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 | Acesso ao texto completo restrito à biblioteca da Embrapa Alimentos e Territórios. Para informações adicionais entre em contato com mara.petrocchi@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Alimentos e Territórios. |
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Data corrente: |
18/07/2023 |
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Data da última atualização: |
16/11/2023 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
BEZERRA, J. N.; GOMEZ, M. C. V.; ROLÓN, M.; CORONEL, C.; ALMEIDA-BEZERRA, J. W.; FIDELIS, K. R.; MENEZES, S. A. de; CRUZ, R. P. da; DUARTE, A. E.; RIBEIRO, P. R. V.; BRITO, E. S. de; COUTINHO, H. D. M.; MORAIS-BRAGA, M. F. B.; BEZERRA, C. F. |
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Afiliação: |
JÉSSICA NOGUEIRA BEZERRA, URCA; MARIA CELESTE VEGA GOMEZ, FUNDACIÓN MOISÉS BERTONI; MÍRIAN ROLÓN, FUNDACIÓN MOISÉS BERTONI; CATHIA CORONEL, FUNDACIÓN MOISÉS BERTONI; JOSÉ WEVERTON ALMEIDA-BEZERRA, UFPE; KLEBER RIBEIRO FIDELIS, UFPE; SAULO ALMEIDA DE MENEZES, UFPE; RAFAEL PEREIRA DA CRUZ, URCA; ANTÔNIA ELIENE DUARTE, URCA; PAULO RICELI VASCONCELOS RIBEIRO, CNAT; EDY SOUSA DE BRITO, CNAT; HENRIQUE DOUGLAS MELO COUTINHO, URCA; MARIA FLAVIANA BEZERRA MORAIS-BRAGA, URCA; CAMILA FONSECA BEZERRA, URCA. |
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Título: |
Chemical composition, Evaluation of Antiparasitary and Cytotoxic Activity of the essential oil of Psidium brownianum MART EX. DC. |
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Ano de publicação: |
2022 |
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Fonte/Imprenta: |
Biocatalysis and Agricultural Biotechnology, v. 39, 102247, 2022. |
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ISSN: |
1878-8181 |
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DOI: |
https://doi.org/10.1016/j.bcab.2021.102247 |
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Idioma: |
Inglês |
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Conteúdo: |
Chagas Disease and Leishmaniasis are neglected parasitic diseases that constitute a major public health problem. In the search for new therapeutic alternatives for such pathologies, the essential oil of the leaves of Psidium brownianum Mart ex DC was investigated egarding its chemical composition, antiparasitic, and cytotoxic effects. The chemical composition of the oil was analyzed by gas chromatography coupled to mass spectrometry (GC/MS), showing two major constituents: Isogermafurene (52.93%) and Germacrone (16.02%). In antiparasitic activity, the oil was tested against the epimastigote forms of Trypanosoma cruzi, revealing 57.05% inhibition at the highest tested concentration (1000 μg/mL). In regard to antiparasitic activity against promastigote forms of Leishmania braziliensis and ishmania infantum, it obtained 92.61% and 84.16% inhibition, respectively, at the highest concentrations (1000 μg/mL). As for the cytotoxic effects, it showed high cytotoxicity, with IC50 = 328.9 μg/mL. The inhibitory concentration (IC50) obtained the best result for the promastigote forms of L. braziliensis (IC50 = 37.53 μg/mL), as well as the selectivity index (SI = 8.76). Such results generate perspectives for new research and may contribute to more effective drug discoveries. |
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Palavras-Chave: |
Anti kinetoplastid; Antiparasitic; Citotóxicos; Doenças parasitárias; Efeito antiparasitário; Parasitic disease; Pathologies; Phytochemistry; Psidium brownianum Mart ex DC; Terapêutica alternativa; Therapeutic alternatives. |
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Thesagro: |
Doença de Chagas; Leishmaniose; Myrtaceae; Óleo Vegetal; Saúde Pública. |
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Thesaurus Nal: |
Chagas disease; Cytotoxicity; Public health; Vegetable oil. |
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Categoria do assunto: |
H Saúde e Patologia |
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Marc: |
LEADER 02922naa a2200541 a 4500
001 2155032
005 2023-11-16
008 2022 bl uuuu u00u1 u #d
022 $a1878-8181
024 7 $ahttps://doi.org/10.1016/j.bcab.2021.102247$2DOI
100 1 $aBEZERRA, J. N.
245 $aChemical composition, Evaluation of Antiparasitary and Cytotoxic Activity of the essential oil of Psidium brownianum MART EX. DC.$h[electronic resource]
260 $c2022
520 $aChagas Disease and Leishmaniasis are neglected parasitic diseases that constitute a major public health problem. In the search for new therapeutic alternatives for such pathologies, the essential oil of the leaves of Psidium brownianum Mart ex DC was investigated egarding its chemical composition, antiparasitic, and cytotoxic effects. The chemical composition of the oil was analyzed by gas chromatography coupled to mass spectrometry (GC/MS), showing two major constituents: Isogermafurene (52.93%) and Germacrone (16.02%). In antiparasitic activity, the oil was tested against the epimastigote forms of Trypanosoma cruzi, revealing 57.05% inhibition at the highest tested concentration (1000 μg/mL). In regard to antiparasitic activity against promastigote forms of Leishmania braziliensis and ishmania infantum, it obtained 92.61% and 84.16% inhibition, respectively, at the highest concentrations (1000 μg/mL). As for the cytotoxic effects, it showed high cytotoxicity, with IC50 = 328.9 μg/mL. The inhibitory concentration (IC50) obtained the best result for the promastigote forms of L. braziliensis (IC50 = 37.53 μg/mL), as well as the selectivity index (SI = 8.76). Such results generate perspectives for new research and may contribute to more effective drug discoveries.
650 $aChagas disease
650 $aCytotoxicity
650 $aPublic health
650 $aVegetable oil
650 $aDoença de Chagas
650 $aLeishmaniose
650 $aMyrtaceae
650 $aÓleo Vegetal
650 $aSaúde Pública
653 $aAnti kinetoplastid
653 $aAntiparasitic
653 $aCitotóxicos
653 $aDoenças parasitárias
653 $aEfeito antiparasitário
653 $aParasitic disease
653 $aPathologies
653 $aPhytochemistry
653 $aPsidium brownianum Mart ex DC
653 $aTerapêutica alternativa
653 $aTherapeutic alternatives
700 1 $aGOMEZ, M. C. V.
700 1 $aROLÓN, M.
700 1 $aCORONEL, C.
700 1 $aALMEIDA-BEZERRA, J. W.
700 1 $aFIDELIS, K. R.
700 1 $aMENEZES, S. A. de
700 1 $aCRUZ, R. P. da
700 1 $aDUARTE, A. E.
700 1 $aRIBEIRO, P. R. V.
700 1 $aBRITO, E. S. de
700 1 $aCOUTINHO, H. D. M.
700 1 $aMORAIS-BRAGA, M. F. B.
700 1 $aBEZERRA, C. F.
773 $tBiocatalysis and Agricultural Biotechnology$gv. 39, 102247, 2022.
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Registro original: |
Embrapa Alimentos e Territórios (CNAT) |
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| Acesso ao texto completo restrito à biblioteca da Embrapa Semiárido. Para informações adicionais entre em contato com cpatsa.biblioteca@embrapa.br. |
Registro Completo
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Biblioteca(s): |
Embrapa Semiárido. |
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Data corrente: |
08/10/2021 |
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Data da última atualização: |
08/10/2021 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 1 |
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Autoria: |
POMPELLI, M. F.; FERREIRA, P. R. B.; CHAVES, A. R. de M.; FIGUEIREDO, R. C. Q. Q.; MARTINS, A. O.; JARMA-OROZC0, A.; BHATT, A.; SILVA, W. B.; ENDRES, L.; ARAÚJO, W. L. |
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Afiliação: |
MARCELO F. POMPELLI, Universidad de Córdoba, Colombia.; PEDRO P. B. FERREIRA, UFRPE; AGNALDO RODRIGUES DE MELO CHAVES, CPATSA; REGINA C.Q.Q. FIGUEIREDO, FIOCRUZ - Centro Ageu Magalhães - Recife /PE; AUXILIADORA O. MARTINS, UFV; ALFREDO JARMA-OROZCO, Universidad de Córdoba, Córdoba, Colombia; ARVIND BHATT, Lushan Botanical Garden, Chinese Academy of Science, Jiujiang, China; WILLIAN BATISTA-SILVA, UFV; LAURÍCIO ENDRES, UNIVERSIDADE FEDERAL DE ALAGOAS; WAGNER L. ARAÚJO, UFV. |
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Título: |
Physiological, metabolic, and stomatal adjustments in response to salt stress in Jatropha curcas. |
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Ano de publicação: |
2021 |
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Fonte/Imprenta: |
Plant Physiology and Biochemistry, v. 168, p. 116-127, 2021. |
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DOI: |
https://doi.org/10.1016/j.plaphy.2021.09.039 |
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Idioma: |
Inglês |
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Conteúdo: |
Salinity is a major issue affecting photosynthesis and crop production worldwide. High salinity induces both osmotic and ionic stress in plant tissues as a result of complex interactions among morphological, physiological, and biochemical processes. Salinity, in turn, can provoke inactivation of some enzymes in the Calvin-Benson cycle and therefore affect the fine adjustment of electron transport in photosystem I and carbon related reactions. Here, we used three contrasting Jatropha curcas genotypes namely CNPAE183 (considered tolerant to salinity), CNPAE218 (sensible), and JCAL171 (intermediate) to understand salinity responses. By performing a long-term (12 months) experiment in land conditions, we investigated distinct mechanisms used by J. curcas to cope with threatening salinity effects by analyzing gas exchange, mineral nutrition and metabolic responses. First, our results highlighted the plasticity of stomatal development and density in J. curcas under salt stress. It also demonstrated that the CNPAE183 presented higher salt-tolerance whereas CNPAE218 displayed a more sensitive salt-tolerance response. Our results also revealed that both tolerance and sensitivity to salinity were connected with an extensive metabolite reprogramming in the Calvin-Benson cycle and Tricarboxylic Acid cycle intermediates with significant changes in amino acids and organic acids. Collectively, these results indicate that the CNPAE183 and CNPAE218 genotypes demonstrated certain characteristics of salt-tolerant-like and salt-sensitive-like genotypes, respectively. Overall, our results highlight the significance of metabolites associated with salt responses and further provide a useful selection criterion in during screening for salt tolerance in J. curcas in breeding programmes. MenosSalinity is a major issue affecting photosynthesis and crop production worldwide. High salinity induces both osmotic and ionic stress in plant tissues as a result of complex interactions among morphological, physiological, and biochemical processes. Salinity, in turn, can provoke inactivation of some enzymes in the Calvin-Benson cycle and therefore affect the fine adjustment of electron transport in photosystem I and carbon related reactions. Here, we used three contrasting Jatropha curcas genotypes namely CNPAE183 (considered tolerant to salinity), CNPAE218 (sensible), and JCAL171 (intermediate) to understand salinity responses. By performing a long-term (12 months) experiment in land conditions, we investigated distinct mechanisms used by J. curcas to cope with threatening salinity effects by analyzing gas exchange, mineral nutrition and metabolic responses. First, our results highlighted the plasticity of stomatal development and density in J. curcas under salt stress. It also demonstrated that the CNPAE183 presented higher salt-tolerance whereas CNPAE218 displayed a more sensitive salt-tolerance response. Our results also revealed that both tolerance and sensitivity to salinity were connected with an extensive metabolite reprogramming in the Calvin-Benson cycle and Tricarboxylic Acid cycle intermediates with significant changes in amino acids and organic acids. Collectively, these results indicate that the CNPAE183 and CNPAE218 genotypes demonstrated certain characterist... Mostrar Tudo |
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Palavras-Chave: |
Estresse a sal; Estresse osmótico; Genótipos tolerante a sal. |
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Thesagro: |
Bioquímica; Fisiologia Vegetal; Metabolismo Vegetal; Morfologia Vegetal. |
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Thesaurus NAL: |
Photosynthesis; Salinity; Soil salinity. |
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Categoria do assunto: |
X Pesquisa, Tecnologia e Engenharia |
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Marc: |
LEADER 02881naa a2200361 a 4500
001 2135185
005 2021-10-08
008 2021 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1016/j.plaphy.2021.09.039$2DOI
100 1 $aPOMPELLI, M. F.
245 $aPhysiological, metabolic, and stomatal adjustments in response to salt stress in Jatropha curcas.$h[electronic resource]
260 $c2021
520 $aSalinity is a major issue affecting photosynthesis and crop production worldwide. High salinity induces both osmotic and ionic stress in plant tissues as a result of complex interactions among morphological, physiological, and biochemical processes. Salinity, in turn, can provoke inactivation of some enzymes in the Calvin-Benson cycle and therefore affect the fine adjustment of electron transport in photosystem I and carbon related reactions. Here, we used three contrasting Jatropha curcas genotypes namely CNPAE183 (considered tolerant to salinity), CNPAE218 (sensible), and JCAL171 (intermediate) to understand salinity responses. By performing a long-term (12 months) experiment in land conditions, we investigated distinct mechanisms used by J. curcas to cope with threatening salinity effects by analyzing gas exchange, mineral nutrition and metabolic responses. First, our results highlighted the plasticity of stomatal development and density in J. curcas under salt stress. It also demonstrated that the CNPAE183 presented higher salt-tolerance whereas CNPAE218 displayed a more sensitive salt-tolerance response. Our results also revealed that both tolerance and sensitivity to salinity were connected with an extensive metabolite reprogramming in the Calvin-Benson cycle and Tricarboxylic Acid cycle intermediates with significant changes in amino acids and organic acids. Collectively, these results indicate that the CNPAE183 and CNPAE218 genotypes demonstrated certain characteristics of salt-tolerant-like and salt-sensitive-like genotypes, respectively. Overall, our results highlight the significance of metabolites associated with salt responses and further provide a useful selection criterion in during screening for salt tolerance in J. curcas in breeding programmes.
650 $aPhotosynthesis
650 $aSalinity
650 $aSoil salinity
650 $aBioquímica
650 $aFisiologia Vegetal
650 $aMetabolismo Vegetal
650 $aMorfologia Vegetal
653 $aEstresse a sal
653 $aEstresse osmótico
653 $aGenótipos tolerante a sal
700 1 $aFERREIRA, P. R. B.
700 1 $aCHAVES, A. R. de M.
700 1 $aFIGUEIREDO, R. C. Q. Q.
700 1 $aMARTINS, A. O.
700 1 $aJARMA-OROZC0, A.
700 1 $aBHATT, A.
700 1 $aSILVA, W. B.
700 1 $aENDRES, L.
700 1 $aARAÚJO, W. L.
773 $tPlant Physiology and Biochemistry$gv. 168, p. 116-127, 2021.
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