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| Registros recuperados : 455 | |
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Registro Completo
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Biblioteca(s): |
Embrapa Agroindústria Tropical; Embrapa Semiárido. |
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Data corrente: |
13/10/2020 |
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Data da última atualização: |
22/08/2022 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
B - 1 |
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Autoria: |
GUEDES, J. A. C.; SANTIAGO, Y. G.; LUZ, L. dos R.; SILVA, M. F. S.; RAMIRES, C. M. C.; LIMA, M. A. C. de; OLIVEIRA, V. R. de; PESSOA. C. do Ó.; CANUTO, K. M.; BRITO, E. S. de; LIMA, M. F.; ALVES, R. E.; ZAMPIERI, D.; NASCIMENTO, R. F. do; ZOCOLO, G. J. |
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Afiliação: |
JHONYSON ARRUDA CARVALHO GUEDES, Departamento de Química Analítica e Físico-Química, Universidade Federal do Ceará; YURI GOMES SANTIAGO, Embrapa Agroindústria Tropical; LICIA DOS REIS LUZ, Departamento de Química Analítica e Físico-Química, Universidade Federal do Ceará; Embrapa Agroindústria Tropical; MARIA FRANCILENE SOUZA SILVA, Núcleo de Pesquisa e Desenvolvimento de Medicamentos - NPDM, Universidade Federal do Ceará; CHRISTIANE MENDES CASSIMIRO RAMIRES, Empresa Paraibana de Pesquisa, Extensão Rural e Regularização Fundiária - EMPAER - PB; MARIA AUXILIADORA COELHO DE LIMA, CPATSA; VISELDO RIBEIRO DE OLIVEIRA, CPATSA; CLAUDIA DO Ó PESSOA, Núcleo de Pesquisa e Desenvolvimento de Medicamentos - NPDM, Universidade Federal do Ceará; KIRLEY MARQUES CANUTO, CNPAT; EDY SOUSA DE BRITO, CNPAT; MARCELO F. LIMA, Universidade Estadual Paulista (Unesp), Instituto de Biociências, Letras e Ciências Exatas (IBILCE), Câmpus São José do Rio Preto; RICARDO ELESBAO ALVES, CNAT; DAVILA ZAMPIERI, Departamento de Química Orgânica e Inorgânica, Universidade Federal do Ceará; RONALDO FERREIRA DO NASCIMENTO, Departamento de Química Analítica e Físico-Química, Universidade Federal do Ceará; GUILHERME JULIAO ZOCOLO, CNPAT. |
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Título: |
Comparative analyses of metabolic fingerprint integrated with cytotoxic activity and in silico approaches of the leaves extract of Spondias mombin L. and Spondias tuberosa Arr. Cam. from Northeast, Brazil. |
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Ano de publicação: |
2020 |
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Fonte/Imprenta: |
Phytochemistry Letters, v. 40, p. 26-36, 2020. |
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DOI: |
DOI: 10.1016/j.phytol.2020.09.003 |
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Idioma: |
Inglês |
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Conteúdo: |
Spondias species are a relevant source of natural-bioactive compounds in Brazilian folk medicine, and its biological potential has not been explored. Thus, this study aimed to determine the metabolomic fingerprint of Spondias mombin and Spondias tuberosa leaves based on the use of reversed-phase liquid chromatography coupled to a high-resolution mass spectrometer (UPLC-HRMS). The analysis by UPLC-HRMS allowed the annotation of 31 metabolites. The multivariate analysis allowed us to identify the biomarkers responsible for the distinction between species. Also, we correlate the biomarkers of S. mombin and S. tuberosa as supposed responsible for the difference in the degree of cytotoxicity between them. The in silico evaluation was performed to give more consistency to the correlation between biomarkers and cytotoxicity, which were compared to commercial drugs. Therefore, this study showed that S. mombin has the potential to become an input for the pharmaceutical industry as a source of raw material that can positively impact the sectors of agricultural production. |
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Palavras-Chave: |
Cromatografia líquida; Espectrometria de massa de alta; High-resolution mass spectrometry; Metabolômica; Planta nativa; Quimiometria. |
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Thesagro: |
Anacardiaceae; Caatinga; Spondias Mombin; Spondias Tuberosa; Umbu. |
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Thesaurus NAL: |
Chemometrics; Dialium guineense; Liquid chromatography; Metabolomics; Yellow mombins. |
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Categoria do assunto: |
--
F Plantas e Produtos de Origem Vegetal |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/216724/1/Comparative-analyses-of-metabolic-fingerprint-2020.pdf
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Marc: |
LEADER 02610naa a2200493 a 4500
001 2125573
005 2022-08-22
008 2020 bl uuuu u00u1 u #d
024 7 $aDOI: 10.1016/j.phytol.2020.09.003$2DOI
100 1 $aGUEDES, J. A. C.
245 $aComparative analyses of metabolic fingerprint integrated with cytotoxic activity and in silico approaches of the leaves extract of Spondias mombin L. and Spondias tuberosa Arr. Cam. from Northeast, Brazil.$h[electronic resource]
260 $c2020
520 $aSpondias species are a relevant source of natural-bioactive compounds in Brazilian folk medicine, and its biological potential has not been explored. Thus, this study aimed to determine the metabolomic fingerprint of Spondias mombin and Spondias tuberosa leaves based on the use of reversed-phase liquid chromatography coupled to a high-resolution mass spectrometer (UPLC-HRMS). The analysis by UPLC-HRMS allowed the annotation of 31 metabolites. The multivariate analysis allowed us to identify the biomarkers responsible for the distinction between species. Also, we correlate the biomarkers of S. mombin and S. tuberosa as supposed responsible for the difference in the degree of cytotoxicity between them. The in silico evaluation was performed to give more consistency to the correlation between biomarkers and cytotoxicity, which were compared to commercial drugs. Therefore, this study showed that S. mombin has the potential to become an input for the pharmaceutical industry as a source of raw material that can positively impact the sectors of agricultural production.
650 $aChemometrics
650 $aDialium guineense
650 $aLiquid chromatography
650 $aMetabolomics
650 $aYellow mombins
650 $aAnacardiaceae
650 $aCaatinga
650 $aSpondias Mombin
650 $aSpondias Tuberosa
650 $aUmbu
653 $aCromatografia líquida
653 $aEspectrometria de massa de alta
653 $aHigh-resolution mass spectrometry
653 $aMetabolômica
653 $aPlanta nativa
653 $aQuimiometria
700 1 $aSANTIAGO, Y. G.
700 1 $aLUZ, L. dos R.
700 1 $aSILVA, M. F. S.
700 1 $aRAMIRES, C. M. C.
700 1 $aLIMA, M. A. C. de
700 1 $aOLIVEIRA, V. R. de
700 1 $aPESSOA. C. do Ó.
700 1 $aCANUTO, K. M.
700 1 $aBRITO, E. S. de
700 1 $aLIMA, M. F.
700 1 $aALVES, R. E.
700 1 $aZAMPIERI, D.
700 1 $aNASCIMENTO, R. F. do
700 1 $aZOCOLO, G. J.
773 $tPhytochemistry Letters$gv. 40, p. 26-36, 2020.
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Embrapa Semiárido (CPATSA) |
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