67.2 mg/g, respectively. Diclofenac sorption kinetics followed a second-order kinetics. Drug release from nanoparticles occurred in a period of up to 48 h and obeyed Korsmeyer-Peppas model, which was characterized mainly by Fickian diffusion transport. 653 $aBiopolímero 653 $aNanopartícula 653 $aNanotecnologia 653 $aQuitosana 700 1 $aTAVARES, E. J. M. 700 1 $aALVES, T. V. G. 700 1 $aMOURA, M. R. de 700 1 $aCOSTA, C. E. F. da 700 1 $aSILVA JÚNIOR, J. O. C. 700 1 $aCOSTA, R. M. R. 773 $tJournal of Nanoparticle Research$gv. 19, n. 8, article 274, 2017.
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