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 | Acesso ao texto completo restrito à biblioteca da Embrapa Pecuária Sudeste. Para informações adicionais entre em contato com cppse.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Gado de Corte; Embrapa Pecuária Sudeste. |
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Data corrente: |
19/02/2018 |
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Data da última atualização: |
18/07/2019 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
ROMEROA, A. R. da S.; SIQUEIRA, F.; SANTIAGO, G. G.; REGITANO, L. C. de A.; SOUZA JÚNIOR, M. D. de; TORRES JúNIOR, R. A. de A.; NASCIMENTO, A. V. do; GRISOLIA, A. B. |
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Afiliação: |
Andrea Renata da Silva Romeroa, Federal University of Dourados - UFGD; FABIANE SIQUEIRA, CNPGC; Gustavo Garcia Santiago, Federal University of Mato Grosso do Sul - UFMS; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE; Maury Dorta de Souza Júnior, Brazilian Association of Canchim Cattle Breeders - ABCCAN; Roberto Augusto de Almeida Torres Júnior; André Vieira do Nascimento, São Paulo State University - UNESP; Alexeia Barufatti Grisolia, Federal University of Dourados - UFGD. |
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Título: |
Prospecting genes associated with navel length, coat and scrotal circumference traits in Canchim cattle. |
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Ano de publicação: |
2018 |
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Fonte/Imprenta: |
Livestock Science, v. 210, p. 33-38, April 2018 |
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Idioma: |
Inglês |
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Conteúdo: |
The aim of this work was to identify genomic regions and genes in association with the navel length, coat and scrotal circumference traits of Canchim breed of cattle, using genome-wide association studies (GWAS). Imputed data from single nucleotide polymorphism type markers were used, with accuracy greater than 95%. The analyses of genome-wide association were conducted by the Bayes B method, implemented in the GenSel program. Non-overlapping windows that explained at least 0.19% of the additive genetic variance were considered as significant, this value corresponds five times the expected for 1 Mb size windows. GWAS indicated 31 regions in association with navel length, one coat region, and four SC-related regions. In these regions, 4 quantitative loci (QTLs) related to navel length and 5 with SC were identified, as for the coat, the QTLs detected did not present previously described relation with this trait. Among the candidate genes in the associated regions, 7 genes were cited in previous studies, with biological functions related to navel length, one for coat and three for SC. The candidate genes TMEM176A and TMEM176AB, which are orthologous in humans, are in association with navel's trait and compose the Androgen Induced 1 cluster. The identification of genes and QTLs, with a function related to the studied traits, previously described in the literature, reinforces the evidence that the found regions are associated with navel length, coat and SC. This information may contribute to the understanding of the genetic architecture involved with of these traits, to guiding genetic validation studies, gene introgression and contribute to include information concerning molecular markers in genetic evaluation of animal improvement programs. MenosThe aim of this work was to identify genomic regions and genes in association with the navel length, coat and scrotal circumference traits of Canchim breed of cattle, using genome-wide association studies (GWAS). Imputed data from single nucleotide polymorphism type markers were used, with accuracy greater than 95%. The analyses of genome-wide association were conducted by the Bayes B method, implemented in the GenSel program. Non-overlapping windows that explained at least 0.19% of the additive genetic variance were considered as significant, this value corresponds five times the expected for 1 Mb size windows. GWAS indicated 31 regions in association with navel length, one coat region, and four SC-related regions. In these regions, 4 quantitative loci (QTLs) related to navel length and 5 with SC were identified, as for the coat, the QTLs detected did not present previously described relation with this trait. Among the candidate genes in the associated regions, 7 genes were cited in previous studies, with biological functions related to navel length, one for coat and three for SC. The candidate genes TMEM176A and TMEM176AB, which are orthologous in humans, are in association with navel's trait and compose the Androgen Induced 1 cluster. The identification of genes and QTLs, with a function related to the studied traits, previously described in the literature, reinforces the evidence that the found regions are associated with navel length, coat and SC. This information may c... Mostrar Tudo |
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Palavras-Chave: |
GWAS; Inference Bayesian; Polymorphisms. |
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Thesaurus Nal: |
Single nucleotide polymorphism. |
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Categoria do assunto: |
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G Melhoramento Genético |
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Marc: |
LEADER 02557naa a2200253 a 4500
001 2087833
005 2019-07-18
008 2018 bl uuuu u00u1 u #d
100 1 $aROMEROA, A. R. da S.
245 $aProspecting genes associated with navel length, coat and scrotal circumference traits in Canchim cattle.$h[electronic resource]
260 $c2018
520 $aThe aim of this work was to identify genomic regions and genes in association with the navel length, coat and scrotal circumference traits of Canchim breed of cattle, using genome-wide association studies (GWAS). Imputed data from single nucleotide polymorphism type markers were used, with accuracy greater than 95%. The analyses of genome-wide association were conducted by the Bayes B method, implemented in the GenSel program. Non-overlapping windows that explained at least 0.19% of the additive genetic variance were considered as significant, this value corresponds five times the expected for 1 Mb size windows. GWAS indicated 31 regions in association with navel length, one coat region, and four SC-related regions. In these regions, 4 quantitative loci (QTLs) related to navel length and 5 with SC were identified, as for the coat, the QTLs detected did not present previously described relation with this trait. Among the candidate genes in the associated regions, 7 genes were cited in previous studies, with biological functions related to navel length, one for coat and three for SC. The candidate genes TMEM176A and TMEM176AB, which are orthologous in humans, are in association with navel's trait and compose the Androgen Induced 1 cluster. The identification of genes and QTLs, with a function related to the studied traits, previously described in the literature, reinforces the evidence that the found regions are associated with navel length, coat and SC. This information may contribute to the understanding of the genetic architecture involved with of these traits, to guiding genetic validation studies, gene introgression and contribute to include information concerning molecular markers in genetic evaluation of animal improvement programs.
650 $aSingle nucleotide polymorphism
653 $aGWAS
653 $aInference Bayesian
653 $aPolymorphisms
700 1 $aSIQUEIRA, F.
700 1 $aSANTIAGO, G. G.
700 1 $aREGITANO, L. C. de A.
700 1 $aSOUZA JÚNIOR, M. D. de
700 1 $aTORRES JúNIOR, R. A. de A.
700 1 $aNASCIMENTO, A. V. do
700 1 $aGRISOLIA, A. B.
773 $tLivestock Science$gv. 210, p. 33-38, April 2018
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Embrapa Gado de Corte (CNPGC) |
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| 1. |  | ROMEROA, A. R. da S.; SIQUEIRA, F.; SANTIAGO, G. G.; REGITANO, L. C. de A.; SOUZA JÚNIOR, M. D. de; TORRES JúNIOR, R. A. de A.; NASCIMENTO, A. V. do; GRISOLIA, A. B. Prospecting genes associated with navel length, coat and scrotal circumference traits in Canchim cattle. Livestock Science, v. 210, p. 33-38, April 2018| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 2 |
| Biblioteca(s): Embrapa Gado de Corte; Embrapa Pecuária Sudeste. |
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