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Registro Completo |
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Biblioteca(s): |
Embrapa Gado de Leite. |
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Data corrente: |
25/07/2022 |
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Data da última atualização: |
25/07/2022 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
SANTOS, C. G. dos; SOUSA, M. F.; VIEIRA, J. I. G.; MORAIS, L. R. de; FERNANDES, A. A. S.; LITTIERE, T. de O.; OTTO, P. I.; MACHADO, M. A.; SILVA, M. V. G. B.; BONAFÉ, C. M.; MAGALHÃES, A. F. B.; VERARDO, L. L. |
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Afiliação: |
CASSIANE GOMES DOS SANTOS, Universidade Federal dos Vales do Jequitinhonha e Mucuri; MARIELE FREITAS SOUSA, Universidade Federal dos Vales do Jequitinhonha e Mucuri; JOÃO INÁCIO GOMES VIEIRA, Universidade Federal dos Vales do Jequitinhonha e Mucuri; LUANA RAFAELA DE MORAIS, Universidade Federal dos Vales do Jequitinhonha e Mucuri; ALINE AUXILIADORA SILVA FERNANDES, Universidade Federal dos Vales do Jequitinhonha e Mucuri; THAYSSA DE OLIVEIRA LITTIERE, Universidade Estadual Paulista "Júlio de Mesquita Filho"; PAMELA ITAJARA OTTO, Universidade Federal de Santa Maria; MARCO ANTONIO MACHADO, CNPGL; MARCOS VINICIUS GUALBERTO B SILVA, CNPGL; CRISTINA MOREIRA BONAFÉ, Universidade Federal dos Vales do Jequitinhonha e Mucuri; ANA FABRÍCIA BRAGA MAGALHÃES, Universidade Federal dos Vales do Jequitinhonha e Mucuri; LUCAS LIMA VERARDO, Universidade Federal dos Vales do Jequitinhonha e Mucuri. |
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Título: |
Candidate genes for tick resistance in cattle: a systematic review combining post-GWAS analyses with sequencing data. |
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Ano de publicação: |
2022 |
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Fonte/Imprenta: |
Journal of Applied Animal Research, v. 50, n. 1, p. 460-470, 2022. |
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DOI: |
https://doi.org/10.1080/09712119.2022.2096035 |
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Idioma: |
Inglês |
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Conteúdo: |
Rhipicephalus microplus causes huge losses in cattle. Host genetic background greatly affects the immune efficiency in resistance or susceptibility to tick infestation, which is one of the many factors that play a role on that trait. We performed a systematic review of genome-wide association studies (GWAS) for tick resistance in cattle resulting in 1353 candidate genes for post-GWAS analyses. From those, genes showing possible structural variants from the bovine genome were classified by the Variant Effect Predictor from Ensembl. Ninety-two candidate genes showed potential structural variants in 5' UTR and coding region and were used for functional annotation. Enriched biological processes (e.g. regulation of eosinophil chemotaxis, RIG-I signalling pathway and monocyte differentiation) and candidate genes (e.g. DAPK2, PUM1, ACIN1, INPP5D) linked with immune system function were identified and thus associated with tick resistance. Besides, gene-transcription factors (TFs) networks were obtained from TFs associated with immune system (FOXO3, PPARG, STAT3, NFKB1, GATA3 and ARNT) and the candidate genes associated with tick resistance in cattle highlighted (e.g. OR4L1, PNP, LRRIQ1, GIMAP8, MYO6, MEP1A and LRFN2). Thus, promising candidate genes with a possible functional role for tick resistance in cattle are presented for further in vitro and/or in vivo analyses. |
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Palavras-Chave: |
Ectoparasita; Sistema imunológico. |
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Thesagro: |
Bovino; Carne; Carrapato; Genoma; Hospedeiro Animal. |
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Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/doc/1144893/1/Candidate-genes-for-tick-resistance-in-cattle.pdf
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Marc: |
LEADER 02437naa a2200349 a 4500
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008 2022 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1080/09712119.2022.2096035$2DOI
100 1 $aSANTOS, C. G. dos
245 $aCandidate genes for tick resistance in cattle$ba systematic review combining post-GWAS analyses with sequencing data.$h[electronic resource]
260 $c2022
520 $aRhipicephalus microplus causes huge losses in cattle. Host genetic background greatly affects the immune efficiency in resistance or susceptibility to tick infestation, which is one of the many factors that play a role on that trait. We performed a systematic review of genome-wide association studies (GWAS) for tick resistance in cattle resulting in 1353 candidate genes for post-GWAS analyses. From those, genes showing possible structural variants from the bovine genome were classified by the Variant Effect Predictor from Ensembl. Ninety-two candidate genes showed potential structural variants in 5' UTR and coding region and were used for functional annotation. Enriched biological processes (e.g. regulation of eosinophil chemotaxis, RIG-I signalling pathway and monocyte differentiation) and candidate genes (e.g. DAPK2, PUM1, ACIN1, INPP5D) linked with immune system function were identified and thus associated with tick resistance. Besides, gene-transcription factors (TFs) networks were obtained from TFs associated with immune system (FOXO3, PPARG, STAT3, NFKB1, GATA3 and ARNT) and the candidate genes associated with tick resistance in cattle highlighted (e.g. OR4L1, PNP, LRRIQ1, GIMAP8, MYO6, MEP1A and LRFN2). Thus, promising candidate genes with a possible functional role for tick resistance in cattle are presented for further in vitro and/or in vivo analyses.
650 $aBovino
650 $aCarne
650 $aCarrapato
650 $aGenoma
650 $aHospedeiro Animal
653 $aEctoparasita
653 $aSistema imunológico
700 1 $aSOUSA, M. F.
700 1 $aVIEIRA, J. I. G.
700 1 $aMORAIS, L. R. de
700 1 $aFERNANDES, A. A. S.
700 1 $aLITTIERE, T. de O.
700 1 $aOTTO, P. I.
700 1 $aMACHADO, M. A.
700 1 $aSILVA, M. V. G. B.
700 1 $aBONAFÉ, C. M.
700 1 $aMAGALHÃES, A. F. B.
700 1 $aVERARDO, L. L.
773 $tJournal of Applied Animal Research$gv. 50, n. 1, p. 460-470, 2022.
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Embrapa Gado de Leite (CNPGL) |
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| 1. |  | SANTOS, C. G. dos; SOUSA, M. F.; VIEIRA, J. I. G.; MORAIS, L. R. de; FERNANDES, A. A. S.; LITTIERE, T. de O.; OTTO, P. I.; MACHADO, M. A.; SILVA, M. V. G. B.; BONAFÉ, C. M.; MAGALHÃES, A. F. B.; VERARDO, L. L. Candidate genes for tick resistance in cattle: a systematic review combining post-GWAS analyses with sequencing data. Journal of Applied Animal Research, v. 50, n. 1, p. 460-470, 2022.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: B - 1 |
| Biblioteca(s): Embrapa Gado de Leite. |
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