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Registro Completo |
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Biblioteca(s): |
Embrapa Caprinos e Ovinos. |
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Data corrente: |
06/07/2017 |
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Data da última atualização: |
06/07/2017 |
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Autoria: |
GILL, M.; FRANCE, J.; SUMMERS, M.; MCBRIDE, B. W.; MILLIGAN, L. P. |
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Título: |
Mathematical integration of protein metabolism in growing lambs. |
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Ano de publicação: |
1989 |
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Fonte/Imprenta: |
The Journal of Nutrition, v. 119, n. 9, p. 1269-1286, Sep. 1989. |
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Idioma: |
Inglês |
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Conteúdo: |
Abstract: A mathematical integration of whole-body protein synthesis and degradation based on protein metabolism in 10 individual tissues in growing lambs is described. The tissues represented are adipose, central nervous system (CNS), gastrointestinal tract (GIT), heart, kidney, liver, muscle, pancreatic and salivary glands (PSG), reticuloendothelial system (RES) and skin, together with a blood pool of amino acids. The fluxes represented in the equations are generally assumed to follow simple or modified mass-action kinetics. The fractional rates for protein synthesis in each tissue were calculated from published values for lambs, where these were available, or alternatively derived using assumptions based on data obtained with rats. The initial protein content of each tissue and the fractional degradation rate were assigned values calculated using data from a slaughter experiment. The model was used to examine whole-body protein synthesis at different rates of growth and to compare the relative contributions of each tissue. The GIT (25-26%) and skin (23-26%) had the highest contributions to total protein synthesis, followed by muscle (21-26%), liver (13-14%), RES (6-7%) and PSG (3-6%), while adipose, CNS, heart and kidney together contributed less than 5%. These values agree reasonably well with experimental values, and thus the model can be used to examine the effect of different growth rates on protein metabolism and its associated energy costs. |
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Palavras-Chave: |
Growth; Models Theoretical. |
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Thesaurus Nal: |
Amino Acids; Mathematical models; Metabolism; Protein synthesis; Sheep. |
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Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
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Marc: |
LEADER 02143naa a2200253 a 4500
001 2072089
005 2017-07-06
008 1989 bl uuuu u00u1 u #d
100 1 $aGILL, M.
245 $aMathematical integration of protein metabolism in growing lambs.
260 $c1989
520 $aAbstract: A mathematical integration of whole-body protein synthesis and degradation based on protein metabolism in 10 individual tissues in growing lambs is described. The tissues represented are adipose, central nervous system (CNS), gastrointestinal tract (GIT), heart, kidney, liver, muscle, pancreatic and salivary glands (PSG), reticuloendothelial system (RES) and skin, together with a blood pool of amino acids. The fluxes represented in the equations are generally assumed to follow simple or modified mass-action kinetics. The fractional rates for protein synthesis in each tissue were calculated from published values for lambs, where these were available, or alternatively derived using assumptions based on data obtained with rats. The initial protein content of each tissue and the fractional degradation rate were assigned values calculated using data from a slaughter experiment. The model was used to examine whole-body protein synthesis at different rates of growth and to compare the relative contributions of each tissue. The GIT (25-26%) and skin (23-26%) had the highest contributions to total protein synthesis, followed by muscle (21-26%), liver (13-14%), RES (6-7%) and PSG (3-6%), while adipose, CNS, heart and kidney together contributed less than 5%. These values agree reasonably well with experimental values, and thus the model can be used to examine the effect of different growth rates on protein metabolism and its associated energy costs.
650 $aAmino Acids
650 $aMathematical models
650 $aMetabolism
650 $aProtein synthesis
650 $aSheep
653 $aGrowth
653 $aModels Theoretical
700 1 $aFRANCE, J.
700 1 $aSUMMERS, M.
700 1 $aMCBRIDE, B. W.
700 1 $aMILLIGAN, L. P.
773 $tThe Journal of Nutrition$gv. 119, n. 9, p. 1269-1286, Sep. 1989.
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Registro original: |
Embrapa Caprinos e Ovinos (CNPC) |
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