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Registro Completo |
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Biblioteca(s): |
Embrapa Pecuária Sudeste. |
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Data corrente: |
19/02/2019 |
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Data da última atualização: |
19/02/2019 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
BAENA, M. M.; TIZIOTO, P. C.; MEIRELLES, S. L. C.; REGITANO, L. C. de A. |
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Afiliação: |
Marielle Moura Baena, UFLA; Polyana Cristiane Tizioto, UFSCAR; Sarah Laguna Conceição Meirelles, UFLA; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE. |
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Título: |
HSF1 and HSPA6 as functional candidate genes associated with heat tolerance in Angus cattle. |
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Ano de publicação: |
2018 |
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Fonte/Imprenta: |
Revista Brasileira de Zootecnia, v.47,e20160390, p. 2-7, 2018. |
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DOI: |
https://doi.org/10.1590/rbz4720160390 |
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Idioma: |
Inglês |
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Conteúdo: |
The purpose of this study was to access and characterize single nucleotide polymorphisms (SNP) located within the HSF1 and HSPA6 candidate genes for adaptability in Angus breed raised in subtropical climate. Samples of DNA from 20 animals representing extreme phenotypes for adaptability traits were obtained. Sequence variations in the candidate genes were described by sequencing target regions. We identified 12 SNP located in the HSF1 gene. Moreover, four of the six SNP found in the HSPA6 gene cause amino acid substitutions in protein-coding regions. We also identified a representative SNP (called tag SNP) in a region of the HSF1 gene with high linkage disequilibrium (r2 = 0.87) that may represent 11 SNP located in this gene. Minor allele frequency observed for the SNP ranged from 0.10 to 0.50 and 0.02 to 0.21 for the HSF1 and the HSPA6 genes, respectively. Overall, almost all SNP analyzed showed significant deviation from the Hardy-Weinberg Equilibrium and half of the loci had heterozygosity greater than 0.50. The data suggest that there is sequence variability in these genes that could be exploited by breeding programs. There is genetic variation in HSF1 and HSPA6 genes in this populations of Angus breed, which is fundamental to obtain response to selection. |
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Palavras-Chave: |
Molecular makers; Raça Angus. |
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Thesagro: |
Bovino; Gado de Corte. |
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Thesaurus Nal: |
Angus; Beef cattle; Thermoregulation. |
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Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/193054/1/10-HSF1HSPA60functionalcandidate.pdf
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Marc: |
LEADER 02041naa a2200253 a 4500
001 2106259
005 2019-02-19
008 2018 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1590/rbz4720160390$2DOI
100 1 $aBAENA, M. M.
245 $aHSF1 and HSPA6 as functional candidate genes associated with heat tolerance in Angus cattle.$h[electronic resource]
260 $c2018
520 $aThe purpose of this study was to access and characterize single nucleotide polymorphisms (SNP) located within the HSF1 and HSPA6 candidate genes for adaptability in Angus breed raised in subtropical climate. Samples of DNA from 20 animals representing extreme phenotypes for adaptability traits were obtained. Sequence variations in the candidate genes were described by sequencing target regions. We identified 12 SNP located in the HSF1 gene. Moreover, four of the six SNP found in the HSPA6 gene cause amino acid substitutions in protein-coding regions. We also identified a representative SNP (called tag SNP) in a region of the HSF1 gene with high linkage disequilibrium (r2 = 0.87) that may represent 11 SNP located in this gene. Minor allele frequency observed for the SNP ranged from 0.10 to 0.50 and 0.02 to 0.21 for the HSF1 and the HSPA6 genes, respectively. Overall, almost all SNP analyzed showed significant deviation from the Hardy-Weinberg Equilibrium and half of the loci had heterozygosity greater than 0.50. The data suggest that there is sequence variability in these genes that could be exploited by breeding programs. There is genetic variation in HSF1 and HSPA6 genes in this populations of Angus breed, which is fundamental to obtain response to selection.
650 $aAngus
650 $aBeef cattle
650 $aThermoregulation
650 $aBovino
650 $aGado de Corte
653 $aMolecular makers
653 $aRaça Angus
700 1 $aTIZIOTO, P. C.
700 1 $aMEIRELLES, S. L. C.
700 1 $aREGITANO, L. C. de A.
773 $tRevista Brasileira de Zootecnia$gv.47,e20160390, p. 2-7, 2018.
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Embrapa Pecuária Sudeste (CPPSE) |
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