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Registro Completo |
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Biblioteca(s): |
Embrapa Pecuária Sudeste. |
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Data corrente: |
09/12/2021 |
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Data da última atualização: |
09/12/2021 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
LOPES, P. D.; OKINO, C. H.; FERNANDO, F. S.; PAVANI, C.; MARIGUELA, V. C.; MONTASSIER, M. DE F. S.; MONTASSIER, H. J. |
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Afiliação: |
PRISCILA DINIZ LOPES, UNESP; CINTIA HIROMI OKINO, CPPSE; FILIPE SANTOS FERNANDO, UNESP; CAREN PAVANI, UNESP; VIVIANE CASAGRANDE MARIGUELA, UNESP; MARIA DE FÁTIMA SILVA MONTASSIER, UNESP; HÉLIO JOSÉ MONTASSIER, UNESP. |
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Título: |
Comparative evaluation of immune responses and protection of chitosan nanoparticles and oil-emulsion adjuvants in avian coronavirus inactivated vaccines in chickens. |
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Ano de publicação: |
2021 |
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Fonte/Imprenta: |
Vaccines, v.9, n.12, 1457, 2021. |
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ISSN: |
2076-393X |
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DOI: |
https://doi.org/10.3390/vaccines9121457 |
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Idioma: |
Inglês |
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Conteúdo: |
Efficient vaccines are the main strategy to control the avian coronavirus (AvCoV), although several drawbacks related to traditional attenuated and inactivated vaccines have been reported. These counterpoints highlight the importance of developing new alternative vaccines against AvCoV, especially those able to induce long-lasting immune responses. This study evaluated and compared two inactivated vaccines formulated with AvCoV BR-I variants, one composed of chitosan nanoparticles (AvCoV-CS) and the second by Montanide oily adjuvant (AvCoV-O). Both developed vaccines were administered in a single dose or associated with the traditional Mass attenuated vaccine. The AvCoV-CS vaccine administered alone or associated with the Mass vaccine was able to induce strong humoral and cell-mediated immune (CMI) responses and complete protection against IBV virulent infection, wherein single administration was characterized by high IgA antibody levels in the mucosa, whereas when associated with the Mass vaccine, the serum IgG antibody was predominantly observed. On the other hand, single administration of the oily vaccine presented poor humoral and CMI responses and consequently incomplete protection against virulent challenge, but when associated with the Mass vaccine, immune responses were developed, and complete protection against infection was observed. Both of our experimental vaccines were able to induce full protection against virulent IBV challenge. A single dose of AvCoV-CS vaccine was sufficient to achieve complete protection, while AvCoV-O required a previous priming by a Mass strain to complete the protection. MenosEfficient vaccines are the main strategy to control the avian coronavirus (AvCoV), although several drawbacks related to traditional attenuated and inactivated vaccines have been reported. These counterpoints highlight the importance of developing new alternative vaccines against AvCoV, especially those able to induce long-lasting immune responses. This study evaluated and compared two inactivated vaccines formulated with AvCoV BR-I variants, one composed of chitosan nanoparticles (AvCoV-CS) and the second by Montanide oily adjuvant (AvCoV-O). Both developed vaccines were administered in a single dose or associated with the traditional Mass attenuated vaccine. The AvCoV-CS vaccine administered alone or associated with the Mass vaccine was able to induce strong humoral and cell-mediated immune (CMI) responses and complete protection against IBV virulent infection, wherein single administration was characterized by high IgA antibody levels in the mucosa, whereas when associated with the Mass vaccine, the serum IgG antibody was predominantly observed. On the other hand, single administration of the oily vaccine presented poor humoral and CMI responses and consequently incomplete protection against virulent challenge, but when associated with the Mass vaccine, immune responses were developed, and complete protection against infection was observed. Both of our experimental vaccines were able to induce full protection against virulent IBV challenge. A single dose of AvCoV-CS vacci... Mostrar Tudo |
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Palavras-Chave: |
Avian infectious bronchitis; Cellular immune response; Delivery carrier adjuvant; Mucosal immunization; Oil adjuvant. |
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Categoria do assunto: |
X Pesquisa, Tecnologia e Engenharia |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/228815/1/ComparativeEvaluationImmune.pdf
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Marc: |
LEADER 02553naa a2200277 a 4500
001 2137397
005 2021-12-09
008 2021 bl uuuu u00u1 u #d
022 $a2076-393X
024 7 $ahttps://doi.org/10.3390/vaccines9121457$2DOI
100 1 $aLOPES, P. D.
245 $aComparative evaluation of immune responses and protection of chitosan nanoparticles and oil-emulsion adjuvants in avian coronavirus inactivated vaccines in chickens.$h[electronic resource]
260 $c2021
520 $aEfficient vaccines are the main strategy to control the avian coronavirus (AvCoV), although several drawbacks related to traditional attenuated and inactivated vaccines have been reported. These counterpoints highlight the importance of developing new alternative vaccines against AvCoV, especially those able to induce long-lasting immune responses. This study evaluated and compared two inactivated vaccines formulated with AvCoV BR-I variants, one composed of chitosan nanoparticles (AvCoV-CS) and the second by Montanide oily adjuvant (AvCoV-O). Both developed vaccines were administered in a single dose or associated with the traditional Mass attenuated vaccine. The AvCoV-CS vaccine administered alone or associated with the Mass vaccine was able to induce strong humoral and cell-mediated immune (CMI) responses and complete protection against IBV virulent infection, wherein single administration was characterized by high IgA antibody levels in the mucosa, whereas when associated with the Mass vaccine, the serum IgG antibody was predominantly observed. On the other hand, single administration of the oily vaccine presented poor humoral and CMI responses and consequently incomplete protection against virulent challenge, but when associated with the Mass vaccine, immune responses were developed, and complete protection against infection was observed. Both of our experimental vaccines were able to induce full protection against virulent IBV challenge. A single dose of AvCoV-CS vaccine was sufficient to achieve complete protection, while AvCoV-O required a previous priming by a Mass strain to complete the protection.
653 $aAvian infectious bronchitis
653 $aCellular immune response
653 $aDelivery carrier adjuvant
653 $aMucosal immunization
653 $aOil adjuvant
700 1 $aOKINO, C. H.
700 1 $aFERNANDO, F. S.
700 1 $aPAVANI, C.
700 1 $aMARIGUELA, V. C.
700 1 $aMONTASSIER, M. DE F. S.
700 1 $aMONTASSIER, H. J.
773 $tVaccines$gv.9, n.12, 1457, 2021.
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Registro original: |
Embrapa Pecuária Sudeste (CPPSE) |
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| Registros recuperados : 47 | |
| 41. |  | OLIVEIRA, P. de; FREITAS, R. J.; KLUTHCOUSKI, J.; RIBEIRO, A. A.; CORDEIRO, L. A. M.; TEIXEIRA, L. P.; MELO, R. A. de C. e; SILVA, A. da; MARCHIÓ, W.; VILELA, L.; BALBINO, L. C. Integração lavoura-pecuária-floresta: caso de sucesso da Fazenda Santa Brígida, no Estado de Goiás. In: BUNGENSTAB, D. J.; ALMEIDA, R. G. de; LAURA, V. A.; BALBINO, L. C.; FERREIRA, A. D. (Ed.). ILPF: inovação com integração de lavoura, pecuária e floresta. Brasília, DF: Embrapa, 2019. Cap. 47. p. 743-752.| Tipo: Capítulo em Livro Técnico-Científico |
| Biblioteca(s): Embrapa Cerrados; Embrapa Hortaliças; Embrapa Meio Ambiente. |
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| 42. | | BEHLING, M.; WRUCK, F. J.; ANTONIO, D. B. A.; MENEGUCI, J. L. P.; PEDREIRA, B. C. e; CARNEVALLI, R. A.; CORDEIRO, L. A. M.; GIL, J.; FARIAS NETO, A. L. de; DOMIT, L. A.; SILVA, J. F. V. Integração Lavoura-Pecuária-Floresta (iLPF). In: GALHARDI JUNIOR, A.; SIQUERI, F.; CAJU, J.; CAMACHO, S. (Ed.). Boletim de Pesquisa de Soja 2013/2014. Rondonópolis: Fundação MT, 2013. 306-325 Boletim de Pesquisa da Soja, 16| Tipo: Capítulo em Livro Técnico-Científico |
| Biblioteca(s): Embrapa Agrossilvipastoril; Embrapa Arroz e Feijão. |
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| 43. | | CORDEIRO, L. A. M.; VILELA, L.; MACEDO, M. C. M.; ZIMMER, A. H.; RAMOS, A. K. B.; BRAGA, G. J.; MACIEL, G. A.; MARCHAO, R. L.; ALMEIDA, R. G. de. Estratégias para recuperação e renovação de pastagens degradadas no Cerrado. Planaltina, DF: Embrapa Cerrados, 2022. 27 p. (Embrapa Cerrados. Documentos, 397).| Biblioteca(s): Embrapa Cerrados; Embrapa Gado de Corte. |
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| 44. | | CORDEIRO, L. A. M.; BALBINO, L. C.; GALERANI, P. R.; DOMIT, L. A.; SILVA, P. C.; KLUTHCOUSKI, J.; VILELA, L.; MARCHÃO, R. L.; SKORUPA, L. A.; WRUCK, F. J. Transferência de tecnologias para adoção da estratégia de integração lavoura-pecuária-floresta. In: CORDEIRO, L. A. M.; VILELA, L.; KLUTHCOUSKI, J.; MARCHÃO, R. L. (Ed.). Integração lavoura-pecuária-floresta: o produtor pergunta, a Embrapa responde. Brasília, DF: Embrapa, 2015. p. 377-393. (Coleção 500 perguntas, 500 respostas).| Tipo: Capítulo em Livro Técnico-Científico |
| Biblioteca(s): Embrapa Agrossilvipastoril; Embrapa Arroz e Feijão; Embrapa Cerrados; Embrapa Meio Ambiente. |
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| 45. | | LANDGRAF, M. L.; ALVES, T. C.; OLIVEIRA, P. P. A.; BERNDT, A.; NOVO, A. L. M.; PEDROSO, A. de F.; PEZZOPANE, J. R. M.; CORDEIRO, L. A. M.; BERNARDI, A. C. de C. Utilização de modelo digital de terreno na classificação da declividade de um sistema de integração lavoura-pecuária-floresta. In: JORNADA CIENTÍFICA DA EMBRAPA SÃO CARLOS, 12., 2020, São Carlos, SP. Anais... São Carlos, SP: Embrapa Instrumentação; Embrapa Pecuária Sudeste, 2020. p.25. (Embrapa Instrumentação. Documentos, 71).| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 46. | | SANTOS, P. M.; MARTHA JUNIOR, G. B.; PEREIRA, V. da F.; SANTOS, C. E. S.; VICTORIA, D. de C.; AQUINO, F. de G.; DRESSLER, M.; MARCELINO, M. Q. dos S.; TONUCCI, R. G.; MINGOTI, R.; GOIS, S. L. L. de; CORDEIRO, L. A. M.; BALSADI, O. V. Políticas públicas para pastagens: da degradação ao uso sustentável. Brasília, DF: Embrapa, 2024. 106 p.| Tipo: Autoria/Organização/Edição de Livros |
| Biblioteca(s): Embrapa Agricultura Digital; Embrapa Cerrados; Embrapa Pecuária Sudeste; Embrapa Territorial; Embrapa Unidades Centrais. |
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| 47. | | GONZAGA, V.; FERREIRA, D. N. M.; MAGARELLI, G.; MARTINS, O. M.; OLIVEIRA, M. R. V. de; COSTA, C. D.; MARQUES, A. S. dos A.; MENDES, M. A. S.; URBEN, A. F.; VILACA, R.; BATISTA, M. de F.; POLEZ, V. L. P.; CORDEIRO, L. A. M.; BENITO, N. P.; CARLOS, M. Fitopatógenos interceptados pela Estação Quarentenária de Germoplasma Vegetal da Embrapa em materiais de intercambio no ano de 2008. Tropical Plant Pathology, Brasília, DF, v. 34, p. S156, 2009. Suplemento. Edição dos Resumos do XLII do Congresso Brasileiro de Fitopatologia, Rio de Janeiro, RJ, 2009.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Recursos Genéticos e Biotecnologia. |
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| Registros recuperados : 47 | |
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