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Registro Completo |
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Biblioteca(s): |
Embrapa Agroenergia; Embrapa Recursos Genéticos e Biotecnologia; Embrapa Soja. |
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Data corrente: |
24/05/2021 |
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Data da última atualização: |
02/06/2021 |
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Tipo da produção científica: |
Capítulo em Livro Técnico-Científico |
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Autoria: |
VIEIRA, L. R.; FREITAS, N. C.; JUSTEN, F.; MIRANDA, V. de J.; GARCIA, B. de O.; NEPOMUCENO, A. L.; FUGANTI-PAGLIARINI, R.; FELIPE, M. S. S.; MOLINARI, H. B. C.; VELINI, E. D.; PINTO, E. R. de C.; DAGLI, M. L. Z.; ANDRADE, G.; FERNANDES, P. M. B.; MERTZ-HENNING, L. M.; KOBAYASHI, A. K. |
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Afiliação: |
LETÍCIA RIOS VIEIRA; NATÁLIA CHAGAS FREITAS; FERNANDA JUSTEN; VÍVIAN DE JESUS MIRANDA; BRUNO DE OLIVEIRA GARCIA, Universidade Federal de Lavras; ALEXANDRE LIMA NEPOMUCENO, CNPSO; RENATA FUGANTI-PAGLIARINI; MARIA SUELI SOARES FELIPE, Universidade Católica de Brasília; HUGO BRUNO CORREA MOLINARI, CNPAE; EDIVALDO DOMINGUES VELINI, Universidade Estadual Paulista; EDUARDO ROMANO DE CAMPOS PINTO, Cenargen; MARIA LUCIA ZAIDAN DAGLI, Universidade de São Paulo; GALDINO ANDRADE, Universidade Estatual de Londrina; PATRICIA MACHADO BUENO FERNANDES, Universidade Federal do Espírito Santo; LILIANE MARCIA MERTZ HENNING, CNPSO; ADILSON KENJI KOBAYASHI, CNPAE. |
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Título: |
Regulatory framework of genome editing in Brazil and worldwide. |
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Ano de publicação: |
2021 |
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Fonte/Imprenta: |
In: MOLINARI, H. B. C.; VIEIRA, L. R.; SILVA, N. V. e; PRADO, G. S.; LOPES FILHO, J. F. (Ed.). CRISPR technology in plant genome editing: biotechnology applied to agriculture. Brasília, DF : Embrapa, 2021. Chapter 5, p. 169-195. |
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Idioma: |
Inglês |
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Conteúdo: |
The regulation of the use of products obtained through genome-editing techniques has been the subject of great debate worldwide. Currently, the discussions are mainly focused on whether products obtained by different strategies of site-directed nucleases (SDN) should or not be classified as Genetically Modified Organisms (GMOs). In the SDN-1 application, the natural DNA cell repair pathway (Non-Homologous End-Joining - NHEJ) is explored to introduce simple random mutations (substitutions, insertions, and deletions) by systems such as CRISPR-Cas, TALENs, or Zinc Fingers Nucleases, which cause silencing of the gene product after breaking DNA (by Double-Strand Break - DSB). In the SDN-2 approach, a template DNA is also used to introduce a change in the sequence of nitrogen bases (A, C, G, T) at the target site where the DSB occurred, exploring another natural repair system directed by a DNA fragment from the same species (Homology-Directed Repair - HDR). In the SDN-3 approach, both NHEJ and HDR can be explored to insert one or more DNA fragments with sequences necessary for the expression of a gene (promoter, coding, and terminator region) at a specific location in the genome. In the following topics, questions related to genome editing regulation in different countries are discussed in detail. |
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Thesagro: |
Biotecnologia; DNA; Engenharia Genética; Genética Vegetal; Legislação. |
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Thesaurus Nal: |
Biotechnology; Genetic engineering; Genetically modified organisms; Plant genetics. |
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Categoria do assunto: |
G Melhoramento Genético |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/223607/1/Regulatory-framework-of-genome-CAP-5.pdf
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Marc: |
LEADER 02642naa a2200409 a 4500
001 2132164
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008 2021 bl uuuu u00u1 u #d
100 1 $aVIEIRA, L. R.
245 $aRegulatory framework of genome editing in Brazil and worldwide.$h[electronic resource]
260 $c2021
520 $aThe regulation of the use of products obtained through genome-editing techniques has been the subject of great debate worldwide. Currently, the discussions are mainly focused on whether products obtained by different strategies of site-directed nucleases (SDN) should or not be classified as Genetically Modified Organisms (GMOs). In the SDN-1 application, the natural DNA cell repair pathway (Non-Homologous End-Joining - NHEJ) is explored to introduce simple random mutations (substitutions, insertions, and deletions) by systems such as CRISPR-Cas, TALENs, or Zinc Fingers Nucleases, which cause silencing of the gene product after breaking DNA (by Double-Strand Break - DSB). In the SDN-2 approach, a template DNA is also used to introduce a change in the sequence of nitrogen bases (A, C, G, T) at the target site where the DSB occurred, exploring another natural repair system directed by a DNA fragment from the same species (Homology-Directed Repair - HDR). In the SDN-3 approach, both NHEJ and HDR can be explored to insert one or more DNA fragments with sequences necessary for the expression of a gene (promoter, coding, and terminator region) at a specific location in the genome. In the following topics, questions related to genome editing regulation in different countries are discussed in detail.
650 $aBiotechnology
650 $aGenetic engineering
650 $aGenetically modified organisms
650 $aPlant genetics
650 $aBiotecnologia
650 $aDNA
650 $aEngenharia Genética
650 $aGenética Vegetal
650 $aLegislação
700 1 $aFREITAS, N. C.
700 1 $aJUSTEN, F.
700 1 $aMIRANDA, V. de J.
700 1 $aGARCIA, B. de O.
700 1 $aNEPOMUCENO, A. L.
700 1 $aFUGANTI-PAGLIARINI, R.
700 1 $aFELIPE, M. S. S.
700 1 $aMOLINARI, H. B. C.
700 1 $aVELINI, E. D.
700 1 $aPINTO, E. R. de C.
700 1 $aDAGLI, M. L. Z.
700 1 $aANDRADE, G.
700 1 $aFERNANDES, P. M. B.
700 1 $aMERTZ-HENNING, L. M.
700 1 $aKOBAYASHI, A. K.
773 $tIn: MOLINARI, H. B. C.; VIEIRA, L. R.; SILVA, N. V. e; PRADO, G. S.; LOPES FILHO, J. F. (Ed.). CRISPR technology in plant genome editing: biotechnology applied to agriculture. Brasília, DF : Embrapa, 2021. Chapter 5, p. 169-195.
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Registro original: |
Embrapa Soja (CNPSO) |
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| Registros recuperados : 1 | |
| 1. |  | VIEIRA, L. R.; FREITAS, N. C.; JUSTEN, F.; MIRANDA, V. de J.; GARCIA, B. de O.; NEPOMUCENO, A. L.; FUGANTI-PAGLIARINI, R.; FELIPE, M. S. S.; MOLINARI, H. B. C.; VELINI, E. D.; PINTO, E. R. de C.; DAGLI, M. L. Z.; ANDRADE, G.; FERNANDES, P. M. B.; MERTZ-HENNING, L. M.; KOBAYASHI, A. K. Regulatory framework of genome editing in Brazil and worldwide. In: MOLINARI, H. B. C.; VIEIRA, L. R.; SILVA, N. V. e; PRADO, G. S.; LOPES FILHO, J. F. (Ed.). CRISPR technology in plant genome editing: biotechnology applied to agriculture. Brasília, DF : Embrapa, 2021. Chapter 5, p. 169-195.| Tipo: Capítulo em Livro Técnico-Científico |
| Biblioteca(s): Embrapa Agroenergia; Embrapa Recursos Genéticos e Biotecnologia; Embrapa Soja. |
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| Registros recuperados : 1 | |
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