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Registro Completo |
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Biblioteca(s): |
Embrapa Gado de Corte. |
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Data corrente: |
19/10/2012 |
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Data da última atualização: |
19/10/2012 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
RAMOS, C. A. N.; ARAUJO, F. R.; ALVES, L. C.; SOUZA, I. I. F. de; GUEDES JUNIOR, D. S.; SOARES, C. O. |
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Afiliação: |
CARLOS A.N. RAMOS, Bolsista CNPGC; FLABIO RIBEIRO ARAUJO, CNPGC; LEUCIO C. ALVES, Laboratório de Doenc¸ as Parasitárias dos Animais Domésticos, Departamento de Medicina Veterinária –UFRPE, Recife, PE; INGRID IEDA FERNANDO DE SOUZA, Bolsista CNPGC; DANIEL S. GUEDES JUNIOR, BolsistaCNPGC; CLEBER OLIVEIRA SOARES, CNPGC. |
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Título: |
Genetic conservation of potentially immunogenic proteins among Brazilian isolates of Babesia bovis. |
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Ano de publicação: |
2012 |
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Fonte/Imprenta: |
Veterinary Parasitology, v. 187, n. 3-4, p. 548-552, julho, 2012. |
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Idioma: |
Português |
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Conteúdo: |
Bovine babesiosis caused by Babesia bovis remains an important constraint for the development of cattle industries worldwide. Effective control can be achieved by vaccination with live attenuated phenotypes of the parasite. However, these vaccines have a number of drawbacks, which justifies the search for better, safer vaccines. In recent years, a number of parasite proteins with immunogenic potential have been discovered. However, there is little information on the genetic conservation of these proteins among different parasite isolates, which hinders their assessment as immunogens. The aim of the present study was to evaluate the conservation of the genes ama-1, acs-1, rap-1, trap, p0 and msa2c among five Brazilian isolates of B. bovis. Through polymerase chain reaction, genetic sequencing and bioinformatics analysis of the genes, a high degree of conservation (98?100%) was found among Brazilian isolates of B. bovis and the T2Bo isolate. Thus, these genes are worth considering as viable candidates to be included in a recombinant cocktail vaccine for cattle babesiosis caused by B. bovis. |
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Palavras-Chave: |
Genetic conservation; Vaccine. |
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Thesagro: |
Babesia bovis. |
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Thesaurus Nal: |
Brazil. |
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Categoria do assunto: |
-- |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/68358/1/2012-Babesia-genoma.pdf
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Marc: |
LEADER 01793naa a2200229 a 4500
001 1937283
005 2012-10-19
008 2012 bl uuuu u00u1 u #d
100 1 $aRAMOS, C. A. N.
245 $aGenetic conservation of potentially immunogenic proteins among Brazilian isolates of Babesia bovis.$h[electronic resource]
260 $c2012
520 $aBovine babesiosis caused by Babesia bovis remains an important constraint for the development of cattle industries worldwide. Effective control can be achieved by vaccination with live attenuated phenotypes of the parasite. However, these vaccines have a number of drawbacks, which justifies the search for better, safer vaccines. In recent years, a number of parasite proteins with immunogenic potential have been discovered. However, there is little information on the genetic conservation of these proteins among different parasite isolates, which hinders their assessment as immunogens. The aim of the present study was to evaluate the conservation of the genes ama-1, acs-1, rap-1, trap, p0 and msa2c among five Brazilian isolates of B. bovis. Through polymerase chain reaction, genetic sequencing and bioinformatics analysis of the genes, a high degree of conservation (98?100%) was found among Brazilian isolates of B. bovis and the T2Bo isolate. Thus, these genes are worth considering as viable candidates to be included in a recombinant cocktail vaccine for cattle babesiosis caused by B. bovis.
650 $aBrazil
650 $aBabesia bovis
653 $aGenetic conservation
653 $aVaccine
700 1 $aARAUJO, F. R.
700 1 $aALVES, L. C.
700 1 $aSOUZA, I. I. F. de
700 1 $aGUEDES JUNIOR, D. S.
700 1 $aSOARES, C. O.
773 $tVeterinary Parasitology$gv. 187, n. 3-4, p. 548-552, julho, 2012.
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Registro original: |
Embrapa Gado de Corte (CNPGC) |
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| 1. |  | RAMOS, C. A. N.; ARAUJO, F. R.; ALVES, L. C.; SOUZA, I. I. F. de; GUEDES JUNIOR, D. S.; SOARES, C. O. Genetic conservation of potentially immunogenic proteins among Brazilian isolates of Babesia bovis. Veterinary Parasitology, v. 187, n. 3-4, p. 548-552, julho, 2012.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Gado de Corte. |
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| Registros recuperados : 1 | |
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