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Registro Completo |
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Biblioteca(s): |
Embrapa Pecuária Sudeste; Embrapa Pecuária Sul; Embrapa Recursos Genéticos e Biotecnologia. |
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Data corrente: |
17/11/2020 |
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Data da última atualização: |
17/11/2020 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
CAVANI, L.; BRAZ, C. U.; GIGLIOTI, R.; OKINO, C. H.; GULIAS GOMES, C. C.; CAETANO, A. R.; OLIVEIRA, M. C. de S.; CARDOSO, F. F.; OLIVEIRA, H. N. de. |
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Afiliação: |
LIGIA CAVANI, UNESP; CAMILA URBANO BRAZ, UNESP; RODRIGO GIGLIOTI, Instituto de Zootecnia; CINTIA HIROMI OKINO, CPPSE; CLAUDIA CRISTINA GULIAS GOMES, CPPSUL; ALEXANDRE RODRIGUES CAETANO, Cenargen; MARCIA CRISTINA DE SENA OLIVEIRA, CPPSE; FERNANDO FLORES CARDOSO, CPPSUL; HENRIQUE NUNES DE OLIVEIRA, UNESP. |
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Título: |
Genomic study of Babesia bovis infection level and its association with tick count in Hereford and Braford cattle. |
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Ano de publicação: |
2020 |
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Fonte/Imprenta: |
Frontiers in Immunology, v. 11, article 1905, aug. 2020. |
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Páginas: |
11 p. |
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DOI: |
https://doi.org/10.3389/fimmu.2020.01905 |
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Idioma: |
Inglês |
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Conteúdo: |
Bovine babesiosis is a tick-borne disease caused by intraerythrocytic protozoa and leads to substantial economic losses for the livestock industry throughout the world. Babesia bovis is considered the most pathogenic species, which causes bovine babesiosis in Brazil. Genomic data could be used to evaluate the viability of improving resistance against B. bovis infection level (IB) through genomic selection, and, for that, knowledge of genetic parameters is needed. Furthermore, genome-wide association studies (GWAS) could be conducted to provide a better understanding of the genetic basis of the host response to B. bovis infection. No previous work in quantitative genetics of B. bovis infection was found. Thus, the objective of this study was to estimate the genetic correlation between IB and tick count (TC), evaluate predictive ability and applicability of genomic selection, and perform GWAS in Hereford and Braford cattle. The single-step genomic best linear unbiased prediction method was used, which allows the estimation of both breeding values and marker effects. Standard phenotyping was conducted for both traits. IB quantifications from the blood of 1,858 animals were carried using quantitative PCR assays. For TC, one to three subsequent tick counts were performed by manually counting adult female ticks on one side of each animal's body that was naturally exposed to ticks. Animals were genotyped using the Illumina BovineSNP50 panel. The posterior mean of IB heritability, estimated by the Bayesian animal model in a bivariate analysis, was low (0.10), and the estimations of genetic correlation between IB and TC were also low (0.15). The cross-validation genomic prediction accuracy for IB ranged from 0.18 to 0.35 and from 0.29 to 0.32 using k-means and random clustering, respectively, suggesting that genomic predictions could be used as a tool to improve genetics for IB, especially if a larger training population is developed. The top 10 single nucleotide polymorphisms from the GWAS explained 5.04% of total genetic variance for IB, which were located on chromosomes 1, 2, 5, 6, 12, 17, 18, 16, 24, and 26. Some candidate genes participate in immunity system pathways indicating that those genes are involved in resistance to B. bovis in cattle. Although the genetic correlation between IB and TC was weak, some candidate genes for IB were also reported in tick infestation studies, and they were also involved in biological resistance processes. This study contributes to improving genetic knowledge regarding infection by B. bovis in cattle. MenosBovine babesiosis is a tick-borne disease caused by intraerythrocytic protozoa and leads to substantial economic losses for the livestock industry throughout the world. Babesia bovis is considered the most pathogenic species, which causes bovine babesiosis in Brazil. Genomic data could be used to evaluate the viability of improving resistance against B. bovis infection level (IB) through genomic selection, and, for that, knowledge of genetic parameters is needed. Furthermore, genome-wide association studies (GWAS) could be conducted to provide a better understanding of the genetic basis of the host response to B. bovis infection. No previous work in quantitative genetics of B. bovis infection was found. Thus, the objective of this study was to estimate the genetic correlation between IB and tick count (TC), evaluate predictive ability and applicability of genomic selection, and perform GWAS in Hereford and Braford cattle. The single-step genomic best linear unbiased prediction method was used, which allows the estimation of both breeding values and marker effects. Standard phenotyping was conducted for both traits. IB quantifications from the blood of 1,858 animals were carried using quantitative PCR assays. For TC, one to three subsequent tick counts were performed by manually counting adult female ticks on one side of each animal's body that was naturally exposed to ticks. Animals were genotyped using the Illumina BovineSNP50 panel. The posterior mean of IB heritability, e... Mostrar Tudo |
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Palavras-Chave: |
Bovine babesiosis; Cross validation; Genetic parameters; Genome wide association studies; Genomic selection. |
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Thesagro: |
Babesia Bovis. |
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Categoria do assunto: |
H Saúde e Patologia |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/217858/1/GenomicStudyBabesia.pdf
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Marc: |
LEADER 03546naa a2200313 a 4500
001 2126663
005 2020-11-17
008 2020 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.3389/fimmu.2020.01905$2DOI
100 1 $aCAVANI, L.
245 $aGenomic study of Babesia bovis infection level and its association with tick count in Hereford and Braford cattle.$h[electronic resource]
260 $c2020
300 $a11 p.
520 $aBovine babesiosis is a tick-borne disease caused by intraerythrocytic protozoa and leads to substantial economic losses for the livestock industry throughout the world. Babesia bovis is considered the most pathogenic species, which causes bovine babesiosis in Brazil. Genomic data could be used to evaluate the viability of improving resistance against B. bovis infection level (IB) through genomic selection, and, for that, knowledge of genetic parameters is needed. Furthermore, genome-wide association studies (GWAS) could be conducted to provide a better understanding of the genetic basis of the host response to B. bovis infection. No previous work in quantitative genetics of B. bovis infection was found. Thus, the objective of this study was to estimate the genetic correlation between IB and tick count (TC), evaluate predictive ability and applicability of genomic selection, and perform GWAS in Hereford and Braford cattle. The single-step genomic best linear unbiased prediction method was used, which allows the estimation of both breeding values and marker effects. Standard phenotyping was conducted for both traits. IB quantifications from the blood of 1,858 animals were carried using quantitative PCR assays. For TC, one to three subsequent tick counts were performed by manually counting adult female ticks on one side of each animal's body that was naturally exposed to ticks. Animals were genotyped using the Illumina BovineSNP50 panel. The posterior mean of IB heritability, estimated by the Bayesian animal model in a bivariate analysis, was low (0.10), and the estimations of genetic correlation between IB and TC were also low (0.15). The cross-validation genomic prediction accuracy for IB ranged from 0.18 to 0.35 and from 0.29 to 0.32 using k-means and random clustering, respectively, suggesting that genomic predictions could be used as a tool to improve genetics for IB, especially if a larger training population is developed. The top 10 single nucleotide polymorphisms from the GWAS explained 5.04% of total genetic variance for IB, which were located on chromosomes 1, 2, 5, 6, 12, 17, 18, 16, 24, and 26. Some candidate genes participate in immunity system pathways indicating that those genes are involved in resistance to B. bovis in cattle. Although the genetic correlation between IB and TC was weak, some candidate genes for IB were also reported in tick infestation studies, and they were also involved in biological resistance processes. This study contributes to improving genetic knowledge regarding infection by B. bovis in cattle.
650 $aBabesia Bovis
653 $aBovine babesiosis
653 $aCross validation
653 $aGenetic parameters
653 $aGenome wide association studies
653 $aGenomic selection
700 1 $aBRAZ, C. U.
700 1 $aGIGLIOTI, R.
700 1 $aOKINO, C. H.
700 1 $aGULIAS GOMES, C. C.
700 1 $aCAETANO, A. R.
700 1 $aOLIVEIRA, M. C. de S.
700 1 $aCARDOSO, F. F.
700 1 $aOLIVEIRA, H. N. de
773 $tFrontiers in Immunology$gv. 11, article 1905, aug. 2020.
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Registro original: |
Embrapa Pecuária Sudeste (CPPSE) |
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Registro Completo
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Biblioteca(s): |
Embrapa Rondônia. |
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Data corrente: |
01/07/1992 |
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Data da última atualização: |
08/12/2010 |
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Autoria: |
OLIVEIRA, M. A. S.; ALVES, P. M. P. |
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Título: |
Novas opcoes de gramineas no controle da cigarrinha-das-pastagens em Rondonia. |
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Ano de publicação: |
1988 |
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Fonte/Imprenta: |
Porto Velho: EMBRAPA-UEPAE Porto Velho, 1988. |
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Páginas: |
18p. |
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Série: |
(EMBRAPA-UEPAE Porto Velho. Boletim de Pesquisa, 9). |
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ISSN: |
0101-6431 |
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Idioma: |
Português |
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Conteúdo: |
A cigarrinha-das-pastagens constitui um dos principais problemas que afetam a produção e persistência das pastagens. Buscando alternativas de controle, desenvolveu-se um trabalho cujo objetivo foi selecionar gramíneas resistentes à referida praga. O experimento foi constituído de 30 espécies de gramíneas forrageiras distribuídas em blocos ao acaso com 4 repetições. As avaliações foram feitas através de amostragens quinzenais durante o período 1984-86. Dentre os materiais introduzidos mostraram-se resistentes à cigarrinha-das-pastagens as seguintes gramíneas: Andropogon gayanus, cv. Planaltina (BRA-000019), Paspalum secans (BR-003778) e Paspalum coryphaeum (BRA-003760). |
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Palavras-Chave: |
Brasil; Cigarrinha-da-Pastagem; Cigarrinha-das-pastagens; Control; Controle; Feed grasses; Flavopicta; Gramineas; Gramineous; Grass; Marandu; Paspalum coryphaeum; Paspalum secans; Pastagens; Pasture; Pest; Pest insects; Pests of plants; Planaltina; Plant; Planta graminea; Plantas gramineas; Porto Velho; Pragas; Rondonia; Spitteburg; Spittlebug; Tobiata. |
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Thesagro: |
Andropogon Gayanus; Brachiaria Brizantha; Capim Andropogon; Capim Brachiaria; Capim Colonião; Cigarrinha; Cigarrinha das Pastagens; Deois Flavopicta; Deois Incompleta; Gramínea; Gramínea Forrageira; Gramineae; Inseto; Panicum Maximum; Pastagem; Planta; Praga; Praga de Planta; Resistência; Variedade; Variedade Resistente. |
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Thesaurus NAL: |
Amazonia; Brazil; Cercopidae; grasses; pastures; pest control; pest resistance; pests; varieties. |
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Categoria do assunto: |
-- |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/23967/1/09-dez88.pdf
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Marc: |
LEADER 02823nam a2200853 a 4500
001 1697955
005 2010-12-08
008 1988 bl uuuu u0uu1 u #d
022 $a0101-6431
100 1 $aOLIVEIRA, M. A. S.
245 $aNovas opcoes de gramineas no controle da cigarrinha-das-pastagens em Rondonia.
260 $aPorto Velho: EMBRAPA-UEPAE Porto Velho$c1988
300 $a18p.
490 $a(EMBRAPA-UEPAE Porto Velho. Boletim de Pesquisa, 9).
520 $aA cigarrinha-das-pastagens constitui um dos principais problemas que afetam a produção e persistência das pastagens. Buscando alternativas de controle, desenvolveu-se um trabalho cujo objetivo foi selecionar gramíneas resistentes à referida praga. O experimento foi constituído de 30 espécies de gramíneas forrageiras distribuídas em blocos ao acaso com 4 repetições. As avaliações foram feitas através de amostragens quinzenais durante o período 1984-86. Dentre os materiais introduzidos mostraram-se resistentes à cigarrinha-das-pastagens as seguintes gramíneas: Andropogon gayanus, cv. Planaltina (BRA-000019), Paspalum secans (BR-003778) e Paspalum coryphaeum (BRA-003760).
650 $aAmazonia
650 $aBrazil
650 $aCercopidae
650 $agrasses
650 $apastures
650 $apest control
650 $apest resistance
650 $apests
650 $avarieties
650 $aAndropogon Gayanus
650 $aBrachiaria Brizantha
650 $aCapim Andropogon
650 $aCapim Brachiaria
650 $aCapim Colonião
650 $aCigarrinha
650 $aCigarrinha das Pastagens
650 $aDeois Flavopicta
650 $aDeois Incompleta
650 $aGramínea
650 $aGramínea Forrageira
650 $aGramineae
650 $aInseto
650 $aPanicum Maximum
650 $aPastagem
650 $aPlanta
650 $aPraga
650 $aPraga de Planta
650 $aResistência
650 $aVariedade
650 $aVariedade Resistente
653 $aBrasil
653 $aCigarrinha-da-Pastagem
653 $aCigarrinha-das-pastagens
653 $aControl
653 $aControle
653 $aFeed grasses
653 $aFlavopicta
653 $aGramineas
653 $aGramineous
653 $aGrass
653 $aMarandu
653 $aPaspalum coryphaeum
653 $aPaspalum secans
653 $aPastagens
653 $aPasture
653 $aPest
653 $aPest insects
653 $aPests of plants
653 $aPlanaltina
653 $aPlant
653 $aPlanta graminea
653 $aPlantas gramineas
653 $aPorto Velho
653 $aPragas
653 $aRondonia
653 $aSpitteburg
653 $aSpittlebug
653 $aTobiata
700 1 $aALVES, P. M. P.
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Embrapa Rondônia (CPAF-RO) |
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