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Registro Completo |
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Biblioteca(s): |
Embrapa Gado de Corte. |
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Data corrente: |
18/12/2018 |
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Data da última atualização: |
18/12/2018 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
BLECHA, I. M. Z.; CSORDAS, B. G.; AGUIRRE, A. de A. R.; CUNHA, R. C.; GARCIA, M. V.; ANDREOTTI, R. |
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Afiliação: |
Isabella Maiumi Zaidan Blecha, Laboratório de Biologia do Carrapato/Embrapa Gado de Corte; Bárbara Guimarães Csordas, Laboratório de Biologia do Carrapato/Embrapa Gado de Corte; André de Abreu Rangel Aguirre, Laboratório de Entomologia Médica/Fundação Oswaldo Cruz – FIOCRUZ; Rodrigo Casquero Cunha, Programa de Pós-graduação em Biotecnologia, Núcleo de Biotecnologia/Centro de Desenvolvimento Tecnológico – CDTec/Universidade Federal de Pelotas – UFPel; Marcos Valério Garcia, Programa de Desenvolvimento Científico Regional – DCR/Fundação de Apoio ao Desenvolvimento do Ensino, Ciência e Tecnologia – FUNDECT; RENATO ANDREOTTI E SILVA, CNPGC. |
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Título: |
Analysis of Bm86 conserved epitopes: is a global vaccine against Cattle Tick Rhipicephalus microplus possible? |
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Ano de publicação: |
2018 |
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Fonte/Imprenta: |
Revista Brasileira de Parasitologia Veterinária, Jaboticabal, v. 27, n. 3, p. 267-279, july.-sept. 2018 |
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Idioma: |
Inglês |
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Notas: |
Título em português: Análise de epítopos conservados da Bm86: é possível uma vacina global contra Carrapato-do-Boi Rhipicephalus microplus? |
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Conteúdo: |
The cattle tick Rhipicephalus microplus causes significant economic losses in agribusiness. Control of this tick is achieved mainly through the application of chemical acaricides, often resulting in contamination of animal food products and of the environment. Another major concern associated with acaricide use is the increasing reports of resistance of this tick vector against the active ingredients of many commercial products. An alternative control method is vaccination. However, the commercially available vaccine based on a protein homologous to Bm86 exhibits variations in efficacy relative to the different geographical locations. This study aimed to identify antigenic determinants of the sequences of proteins homologous to Bm86. Phylogenetic analyses were performed to determine the extent of divergence between different populations of R. microplus to identify the sequence that could be used as a universal vaccine against the multiple geographically distinct populations of R. microplus and related tick species. Considering the extensive sequence and functional polymorphism observed among strains of R. microplus from different geographical regions, we can conclude that it may be possible to achieve effective vaccination against these cattle ticks using a single universal Bm86-based antigen. |
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Palavras-Chave: |
Análise filogenética; Immuno-bioinformatics; Imuno Bioinformática; Phylogenetic analyses. |
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Thesagro: |
Boi; Carrapato. |
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Thesaurus Nal: |
Rhipicephalus microplus; Ticks. |
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Categoria do assunto: |
-- |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/188726/1/Analysis-of-Bm86-conserved.pdf
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Marc: |
LEADER 02358naa a2200289 a 4500
001 2101841
005 2018-12-18
008 2018 bl uuuu u00u1 u #d
100 1 $aBLECHA, I. M. Z.
245 $aAnalysis of Bm86 conserved epitopes$bis a global vaccine against Cattle Tick Rhipicephalus microplus possible?$h[electronic resource]
260 $c2018
500 $aTítulo em português: Análise de epítopos conservados da Bm86: é possível uma vacina global contra Carrapato-do-Boi Rhipicephalus microplus?
520 $aThe cattle tick Rhipicephalus microplus causes significant economic losses in agribusiness. Control of this tick is achieved mainly through the application of chemical acaricides, often resulting in contamination of animal food products and of the environment. Another major concern associated with acaricide use is the increasing reports of resistance of this tick vector against the active ingredients of many commercial products. An alternative control method is vaccination. However, the commercially available vaccine based on a protein homologous to Bm86 exhibits variations in efficacy relative to the different geographical locations. This study aimed to identify antigenic determinants of the sequences of proteins homologous to Bm86. Phylogenetic analyses were performed to determine the extent of divergence between different populations of R. microplus to identify the sequence that could be used as a universal vaccine against the multiple geographically distinct populations of R. microplus and related tick species. Considering the extensive sequence and functional polymorphism observed among strains of R. microplus from different geographical regions, we can conclude that it may be possible to achieve effective vaccination against these cattle ticks using a single universal Bm86-based antigen.
650 $aRhipicephalus microplus
650 $aTicks
650 $aBoi
650 $aCarrapato
653 $aAnálise filogenética
653 $aImmuno-bioinformatics
653 $aImuno Bioinformática
653 $aPhylogenetic analyses
700 1 $aCSORDAS, B. G.
700 1 $aAGUIRRE, A. de A. R.
700 1 $aCUNHA, R. C.
700 1 $aGARCIA, M. V.
700 1 $aANDREOTTI, R.
773 $tRevista Brasileira de Parasitologia Veterinária, Jaboticabal$gv. 27, n. 3, p. 267-279, july.-sept. 2018
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Registro original: |
Embrapa Gado de Corte (CNPGC) |
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| 1. |  | BLECHA, I. M. Z.; CSORDAS, B. G.; AGUIRRE, A. de A. R.; CUNHA, R. C.; GARCIA, M. V.; ANDREOTTI, R. Analysis of Bm86 conserved epitopes: is a global vaccine against Cattle Tick Rhipicephalus microplus possible? Revista Brasileira de Parasitologia Veterinária, Jaboticabal, v. 27, n. 3, p. 267-279, july.-sept. 2018 Título em português: Análise de epítopos conservados da Bm86: é possível uma vacina global contra Carrapato-do-Boi Rhipicephalus microplus?| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 2 |
| Biblioteca(s): Embrapa Gado de Corte. |
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| Registros recuperados : 1 | |
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