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Registro Completo |
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Biblioteca(s): |
Embrapa Amazônia Oriental. |
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Data corrente: |
22/02/2013 |
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Data da última atualização: |
10/11/2022 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
GUIMARÃES-SANTOS, A.; LAMEIRA, O. A. |
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Afiliação: |
Adriano Guimarães-Santos, UFPA; OSMAR ALVES LAMEIRA, CPATU. |
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Título: |
Copaiba oil-resin treatment is neuroprotective and reduces neutrophil recruitment and microglia activation after motor cortex excitotoxic injury. |
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Ano de publicação: |
2012 |
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Fonte/Imprenta: |
Evidence-Based Complementary and Alternative Medicine, v. 2012, p. 1-9, 2012. |
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Idioma: |
Inglês |
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Conteúdo: |
The oil-resin of Copaifera reticulata Ducke is used in the Brazilian folk medicine as an anti-in?ammatory and healing agent. However, there are no investigations on the possible anti-in?ammatory and neuroprotective roles of copaiba oil-resin (COR) after neural disorders. We have investigated the anti-in?ammatory and neuroprotective e?ects of COR following an acute damage to the motor cortex of adult rats. Animals were injected with the neurotoxin N-Methyl-D-Aspartate (NMDA) (n = 10) and treated with a single dose of COR (400 mg/kg, i.p.) soon after surgery (Group 1) or with two daily doses (200 mg/kg, i.p.) during 3 days (Group 2) alter injury. Control animals were treated with vehicle only. COR treatment induced tissue preservation and decreased the recruitment of neutrophils and microglial activation in the injury site compared to vehicle animals. The results suggest that COR treatment induces neuroprotection by modulating in?ammatory response following an acute damage to the central nervous system. |
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Palavras-Chave: |
Óleo resina. |
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Thesagro: |
Copaiba; Planta medicinal. |
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Categoria do assunto: |
F Plantas e Produtos de Origem Vegetal |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/77067/1/918174.pdf
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Marc: |
LEADER 01610naa a2200169 a 4500
001 1950612
005 2022-11-10
008 2012 bl uuuu u00u1 u #d
100 1 $aGUIMARÃES-SANTOS, A.
245 $aCopaiba oil-resin treatment is neuroprotective and reduces neutrophil recruitment and microglia activation after motor cortex excitotoxic injury.$h[electronic resource]
260 $c2012
520 $aThe oil-resin of Copaifera reticulata Ducke is used in the Brazilian folk medicine as an anti-in?ammatory and healing agent. However, there are no investigations on the possible anti-in?ammatory and neuroprotective roles of copaiba oil-resin (COR) after neural disorders. We have investigated the anti-in?ammatory and neuroprotective e?ects of COR following an acute damage to the motor cortex of adult rats. Animals were injected with the neurotoxin N-Methyl-D-Aspartate (NMDA) (n = 10) and treated with a single dose of COR (400 mg/kg, i.p.) soon after surgery (Group 1) or with two daily doses (200 mg/kg, i.p.) during 3 days (Group 2) alter injury. Control animals were treated with vehicle only. COR treatment induced tissue preservation and decreased the recruitment of neutrophils and microglial activation in the injury site compared to vehicle animals. The results suggest that COR treatment induces neuroprotection by modulating in?ammatory response following an acute damage to the central nervous system.
650 $aCopaiba
650 $aPlanta medicinal
653 $aÓleo resina
700 1 $aLAMEIRA, O. A.
773 $tEvidence-Based Complementary and Alternative Medicine$gv. 2012, p. 1-9, 2012.
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Registro original: |
Embrapa Amazônia Oriental (CPATU) |
