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Registro Completo |
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Biblioteca(s): |
Embrapa Gado de Corte. |
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Data corrente: |
21/02/2018 |
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Data da última atualização: |
21/02/2018 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
BIGI, M. M.; BLANCO, F. C.; ARAUJO, F. R.; THACKER, T. C.; ZUMÁRRAGA, M. J.; CATALDI, A. A.; SORIA, M. A.; BIGI, F. |
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Afiliação: |
María M. Bigi, School of Agronomy - UBA; Federico Carlos Blanco, Biotechnology Institute/National Institute of Agricultural Technology - INTA; FLABIO RIBEIRO ARAUJO, CNPGC; Tyler C. Thacker, United States Department of Agriculture/Agricultural Research Service/National Animal Disease Center; Martín J. Zumárraga, Biotechnology Institute/National Institute of Agricultural Technology - INTA; Angel A. Cataldi, Biotechnology Institute/National Institute of Agricultural Technology - INTA; Marcelo A. Soria, School of Agronomy - UBA; Fabiana Bigi, Biotechnology Institute/National Institute of Agricultural Technology - INTA. |
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Título: |
Polymorphisms of 20 regulatory proteins between Mycobacterium tuberculosis and Mycobacterium bovis. |
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Ano de publicação: |
2016 |
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Fonte/Imprenta: |
Microbiology and Immunology, v. 60, n. 8, p. 552-560, August 2016 |
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Idioma: |
Inglês |
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Conteúdo: |
Mycobacterium tuberculosis and Mycobacterium bovis are responsible for tuberculosis in humans and animals, respectively. Both species are closely related and belong to the Mycobacterium tuberculosis complex (MTC). M. tuberculosis is the most ancient species from which M. bovis and other members of the MTCevolved. The genome of M. bovis is over>99.95% identical to that of M. tuberculosis but with seven deletions ranging in size from 1 to 12.7 kb. In addition, 1200 single nucleotide mutations in coding regions distinguish M. bovis from M. tuberculosis. In the present study, we assessed 75 M. tuberculosis genomes and 23 M. bovis genomes to identify non-synonymous mutations in 202 coding sequences of regulatory genes between both species. We identified species-specific variants in 20 regulatory proteins and confirmed differential expression of hypoxia-related genes between M. bovis and M. tuberculosis. |
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Palavras-Chave: |
Regulator. |
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Thesagro: |
Anoxia; Mycobacterium Bovis; Polimorfismo. |
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Thesaurus Nal: |
Mycobacterium tuberculosis; Polymorphism. |
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Categoria do assunto: |
-- |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/172939/1/27-Polymorphisms-of-20-regulatory-proteins-between-Mycobacterium-tuberculosis-and-Mycobacterium-bovis-2016.pdf
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Marc: |
LEADER 01718naa a2200277 a 4500
001 2087980
005 2018-02-21
008 2016 bl uuuu u00u1 u #d
100 1 $aBIGI, M. M.
245 $aPolymorphisms of 20 regulatory proteins between Mycobacterium tuberculosis and Mycobacterium bovis.$h[electronic resource]
260 $c2016
520 $aMycobacterium tuberculosis and Mycobacterium bovis are responsible for tuberculosis in humans and animals, respectively. Both species are closely related and belong to the Mycobacterium tuberculosis complex (MTC). M. tuberculosis is the most ancient species from which M. bovis and other members of the MTCevolved. The genome of M. bovis is over>99.95% identical to that of M. tuberculosis but with seven deletions ranging in size from 1 to 12.7 kb. In addition, 1200 single nucleotide mutations in coding regions distinguish M. bovis from M. tuberculosis. In the present study, we assessed 75 M. tuberculosis genomes and 23 M. bovis genomes to identify non-synonymous mutations in 202 coding sequences of regulatory genes between both species. We identified species-specific variants in 20 regulatory proteins and confirmed differential expression of hypoxia-related genes between M. bovis and M. tuberculosis.
650 $aMycobacterium tuberculosis
650 $aPolymorphism
650 $aAnoxia
650 $aMycobacterium Bovis
650 $aPolimorfismo
653 $aRegulator
700 1 $aBLANCO, F. C.
700 1 $aARAUJO, F. R.
700 1 $aTHACKER, T. C.
700 1 $aZUMÁRRAGA, M. J.
700 1 $aCATALDI, A. A.
700 1 $aSORIA, M. A.
700 1 $aBIGI, F.
773 $tMicrobiology and Immunology$gv. 60, n. 8, p. 552-560, August 2016
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Embrapa Gado de Corte (CNPGC) |
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| 1. |  | BIGI, M. M.; BLANCO, F. C.; ARAUJO, F. R.; THACKER, T. C.; ZUMÁRRAGA, M. J.; CATALDI, A. A.; SORIA, M. A.; BIGI, F. Polymorphisms of 20 regulatory proteins between Mycobacterium tuberculosis and Mycobacterium bovis. Microbiology and Immunology, v. 60, n. 8, p. 552-560, August 2016| Tipo: Artigo em Periódico Indexado | Circulação/Nível: B - 2 |
| Biblioteca(s): Embrapa Gado de Corte. |
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