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Registro Completo |
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Biblioteca(s): |
Embrapa Amapá. |
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Data corrente: |
29/07/2022 |
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Data da última atualização: |
08/08/2022 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
ÇIÇEK, S. S.; PÉREZ, M. G; WENZEL-STORJOHANN, A.; BEZERRA, R. M.; SEGOVIA, J. F. O.; GIRRESER, U.; KANZAKI, I.; TASDEMIR, D. |
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Afiliação: |
SERHAT S. ÇIÇEK, KIEL UNIVERSITY; MAYRA GALARZA PÉREZ, KIEL UNIVERSITY; ARLETTE WENZEL-STORJOHANN, GEOMAR; ROBERTO M. BEZERRA, UNIFAP; JORGE FEDERICO ORELLANA SEGOVIA, CPAF-AP; ULRICH GIRRESER, KIEL UNIVERSITY; ISAMU KANZAKI, UNB; DENIZ TASDEMIR, GEOMAR. |
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Título: |
Antimicrobial prenylated isoflavones from the leaves of the Amazonian medicinal plant vatairea guianensis Aubl. |
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Ano de publicação: |
2022 |
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Fonte/Imprenta: |
Journal of Natural Products, v. 85, p. 927-935, 2022. |
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DOI: |
https://doi.org/10.1021/acs.jnatprod.1c01035 |
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Idioma: |
Inglês |
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Conteúdo: |
Vatairea guianenis Aubl. (Fabaceae) is an Amazonian medicinal plant species traditionally used for treating skin diseases. In an initial screening, a V. guianensis leaf extract and its subextracts showed antibacterial and antifungal activities. The EtOAc subextract was selected for chemical workup and afforded five known (1-4 and 8) and six undescribed isoflavones, vatairenones C-H( 5-7 and 9-11). All isoflavones are prenylated in position C-8, displaying either chain-prenylated (1-7) or ring-closed forms (8-11). The most bioactive compound (3) exhibited in vitro activity against clinically relevant bacteria and fungi with IC50 values ranging from 6.8 to 26.9 μM. Due to its broad antimicrobial activity and low general toxicity, compound 3 is a potential lead compound for structural modifications. The results of the present study support the ethnomedicinal use of V. guianensis in the treatment of dermatological disorders. 1H NMR spectra of some of the isolated compounds showed intricate signal patterns, which might explain repeated errors in assigning the correct structure of the isoflavonoid B-ring in the literature and which we resolved by higher order spectra simulations. |
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Thesagro: |
Planta Medicinal. |
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Thesaurus Nal: |
Fabaceae; Medicinal plants. |
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Categoria do assunto: |
F Plantas e Produtos de Origem Vegetal |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/doc/1145058/1/CPAF-AP-2022-Antimicrobial-Prenylated-Isoflavones.pdf
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Marc: |
LEADER 01980naa a2200253 a 4500
001 2145058
005 2022-08-08
008 2022 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1021/acs.jnatprod.1c01035$2DOI
100 1 $aÇIÇEK, S. S.
245 $aAntimicrobial prenylated isoflavones from the leaves of the Amazonian medicinal plant vatairea guianensis Aubl.$h[electronic resource]
260 $c2022
520 $aVatairea guianenis Aubl. (Fabaceae) is an Amazonian medicinal plant species traditionally used for treating skin diseases. In an initial screening, a V. guianensis leaf extract and its subextracts showed antibacterial and antifungal activities. The EtOAc subextract was selected for chemical workup and afforded five known (1-4 and 8) and six undescribed isoflavones, vatairenones C-H( 5-7 and 9-11). All isoflavones are prenylated in position C-8, displaying either chain-prenylated (1-7) or ring-closed forms (8-11). The most bioactive compound (3) exhibited in vitro activity against clinically relevant bacteria and fungi with IC50 values ranging from 6.8 to 26.9 μM. Due to its broad antimicrobial activity and low general toxicity, compound 3 is a potential lead compound for structural modifications. The results of the present study support the ethnomedicinal use of V. guianensis in the treatment of dermatological disorders. 1H NMR spectra of some of the isolated compounds showed intricate signal patterns, which might explain repeated errors in assigning the correct structure of the isoflavonoid B-ring in the literature and which we resolved by higher order spectra simulations.
650 $aFabaceae
650 $aMedicinal plants
650 $aPlanta Medicinal
700 1 $aPÉREZ, M. G
700 1 $aWENZEL-STORJOHANN, A.
700 1 $aBEZERRA, R. M.
700 1 $aSEGOVIA, J. F. O.
700 1 $aGIRRESER, U.
700 1 $aKANZAKI, I.
700 1 $aTASDEMIR, D.
773 $tJournal of Natural Products$gv. 85, p. 927-935, 2022.
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Registro original: |
Embrapa Amapá (CPAF-AP) |
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| 1. |  | ÇIÇEK, S. S.; PÉREZ, M. G; WENZEL-STORJOHANN, A.; BEZERRA, R. M.; SEGOVIA, J. F. O.; GIRRESER, U.; KANZAKI, I.; TASDEMIR, D. Antimicrobial prenylated isoflavones from the leaves of the Amazonian medicinal plant vatairea guianensis Aubl. Journal of Natural Products, v. 85, p. 927-935, 2022.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
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