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Registro Completo |
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Biblioteca(s): |
Embrapa Caprinos e Ovinos. |
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Data corrente: |
27/11/2002 |
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Data da última atualização: |
27/11/2002 |
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Autoria: |
BAGUMA-NIBASHEKA, M.; THOMAS BREMMA, J.; NATHANIELSZ, P. W. |
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Título: |
Delay of preterm delivery in sheep by Omega-3 long-chain polyunsaturates. |
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Ano de publicação: |
1999 |
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Fonte/Imprenta: |
Biology of Reproduction, v. 60, n. 3, p. 698-701, 1999. |
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Idioma: |
Inglês |
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Conteúdo: |
A positive correlation has been shown between dietary intake of long-chain omega-3 fatty acids in late pregnancy and gestation length in pregnant women and experimental animals. To determine whether omega-3 fatty acids have an effect on preterm labor in sheep, a fish oil concentrate emulsion was continuously infused to six pregnant ewes from 124 days gestational age. At 125 days, betamethasone was administered to the fetus to produce preterm labor. Both the onset of labor and the time of delivery were delayed by the fish oil emulsion. Two of lhe omega-3-infused reverted from contractions to nonlabor, an effect never previously observed for experimental glucocorticoid-induced preterm labor in sheep. Maternal plasma estradiol and maternal and fetal prostaglandin E2 rose in control ewes but not in those infused with omega-3 fatty acid. The ability of omega-3 fall acids to delay premature delivery in sheep indicates their possible use as tocolytics in humans. Premature labor is lhe major cause of neonatal death and long-term disability, and these studies present information that mar lead to a novel therapeutic regimen for the prevention of preterm delivery in human pregnancy.
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Palavras-Chave: |
Ácido graxo polisaturado. |
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Thesagro: |
Nutrição Animal; Ovino; Prenhez; Reprodução Animal. |
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Categoria do assunto: |
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Marc: |
LEADER 01776naa a2200205 a 4500
001 1528903
005 2002-11-27
008 1999 bl uuuu u00u1 u #d
100 1 $aBAGUMA-NIBASHEKA, M.
245 $aDelay of preterm delivery in sheep by Omega-3 long-chain polyunsaturates.
260 $c1999
520 $aA positive correlation has been shown between dietary intake of long-chain omega-3 fatty acids in late pregnancy and gestation length in pregnant women and experimental animals. To determine whether omega-3 fatty acids have an effect on preterm labor in sheep, a fish oil concentrate emulsion was continuously infused to six pregnant ewes from 124 days gestational age. At 125 days, betamethasone was administered to the fetus to produce preterm labor. Both the onset of labor and the time of delivery were delayed by the fish oil emulsion. Two of lhe omega-3-infused reverted from contractions to nonlabor, an effect never previously observed for experimental glucocorticoid-induced preterm labor in sheep. Maternal plasma estradiol and maternal and fetal prostaglandin E2 rose in control ewes but not in those infused with omega-3 fatty acid. The ability of omega-3 fall acids to delay premature delivery in sheep indicates their possible use as tocolytics in humans. Premature labor is lhe major cause of neonatal death and long-term disability, and these studies present information that mar lead to a novel therapeutic regimen for the prevention of preterm delivery in human pregnancy.
650 $aNutrição Animal
650 $aOvino
650 $aPrenhez
650 $aReprodução Animal
653 $aÁcido graxo polisaturado
700 1 $aTHOMAS BREMMA, J.
700 1 $aNATHANIELSZ, P. W.
773 $tBiology of Reproduction$gv. 60, n. 3, p. 698-701, 1999.
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Registro original: |
Embrapa Caprinos e Ovinos (CNPC) |
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