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Registro Completo |
Biblioteca(s): |
Embrapa Florestas. |
Data corrente: |
14/07/2017 |
Data da última atualização: |
03/01/2018 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Autoria: |
SANTOS, V. S.; MARTINS FILHO, S.; RESENDE, M. D. V. de; AZEVEDO, C. F.; LOPES, P. S.; GUIMARÃES, S. E. F.; SILVA, F. F. |
Afiliação: |
V. S. SANTOS, Departamento de Estatística, Universidade Federal de Viçosa; S. MARTINS FILHO, Departamento de Estatística, Universidade Federal de Viçosa; MARCOS DEON VILELA DE RESENDE, CNPF; C. F. AZEVEDO, Departamento de Estatística, Universidade Federal de Viçosa; P. S. LOPES, Departamento de Zootecnia, Universidade Federal de Viçosa; S. E. F. GUIMARÃES, Departamento de Zootecnia, Universidade Federal de Viçosa; F. F. SILVA, Departamento de Zootecnia, Universidade Federal de Viçosa. |
Título: |
Genomic prediction for additive and dominance effects of censored traits in pigs. |
Ano de publicação: |
2016 |
Fonte/Imprenta: |
Genetics and Molecular Research, v. 15, n. 4, gmr15048764, Oct. 2016. |
DOI: |
http://dx.doi.org/10.4238/gmr15048764 |
Idioma: |
Inglês |
Conteúdo: |
Age at the time of slaughter is a commonly used trait in animal breeding programs. Since studying this trait involves incomplete observations (censoring), analysis can be performed using survival models or modified linear models, for example, by sampling censored data from truncated normal distributions. For genomic selection, the greatest genetic gains can be achieved by including non-additive genetic effects like dominance. Thus, censored traits with effects on both survival models have not yet been studied under a genomic selection approach. We aimed to predict genomic values using the Cox model with dominance effects and compare these results with the linear model with and without censoring. Linear models were fitted via the maximum likelihood method. For censored data, sampling through the truncated normal distribution was used, and the model was called
the truncated normal linear via Gibbs sampling (TNL). We used an F2
pig population; the response variable was time (days) from birth to
slaughter. Data were previously adjusted for fixed effects of sex and
contemporary group. The model predictive ability was calculated based
on correlation of predicted genomic values with adjusted phenotypic
values. The results showed that both with and without censoring, there
was high agreement between Cox and linear models in selection of
individuals and markers. Despite including the dominance effect, there
was no increase in predictive ability. This study showed, for the first
time, the possibility of performing genomic prediction of traits with
censored records while using the Cox survival model with additive and
dominance effects. MenosAge at the time of slaughter is a commonly used trait in animal breeding programs. Since studying this trait involves incomplete observations (censoring), analysis can be performed using survival models or modified linear models, for example, by sampling censored data from truncated normal distributions. For genomic selection, the greatest genetic gains can be achieved by including non-additive genetic effects like dominance. Thus, censored traits with effects on both survival models have not yet been studied under a genomic selection approach. We aimed to predict genomic values using the Cox model with dominance effects and compare these results with the linear model with and without censoring. Linear models were fitted via the maximum likelihood method. For censored data, sampling through the truncated normal distribution was used, and the model was called
the truncated normal linear via Gibbs sampling (TNL). We used an F2
pig population; the response variable was time (days) from birth to
slaughter. Data were previously adjusted for fixed effects of sex and
contemporary group. The model predictive ability was calculated based
on correlation of predicted genomic values with adjusted phenotypic
values. The results showed that both with and without censoring, there
was high agreement between Cox and linear models in selection of
individuals and markers. Despite including the dominance effect, there
was no increase in predictive ability. This study showed, for the first
time,... Mostrar Tudo |
Palavras-Chave: |
Censored data; GBLUP; Mixed model; Modelo mixto; Survival models. |
Thesagro: |
Porco; Suíno. |
Thesaurus Nal: |
Animal breeding; Swine. |
Categoria do assunto: |
G Melhoramento Genético |
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/161816/1/2016-M.Deon-GMR-Genomic.pdf
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Marc: |
LEADER 02545naa a2200313 a 4500 001 2072712 005 2018-01-03 008 2016 bl uuuu u00u1 u #d 024 7 $ahttp://dx.doi.org/10.4238/gmr15048764$2DOI 100 1 $aSANTOS, V. S. 245 $aGenomic prediction for additive and dominance effects of censored traits in pigs.$h[electronic resource] 260 $c2016 520 $aAge at the time of slaughter is a commonly used trait in animal breeding programs. Since studying this trait involves incomplete observations (censoring), analysis can be performed using survival models or modified linear models, for example, by sampling censored data from truncated normal distributions. For genomic selection, the greatest genetic gains can be achieved by including non-additive genetic effects like dominance. Thus, censored traits with effects on both survival models have not yet been studied under a genomic selection approach. We aimed to predict genomic values using the Cox model with dominance effects and compare these results with the linear model with and without censoring. Linear models were fitted via the maximum likelihood method. For censored data, sampling through the truncated normal distribution was used, and the model was called the truncated normal linear via Gibbs sampling (TNL). We used an F2 pig population; the response variable was time (days) from birth to slaughter. Data were previously adjusted for fixed effects of sex and contemporary group. The model predictive ability was calculated based on correlation of predicted genomic values with adjusted phenotypic values. The results showed that both with and without censoring, there was high agreement between Cox and linear models in selection of individuals and markers. Despite including the dominance effect, there was no increase in predictive ability. This study showed, for the first time, the possibility of performing genomic prediction of traits with censored records while using the Cox survival model with additive and dominance effects. 650 $aAnimal breeding 650 $aSwine 650 $aPorco 650 $aSuíno 653 $aCensored data 653 $aGBLUP 653 $aMixed model 653 $aModelo mixto 653 $aSurvival models 700 1 $aMARTINS FILHO, S. 700 1 $aRESENDE, M. D. V. de 700 1 $aAZEVEDO, C. F. 700 1 $aLOPES, P. S. 700 1 $aGUIMARÃES, S. E. F. 700 1 $aSILVA, F. F. 773 $tGenetics and Molecular Research$gv. 15, n. 4, gmr15048764, Oct. 2016.
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Embrapa Florestas (CNPF) |
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1. | | SANTOS, V. S.; MARTINS FILHO, S.; RESENDE, M. D. V. de; AZEVEDO, C. F.; LOPES, P. S.; GUIMARÃES, S. E. F.; SILVA, F. F. Genomic prediction for additive and dominance effects of censored traits in pigs. Genetics and Molecular Research, v. 15, n. 4, gmr15048764, Oct. 2016.Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
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