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 | Acesso ao texto completo restrito à biblioteca da Embrapa Amazônia Ocidental. Para informações adicionais entre em contato com cpaa.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Amazônia Ocidental. |
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Data corrente: |
19/09/2006 |
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Data da última atualização: |
06/01/2015 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
FUKUMASU, H.; AVANZO, J. L.; HEIDOR, R.; SILVA, T. C.; ATROCH, A.; MORENO, F. S.; DAGLI, M. L. Z. |
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Afiliação: |
H. Fukumasu, USP; J.L. Avanzo, USP; R. Heidor, USP; T.C. Silva, USP; André Atroch, CPAA; F.S. Moreno, USP; M.L.Z. Dagli, USP. |
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Título: |
Protective effects of guarana (Paullinia cupana Mart. var. Sorbilis) against DEN-induced DNA damage on mouse liver. |
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Ano de publicação: |
2006 |
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Fonte/Imprenta: |
Food and Chemical Toxicology, v. 44, n. 6 , p. 862-867, jun. 2006. |
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Idioma: |
Inglês |
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Conteúdo: |
Guarana (Paullinia cupana Mart. var. Sorbilis) is a plant originally from Brazil, which is rich in tannins. Some tannins are known to present protective effects against DNA damage. This study was performed to investigate the anti-genotoxic/cytotoxic properties of guarana in hepatocytes of mice injected with N-nitrosodiethylamine (DEN). The protective effect of guarana was evaluated both by comet assay and DNA smear fragmentation technique in two month-old female BALB/c mice. These were treated previously with 2.0 mg/g bw of guarana for 16 days and then injected with DEN (160 µg/g body weight) to induce DNA damage. The DEN-only treated group presented higher comet image length than the guarana plus DEN and untreated groups (116.06 ± 5.0 µm, 104.09 ± 3.3 µm and 93.28 ± 14.4 µm, respectively; p < 0.01). Guarana treatment presented a 52.54% reduction in comet image length when animals were exposed to DEN (p < 0.05). DNA samples from the guarana plus DEN group clearly showed less EtBr fluorescence intensity when compared to the DEN-only group, reinforcing the comet assay data. These results show, for the first time, that guarana has a protective effect against DEN-induced DNA damage in mouse liver. |
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Thesagro: |
DNA; Guaraná; Paullinia Cupana. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 01876naa a2200229 a 4500
001 1678895
005 2015-01-06
008 2006 bl --- 0-- u #d
100 1 $aFUKUMASU, H.
245 $aProtective effects of guarana (Paullinia cupana Mart. var. Sorbilis) against DEN-induced DNA damage on mouse liver.
260 $c2006
520 $aGuarana (Paullinia cupana Mart. var. Sorbilis) is a plant originally from Brazil, which is rich in tannins. Some tannins are known to present protective effects against DNA damage. This study was performed to investigate the anti-genotoxic/cytotoxic properties of guarana in hepatocytes of mice injected with N-nitrosodiethylamine (DEN). The protective effect of guarana was evaluated both by comet assay and DNA smear fragmentation technique in two month-old female BALB/c mice. These were treated previously with 2.0 mg/g bw of guarana for 16 days and then injected with DEN (160 µg/g body weight) to induce DNA damage. The DEN-only treated group presented higher comet image length than the guarana plus DEN and untreated groups (116.06 ± 5.0 µm, 104.09 ± 3.3 µm and 93.28 ± 14.4 µm, respectively; p < 0.01). Guarana treatment presented a 52.54% reduction in comet image length when animals were exposed to DEN (p < 0.05). DNA samples from the guarana plus DEN group clearly showed less EtBr fluorescence intensity when compared to the DEN-only group, reinforcing the comet assay data. These results show, for the first time, that guarana has a protective effect against DEN-induced DNA damage in mouse liver.
650 $aDNA
650 $aGuaraná
650 $aPaullinia Cupana
700 1 $aAVANZO, J. L.
700 1 $aHEIDOR, R.
700 1 $aSILVA, T. C.
700 1 $aATROCH, A.
700 1 $aMORENO, F. S.
700 1 $aDAGLI, M. L. Z.
773 $tFood and Chemical Toxicology$gv. 44, n. 6 , p. 862-867, jun. 2006.
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Registro original: |
Embrapa Amazônia Ocidental (CPAA) |
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| Registros recuperados : 5 | |
| 1. |  | ALEXANDRE, P.; SANTANA, M. H. A.; GOMES, R. da C.; FERRAZ, J. B. S.; FUKUMASU, H. Molecular characterization of constitutive androstane receptor (CAR) and its association with feed efficiency of Nellore (Bos indicus) cattle. Journal of Animal Science v.90, (Supplement 3/J) ; Journal of Dairy Science, v.95, (Supplement 2), p.524, 2012. Edição dos trabalhos do: ADSA-PSA-AMPA-ASAS-CSAS-WSASAS JOINT ANNUAL MEETING, 2012, Phoenix-AR. Breeding and Genetics: Molecular Biology and Genomics. W68.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Gado de Corte. |
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| 2. | | FUKUMASU, H.; AVANZO, J. L.; HEIDOR, R.; SILVA, T. C.; ATROCH, A.; MORENO, F. S.; DAGLI, M. L. Z. Protective effects of guarana (Paullinia cupana Mart. var. Sorbilis) against DEN-induced DNA damage on mouse liver. Food and Chemical Toxicology, v. 44, n. 6 , p. 862-867, jun. 2006.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: Internacional - A |
| Biblioteca(s): Embrapa Amazônia Ocidental. |
|  |
| 3. | | ALEXANDRE, P. A.; GOMES, R. da C.; SANTANA, M. H. A.; SILVA, S. L.; MUDADU, M. de A.; REGITANO, L. C. de A.; MEIRELLES, F. V.; FERRAZ, J. B. S.; FUKUMASU, H. Bovine NR1I3 gene polymorphisms and its association with feed efficiency traits in Nellore cattle. Meta Gene, v. 2, p. 206-217, 2014| Tipo: Artigo de Divulgação na Mídia |
| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 4. | | FUKUMASU, H.; SILVA, T. C. da; AVANZO, J. L.; LIMA, C. E. de; MACKOWIAK, I. I.; ATROCH, A.; SPINOSA, H. de S.; MORENO, F. S.; DAGLI, M. L. Z. Chemopreventive effects of Paullinia cupana Mart var. sorbilis, the guarana, on mouse hepatocarcinogenesis. Cancer Letters, v. 233, n. 1, p. 158-164, fev. 2006.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: Internacional - C |
| Biblioteca(s): Embrapa Amazônia Ocidental. |
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| 5. | | SANTANA, M. H. de A.; OLIVEIRA JUNIOR, G. A.; CESAR, A. S. M.; FREUA, M. C.; GOMES, R. da C.; SILVA, S. da L.; LEME, P. R.; FUKUMASU, H.; CARVALHO, M. E.; VENTURA, R. V.; COUTINHO, L. L.; KADARMIDEEN, H. N.; FERRAZ, J. B. S. Copy number variations and genome-wide associations reveal putative genes and metabolic pathways involved with the feed conversion ratio in beef cattle. Journal of Applied Gentics, v. 57, n. 4, p. 495-504, 2016| Tipo: Artigo em Periódico Indexado | Circulação/Nível: B - 1 |
| Biblioteca(s): Embrapa Gado de Corte. |
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| Registros recuperados : 5 | |
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| Nenhum registro encontrado para a expressão de busca informada. |
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