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Registro Completo |
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Biblioteca(s): |
Embrapa Agroindústria Tropical; Embrapa Semiárido. |
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Data corrente: |
03/01/2020 |
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Data da última atualização: |
03/07/2020 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
GUEDES, J. A. C.; ALVES FILHO, E. DE G.; SILVA, M. F. S.; RODRIGUES, T. H. S.; RAMIRES, C. M. C.; LIMA, M. A. C. de; SILVA, G. S. DA; PESSOA, C. DO Ó; CANUTO, K. M.; BRITO, E. S. de; ALVES, R. E.; NASCIMENTO, R. F. DO; ZOCOLO, G. J. |
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Afiliação: |
JHONYSON ARRUDA CARVALHO GUEDES, Departamento de Química Analítica e Físico-Química, Universidade Federal do Ceará; ELENILSON DE GODOY ALVES FILHO, Embrapa Agroindústria Tropical; MARIA FRANCILENE SOUZA SILVA, Departamento de Fisiologia e Farmacologia, Universidade Federal do Ceará; TIGRESSA HELENA SOARES RODRIGUES, Universidade Estadual do Vale do Acaraú, Sobral; CHRISTIANE MENDES CASSIMIRO RAMIRES, Empresa Estadual de Pesquisa Agropecuária da Paraíba (EMEPA); MARIA AUXILIADORA COELHO DE LIMA, CPATSA; GISELE SILVESTRE DA SILVA, Embrapa Agroindústria Tropical; CLAUDIA DO Ó PESSOA, Departamento de Fisiologia e Farmacologia, Universidade Federal do Ceará; KIRLEY MARQUES CANUTO, CNPAT; EDY SOUSA DE BRITO, CNPAT; RICARDO ELESBAO ALVES, CNAT; RONALDO FERREIRA DO NASCIMENTO, Departamento de Química Analítica e Físico-Química, Universidade Federal do Ceará; GUILHERME JULIAO ZOCOLO, CNPAT. |
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Título: |
GC-MS-based metabolomic profiles combined with chemometric tools and cytotoxic activities of non-polar leaf extracts of Spondias mombin L. and Spondias tuberosa Arr. Cam. |
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Ano de publicação: |
2020 |
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Fonte/Imprenta: |
Journal of the Brazilian Chemical Society, Campinas, v. 31, n. 2, p. 331-340, 2020. |
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DOI: |
https://doi.org/10.21577/0103-5053.20190185 |
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Idioma: |
Inglês |
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Conteúdo: |
Agroindustrial residues, such as leaves of fruit plants, can be sources of bioactive molecules, thus adding value to co-products that are rarely explored in agroindustry. In this context, this study aimed to look into the phytochemical profiles in detail and to explore the antitumor potential of S. tuberosa and S. mombin leaves. We observed that, S. tuberosa leaf extract was cytotoxic in both tumor and healthy cells. S. mombin extracts selectively inhibited cell proliferation in the tumor cell line for prostate cancer (PC3) and did not significantly affect healthy cells. The metabolic profiles of the extracts were evaluated by gas chromatography coupled with mass spectrometry and twenty-three metabolites were identified. The correlation of metabolic profiles with cytotoxic tests indicated possible chemical markers that may be responsible for the inhibition of cell proliferation. This study revealed that the unexplored co-products in agroindustry may have great therapeutic potential, and therefore should be screened for biologically active compounds |
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Palavras-Chave: |
Agroindustria; Co-produto; Metabolômica; Residuo agroindustrial. |
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Thesagro: |
Cromatografia; Spondias Mombin; Umbu. |
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Thesaurus Nal: |
Chromatography; Metabolomics; Spondias; Yellow mombins. |
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Categoria do assunto: |
--
F Plantas e Produtos de Origem Vegetal |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/208109/1/ART19066.pdf
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/210746/1/Based-Metabolomic-Profiles-Combined-with-Chemometric-Tools.pdf
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Marc: |
LEADER 02354naa a2200409 a 4500
001 2118083
005 2020-07-03
008 2020 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.21577/0103-5053.20190185$2DOI
100 1 $aGUEDES, J. A. C.
245 $aGC-MS-based metabolomic profiles combined with chemometric tools and cytotoxic activities of non-polar leaf extracts of Spondias mombin L. and Spondias tuberosa Arr. Cam.$h[electronic resource]
260 $c2020
520 $aAgroindustrial residues, such as leaves of fruit plants, can be sources of bioactive molecules, thus adding value to co-products that are rarely explored in agroindustry. In this context, this study aimed to look into the phytochemical profiles in detail and to explore the antitumor potential of S. tuberosa and S. mombin leaves. We observed that, S. tuberosa leaf extract was cytotoxic in both tumor and healthy cells. S. mombin extracts selectively inhibited cell proliferation in the tumor cell line for prostate cancer (PC3) and did not significantly affect healthy cells. The metabolic profiles of the extracts were evaluated by gas chromatography coupled with mass spectrometry and twenty-three metabolites were identified. The correlation of metabolic profiles with cytotoxic tests indicated possible chemical markers that may be responsible for the inhibition of cell proliferation. This study revealed that the unexplored co-products in agroindustry may have great therapeutic potential, and therefore should be screened for biologically active compounds
650 $aChromatography
650 $aMetabolomics
650 $aSpondias
650 $aYellow mombins
650 $aCromatografia
650 $aSpondias Mombin
650 $aUmbu
653 $aAgroindustria
653 $aCo-produto
653 $aMetabolômica
653 $aResiduo agroindustrial
700 1 $aALVES FILHO, E. DE G.
700 1 $aSILVA, M. F. S.
700 1 $aRODRIGUES, T. H. S.
700 1 $aRAMIRES, C. M. C.
700 1 $aLIMA, M. A. C. de
700 1 $aSILVA, G. S. DA
700 1 $aPESSOA, C. DO Ó
700 1 $aCANUTO, K. M.
700 1 $aBRITO, E. S. de
700 1 $aALVES, R. E.
700 1 $aNASCIMENTO, R. F. DO
700 1 $aZOCOLO, G. J.
773 $tJournal of the Brazilian Chemical Society, Campinas$gv. 31, n. 2, p. 331-340, 2020.
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Registro original: |
Embrapa Agroindústria Tropical (CNPAT) |
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| Registros recuperados : 1 | |
| 1. |  | GUEDES, J. A. C.; ALVES FILHO, E. DE G.; SILVA, M. F. S.; RODRIGUES, T. H. S.; RAMIRES, C. M. C.; LIMA, M. A. C. de; SILVA, G. S. DA; PESSOA, C. DO Ó; CANUTO, K. M.; BRITO, E. S. de; ALVES, R. E.; NASCIMENTO, R. F. DO; ZOCOLO, G. J. GC-MS-based metabolomic profiles combined with chemometric tools and cytotoxic activities of non-polar leaf extracts of Spondias mombin L. and Spondias tuberosa Arr. Cam. Journal of the Brazilian Chemical Society, Campinas, v. 31, n. 2, p. 331-340, 2020.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 2 |
| Biblioteca(s): Embrapa Agroindústria Tropical; Embrapa Semiárido. |
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| Registros recuperados : 1 | |
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