| |
|
|
|
Registro Completo |
|
Biblioteca(s): |
Embrapa Agricultura Digital. |
|
Data corrente: |
17/10/2017 |
|
Data da última atualização: |
17/10/2017 |
|
Autoria: |
ROJAS, T. C. G.; MALUTA, R. P.; KOENIGKAN, L. V.; SILVEIRA, W. D. da. |
|
Afiliação: |
THAÍS C. G. ROJAS, IB/Unicamp; RENATO P. MALUTA, IB/Unicamp; LUCIANO VIEIRA KOENIGKAN, CNPTIA; WANDERLEY DIAS DA SILVEIRA, IB/Unicamp. |
|
Título: |
In silico phylogenetic and virulence gene profile analyses of avian pathogenic Escherichia coli genome sequences. |
|
Ano de publicação: |
2014 |
|
Fonte/Imprenta: |
Pesquisa Veterinária Brasileira, Rio de Janeiro, v. 34, n. 2, p. 129-133, fev. 2014. |
|
DOI: |
http://dx.doi.org/10.1590/S0100-736X2014000200006 |
|
Idioma: |
Inglês |
|
Conteúdo: |
Avian pathogenic Escherichia coli (APEC) infections are responsible for significant losses in the poultry industry worldwide. A zoonotic risk has been attributed to APEC strains because they present similarities to extraintestinal pathogenic E. coli (ExPEC) associated with illness in humans, mainly urinary tract infections and neonatal meningitis. Here, we present in silico analyses with pathogenic E. coli genome sequences, including recently available APEC genomes. The phylogenetic tree, based on multi-locus sequence typing (MLST) of seven housekeeping genes, revealed high diversity in the allelic composition. Nevertheless, despite this diversity, the phylogenetic tree was able to cluster the different pathotypes together. An in silico virulence gene profile was also determined for each of these strains, through the presence or absence of 83 well-known virulence genes/traits described in pathogenic E. coli strains. The MLST phylogeny and the virulence gene profiles demonstrated a certain genetic similarity between Brazilian APEC strains, APEC isolated in the United States, UPEC (uropathogenic E. coli) and diarrheagenic strains isolated from humans. This correlation corroborates and reinforces the zoonotic potential hypothesis proposed to APEC. |
|
Palavras-Chave: |
Análise in silico; Árvore filogenética; Avian pathogenic Escherichia coli; Genes associados à virulência; Multi-locus Sequence Typing; Phylogenetic tree; Tipagem de sequência multilocus; Virulence genes. |
|
Thesagro: |
Escherichia Coli. |
|
Categoria do assunto: |
-- |
|
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/165169/1/AP-Insilico-Rojasetal-2014.pdf
|
|
Marc: |
LEADER 02243naa a2200277 a 4500
001 2077504
005 2017-10-17
008 2014 bl uuuu u00u1 u #d
024 7 $ahttp://dx.doi.org/10.1590/S0100-736X2014000200006$2DOI
100 1 $aROJAS, T. C. G.
245 $aIn silico phylogenetic and virulence gene profile analyses of avian pathogenic Escherichia coli genome sequences.$h[electronic resource]
260 $c2014
520 $aAvian pathogenic Escherichia coli (APEC) infections are responsible for significant losses in the poultry industry worldwide. A zoonotic risk has been attributed to APEC strains because they present similarities to extraintestinal pathogenic E. coli (ExPEC) associated with illness in humans, mainly urinary tract infections and neonatal meningitis. Here, we present in silico analyses with pathogenic E. coli genome sequences, including recently available APEC genomes. The phylogenetic tree, based on multi-locus sequence typing (MLST) of seven housekeeping genes, revealed high diversity in the allelic composition. Nevertheless, despite this diversity, the phylogenetic tree was able to cluster the different pathotypes together. An in silico virulence gene profile was also determined for each of these strains, through the presence or absence of 83 well-known virulence genes/traits described in pathogenic E. coli strains. The MLST phylogeny and the virulence gene profiles demonstrated a certain genetic similarity between Brazilian APEC strains, APEC isolated in the United States, UPEC (uropathogenic E. coli) and diarrheagenic strains isolated from humans. This correlation corroborates and reinforces the zoonotic potential hypothesis proposed to APEC.
650 $aEscherichia Coli
653 $aAnálise in silico
653 $aÁrvore filogenética
653 $aAvian pathogenic Escherichia coli
653 $aGenes associados à virulência
653 $aMulti-locus Sequence Typing
653 $aPhylogenetic tree
653 $aTipagem de sequência multilocus
653 $aVirulence genes
700 1 $aMALUTA, R. P.
700 1 $aKOENIGKAN, L. V.
700 1 $aSILVEIRA, W. D. da
773 $tPesquisa Veterinária Brasileira, Rio de Janeiro$gv. 34, n. 2, p. 129-133, fev. 2014.
Download
Esconder MarcMostrar Marc Completo |
|
Registro original: |
Embrapa Agricultura Digital (CNPTIA) |
|
|
Biblioteca |
ID |
Origem |
Tipo/Formato |
Classificação |
Cutter |
Registro |
Volume |
Status |
URL |
Voltar
|
|
|
| Registros recuperados : 1 | |
| Registros recuperados : 1 | |
|
| Nenhum registro encontrado para a expressão de busca informada. |
|
|
